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The map label for this gene is pdhS [H]

Identifier: 183222693

GI number: 183222693

Start: 3457822

End: 3459060

Strand: Direct

Name: pdhS [H]

Synonym: LEPBI_I3349

Alternate gene names: 183222693

Gene position: 3457822-3459060 (Clockwise)

Preceding gene: 183222683

Following gene: 183222694

Centisome position: 96.06

GC content: 36.32

Gene sequence:

>1239_bases
ATGTCATTCCCTATGACTGCCTCTCAAAAATCATACGAAGACTTGCTTCTGGAAATCCAAAGACTTGAAGCGGAGAACCA
GGCTCTCAAACAAAACCAAAAAAATTTCCAACATCACCAAACTAAAATTAGTGATCTTTTGCAATTCACTCAGTTCTCCA
TTGATACAGTTTCTGATTCGATCCTTTGGTTGGATGAAAAAGGAAAATATGTTTTTGTGAATAATGCCACTTGTATCAAT
TACGGATACACGAAAGAGGAACTCCTCTCAATGACCATGTTCCAAGTTGATCCATTGTTCACAAAAGAGATTTGGGAAGT
CCATTGGAATGAAATTTTGGAAAAAAAATCATTCACTTTAGAAACGATCAACAAAAGAAAGGACGGTACACCTTTTCCCA
TTGAGGTGACTGTCAACTTGGTTGAGTATGATGGTAAAAAGTACAACTGCGCTATTGTACGCGATATCACCGAACAAAAG
CTAAATGAAGCTAAGTTGAAACAAGCAGCCATACGTTTAGAAGAATTAAATGCAACGAAAGACAAATTTTTTTCAATCAT
TGCCCATGACCTGAGAGGACCTCTTGGAGCACATAAGGATTTTACAAAACTACTCATCGAAAGATTCGTTTCCCTAAGTG
ACGAGGAACGAGAGATTAATTTACAAATCATAAGTGAATCTTCTGAAAAATTATACTCCTTAATGGAAAATTTACTCCAT
TGGGCGAGTAATCAAAATGGAAGTATCCAATTCCAACCAACTCAGCTAAAATTATATACTTTGATTCAAAAAACAATTGA
GTTCTTAACTTTATCCATCCAGAAAAAACAAATCCAAGTTTTGAATCTAATCCCCGAATCACTCGAGATTGTAGCAGATG
CGTTTATGGTCGAAACGATTTTTCGTAACCTGATTGCAAATGCAATCAAATACAGCGAAACAAACCAAAGGATAAAAATT
GGTTGGATCCAATCGGAATCAAATGATCCATCCCAAAATCGTTCCCATCGATTTTATGTAAAAGATGAAGGTGTTGGAAT
GACGAAGGAACAATTGTTATCTTTATTCCGATTGGAACGAAAGTATTCGACTCCAGGCACTGCAAAGGAGACAGGCACTG
GACTTGGTCTCATTTTAAGTAAAGATTTTGTGGAACAACATCAAGGAAACATTTGGGTCGAAAGCGAGCCAAAACATGGG
ACAACTTTTTATATTGAACTAGGACATATCACAATATAA

Upstream 100 bases:

>100_bases
ATTTCTAAAAACCCTACTTGGTCAAGTCAATTTCCAAGATTGGGATTTCTCTGGTTCCACCCACATAGTTCTTGGCAATT
TATTCTAACATGACTAGAAT

Downstream 100 bases:

>100_bases
ACGAAGTTTCCTTCTTATGATCTGAAATTTTTTTCCATACGACTTAGCTGATTTTATTTTTGAATCGATACCAAAACCAT
CATTTGGATTTTTGAAAGTA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MSFPMTASQKSYEDLLLEIQRLEAENQALKQNQKNFQHHQTKISDLLQFTQFSIDTVSDSILWLDEKGKYVFVNNATCIN
YGYTKEELLSMTMFQVDPLFTKEIWEVHWNEILEKKSFTLETINKRKDGTPFPIEVTVNLVEYDGKKYNCAIVRDITEQK
LNEAKLKQAAIRLEELNATKDKFFSIIAHDLRGPLGAHKDFTKLLIERFVSLSDEEREINLQIISESSEKLYSLMENLLH
WASNQNGSIQFQPTQLKLYTLIQKTIEFLTLSIQKKQIQVLNLIPESLEIVADAFMVETIFRNLIANAIKYSETNQRIKI
GWIQSESNDPSQNRSHRFYVKDEGVGMTKEQLLSLFRLERKYSTPGTAKETGTGLGLILSKDFVEQHQGNIWVESEPKHG
TTFYIELGHITI

Sequences:

>Translated_412_residues
MSFPMTASQKSYEDLLLEIQRLEAENQALKQNQKNFQHHQTKISDLLQFTQFSIDTVSDSILWLDEKGKYVFVNNATCIN
YGYTKEELLSMTMFQVDPLFTKEIWEVHWNEILEKKSFTLETINKRKDGTPFPIEVTVNLVEYDGKKYNCAIVRDITEQK
LNEAKLKQAAIRLEELNATKDKFFSIIAHDLRGPLGAHKDFTKLLIERFVSLSDEEREINLQIISESSEKLYSLMENLLH
WASNQNGSIQFQPTQLKLYTLIQKTIEFLTLSIQKKQIQVLNLIPESLEIVADAFMVETIFRNLIANAIKYSETNQRIKI
GWIQSESNDPSQNRSHRFYVKDEGVGMTKEQLLSLFRLERKYSTPGTAKETGTGLGLILSKDFVEQHQGNIWVESEPKHG
TTFYIELGHITI
>Mature_411_residues
SFPMTASQKSYEDLLLEIQRLEAENQALKQNQKNFQHHQTKISDLLQFTQFSIDTVSDSILWLDEKGKYVFVNNATCINY
GYTKEELLSMTMFQVDPLFTKEIWEVHWNEILEKKSFTLETINKRKDGTPFPIEVTVNLVEYDGKKYNCAIVRDITEQKL
NEAKLKQAAIRLEELNATKDKFFSIIAHDLRGPLGAHKDFTKLLIERFVSLSDEEREINLQIISESSEKLYSLMENLLHW
ASNQNGSIQFQPTQLKLYTLIQKTIEFLTLSIQKKQIQVLNLIPESLEIVADAFMVETIFRNLIANAIKYSETNQRIKIG
WIQSESNDPSQNRSHRFYVKDEGVGMTKEQLLSLFRLERKYSTPGTAKETGTGLGLILSKDFVEQHQGNIWVESEPKHGT
TFYIELGHITI

Specific function: Functions as a polar differentiation marker. Essential protein that, by localizing in the old pole of dividing cells, controls cell division and maturation, probably through control of DivK phosphorylation status and cellular distribution, which in turn r

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm. Note=Localizes at the old pole of dividing cells. Colocalizes with divK (By similarity) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=275, Percent_Identity=27.2727272727273, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1789149, Length=260, Percent_Identity=24.6153846153846, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788549, Length=363, Percent_Identity=24.5179063360882, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI48994928, Length=399, Percent_Identity=23.0576441102757, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788393, Length=245, Percent_Identity=23.265306122449, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI145693157, Length=269, Percent_Identity=23.7918215613383, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87081816, Length=410, Percent_Identity=21.219512195122, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790436, Length=248, Percent_Identity=28.6290322580645, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI87082128, Length=241, Percent_Identity=23.6514522821577, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786783, Length=242, Percent_Identity=22.7272727272727, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790346, Length=245, Percent_Identity=25.3061224489796, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786600, Length=276, Percent_Identity=22.8260869565217, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47716; Mature: 47585

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFPMTASQKSYEDLLLEIQRLEAENQALKQNQKNFQHHQTKISDLLQFTQFSIDTVSDS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ILWLDEKGKYVFVNNATCINYGYTKEELLSMTMFQVDPLFTKEIWEVHWNEILEKKSFTL
EEEEECCCCEEEEECCEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHH
ETINKRKDGTPFPIEVTVNLVEYDGKKYNCAIVRDITEQKLNEAKLKQAAIRLEELNATK
HHHHCCCCCCCCEEEEEEEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHH
DKFFSIIAHDLRGPLGAHKDFTKLLIERFVSLSDEEREINLQIISESSEKLYSLMENLLH
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHH
WASNQNGSIQFQPTQLKLYTLIQKTIEFLTLSIQKKQIQVLNLIPESLEIVADAFMVETI
HHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
FRNLIANAIKYSETNQRIKIGWIQSESNDPSQNRSHRFYVKDEGVGMTKEQLLSLFRLER
HHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHH
KYSTPGTAKETGTGLGLILSKDFVEQHQGNIWVESEPKHGTTFYIELGHITI
HCCCCCCCCCCCCCEEEEEEHHHHHHHCCCEEEECCCCCCCEEEEEECCEEC
>Mature Secondary Structure 
SFPMTASQKSYEDLLLEIQRLEAENQALKQNQKNFQHHQTKISDLLQFTQFSIDTVSDS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ILWLDEKGKYVFVNNATCINYGYTKEELLSMTMFQVDPLFTKEIWEVHWNEILEKKSFTL
EEEEECCCCEEEEECCEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHH
ETINKRKDGTPFPIEVTVNLVEYDGKKYNCAIVRDITEQKLNEAKLKQAAIRLEELNATK
HHHHCCCCCCCCEEEEEEEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHH
DKFFSIIAHDLRGPLGAHKDFTKLLIERFVSLSDEEREINLQIISESSEKLYSLMENLLH
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHH
WASNQNGSIQFQPTQLKLYTLIQKTIEFLTLSIQKKQIQVLNLIPESLEIVADAFMVETI
HHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
FRNLIANAIKYSETNQRIKIGWIQSESNDPSQNRSHRFYVKDEGVGMTKEQLLSLFRLER
HHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHH
KYSTPGTAKETGTGLGLILSKDFVEQHQGNIWVESEPKHGTTFYIELGHITI
HCCCCCCCCCCCCCEEEEEEHHHHHHHCCCEEEECCCCCCCEEEEEECCEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA