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The map label for this gene is acoA [H]

Identifier: 187735389

GI number: 187735389

Start: 1056183

End: 1057121

Strand: Reverse

Name: acoA [H]

Synonym: Amuc_0887

Alternate gene names: 187735389

Gene position: 1057121-1056183 (Counterclockwise)

Preceding gene: 187735390

Following gene: 187735388

Centisome position: 39.68

GC content: 61.34

Gene sequence:

>939_bases
ATGTTGCTGGCGCGGGCTTTTGACACCAAAATTTCCAGCCTTTACAAAGCGGGCAAAATTACGGGGGGCGTTTACCTGGG
CCGCGGACATGAAGCGATTGCCGCATGCGGAGGCGTCTTTCTGACTGCCGGCTACGATGTAATCGCCCCGTTCATCCGGG
AACAGGCGGCACGCGTCACCTGGGGGGAACCGATTATTGAAGCGGCACGCGCCTACCTGGGTTCCGCCCTGGGATATATG
AAAGGGCGGGACGGCAATGTCCACCGGGGCCTGCCAGCGGAAGGCTATATGGCTCCCATCAGCCATCTGGGCAGCACGGT
GGCTTTCGTCATCGGCTGCCTTTTCGCCAAGCGCCTGGACGGCAAACTGCCCGGCCCCGTGGGAGTAGCTTTCTGCGGCG
ACGGCACCACGTCCACGGGTGCTTTTCACGAAGCCGCCAATATGGCGAACGTGGAGCGGCTGCCTCTGGTGCTCGTGGTA
ACCAATAATCAATTTGCCTACTCCACCCCCAATATCAGGGAATTCGGAGAAGCCTCCCTGGCGGACAGGGGCCGCGGCTA
CGGCTTCACCGTGCATGAAACGGACGGCACGGACTTCATGGCCACGCTGGAAACCTTCCGGACCGCCGTCAATAACGCGA
GGGAAGGCCGGGGCCCCCAGTGGGTGCTTGCCAAGACCCTCCGCATGTGCGGGCACGGGGAACATGACGACGCCTCCTAC
ATCCCCAGGGAGCTGAAAGAGGAATATGAAAAAAAAGACCCCGTGGCAGTCGCGGAACGGCAGCTGCTGGCAGCCGGCTG
GCTCACGCCGGAAGAAACGGCGGCTTTGAAAAAACAGTATGCCGATGAAGTCCAGCTGGCCGTAGCCACCGCGCAGCGGG
AACCGGAACCGGACCCCTTCCGGGAAGACTGGAACGCCACGGTATGGAGACCTTATTAA

Upstream 100 bases:

>100_bases
GCATTGCATTTCCTTATGCAGCATATAAAATAATGGGGTGGCACATTGCGACACTACACAACCGGACTTAAAGGAAAATG
CCGTCAGGGCTTTCAAGGCC

Downstream 100 bases:

>100_bases
GCCAGCAAACGGAATATTCCCATGAGCGTAACATACATTGATGCCATCCACGACGCCCAGAAAGACCTGCTTACGGAAGA
CAGGGACGTCTTTCTGTACG

Product: dehydrogenase E1 component

Products: [dihydrolipoyllysine-residue acetyltransferase] ; $S-acetyldihydrolipoyllysine; CO2

Alternate protein names: Acetoin:DCPIP oxidoreductase-alpha; Ao:DCPIP OR [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MLLARAFDTKISSLYKAGKITGGVYLGRGHEAIAACGGVFLTAGYDVIAPFIREQAARVTWGEPIIEAARAYLGSALGYM
KGRDGNVHRGLPAEGYMAPISHLGSTVAFVIGCLFAKRLDGKLPGPVGVAFCGDGTTSTGAFHEAANMANVERLPLVLVV
TNNQFAYSTPNIREFGEASLADRGRGYGFTVHETDGTDFMATLETFRTAVNNAREGRGPQWVLAKTLRMCGHGEHDDASY
IPRELKEEYEKKDPVAVAERQLLAAGWLTPEETAALKKQYADEVQLAVATAQREPEPDPFREDWNATVWRPY

Sequences:

>Translated_312_residues
MLLARAFDTKISSLYKAGKITGGVYLGRGHEAIAACGGVFLTAGYDVIAPFIREQAARVTWGEPIIEAARAYLGSALGYM
KGRDGNVHRGLPAEGYMAPISHLGSTVAFVIGCLFAKRLDGKLPGPVGVAFCGDGTTSTGAFHEAANMANVERLPLVLVV
TNNQFAYSTPNIREFGEASLADRGRGYGFTVHETDGTDFMATLETFRTAVNNAREGRGPQWVLAKTLRMCGHGEHDDASY
IPRELKEEYEKKDPVAVAERQLLAAGWLTPEETAALKKQYADEVQLAVATAQREPEPDPFREDWNATVWRPY
>Mature_312_residues
MLLARAFDTKISSLYKAGKITGGVYLGRGHEAIAACGGVFLTAGYDVIAPFIREQAARVTWGEPIIEAARAYLGSALGYM
KGRDGNVHRGLPAEGYMAPISHLGSTVAFVIGCLFAKRLDGKLPGPVGVAFCGDGTTSTGAFHEAANMANVERLPLVLVV
TNNQFAYSTPNIREFGEASLADRGRGYGFTVHETDGTDFMATLETFRTAVNNAREGRGPQWVLAKTLRMCGHGEHDDASY
IPRELKEEYEKKDPVAVAERQLLAAGWLTPEETAALKKQYADEVQLAVATAQREPEPDPFREDWNATVWRPY

Specific function: Catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde, in vitro. The alpha subunit is probably the catalytic subunit of the enzyme [H]

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=221, Percent_Identity=28.9592760180996, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI4885543, Length=303, Percent_Identity=27.3927392739274, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI258645172, Length=221, Percent_Identity=28.9592760180996, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI4505685, Length=307, Percent_Identity=28.6644951140065, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI291084742, Length=307, Percent_Identity=28.6644951140065, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI291084744, Length=312, Percent_Identity=27.8846153846154, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI32564172, Length=314, Percent_Identity=28.343949044586, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17536047, Length=314, Percent_Identity=28.343949044586, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI86563355, Length=222, Percent_Identity=26.5765765765766, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI86563357, Length=222, Percent_Identity=26.5765765765766, Blast_Score=78, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6321026, Length=302, Percent_Identity=28.1456953642384, Blast_Score=83, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24639748, Length=313, Percent_Identity=28.7539936102236, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355903, Length=301, Percent_Identity=24.9169435215947, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24639746, Length=299, Percent_Identity=26.7558528428094, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24639740, Length=299, Percent_Identity=26.7558528428094, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24639744, Length=299, Percent_Identity=26.7558528428094, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI28571106, Length=299, Percent_Identity=26.7558528428094, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: 1.2.4.1

Molecular weight: Translated: 33917; Mature: 33917

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLARAFDTKISSLYKAGKITGGVYLGRGHEAIAACGGVFLTAGYDVIAPFIREQAARVT
CCCCHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHCHHHHHCCHHHHHHHHHHHHHCCC
WGEPIIEAARAYLGSALGYMKGRDGNVHRGLPAEGYMAPISHLGSTVAFVIGCLFAKRLD
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GKLPGPVGVAFCGDGTTSTGAFHEAANMANVERLPLVLVVTNNQFAYSTPNIREFGEASL
CCCCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCEEEEEECCEEEECCCCHHHHCCHHH
ADRGRGYGFTVHETDGTDFMATLETFRTAVNNAREGRGPQWVLAKTLRMCGHGEHDDASY
HHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHH
IPRELKEEYEKKDPVAVAERQLLAAGWLTPEETAALKKQYADEVQLAVATAQREPEPDPF
CHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
REDWNATVWRPY
CCCCCCEEECCC
>Mature Secondary Structure
MLLARAFDTKISSLYKAGKITGGVYLGRGHEAIAACGGVFLTAGYDVIAPFIREQAARVT
CCCCHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHCHHHHHCCHHHHHHHHHHHHHCCC
WGEPIIEAARAYLGSALGYMKGRDGNVHRGLPAEGYMAPISHLGSTVAFVIGCLFAKRLD
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GKLPGPVGVAFCGDGTTSTGAFHEAANMANVERLPLVLVVTNNQFAYSTPNIREFGEASL
CCCCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCEEEEEECCEEEECCCCHHHHCCHHH
ADRGRGYGFTVHETDGTDFMATLETFRTAVNNAREGRGPQWVLAKTLRMCGHGEHDDASY
HHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHH
IPRELKEEYEKKDPVAVAERQLLAAGWLTPEETAALKKQYADEVQLAVATAQREPEPDPF
CHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
REDWNATVWRPY
CCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: pyruvate; [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine

Specific reaction: pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S- $acetyldihydrolipoyllysine + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2061286 [H]