Definition | Akkermansia muciniphila ATCC BAA-835, complete genome. |
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Accession | NC_010655 |
Length | 2,664,102 |
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The map label for this gene is metK
Identifier: 187735563
GI number: 187735563
Start: 1274628
End: 1275812
Strand: Direct
Name: metK
Synonym: Amuc_1068
Alternate gene names: 187735563
Gene position: 1274628-1275812 (Clockwise)
Preceding gene: 187735561
Following gene: 187735564
Centisome position: 47.84
GC content: 56.79
Gene sequence:
>1185_bases ATGAGCAGAAACACCCCTCACATCTTTACGTCGGAATCCGTTGGAGAAGGCCATCCGGACAAGGTGGCCGACTACATTTC CGACTCTATTTTAGACGCCTGCCTGGCTCAAGACAAAACTAGCCGCGTTGCATGTGAAACGTTGGTGAAGAGCAATATGG TCATTATTGCCGGAGAGCTGACGACCAAGGCGGTGATCGATCCGGAAAAAATCGCCCGCCAGGCCATTCGGGAGATCGGG TACTGCAACAGGCAGGACGACGACGTTTTCCATGCGGATACCGTCTTTTTCACGAATCTGCTCACGGAACAGTCCCCGGA TATTGCCCAGGGGGTGGATGCCCGGGAGGCGGAGGGCAAGGGCCATGCGGAGCAGGGCGCCGGAGACCAGGGCATTATGT TCGGCTTCGCAACGAATGAGACGCCGGAGCTGCTTCCGGCCCCCATCGTGTTTGCGCACAAACTGCTCATTGAGCTGGCC AGGAGGCGCAAACGCGGGCATGTGGACTGGCTGCGTCCGGACTGCAAGTCCCAGGTGGCTGTGGCCTATGACGAAGACGG GCGTCCCGCGCATATTGAAAACGTAGTTATTTCCACCCAGCACACGGAAGACGTGGACCATGACACGATTTACTCATATT GCGTCAAACTCATTAAAAATGTGCTTCCTGCGGAGCTTCTGGATGAGAGGACGGAATATTTCATCAACCCCACCGGGAAA TTCGTCGTGGGCGGTCCCCACGGGGATTCCGGCCTGACGGGCCGCAAAATTATTGTGGACACGTACGGCGGCATGGGGCG CCACGGCGGCGGAGCCTTTTCCGGAAAAGACCCGTCCAAGGTGGACCGTTCCGCCGCGTATATGTGCCGCTGGGTTGCCA AGCACATTGTGGCTGCCGGACTGGCGGATAAATGTGAATTGCAGGTGGCTTACGCCATCGGCTACCCCGCTCCGGTTTCC ATCCGGGTGGATACGTTCGGTACCGGGAAGGTGGAGGAAATATCCATTGAAAATGCGCTGGAAAACATCTTTTCCTTCAA GCCTGCGGATATGGTGGAACAGCTGAACCTGCTTCGGCCTATTTACCGGAAGACGACGCACTACGGGCATTTCACCAATC CGGAGCTGCCCTGGGAACAGCTGGACGAAACGCGCCTGGCCTCCCTGAAACAACTTCTTCATTAA
Upstream 100 bases:
>100_bases GTTGATGATGCGCAGGCGGGTGGGATCTGCCAGGAGTTTGAGCGTTTTTAGGGTTGACTTCATAGCGGAATAATATATCA ACACATCGAGATTTATCGAT
Downstream 100 bases:
>100_bases TTCCTACGACAACGCTTACAGACATGTTTTCAGAAACGGAACAATACAAGGTGCGCGATATCGGCCTGGCGGATTTCGGA CGCAGGGAACTGGATATTGC
Product: Methionine adenosyltransferase
Products: NA
Alternate protein names: AdoMet synthase; MAT; Methionine adenosyltransferase
Number of amino acids: Translated: 394; Mature: 393
Protein sequence:
>394_residues MSRNTPHIFTSESVGEGHPDKVADYISDSILDACLAQDKTSRVACETLVKSNMVIIAGELTTKAVIDPEKIARQAIREIG YCNRQDDDVFHADTVFFTNLLTEQSPDIAQGVDAREAEGKGHAEQGAGDQGIMFGFATNETPELLPAPIVFAHKLLIELA RRRKRGHVDWLRPDCKSQVAVAYDEDGRPAHIENVVISTQHTEDVDHDTIYSYCVKLIKNVLPAELLDERTEYFINPTGK FVVGGPHGDSGLTGRKIIVDTYGGMGRHGGGAFSGKDPSKVDRSAAYMCRWVAKHIVAAGLADKCELQVAYAIGYPAPVS IRVDTFGTGKVEEISIENALENIFSFKPADMVEQLNLLRPIYRKTTHYGHFTNPELPWEQLDETRLASLKQLLH
Sequences:
>Translated_394_residues MSRNTPHIFTSESVGEGHPDKVADYISDSILDACLAQDKTSRVACETLVKSNMVIIAGELTTKAVIDPEKIARQAIREIG YCNRQDDDVFHADTVFFTNLLTEQSPDIAQGVDAREAEGKGHAEQGAGDQGIMFGFATNETPELLPAPIVFAHKLLIELA RRRKRGHVDWLRPDCKSQVAVAYDEDGRPAHIENVVISTQHTEDVDHDTIYSYCVKLIKNVLPAELLDERTEYFINPTGK FVVGGPHGDSGLTGRKIIVDTYGGMGRHGGGAFSGKDPSKVDRSAAYMCRWVAKHIVAAGLADKCELQVAYAIGYPAPVS IRVDTFGTGKVEEISIENALENIFSFKPADMVEQLNLLRPIYRKTTHYGHFTNPELPWEQLDETRLASLKQLLH >Mature_393_residues SRNTPHIFTSESVGEGHPDKVADYISDSILDACLAQDKTSRVACETLVKSNMVIIAGELTTKAVIDPEKIARQAIREIGY CNRQDDDVFHADTVFFTNLLTEQSPDIAQGVDAREAEGKGHAEQGAGDQGIMFGFATNETPELLPAPIVFAHKLLIELAR RRKRGHVDWLRPDCKSQVAVAYDEDGRPAHIENVVISTQHTEDVDHDTIYSYCVKLIKNVLPAELLDERTEYFINPTGKF VVGGPHGDSGLTGRKIIVDTYGGMGRHGGGAFSGKDPSKVDRSAAYMCRWVAKHIVAAGLADKCELQVAYAIGYPAPVSI RVDTFGTGKVEEISIENALENIFSFKPADMVEQLNLLRPIYRKTTHYGHFTNPELPWEQLDETRLASLKQLLH
Specific function: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the e
COG id: COG0192
COG function: function code H; S-adenosylmethionine synthetase
Gene ontology:
Cell location: Cytoplasm
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the AdoMet synthase family
Homologues:
Organism=Homo sapiens, GI5174529, Length=376, Percent_Identity=50.2659574468085, Blast_Score=347, Evalue=1e-95, Organism=Homo sapiens, GI4557737, Length=378, Percent_Identity=49.7354497354497, Blast_Score=343, Evalue=1e-94, Organism=Escherichia coli, GI1789311, Length=381, Percent_Identity=56.4304461942257, Blast_Score=436, Evalue=1e-123, Organism=Caenorhabditis elegans, GI17538498, Length=385, Percent_Identity=48.3116883116883, Blast_Score=352, Evalue=2e-97, Organism=Caenorhabditis elegans, GI25145633, Length=390, Percent_Identity=48.4615384615385, Blast_Score=350, Evalue=5e-97, Organism=Caenorhabditis elegans, GI17538494, Length=377, Percent_Identity=49.0716180371353, Blast_Score=350, Evalue=6e-97, Organism=Caenorhabditis elegans, GI17551082, Length=377, Percent_Identity=49.0716180371353, Blast_Score=347, Evalue=5e-96, Organism=Caenorhabditis elegans, GI32565905, Length=377, Percent_Identity=45.3580901856764, Blast_Score=302, Evalue=2e-82, Organism=Caenorhabditis elegans, GI32565911, Length=340, Percent_Identity=46.1764705882353, Blast_Score=293, Evalue=1e-79, Organism=Caenorhabditis elegans, GI25145635, Length=338, Percent_Identity=46.4497041420118, Blast_Score=289, Evalue=2e-78, Organism=Caenorhabditis elegans, GI32565903, Length=284, Percent_Identity=50, Blast_Score=267, Evalue=9e-72, Organism=Caenorhabditis elegans, GI32565909, Length=74, Percent_Identity=56.7567567567568, Blast_Score=97, Evalue=2e-20, Organism=Saccharomyces cerevisiae, GI6323209, Length=379, Percent_Identity=52.7704485488127, Blast_Score=376, Evalue=1e-105, Organism=Saccharomyces cerevisiae, GI6320710, Length=386, Percent_Identity=51.5544041450777, Blast_Score=375, Evalue=1e-105, Organism=Drosophila melanogaster, GI45552159, Length=384, Percent_Identity=47.65625, Blast_Score=330, Evalue=8e-91, Organism=Drosophila melanogaster, GI24580529, Length=384, Percent_Identity=47.65625, Blast_Score=330, Evalue=8e-91, Organism=Drosophila melanogaster, GI24580537, Length=384, Percent_Identity=47.65625, Blast_Score=330, Evalue=8e-91, Organism=Drosophila melanogaster, GI24580533, Length=384, Percent_Identity=47.65625, Blast_Score=330, Evalue=8e-91, Organism=Drosophila melanogaster, GI24580535, Length=384, Percent_Identity=47.65625, Blast_Score=330, Evalue=8e-91, Organism=Drosophila melanogaster, GI24580531, Length=384, Percent_Identity=47.65625, Blast_Score=330, Evalue=8e-91, Organism=Drosophila melanogaster, GI24580527, Length=386, Percent_Identity=47.1502590673575, Blast_Score=327, Evalue=1e-89, Organism=Drosophila melanogaster, GI24580525, Length=386, Percent_Identity=47.1502590673575, Blast_Score=327, Evalue=1e-89, Organism=Drosophila melanogaster, GI24580541, Length=367, Percent_Identity=46.3215258855586, Blast_Score=302, Evalue=3e-82, Organism=Drosophila melanogaster, GI24580539, Length=125, Percent_Identity=48, Blast_Score=112, Evalue=5e-25,
Paralogues:
None
Copy number: 7,000 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): METK_AKKM8 (B2UR09)
Other databases:
- EMBL: CP001071 - RefSeq: YP_001877675.1 - ProteinModelPortal: B2UR09 - SMR: B2UR09 - GeneID: 6274042 - GenomeReviews: CP001071_GR - KEGG: amu:Amuc_1068 - HOGENOM: HBG443662 - OMA: IYYAHRL - ProtClustDB: CLSK2335900 - GO: GO:0005737 - HAMAP: MF_00086 - InterPro: IPR022631 - InterPro: IPR022630 - InterPro: IPR022629 - InterPro: IPR022628 - InterPro: IPR002133 - InterPro: IPR022636 - PANTHER: PTHR11964 - PIRSF: PIRSF000497 - TIGRFAMs: TIGR01034
Pfam domain/function: PF02773 S-AdoMet_synt_C; PF02772 S-AdoMet_synt_M; PF00438 S-AdoMet_synt_N; SSF55973 S-AdoMet_synt
EC number: =2.5.1.6
Molecular weight: Translated: 43516; Mature: 43384
Theoretical pI: Translated: 5.56; Mature: 5.56
Prosite motif: PS00376 ADOMET_SYNTHASE_1; PS00377 ADOMET_SYNTHASE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.8 %Cys (Translated Protein) 1.5 %Met (Translated Protein) 3.3 %Cys+Met (Translated Protein) 1.8 %Cys (Mature Protein) 1.3 %Met (Mature Protein) 3.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSRNTPHIFTSESVGEGHPDKVADYISDSILDACLAQDKTSRVACETLVKSNMVIIAGEL CCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEEECC TTKAVIDPEKIARQAIREIGYCNRQDDDVFHADTVFFTNLLTEQSPDIAQGVDAREAEGK CHHHCCCHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHCCCCCHHHCCCCHHCCCC GHAEQGAGDQGIMFGFATNETPELLPAPIVFAHKLLIELARRRKRGHVDWLRPDCKSQVA CCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE VAYDEDGRPAHIENVVISTQHTEDVDHDTIYSYCVKLIKNVLPAELLDERTEYFINPTGK EEECCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHEEECCCCC FVVGGPHGDSGLTGRKIIVDTYGGMGRHGGGAFSGKDPSKVDRSAAYMCRWVAKHIVAAG EEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC LADKCELQVAYAIGYPAPVSIRVDTFGTGKVEEISIENALENIFSFKPADMVEQLNLLRP CCCCCEEEEEEEECCCCCEEEEEECCCCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHHHH IYRKTTHYGHFTNPELPWEQLDETRLASLKQLLH HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHC >Mature Secondary Structure SRNTPHIFTSESVGEGHPDKVADYISDSILDACLAQDKTSRVACETLVKSNMVIIAGEL CCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEEECC TTKAVIDPEKIARQAIREIGYCNRQDDDVFHADTVFFTNLLTEQSPDIAQGVDAREAEGK CHHHCCCHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHCCCCCHHHCCCCHHCCCC GHAEQGAGDQGIMFGFATNETPELLPAPIVFAHKLLIELARRRKRGHVDWLRPDCKSQVA CCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE VAYDEDGRPAHIENVVISTQHTEDVDHDTIYSYCVKLIKNVLPAELLDERTEYFINPTGK EEECCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHEEECCCCC FVVGGPHGDSGLTGRKIIVDTYGGMGRHGGGAFSGKDPSKVDRSAAYMCRWVAKHIVAAG EEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC LADKCELQVAYAIGYPAPVSIRVDTFGTGKVEEISIENALENIFSFKPADMVEQLNLLRP CCCCCEEEEEEEECCCCCEEEEEECCCCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHHHH IYRKTTHYGHFTNPELPWEQLDETRLASLKQLLH HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA