Definition Akkermansia muciniphila ATCC BAA-835, complete genome.
Accession NC_010655
Length 2,664,102

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The map label for this gene is metK

Identifier: 187735563

GI number: 187735563

Start: 1274628

End: 1275812

Strand: Direct

Name: metK

Synonym: Amuc_1068

Alternate gene names: 187735563

Gene position: 1274628-1275812 (Clockwise)

Preceding gene: 187735561

Following gene: 187735564

Centisome position: 47.84

GC content: 56.79

Gene sequence:

>1185_bases
ATGAGCAGAAACACCCCTCACATCTTTACGTCGGAATCCGTTGGAGAAGGCCATCCGGACAAGGTGGCCGACTACATTTC
CGACTCTATTTTAGACGCCTGCCTGGCTCAAGACAAAACTAGCCGCGTTGCATGTGAAACGTTGGTGAAGAGCAATATGG
TCATTATTGCCGGAGAGCTGACGACCAAGGCGGTGATCGATCCGGAAAAAATCGCCCGCCAGGCCATTCGGGAGATCGGG
TACTGCAACAGGCAGGACGACGACGTTTTCCATGCGGATACCGTCTTTTTCACGAATCTGCTCACGGAACAGTCCCCGGA
TATTGCCCAGGGGGTGGATGCCCGGGAGGCGGAGGGCAAGGGCCATGCGGAGCAGGGCGCCGGAGACCAGGGCATTATGT
TCGGCTTCGCAACGAATGAGACGCCGGAGCTGCTTCCGGCCCCCATCGTGTTTGCGCACAAACTGCTCATTGAGCTGGCC
AGGAGGCGCAAACGCGGGCATGTGGACTGGCTGCGTCCGGACTGCAAGTCCCAGGTGGCTGTGGCCTATGACGAAGACGG
GCGTCCCGCGCATATTGAAAACGTAGTTATTTCCACCCAGCACACGGAAGACGTGGACCATGACACGATTTACTCATATT
GCGTCAAACTCATTAAAAATGTGCTTCCTGCGGAGCTTCTGGATGAGAGGACGGAATATTTCATCAACCCCACCGGGAAA
TTCGTCGTGGGCGGTCCCCACGGGGATTCCGGCCTGACGGGCCGCAAAATTATTGTGGACACGTACGGCGGCATGGGGCG
CCACGGCGGCGGAGCCTTTTCCGGAAAAGACCCGTCCAAGGTGGACCGTTCCGCCGCGTATATGTGCCGCTGGGTTGCCA
AGCACATTGTGGCTGCCGGACTGGCGGATAAATGTGAATTGCAGGTGGCTTACGCCATCGGCTACCCCGCTCCGGTTTCC
ATCCGGGTGGATACGTTCGGTACCGGGAAGGTGGAGGAAATATCCATTGAAAATGCGCTGGAAAACATCTTTTCCTTCAA
GCCTGCGGATATGGTGGAACAGCTGAACCTGCTTCGGCCTATTTACCGGAAGACGACGCACTACGGGCATTTCACCAATC
CGGAGCTGCCCTGGGAACAGCTGGACGAAACGCGCCTGGCCTCCCTGAAACAACTTCTTCATTAA

Upstream 100 bases:

>100_bases
GTTGATGATGCGCAGGCGGGTGGGATCTGCCAGGAGTTTGAGCGTTTTTAGGGTTGACTTCATAGCGGAATAATATATCA
ACACATCGAGATTTATCGAT

Downstream 100 bases:

>100_bases
TTCCTACGACAACGCTTACAGACATGTTTTCAGAAACGGAACAATACAAGGTGCGCGATATCGGCCTGGCGGATTTCGGA
CGCAGGGAACTGGATATTGC

Product: Methionine adenosyltransferase

Products: NA

Alternate protein names: AdoMet synthase; MAT; Methionine adenosyltransferase

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MSRNTPHIFTSESVGEGHPDKVADYISDSILDACLAQDKTSRVACETLVKSNMVIIAGELTTKAVIDPEKIARQAIREIG
YCNRQDDDVFHADTVFFTNLLTEQSPDIAQGVDAREAEGKGHAEQGAGDQGIMFGFATNETPELLPAPIVFAHKLLIELA
RRRKRGHVDWLRPDCKSQVAVAYDEDGRPAHIENVVISTQHTEDVDHDTIYSYCVKLIKNVLPAELLDERTEYFINPTGK
FVVGGPHGDSGLTGRKIIVDTYGGMGRHGGGAFSGKDPSKVDRSAAYMCRWVAKHIVAAGLADKCELQVAYAIGYPAPVS
IRVDTFGTGKVEEISIENALENIFSFKPADMVEQLNLLRPIYRKTTHYGHFTNPELPWEQLDETRLASLKQLLH

Sequences:

>Translated_394_residues
MSRNTPHIFTSESVGEGHPDKVADYISDSILDACLAQDKTSRVACETLVKSNMVIIAGELTTKAVIDPEKIARQAIREIG
YCNRQDDDVFHADTVFFTNLLTEQSPDIAQGVDAREAEGKGHAEQGAGDQGIMFGFATNETPELLPAPIVFAHKLLIELA
RRRKRGHVDWLRPDCKSQVAVAYDEDGRPAHIENVVISTQHTEDVDHDTIYSYCVKLIKNVLPAELLDERTEYFINPTGK
FVVGGPHGDSGLTGRKIIVDTYGGMGRHGGGAFSGKDPSKVDRSAAYMCRWVAKHIVAAGLADKCELQVAYAIGYPAPVS
IRVDTFGTGKVEEISIENALENIFSFKPADMVEQLNLLRPIYRKTTHYGHFTNPELPWEQLDETRLASLKQLLH
>Mature_393_residues
SRNTPHIFTSESVGEGHPDKVADYISDSILDACLAQDKTSRVACETLVKSNMVIIAGELTTKAVIDPEKIARQAIREIGY
CNRQDDDVFHADTVFFTNLLTEQSPDIAQGVDAREAEGKGHAEQGAGDQGIMFGFATNETPELLPAPIVFAHKLLIELAR
RRKRGHVDWLRPDCKSQVAVAYDEDGRPAHIENVVISTQHTEDVDHDTIYSYCVKLIKNVLPAELLDERTEYFINPTGKF
VVGGPHGDSGLTGRKIIVDTYGGMGRHGGGAFSGKDPSKVDRSAAYMCRWVAKHIVAAGLADKCELQVAYAIGYPAPVSI
RVDTFGTGKVEEISIENALENIFSFKPADMVEQLNLLRPIYRKTTHYGHFTNPELPWEQLDETRLASLKQLLH

Specific function: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the e

COG id: COG0192

COG function: function code H; S-adenosylmethionine synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AdoMet synthase family

Homologues:

Organism=Homo sapiens, GI5174529, Length=376, Percent_Identity=50.2659574468085, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI4557737, Length=378, Percent_Identity=49.7354497354497, Blast_Score=343, Evalue=1e-94,
Organism=Escherichia coli, GI1789311, Length=381, Percent_Identity=56.4304461942257, Blast_Score=436, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17538498, Length=385, Percent_Identity=48.3116883116883, Blast_Score=352, Evalue=2e-97,
Organism=Caenorhabditis elegans, GI25145633, Length=390, Percent_Identity=48.4615384615385, Blast_Score=350, Evalue=5e-97,
Organism=Caenorhabditis elegans, GI17538494, Length=377, Percent_Identity=49.0716180371353, Blast_Score=350, Evalue=6e-97,
Organism=Caenorhabditis elegans, GI17551082, Length=377, Percent_Identity=49.0716180371353, Blast_Score=347, Evalue=5e-96,
Organism=Caenorhabditis elegans, GI32565905, Length=377, Percent_Identity=45.3580901856764, Blast_Score=302, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI32565911, Length=340, Percent_Identity=46.1764705882353, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI25145635, Length=338, Percent_Identity=46.4497041420118, Blast_Score=289, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI32565903, Length=284, Percent_Identity=50, Blast_Score=267, Evalue=9e-72,
Organism=Caenorhabditis elegans, GI32565909, Length=74, Percent_Identity=56.7567567567568, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323209, Length=379, Percent_Identity=52.7704485488127, Blast_Score=376, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6320710, Length=386, Percent_Identity=51.5544041450777, Blast_Score=375, Evalue=1e-105,
Organism=Drosophila melanogaster, GI45552159, Length=384, Percent_Identity=47.65625, Blast_Score=330, Evalue=8e-91,
Organism=Drosophila melanogaster, GI24580529, Length=384, Percent_Identity=47.65625, Blast_Score=330, Evalue=8e-91,
Organism=Drosophila melanogaster, GI24580537, Length=384, Percent_Identity=47.65625, Blast_Score=330, Evalue=8e-91,
Organism=Drosophila melanogaster, GI24580533, Length=384, Percent_Identity=47.65625, Blast_Score=330, Evalue=8e-91,
Organism=Drosophila melanogaster, GI24580535, Length=384, Percent_Identity=47.65625, Blast_Score=330, Evalue=8e-91,
Organism=Drosophila melanogaster, GI24580531, Length=384, Percent_Identity=47.65625, Blast_Score=330, Evalue=8e-91,
Organism=Drosophila melanogaster, GI24580527, Length=386, Percent_Identity=47.1502590673575, Blast_Score=327, Evalue=1e-89,
Organism=Drosophila melanogaster, GI24580525, Length=386, Percent_Identity=47.1502590673575, Blast_Score=327, Evalue=1e-89,
Organism=Drosophila melanogaster, GI24580541, Length=367, Percent_Identity=46.3215258855586, Blast_Score=302, Evalue=3e-82,
Organism=Drosophila melanogaster, GI24580539, Length=125, Percent_Identity=48, Blast_Score=112, Evalue=5e-25,

