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The map label for this gene is bfmBAB [H]

Identifier: 187735388

GI number: 187735388

Start: 1055187

End: 1056161

Strand: Reverse

Name: bfmBAB [H]

Synonym: Amuc_0886

Alternate gene names: 187735388

Gene position: 1056161-1055187 (Counterclockwise)

Preceding gene: 187735389

Following gene: 187735387

Centisome position: 39.64

GC content: 62.87

Gene sequence:

>975_bases
ATGAGCGTAACATACATTGATGCCATCCACGACGCCCAGAAAGACCTGCTTACGGAAGACAGGGACGTCTTTCTGTACGG
GCAGGACATAGGCGTTTTCGGCGGCGCATTCAAAGCGACCAAGGGCCTCAAGGAGCTGTTCCCGGACCGGGTGATTGACG
CCCCCATCAGTGAGGACGCCATGGCCGGCATGGTGACCGGGGCCGCCGTCATGGGCAAGAAGCCCATTATGGAAGTCCAG
TTTGCCGACTTCAGCACGATCGCTTTCAACCAGATTGTCAACATGGCGGCCACCCATTACTACCGCACGGGCATTCCCGC
CAACATCACGGTGCGCCTGCCCTGCGGGGGAACCCCCGGCACCGGCCCTTTCCACAGCCAGAGCCTGGAAGCCTTGTTCG
CCCATTATCCGGGCCTGCACGTCATGACTCCGGCCACGGTAGCGGATGCTTACTGGATGCTGCGCCAGGCCGTGGAAATT
CCGGACCCCGTCATTTTTCTGGAGCACAAGTTCCTGTACCGCTGGCTGAAGGCGGAGGACAACTACCGGGAGGCCCCGGT
CATCCCGTTCGGCACGGCCCGGATCGCCCGCACGGGGAAGCATGCCACCGTGGTGGCGTACAGCGCCATGGTGCCGGAAG
CCGTGCGCGCGGCGGACCTGCTTGAGAAGGAAAGCGGCTATGAAGTGGAGGTCGTGGATCTTCGGACGGTGCGCCCGCTG
GACATGGATACCGTTATCGCCTCCGTAGCGCGCACCGGCCGCGTCCTGGTCGTCGGGGAAGATTTTCCGTGGGGAGGCGT
CACGGCGGAAGTTGTTTCACGCATTGTCGCGGAAGGCTTCCACCTGCTGGATGCCCCGCCCCAGAGGCTCAACGCACGGG
ATACCCCCATCCCCCAGCACCCCAACCTCTGGAAGGCGCACCGCCCCACGCTGGAATCCATTGCCGCCTCCATCCGCCAT
CTTCTATCCATTTGA

Upstream 100 bases:

>100_bases
CGTAGCCACCGCGCAGCGGGAACCGGAACCGGACCCCTTCCGGGAAGACTGGAACGCCACGGTATGGAGACCTTATTAAG
CCAGCAAACGGAATATTCCC

Downstream 100 bases:

>100_bases
TTCAACCCAGTTTCCATCATGCCTAAAGTACCCATTCTGATGCCCCAGCTCGGGGATTCCATTGCGGAAGCCACTGTGCT
GCGCCTGCTGGCGGCCCAGG

Product: Transketolase central region

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MSVTYIDAIHDAQKDLLTEDRDVFLYGQDIGVFGGAFKATKGLKELFPDRVIDAPISEDAMAGMVTGAAVMGKKPIMEVQ
FADFSTIAFNQIVNMAATHYYRTGIPANITVRLPCGGTPGTGPFHSQSLEALFAHYPGLHVMTPATVADAYWMLRQAVEI
PDPVIFLEHKFLYRWLKAEDNYREAPVIPFGTARIARTGKHATVVAYSAMVPEAVRAADLLEKESGYEVEVVDLRTVRPL
DMDTVIASVARTGRVLVVGEDFPWGGVTAEVVSRIVAEGFHLLDAPPQRLNARDTPIPQHPNLWKAHRPTLESIAASIRH
LLSI

Sequences:

>Translated_324_residues
MSVTYIDAIHDAQKDLLTEDRDVFLYGQDIGVFGGAFKATKGLKELFPDRVIDAPISEDAMAGMVTGAAVMGKKPIMEVQ
FADFSTIAFNQIVNMAATHYYRTGIPANITVRLPCGGTPGTGPFHSQSLEALFAHYPGLHVMTPATVADAYWMLRQAVEI
PDPVIFLEHKFLYRWLKAEDNYREAPVIPFGTARIARTGKHATVVAYSAMVPEAVRAADLLEKESGYEVEVVDLRTVRPL
DMDTVIASVARTGRVLVVGEDFPWGGVTAEVVSRIVAEGFHLLDAPPQRLNARDTPIPQHPNLWKAHRPTLESIAASIRH
LLSI
>Mature_323_residues
SVTYIDAIHDAQKDLLTEDRDVFLYGQDIGVFGGAFKATKGLKELFPDRVIDAPISEDAMAGMVTGAAVMGKKPIMEVQF
ADFSTIAFNQIVNMAATHYYRTGIPANITVRLPCGGTPGTGPFHSQSLEALFAHYPGLHVMTPATVADAYWMLRQAVEIP
DPVIFLEHKFLYRWLKAEDNYREAPVIPFGTARIARTGKHATVVAYSAMVPEAVRAADLLEKESGYEVEVVDLRTVRPLD
MDTVIASVARTGRVLVVGEDFPWGGVTAEVVSRIVAEGFHLLDAPPQRLNARDTPIPQHPNLWKAHRPTLESIAASIRHL
LSI

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI156564403, Length=332, Percent_Identity=37.9518072289157, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI291084858, Length=330, Percent_Identity=36.6666666666667, Blast_Score=201, Evalue=9e-52,
Organism=Homo sapiens, GI4557353, Length=317, Percent_Identity=36.2776025236593, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI34101272, Length=317, Percent_Identity=36.2776025236593, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17538422, Length=329, Percent_Identity=35.5623100303951, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17506935, Length=301, Percent_Identity=36.2126245847176, Blast_Score=165, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6319698, Length=329, Percent_Identity=35.8662613981763, Blast_Score=208, Evalue=1e-54,
Organism=Drosophila melanogaster, GI21358145, Length=326, Percent_Identity=36.5030674846626, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24650940, Length=326, Percent_Identity=36.5030674846626, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI160714832, Length=298, Percent_Identity=34.8993288590604, Blast_Score=174, Evalue=7e-44,
Organism=Drosophila melanogaster, GI160714828, Length=298, Percent_Identity=34.8993288590604, Blast_Score=174, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24650943, Length=90, Percent_Identity=37.7777777777778, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24650945, Length=90, Percent_Identity=37.7777777777778, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 35589; Mature: 35458

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTYIDAIHDAQKDLLTEDRDVFLYGQDIGVFGGAFKATKGLKELFPDRVIDAPISEDA
CCEEEEHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCHHHCCCCCCHHH
MAGMVTGAAVMGKKPIMEVQFADFSTIAFNQIVNMAATHYYRTGIPANITVRLPCGGTPG
HHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCC
TGPFHSQSLEALFAHYPGLHVMTPATVADAYWMLRQAVEIPDPVIFLEHKFLYRWLKAED
CCCCCHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCC
NYREAPVIPFGTARIARTGKHATVVAYSAMVPEAVRAADLLEKESGYEVEVVDLRTVRPL
CCCCCCCCCCCCHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCC
DMDTVIASVARTGRVLVVGEDFPWGGVTAEVVSRIVAEGFHLLDAPPQRLNARDTPIPQH
CHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHCCCEECCCCHHHCCCCCCCCCCC
PNLWKAHRPTLESIAASIRHLLSI
CCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVTYIDAIHDAQKDLLTEDRDVFLYGQDIGVFGGAFKATKGLKELFPDRVIDAPISEDA
CEEEEHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCHHHCCCCCCHHH
MAGMVTGAAVMGKKPIMEVQFADFSTIAFNQIVNMAATHYYRTGIPANITVRLPCGGTPG
HHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCC
TGPFHSQSLEALFAHYPGLHVMTPATVADAYWMLRQAVEIPDPVIFLEHKFLYRWLKAED
CCCCCHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCC
NYREAPVIPFGTARIARTGKHATVVAYSAMVPEAVRAADLLEKESGYEVEVVDLRTVRPL
CCCCCCCCCCCCHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCC
DMDTVIASVARTGRVLVVGEDFPWGGVTAEVVSRIVAEGFHLLDAPPQRLNARDTPIPQH
CHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHCCCEECCCCHHHCCCCCCCCCCC
PNLWKAHRPTLESIAASIRHLLSI
CCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]