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The map label for this gene is hisQ [H]

Identifier: 186476915

GI number: 186476915

Start: 2426230

End: 2426919

Strand: Direct

Name: hisQ [H]

Synonym: Bphy_2164

Alternate gene names: 186476915

Gene position: 2426230-2426919 (Clockwise)

Preceding gene: 186476914

Following gene: 186476916

Centisome position: 69.74

GC content: 60.87

Gene sequence:

>690_bases
ATGCTCTTTCAAGGCTACGGCCCGATCATCTTTGCCGGCACGGTGCAGACCGTGAAGCTGGCTATCCTGTCGCTCGCGCT
CGCATTCCTGCTCGGTCTGCTCGGCGCGGCAGCGAAGCTGTCGAAGAACCGGGTGACATACAGCGTCGGCACGATCTATA
CGACGCTGATTCGCGGCGTCCCGGATCTCGTGCTGATGCTGCTGCTCTTCTACAGCATCCAGATCTGGCTGAACAATCTG
ACCGACATGCTCGGCTGGGACCAGATCGACATCGATCCGTTCGTCGCCGGCGTCGCCGTGCTCGGCTTCATTTACGGCGC
GTACTTCACCGAGACATTCCGCGGCGCATTCCTCGCCGTGCCGCGCGGCCAGCTCGAAGCGGGCGCCGCGTACGGCATGA
CGGGCTGGCAGGTATTCTCGCGGATCATGTTTCCACAGATGATGCGCTTCGCGCTGCCCGGCATCGGCAATAACTGGCAG
GTGATGGTCAAAGCGACGGCGCTCGTGTCGATCATCGGTCTCGCGGACGTCGTCAAGGCGTCGCAGGACGCCGGCAAAGG
CACGTTGCGTTTCTTCTTTTTCACGCTGATGGCAGGCGCCATCTATCTGCTCATCACGACGGCTTCGAACTTCGTGCTGA
TGTACCTCGAAAAACGCTACTCGACTGGCGTGCGCAAGGCGGAACTATGA

Upstream 100 bases:

>100_bases
GCACGGGAGACATCGAAGGCCATCGGTCTTCGCGCGAACCGCCGCAGCGTACGATTGCCGCGTCTTTCGCGGCGCGCGGA
AGCGTCGTCAAGGACTCACT

Downstream 100 bases:

>100_bases
TCGAGCTGATCCAGCAATACTGGCGCAACTATCTGTATACGGACGGTTACCGCTTCACGGGCGTCGCCATCACGCTGTGG
CTGCTGGTGATTTCCATTGG

Product: polar amino acid ABC transporter inner membrane subunit

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MLFQGYGPIIFAGTVQTVKLAILSLALAFLLGLLGAAAKLSKNRVTYSVGTIYTTLIRGVPDLVLMLLLFYSIQIWLNNL
TDMLGWDQIDIDPFVAGVAVLGFIYGAYFTETFRGAFLAVPRGQLEAGAAYGMTGWQVFSRIMFPQMMRFALPGIGNNWQ
VMVKATALVSIIGLADVVKASQDAGKGTLRFFFFTLMAGAIYLLITTASNFVLMYLEKRYSTGVRKAEL

Sequences:

>Translated_229_residues
MLFQGYGPIIFAGTVQTVKLAILSLALAFLLGLLGAAAKLSKNRVTYSVGTIYTTLIRGVPDLVLMLLLFYSIQIWLNNL
TDMLGWDQIDIDPFVAGVAVLGFIYGAYFTETFRGAFLAVPRGQLEAGAAYGMTGWQVFSRIMFPQMMRFALPGIGNNWQ
VMVKATALVSIIGLADVVKASQDAGKGTLRFFFFTLMAGAIYLLITTASNFVLMYLEKRYSTGVRKAEL
>Mature_229_residues
MLFQGYGPIIFAGTVQTVKLAILSLALAFLLGLLGAAAKLSKNRVTYSVGTIYTTLIRGVPDLVLMLLLFYSIQIWLNNL
TDMLGWDQIDIDPFVAGVAVLGFIYGAYFTETFRGAFLAVPRGQLEAGAAYGMTGWQVFSRIMFPQMMRFALPGIGNNWQ
VMVKATALVSIIGLADVVKASQDAGKGTLRFFFFTLMAGAIYLLITTASNFVLMYLEKRYSTGVRKAEL

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4215

COG function: function code E; ABC-type arginine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788646, Length=225, Percent_Identity=61.7777777777778, Blast_Score=283, Evalue=6e-78,
Organism=Escherichia coli, GI1787087, Length=223, Percent_Identity=35.4260089686099, Blast_Score=133, Evalue=8e-33,
Organism=Escherichia coli, GI1787030, Length=212, Percent_Identity=30.188679245283, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1788226, Length=221, Percent_Identity=28.5067873303167, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788645, Length=218, Percent_Identity=29.3577981651376, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1786873, Length=212, Percent_Identity=27.3584905660377, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1786874, Length=181, Percent_Identity=30.3867403314917, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87082239, Length=220, Percent_Identity=27.7272727272727, Blast_Score=73, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 25089; Mature: 25089

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFQGYGPIIFAGTVQTVKLAILSLALAFLLGLLGAAAKLSKNRVTYSVGTIYTTLIRGV
CCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHCC
PDLVLMLLLFYSIQIWLNNLTDMLGWDQIDIDPFVAGVAVLGFIYGAYFTETFRGAFLAV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEC
PRGQLEAGAAYGMTGWQVFSRIMFPQMMRFALPGIGNNWQVMVKATALVSIIGLADVVKA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHH
SQDAGKGTLRFFFFTLMAGAIYLLITTASNFVLMYLEKRYSTGVRKAEL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLFQGYGPIIFAGTVQTVKLAILSLALAFLLGLLGAAAKLSKNRVTYSVGTIYTTLIRGV
CCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHCC
PDLVLMLLLFYSIQIWLNNLTDMLGWDQIDIDPFVAGVAVLGFIYGAYFTETFRGAFLAV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEC
PRGQLEAGAAYGMTGWQVFSRIMFPQMMRFALPGIGNNWQVMVKATALVSIIGLADVVKA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHH
SQDAGKGTLRFFFFTLMAGAIYLLITTASNFVLMYLEKRYSTGVRKAEL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]