Paralogues:

None

Copy number: 7,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): METK_AKKM8 (B2UR09)

Other databases:

- EMBL:   CP001071
- RefSeq:   YP_001877675.1
- ProteinModelPortal:   B2UR09
- SMR:   B2UR09
- GeneID:   6274042
- GenomeReviews:   CP001071_GR
- KEGG:   amu:Amuc_1068
- HOGENOM:   HBG443662
- OMA:   IYYAHRL
- ProtClustDB:   CLSK2335900
- GO:   GO:0005737
- HAMAP:   MF_00086
- InterPro:   IPR022631
- InterPro:   IPR022630
- InterPro:   IPR022629
- InterPro:   IPR022628
- InterPro:   IPR002133
- InterPro:   IPR022636
- PANTHER:   PTHR11964
- PIRSF:   PIRSF000497
- TIGRFAMs:   TIGR01034

Pfam domain/function: PF02773 S-AdoMet_synt_C; PF02772 S-AdoMet_synt_M; PF00438 S-AdoMet_synt_N; SSF55973 S-AdoMet_synt

EC number: =2.5.1.6

Molecular weight: Translated: 43516; Mature: 43384

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00376 ADOMET_SYNTHASE_1; PS00377 ADOMET_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRNTPHIFTSESVGEGHPDKVADYISDSILDACLAQDKTSRVACETLVKSNMVIIAGEL
CCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEEECC
TTKAVIDPEKIARQAIREIGYCNRQDDDVFHADTVFFTNLLTEQSPDIAQGVDAREAEGK
CHHHCCCHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHCCCCCHHHCCCCHHCCCC
GHAEQGAGDQGIMFGFATNETPELLPAPIVFAHKLLIELARRRKRGHVDWLRPDCKSQVA
CCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
VAYDEDGRPAHIENVVISTQHTEDVDHDTIYSYCVKLIKNVLPAELLDERTEYFINPTGK
EEECCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHEEECCCCC
FVVGGPHGDSGLTGRKIIVDTYGGMGRHGGGAFSGKDPSKVDRSAAYMCRWVAKHIVAAG
EEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
LADKCELQVAYAIGYPAPVSIRVDTFGTGKVEEISIENALENIFSFKPADMVEQLNLLRP
CCCCCEEEEEEEECCCCCEEEEEECCCCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHHHH
IYRKTTHYGHFTNPELPWEQLDETRLASLKQLLH
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
SRNTPHIFTSESVGEGHPDKVADYISDSILDACLAQDKTSRVACETLVKSNMVIIAGEL
CCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEEECC
TTKAVIDPEKIARQAIREIGYCNRQDDDVFHADTVFFTNLLTEQSPDIAQGVDAREAEGK
CHHHCCCHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHCCCCCHHHCCCCHHCCCC
GHAEQGAGDQGIMFGFATNETPELLPAPIVFAHKLLIELARRRKRGHVDWLRPDCKSQVA
CCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
VAYDEDGRPAHIENVVISTQHTEDVDHDTIYSYCVKLIKNVLPAELLDERTEYFINPTGK
EEECCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHEEECCCCC
FVVGGPHGDSGLTGRKIIVDTYGGMGRHGGGAFSGKDPSKVDRSAAYMCRWVAKHIVAAG
EEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
LADKCELQVAYAIGYPAPVSIRVDTFGTGKVEEISIENALENIFSFKPADMVEQLNLLRP
CCCCCEEEEEEEECCCCCEEEEEECCCCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHHHH
IYRKTTHYGHFTNPELPWEQLDETRLASLKQLLH
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA