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The map label for this gene is clpP [H]

Identifier: 187735546

GI number: 187735546

Start: 1254017

End: 1254673

Strand: Reverse

Name: clpP [H]

Synonym: Amuc_1051

Alternate gene names: 187735546

Gene position: 1254673-1254017 (Counterclockwise)

Preceding gene: 187735547

Following gene: 187735545

Centisome position: 47.1

GC content: 53.27

Gene sequence:

>657_bases
ATGTTTCAAGACCAATCTTCCAAATCAACCCCCGCAAACTCCTATTATGTGCCCATGGTGGTGGAGCAGGACGGCCGCGG
CGAACGAGCCTTTGACATTTACTCCCGTCTCCTGAAAGACCGCGTTATCTTCATCGGCTCCGCTATTGACGACGATGTGG
CGAATTCCGTCATTGCCCAGCTTCTGTTCCTTCAGATGGCTGACCCGAAAAAAGACATCCACGTCTACATCAACTCCCCC
GGAGGATCCGTCACGGCGGGTCTCGCAATTTACGATACGATGCAATTCGTCTCTTGTGACGTAAATACATATTGCCTGGG
CATAGCGGCCTCCATGGGTTCCGTCCTTCTGGCTGCGGGAACTCCCGGCAAACGCTTCTGCCTGCCGAACTCCCACGTAA
TGATTCACCAGGTTTCCGGAGGTGCCCAGGGAACCGCTTCAGATGTGGAACGCACCATCGGCTTCATGTTCAACCTCAAA
AAACGCCTCAACGGCATTCTGGCCAAACATACCGGTAAAACGGAAAAGCAAATTGAAAAGGATGCTGACCGCGACAACTA
CATGACTGCCGAGGAAGCCGTGGCCTACGGCCTGGTGGATAAAGTTCTGGCGCATCACTCTGATGACCAGGGCGACAAGA
AAAAAACCAAGGCCTGA

Upstream 100 bases:

>100_bases
TTACCAGGGGGAGTTGGCGCACACATGCCCGACTCCCCCGTTTTGCATCTTTCGGACGGGTAACGTACATTGAAAAAACA
ACATCCAATCTTCCATAAAC

Downstream 100 bases:

>100_bases
CCCTTTCCCTCCGCCATTTCTCTCTCTACCTGAAAAACCATGTCCGGTTCCACCCCTCATCTTCCTGCCTGTTCCTGCTG
CGGCAAGCCCGGGAACAAGG

Product: Endopeptidase Clp

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MFQDQSSKSTPANSYYVPMVVEQDGRGERAFDIYSRLLKDRVIFIGSAIDDDVANSVIAQLLFLQMADPKKDIHVYINSP
GGSVTAGLAIYDTMQFVSCDVNTYCLGIAASMGSVLLAAGTPGKRFCLPNSHVMIHQVSGGAQGTASDVERTIGFMFNLK
KRLNGILAKHTGKTEKQIEKDADRDNYMTAEEAVAYGLVDKVLAHHSDDQGDKKKTKA

Sequences:

>Translated_218_residues
MFQDQSSKSTPANSYYVPMVVEQDGRGERAFDIYSRLLKDRVIFIGSAIDDDVANSVIAQLLFLQMADPKKDIHVYINSP
GGSVTAGLAIYDTMQFVSCDVNTYCLGIAASMGSVLLAAGTPGKRFCLPNSHVMIHQVSGGAQGTASDVERTIGFMFNLK
KRLNGILAKHTGKTEKQIEKDADRDNYMTAEEAVAYGLVDKVLAHHSDDQGDKKKTKA
>Mature_218_residues
MFQDQSSKSTPANSYYVPMVVEQDGRGERAFDIYSRLLKDRVIFIGSAIDDDVANSVIAQLLFLQMADPKKDIHVYINSP
GGSVTAGLAIYDTMQFVSCDVNTYCLGIAASMGSVLLAAGTPGKRFCLPNSHVMIHQVSGGAQGTASDVERTIGFMFNLK
KRLNGILAKHTGKTEKQIEKDADRDNYMTAEEAVAYGLVDKVLAHHSDDQGDKKKTKA

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=197, Percent_Identity=57.8680203045685, Blast_Score=235, Evalue=2e-62,
Organism=Escherichia coli, GI1786641, Length=191, Percent_Identity=58.1151832460733, Blast_Score=249, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI17538017, Length=190, Percent_Identity=54.7368421052632, Blast_Score=223, Evalue=6e-59,
Organism=Drosophila melanogaster, GI20129427, Length=196, Percent_Identity=53.5714285714286, Blast_Score=224, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23729; Mature: 23729

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00381 CLP_PROTEASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQDQSSKSTPANSYYVPMVVEQDGRGERAFDIYSRLLKDRVIFIGSAIDDDVANSVIAQ
CCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHH
LLFLQMADPKKDIHVYINSPGGSVTAGLAIYDTMQFVSCDVNTYCLGIAASMGSVLLAAG
HHHHHHCCCCCEEEEEEECCCCCEEEHHHHHHHHHHHCCCCCHHHHHHHHHHCCEEEEEC
TPGKRFCLPNSHVMIHQVSGGAQGTASDVERTIGFMFNLKKRLNGILAKHTGKTEKQIEK
CCCCEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DADRDNYMTAEEAVAYGLVDKVLAHHSDDQGDKKKTKA
HCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHCCCC
>Mature Secondary Structure
MFQDQSSKSTPANSYYVPMVVEQDGRGERAFDIYSRLLKDRVIFIGSAIDDDVANSVIAQ
CCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHH
LLFLQMADPKKDIHVYINSPGGSVTAGLAIYDTMQFVSCDVNTYCLGIAASMGSVLLAAG
HHHHHHCCCCCEEEEEEECCCCCEEEHHHHHHHHHHHCCCCCHHHHHHHHHHCCEEEEEC
TPGKRFCLPNSHVMIHQVSGGAQGTASDVERTIGFMFNLKKRLNGILAKHTGKTEKQIEK
CCCCEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DADRDNYMTAEEAVAYGLVDKVLAHHSDDQGDKKKTKA
HCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA