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The map label for this gene is guaA [H]

Identifier: 187735243

GI number: 187735243

Start: 873861

End: 875384

Strand: Direct

Name: guaA [H]

Synonym: Amuc_0738

Alternate gene names: 187735243

Gene position: 873861-875384 (Clockwise)

Preceding gene: 187735242

Following gene: 187735244

Centisome position: 32.8

GC content: 59.84

Gene sequence:

>1524_bases
ATGGACGACAAGCACCTCGTAGCCGTCATTGACTTCGGCTCCCAATACACCCAGCTCATCGTACGCCGCGTGCGCGAACT
GGGCTACATGGCCAAGCTGTATGCGCTGGAAGACCTGGACCAGATTCACGAACCCGGCGCCGTCATCCTTTCCGGCGGCC
CCAAAAGCACCACGGATGCGGACGCCCCGGACATTGACTTTGAATGGCTCCAAAGCCTGAATGTCCCCGTCCTGGGCGTG
TGCTACGGCATGCAGCTGCTGAACATCAAGCACGGCGGCACCGTAAAAGCCAGCAACAAGCGGGAATACGGCCCCGCCGC
CCTGCTGCCGGAAACCTGCGTGGGCCTGTACCGGGACATGTCCCCTTCCTCCCAGGTATGGATGAGCCATTCGGACACGG
TGGACCATCTGGCGGAAGGCTGCCGCGTAATCGCCCGCAATGCGGAAGGCGTCCCCGTCTCCCTCCAATGGGGAGAAACC
ACCTTCGGCATCCAATTTCATCCGGAAGTGACCCATTCCCATGAAGGGCGCACCATCCTGCGCAACTTCCTTTCCTGTGC
GGCCAACCTTAAAAAGTTCGACATCGGAGACTTTAAAAGGGAACTCATCCGGGAAATCCGGGAACGCGTAGGCAACAGGC
AGGTGGTCTGCGGCGTCTCCGGCGGCGTGGACAGCACCGTTCTGGCCGTTCTGTTGCATGAAGCGGGCGTGAACATGCGC
GCCATCTTTGTGGATAACGGTCTGCTCCGCAAAAACGAGGCAGAGGAAGTGCGGGCCAATTTCGCCCGTATGAACGTGGA
AATTGAAACGGTGGATGCCTCCGAACGCTTCCTGGCGGCTCTGGACGGAGAAAGCGATCCGGAAAAGAAACGCCGTATCA
TCGGAGGCCTGTTCATCGACGTTTTCTGGGATGCCGTGGGAGACGCGGAAATGCTCGCCCAGGGCACCCTGTACCCGGAC
GTGATCGAAAGCGCCTCCAACGCCAAATCCAAGGCCTCCGTCATCAAGACCCACCACAATCGCGTGGAACGCGTGCTGGA
ACTCCAGGCGCAGGGGAAAGTACTGGAACCCCTGGCGGAACTGTTCAAGGACGAAGTTCGAGAACTGGGCGCCTCCATGG
GCATCCCGCATGACATTCTGTGGCGCCACCCCTTCCCCGGCCCCGGCCTGGCCGTGCGCTGCCCCGGCGTAGTCACCAAA
GAACGCCTGGACATCATCCGGGAATGCGATGCCATTTTCATCGGCAATCTGAAAAAATACGGCTGGTACGACAAAGTCTG
GCAGGCCTATGCCGGCCTCATCCCTGTAAAAACGGTGGGAGTGAAGGGGGACGAACGCTCCTATGAATGGGCTACCAACC
TGCGCGCCATCGTGTCGGAAGACGCCATGACGGCGGACTGGGTGGAACTCCCCCCGGCCCTGCTGAGGGAAACCAGCAAC
CGCATCCTCAATGAAGTAAAGGGCATCAACCGCGTCCTTTACGACATTTCCACCAAGCCCCCGGCTTCCATTGAGTGGGA
GTAA

Upstream 100 bases:

>100_bases
GTTCGTTCAAATCACCTCCGGCGGGCTGAAGGAAAGCCATCCCCACGATATCACCATCACGGAAGAACCCGTCAATTATT
CCTGTTAACTCCTCCCTCAC

Downstream 100 bases:

>100_bases
AGCTTCCGCACCCTGTTGACGGCCGTTCAGCAGGGTGCCTCCGCTCCTCCTCTCCGGTAACAAAAATCAAGAAAGGAGAA
AATAATGACTGAACTGGAAA

Product: GMP synthase, large subunit

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MDDKHLVAVIDFGSQYTQLIVRRVRELGYMAKLYALEDLDQIHEPGAVILSGGPKSTTDADAPDIDFEWLQSLNVPVLGV
CYGMQLLNIKHGGTVKASNKREYGPAALLPETCVGLYRDMSPSSQVWMSHSDTVDHLAEGCRVIARNAEGVPVSLQWGET
TFGIQFHPEVTHSHEGRTILRNFLSCAANLKKFDIGDFKRELIREIRERVGNRQVVCGVSGGVDSTVLAVLLHEAGVNMR
AIFVDNGLLRKNEAEEVRANFARMNVEIETVDASERFLAALDGESDPEKKRRIIGGLFIDVFWDAVGDAEMLAQGTLYPD
VIESASNAKSKASVIKTHHNRVERVLELQAQGKVLEPLAELFKDEVRELGASMGIPHDILWRHPFPGPGLAVRCPGVVTK
ERLDIIRECDAIFIGNLKKYGWYDKVWQAYAGLIPVKTVGVKGDERSYEWATNLRAIVSEDAMTADWVELPPALLRETSN
RILNEVKGINRVLYDISTKPPASIEWE

Sequences:

>Translated_507_residues
MDDKHLVAVIDFGSQYTQLIVRRVRELGYMAKLYALEDLDQIHEPGAVILSGGPKSTTDADAPDIDFEWLQSLNVPVLGV
CYGMQLLNIKHGGTVKASNKREYGPAALLPETCVGLYRDMSPSSQVWMSHSDTVDHLAEGCRVIARNAEGVPVSLQWGET
TFGIQFHPEVTHSHEGRTILRNFLSCAANLKKFDIGDFKRELIREIRERVGNRQVVCGVSGGVDSTVLAVLLHEAGVNMR
AIFVDNGLLRKNEAEEVRANFARMNVEIETVDASERFLAALDGESDPEKKRRIIGGLFIDVFWDAVGDAEMLAQGTLYPD
VIESASNAKSKASVIKTHHNRVERVLELQAQGKVLEPLAELFKDEVRELGASMGIPHDILWRHPFPGPGLAVRCPGVVTK
ERLDIIRECDAIFIGNLKKYGWYDKVWQAYAGLIPVKTVGVKGDERSYEWATNLRAIVSEDAMTADWVELPPALLRETSN
RILNEVKGINRVLYDISTKPPASIEWE
>Mature_507_residues
MDDKHLVAVIDFGSQYTQLIVRRVRELGYMAKLYALEDLDQIHEPGAVILSGGPKSTTDADAPDIDFEWLQSLNVPVLGV
CYGMQLLNIKHGGTVKASNKREYGPAALLPETCVGLYRDMSPSSQVWMSHSDTVDHLAEGCRVIARNAEGVPVSLQWGET
TFGIQFHPEVTHSHEGRTILRNFLSCAANLKKFDIGDFKRELIREIRERVGNRQVVCGVSGGVDSTVLAVLLHEAGVNMR
AIFVDNGLLRKNEAEEVRANFARMNVEIETVDASERFLAALDGESDPEKKRRIIGGLFIDVFWDAVGDAEMLAQGTLYPD
VIESASNAKSKASVIKTHHNRVERVLELQAQGKVLEPLAELFKDEVRELGASMGIPHDILWRHPFPGPGLAVRCPGVVTK
ERLDIIRECDAIFIGNLKKYGWYDKVWQAYAGLIPVKTVGVKGDERSYEWATNLRAIVSEDAMTADWVELPPALLRETSN
RILNEVKGINRVLYDISTKPPASIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=550, Percent_Identity=36.3636363636364, Blast_Score=297, Evalue=2e-80,
Organism=Escherichia coli, GI1788854, Length=526, Percent_Identity=48.4790874524715, Blast_Score=453, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI133901714, Length=568, Percent_Identity=35.0352112676056, Blast_Score=290, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI71992710, Length=568, Percent_Identity=34.8591549295775, Blast_Score=290, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI71992717, Length=568, Percent_Identity=34.8591549295775, Blast_Score=290, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6323873, Length=521, Percent_Identity=47.9846449136276, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI281365319, Length=551, Percent_Identity=34.6642468239564, Blast_Score=280, Evalue=1e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 56408; Mature: 56408

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDKHLVAVIDFGSQYTQLIVRRVRELGYMAKLYALEDLDQIHEPGAVILSGGPKSTTDA
CCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCC
DAPDIDFEWLQSLNVPVLGVCYGMQLLNIKHGGTVKASNKREYGPAALLPETCVGLYRDM
CCCCCCHHHHHHCCCCHHHHHHCHHEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHCC
SPSSQVWMSHSDTVDHLAEGCRVIARNAEGVPVSLQWGETTFGIQFHPEVTHSHEGRTIL
CCCCCEEECCCCCHHHHHHHHHEECCCCCCCEEEEEECCEEEEEEECCCCCCCCCCHHHH
RNFLSCAANLKKFDIGDFKRELIREIRERVGNRQVVCGVSGGVDSTVLAVLLHEAGVNMR
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCEE
AIFVDNGLLRKNEAEEVRANFARMNVEIETVDASERFLAALDGESDPEKKRRIIGGLFID
EEEECCCCCCCCCHHHHHHHHHHEEEEEEEECCHHHHHHCCCCCCCHHHHHHHHHHHHHH
VFWDAVGDAEMLAQGTLYPDVIESASNAKSKASVIKTHHNRVERVLELQAQGKVLEPLAE
HHHHHCCCHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LFKDEVRELGASMGIPHDILWRHPFPGPGLAVRCPGVVTKERLDIIRECDAIFIGNLKKY
HHHHHHHHHHHHCCCCHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHCCHHEECCCHHC
GWYDKVWQAYAGLIPVKTVGVKGDERSYEWATNLRAIVSEDAMTADWVELPPALLRETSN
CCHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHH
RILNEVKGINRVLYDISTKPPASIEWE
HHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MDDKHLVAVIDFGSQYTQLIVRRVRELGYMAKLYALEDLDQIHEPGAVILSGGPKSTTDA
CCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCC
DAPDIDFEWLQSLNVPVLGVCYGMQLLNIKHGGTVKASNKREYGPAALLPETCVGLYRDM
CCCCCCHHHHHHCCCCHHHHHHCHHEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHCC
SPSSQVWMSHSDTVDHLAEGCRVIARNAEGVPVSLQWGETTFGIQFHPEVTHSHEGRTIL
CCCCCEEECCCCCHHHHHHHHHEECCCCCCCEEEEEECCEEEEEEECCCCCCCCCCHHHH
RNFLSCAANLKKFDIGDFKRELIREIRERVGNRQVVCGVSGGVDSTVLAVLLHEAGVNMR
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCEE
AIFVDNGLLRKNEAEEVRANFARMNVEIETVDASERFLAALDGESDPEKKRRIIGGLFID
EEEECCCCCCCCCHHHHHHHHHHEEEEEEEECCHHHHHHCCCCCCCHHHHHHHHHHHHHH
VFWDAVGDAEMLAQGTLYPDVIESASNAKSKASVIKTHHNRVERVLELQAQGKVLEPLAE
HHHHHCCCHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LFKDEVRELGASMGIPHDILWRHPFPGPGLAVRCPGVVTKERLDIIRECDAIFIGNLKKY
HHHHHHHHHHHHCCCCHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHCCHHEECCCHHC
GWYDKVWQAYAGLIPVKTVGVKGDERSYEWATNLRAIVSEDAMTADWVELPPALLRETSN
CCHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHH
RILNEVKGINRVLYDISTKPPASIEWE
HHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA