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The map label for this gene is guaB [H]

Identifier: 187735242

GI number: 187735242

Start: 872397

End: 873848

Strand: Direct

Name: guaB [H]

Synonym: Amuc_0737

Alternate gene names: 187735242

Gene position: 872397-873848 (Clockwise)

Preceding gene: 187735236

Following gene: 187735243

Centisome position: 32.75

GC content: 61.16

Gene sequence:

>1452_bases
ATGGCAGATTTCCCTCTTGGATTAAGTTTTGATGACGTGCTCCTGCTGCCCCGCCTGAGCGCGATTCTTCCCGGCGATGC
AGACATCAGTTCCCAGCTTGTTCCCGGCTTTGACATGAAAATCCCCGTGTTGTCCGCGGCCATGGATACCGTTTCCGAAT
CGGAACTGGCGATTGCCCTGGCGCGGGAAGGCGGCCTGGCCGTCATCCACCGCAACAACCCCATTGACATCCAGGCGGCC
ATGGTTTCCCGCGTGAAGCGTTTTGAAAACGCGGTCATCCCGAACCCCGTCACGGTCAACAAGGACATGACGCTGGAAGA
AGTCCACCAGATCATGATGGATCAAGGTTACTCCGGCTTCCCCGTCGTGGATGCCAACCGCAAGCTGGAAGGCATCATCA
CCGGCCGCGACATGCGCGGCGTGGACGATTACCAAAATGTCCAGGTCAAGGACGTAATGACCCCCCTTTCCCGCCTAATT
ACGGCAGCTCCCATCACGACCATTGAGGAAGCGCGCCACATCCTTTACACCCACCGCATTGAAAAGCTTCCTTTGGTGGA
TGAACACGGCGTACTGGCCGGCCTTATCACGGAAACGGATATCCAGAAGCGCGCCATGTTTGCAGACGCTTCCAAGGATG
AACACGGCCACCTGCGCTGCGGCGCCGCCGTGGGTGTCGGCCCCGATTATCTGGACCGAGCCAAAGCCCTGATTTCCGCC
GGAGCGGACGCCCTGTTCATTGACGCCGCCACAGGACACACGACCCGCGTGATGGACGTGGTTTCCAACCTCCGCAAGCT
GACGGACCGTCCCATCGTGGCCGGCAACGTGGTTACGGCGGAAGGGGCAGCCGATCTCATCAAGGCGGGCGTGCAGGCCA
TCAAGGTGGGCGTGGGCCCCGGCTCCATTTGCACTACCCGCGTCATATCCGGCGTGGGCATGCCCCAATTCACCGCCATT
CAGGAGGTAGCCTCCGTGGCGCGTCCCGCGGGCGTCACCGTCATTGCGGACGGCGGCATCCGCTATTCCGGAGACATTGT
CAAAGCCCTGGCCGCAGGCGCCGACCTGGTAATGCTGGGCGGACTGCTGGCAGGTACGGAAGAAAGCCCCGGCAAGGTGG
TTCATTACCAGGGCCGCCACTTCAAGCAGTATCGCGGCATGGGCTCCCTGGGCGCCATGCGCCGCGGCTCCGGCGACCGC
TACGGTCAGAACAGCTCCGGCAAGCTCGTTGCGGAAGGCGTGGAAGCGCGCGTTCCGTATAAAGGCATGCTGGCGGACGT
GGTATTCCAGCTCATGGGCGGCCTGCGCTCCGGCATGGGTTATCTGGGTGCGCACAATCTGGAGGAACTCCGGAACAAGG
CCCGGTTCGTTCAAATCACCTCCGGCGGGCTGAAGGAAAGCCATCCCCACGATATCACCATCACGGAAGAACCCGTCAAT
TATTCCTGTTAA

Upstream 100 bases:

>100_bases
TATTGCATGGGGCAGAGAAAGGAACTGTGCCGCTCATTCAAAAATAAGATTCTCCTGTGTTTCGGCTTGCGTTAGAGGAT
GTCCGGCTGTAGATTATCGC

Downstream 100 bases:

>100_bases
CTCCTCCCTCACATGGACGACAAGCACCTCGTAGCCGTCATTGACTTCGGCTCCCAATACACCCAGCTCATCGTACGCCG
CGTGCGCGAACTGGGCTACA

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MADFPLGLSFDDVLLLPRLSAILPGDADISSQLVPGFDMKIPVLSAAMDTVSESELAIALAREGGLAVIHRNNPIDIQAA
MVSRVKRFENAVIPNPVTVNKDMTLEEVHQIMMDQGYSGFPVVDANRKLEGIITGRDMRGVDDYQNVQVKDVMTPLSRLI
TAAPITTIEEARHILYTHRIEKLPLVDEHGVLAGLITETDIQKRAMFADASKDEHGHLRCGAAVGVGPDYLDRAKALISA
GADALFIDAATGHTTRVMDVVSNLRKLTDRPIVAGNVVTAEGAADLIKAGVQAIKVGVGPGSICTTRVISGVGMPQFTAI
QEVASVARPAGVTVIADGGIRYSGDIVKALAAGADLVMLGGLLAGTEESPGKVVHYQGRHFKQYRGMGSLGAMRRGSGDR
YGQNSSGKLVAEGVEARVPYKGMLADVVFQLMGGLRSGMGYLGAHNLEELRNKARFVQITSGGLKESHPHDITITEEPVN
YSC

Sequences:

>Translated_483_residues
MADFPLGLSFDDVLLLPRLSAILPGDADISSQLVPGFDMKIPVLSAAMDTVSESELAIALAREGGLAVIHRNNPIDIQAA
MVSRVKRFENAVIPNPVTVNKDMTLEEVHQIMMDQGYSGFPVVDANRKLEGIITGRDMRGVDDYQNVQVKDVMTPLSRLI
TAAPITTIEEARHILYTHRIEKLPLVDEHGVLAGLITETDIQKRAMFADASKDEHGHLRCGAAVGVGPDYLDRAKALISA
GADALFIDAATGHTTRVMDVVSNLRKLTDRPIVAGNVVTAEGAADLIKAGVQAIKVGVGPGSICTTRVISGVGMPQFTAI
QEVASVARPAGVTVIADGGIRYSGDIVKALAAGADLVMLGGLLAGTEESPGKVVHYQGRHFKQYRGMGSLGAMRRGSGDR
YGQNSSGKLVAEGVEARVPYKGMLADVVFQLMGGLRSGMGYLGAHNLEELRNKARFVQITSGGLKESHPHDITITEEPVN
YSC
>Mature_482_residues
ADFPLGLSFDDVLLLPRLSAILPGDADISSQLVPGFDMKIPVLSAAMDTVSESELAIALAREGGLAVIHRNNPIDIQAAM
VSRVKRFENAVIPNPVTVNKDMTLEEVHQIMMDQGYSGFPVVDANRKLEGIITGRDMRGVDDYQNVQVKDVMTPLSRLIT
AAPITTIEEARHILYTHRIEKLPLVDEHGVLAGLITETDIQKRAMFADASKDEHGHLRCGAAVGVGPDYLDRAKALISAG
ADALFIDAATGHTTRVMDVVSNLRKLTDRPIVAGNVVTAEGAADLIKAGVQAIKVGVGPGSICTTRVISGVGMPQFTAIQ
EVASVARPAGVTVIADGGIRYSGDIVKALAAGADLVMLGGLLAGTEESPGKVVHYQGRHFKQYRGMGSLGAMRRGSGDRY
GQNSSGKLVAEGVEARVPYKGMLADVVFQLMGGLRSGMGYLGAHNLEELRNKARFVQITSGGLKESHPHDITITEEPVNY
SC

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=453, Percent_Identity=38.4105960264901, Blast_Score=294, Evalue=1e-79,
Organism=Homo sapiens, GI34328928, Length=453, Percent_Identity=38.4105960264901, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI156616279, Length=453, Percent_Identity=38.4105960264901, Blast_Score=293, Evalue=3e-79,
Organism=Homo sapiens, GI34328930, Length=453, Percent_Identity=38.4105960264901, Blast_Score=293, Evalue=4e-79,
Organism=Homo sapiens, GI217035152, Length=448, Percent_Identity=38.3928571428571, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI66933016, Length=483, Percent_Identity=36.231884057971, Blast_Score=285, Evalue=8e-77,
Organism=Homo sapiens, GI217035148, Length=453, Percent_Identity=37.7483443708609, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI217035150, Length=453, Percent_Identity=36.2030905077263, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI156104880, Length=288, Percent_Identity=35.7638888888889, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI50541956, Length=257, Percent_Identity=38.1322957198444, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI50541954, Length=257, Percent_Identity=37.7431906614786, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI50541952, Length=257, Percent_Identity=37.7431906614786, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI50541948, Length=257, Percent_Identity=37.7431906614786, Blast_Score=166, Evalue=3e-41,
Organism=Escherichia coli, GI1788855, Length=477, Percent_Identity=51.5723270440252, Blast_Score=422, Evalue=1e-119,
Organism=Escherichia coli, GI1786293, Length=214, Percent_Identity=41.1214953271028, Blast_Score=163, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71994385, Length=479, Percent_Identity=35.4906054279749, Blast_Score=244, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI71994389, Length=426, Percent_Identity=36.3849765258216, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17560440, Length=262, Percent_Identity=35.8778625954198, Blast_Score=161, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6322012, Length=487, Percent_Identity=36.3449691991786, Blast_Score=289, Evalue=6e-79,
Organism=Saccharomyces cerevisiae, GI6323464, Length=487, Percent_Identity=36.5503080082135, Blast_Score=280, Evalue=4e-76,
Organism=Saccharomyces cerevisiae, GI6323585, Length=460, Percent_Identity=35.6521739130435, Blast_Score=278, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6319352, Length=340, Percent_Identity=35.8823529411765, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6319353, Length=142, Percent_Identity=37.3239436619718, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24641071, Length=486, Percent_Identity=35.3909465020576, Blast_Score=285, Evalue=5e-77,
Organism=Drosophila melanogaster, GI24641073, Length=486, Percent_Identity=35.3909465020576, Blast_Score=285, Evalue=5e-77,
Organism=Drosophila melanogaster, GI28571163, Length=445, Percent_Identity=35.9550561797753, Blast_Score=259, Evalue=3e-69,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51393; Mature: 51262

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADFPLGLSFDDVLLLPRLSAILPGDADISSQLVPGFDMKIPVLSAAMDTVSESELAIAL
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEE
AREGGLAVIHRNNPIDIQAAMVSRVKRFENAVIPNPVTVNKDMTLEEVHQIMMDQGYSGF
ECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHCCCCCC
PVVDANRKLEGIITGRDMRGVDDYQNVQVKDVMTPLSRLITAAPITTIEEARHILYTHRI
CEEECCCCEEEEEECCCCCCCCCHHCEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
EKLPLVDEHGVLAGLITETDIQKRAMFADASKDEHGHLRCGAAVGVGPDYLDRAKALISA
HHCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCEEECEECCCCHHHHHHHHHHHHC
GADALFIDAATGHTTRVMDVVSNLRKLTDRPIVAGNVVTAEGAADLIKAGVQAIKVGVGP
CCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEECCEEECCCHHHHHHHCHHEEEEECCC
GSICTTRVISGVGMPQFTAIQEVASVARPAGVTVIADGGIRYSGDIVKALAAGADLVMLG
CHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEECCCEEECHHHHHHHHCCCCHHHHH
GLLAGTEESPGKVVHYQGRHFKQYRGMGSLGAMRRGSGDRYGQNSSGKLVAEGVEARVPY
HHHCCCCCCCCCEEEECCCHHHHHCCCCCHHHHHCCCCCCCCCCCCCCEEECCCCCCCCH
KGMLADVVFQLMGGLRSGMGYLGAHNLEELRNKARFVQITSGGLKESHPHDITITEEPVN
HHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHCCCEEEEEECCCCCCCCCCCEEEECCCCC
YSC
CCC
>Mature Secondary Structure 
ADFPLGLSFDDVLLLPRLSAILPGDADISSQLVPGFDMKIPVLSAAMDTVSESELAIAL
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEE
AREGGLAVIHRNNPIDIQAAMVSRVKRFENAVIPNPVTVNKDMTLEEVHQIMMDQGYSGF
ECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHCCCCCC
PVVDANRKLEGIITGRDMRGVDDYQNVQVKDVMTPLSRLITAAPITTIEEARHILYTHRI
CEEECCCCEEEEEECCCCCCCCCHHCEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
EKLPLVDEHGVLAGLITETDIQKRAMFADASKDEHGHLRCGAAVGVGPDYLDRAKALISA
HHCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCEEECEECCCCHHHHHHHHHHHHC
GADALFIDAATGHTTRVMDVVSNLRKLTDRPIVAGNVVTAEGAADLIKAGVQAIKVGVGP
CCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEECCEEECCCHHHHHHHCHHEEEEECCC
GSICTTRVISGVGMPQFTAIQEVASVARPAGVTVIADGGIRYSGDIVKALAAGADLVMLG
CHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEECCCEEECHHHHHHHHCCCCHHHHH
GLLAGTEESPGKVVHYQGRHFKQYRGMGSLGAMRRGSGDRYGQNSSGKLVAEGVEARVPY
HHHCCCCCCCCCEEEECCCHHHHHCCCCCHHHHHCCCCCCCCCCCCCCEEECCCCCCCCH
KGMLADVVFQLMGGLRSGMGYLGAHNLEELRNKARFVQITSGGLKESHPHDITITEEPVN
HHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHCCCEEEEEECCCCCCCCCCCEEEECCCCC
YSC
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]