| Definition | Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)' chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_010602 |
| Length | 3,599,677 |
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The map label for this gene is dkgA [C]
Identifier: 183221817
GI number: 183221817
Start: 2523373
End: 2524200
Strand: Reverse
Name: dkgA [C]
Synonym: LEPBI_I2448
Alternate gene names: 183221817
Gene position: 2524200-2523373 (Counterclockwise)
Preceding gene: 183221818
Following gene: 183221814
Centisome position: 70.12
GC content: 37.92
Gene sequence:
>828_bases ATGTCTGAACTCAATCTTACCTCCACAATTCCTACAAACCAGTCGATCGATGTTCCGTTACTCGGATTAGGGGTCTGGAA ATCACGACCAAAAGAATGTTATGATGCAGTGAAGTCTGCTTTGGAATTCGGTTACCGCCATATAGATACAGCCGCAATTT ATGGGAATGAAGCCGATGTGGGGAGAGCCTTAAAAGAGAGTGGAATCAAACGCAGTGATATTTTTCTTGTCACCAAACTT TGGAATGCGGACCAAGGGTATGATGAAGCGCAAAAGGCAATTGATATATCTTTAAAAAAATTAGGTACCGACTATGTCGA TATGTATTTAATCCACTTCCCTGTTTCTGGGAAACGAAATGATTCTTGGAGAGCCTTAGAGAAAATAAAAGGAGAAGGAA AGGCAAGGTCAATTGGAGTTAGTAATTTTATGGTTCCACACCTAGAAGAGTTACTGAAAGAAACAGACATCATTCCTGCA ATGAACCAAGTAGAATACCATCCATTTTTACAGGATTTAGAACTCAAAGAGTATTGTATTAAAAAAGGGATCGTATTGGA AGCCTATAGTCCGTTAGCTCATGGTCAAAAATTAGAAGATGAAAGGATCACAAATTTAGCAAAAAAGTATCATAAATCGA ATGCGCAAATTTTAATTCGATGGTCTTTACAAAATGGGAATGTCGTCATCCCAAAATCCAAAAATCCGATTCGCATCAAG GAAAATGCGGATGTATTTGATTTTGTTTTATCCCCAGATGATATGAAGGAAATCCATAGTTGGAATGAAAACTTTCGCAC TTGTTGGGATCCAACTACAGTGGATTAA
Upstream 100 bases:
>100_bases TCCAGGAAGCTACTGGCGTAAAAAAATAAGTTCATAGAAACCATTGAAACCCTACTGTAAATCAGTTTATGGTAGGGTTT TTTCGTCTAAAGAAGTAATT
Downstream 100 bases:
>100_bases TCATTCCATCTTAATTTTGTTTCTTCTTAAAAACGAGGACTGCCGATTGTCGGTTGTCCTTCGTGCCTAAGTAACCATAA CCGAATGGAAACGGTAAGAT
Product: 2,5-diketo-D-gluconic acid reductase A
Products: aldehyde; NADPH; H+
Alternate protein names: NA
Number of amino acids: Translated: 275; Mature: 274
Protein sequence:
>275_residues MSELNLTSTIPTNQSIDVPLLGLGVWKSRPKECYDAVKSALEFGYRHIDTAAIYGNEADVGRALKESGIKRSDIFLVTKL WNADQGYDEAQKAIDISLKKLGTDYVDMYLIHFPVSGKRNDSWRALEKIKGEGKARSIGVSNFMVPHLEELLKETDIIPA MNQVEYHPFLQDLELKEYCIKKGIVLEAYSPLAHGQKLEDERITNLAKKYHKSNAQILIRWSLQNGNVVIPKSKNPIRIK ENADVFDFVLSPDDMKEIHSWNENFRTCWDPTTVD
Sequences:
>Translated_275_residues MSELNLTSTIPTNQSIDVPLLGLGVWKSRPKECYDAVKSALEFGYRHIDTAAIYGNEADVGRALKESGIKRSDIFLVTKL WNADQGYDEAQKAIDISLKKLGTDYVDMYLIHFPVSGKRNDSWRALEKIKGEGKARSIGVSNFMVPHLEELLKETDIIPA MNQVEYHPFLQDLELKEYCIKKGIVLEAYSPLAHGQKLEDERITNLAKKYHKSNAQILIRWSLQNGNVVIPKSKNPIRIK ENADVFDFVLSPDDMKEIHSWNENFRTCWDPTTVD >Mature_274_residues SELNLTSTIPTNQSIDVPLLGLGVWKSRPKECYDAVKSALEFGYRHIDTAAIYGNEADVGRALKESGIKRSDIFLVTKLW NADQGYDEAQKAIDISLKKLGTDYVDMYLIHFPVSGKRNDSWRALEKIKGEGKARSIGVSNFMVPHLEELLKETDIIPAM NQVEYHPFLQDLELKEYCIKKGIVLEAYSPLAHGQKLEDERITNLAKKYHKSNAQILIRWSLQNGNVVIPKSKNPIRIKE NADVFDFVLSPDDMKEIHSWNENFRTCWDPTTVD
Specific function: Reduction [C]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI24497577, Length=293, Percent_Identity=38.2252559726962, Blast_Score=213, Evalue=2e-55, Organism=Homo sapiens, GI5174391, Length=293, Percent_Identity=38.2252559726962, Blast_Score=213, Evalue=2e-55, Organism=Homo sapiens, GI223468663, Length=299, Percent_Identity=38.7959866220736, Blast_Score=203, Evalue=2e-52, Organism=Homo sapiens, GI4502049, Length=299, Percent_Identity=40.133779264214, Blast_Score=193, Evalue=1e-49, Organism=Homo sapiens, GI5174695, Length=298, Percent_Identity=37.248322147651, Blast_Score=187, Evalue=9e-48, Organism=Homo sapiens, GI310109922, Length=269, Percent_Identity=41.635687732342, Blast_Score=183, Evalue=1e-46, Organism=Homo sapiens, GI5453543, Length=289, Percent_Identity=39.1003460207612, Blast_Score=182, Evalue=3e-46, Organism=Homo sapiens, GI310109920, Length=289, Percent_Identity=39.1003460207612, Blast_Score=182, Evalue=4e-46, Organism=Homo sapiens, GI45446745, Length=289, Percent_Identity=39.1003460207612, Blast_Score=181, Evalue=6e-46, Organism=Homo sapiens, GI4503285, Length=289, Percent_Identity=39.1003460207612, Blast_Score=181, Evalue=6e-46, Organism=Homo sapiens, GI24497585, Length=291, Percent_Identity=38.1443298969072, Blast_Score=178, Evalue=5e-45, Organism=Homo sapiens, GI93277124, Length=306, Percent_Identity=34.9673202614379, Blast_Score=174, Evalue=6e-44, Organism=Homo sapiens, GI291291012, Length=269, Percent_Identity=38.6617100371747, Blast_Score=173, Evalue=1e-43, Organism=Homo sapiens, GI24497583, Length=290, Percent_Identity=37.5862068965517, Blast_Score=171, Evalue=5e-43, Organism=Homo sapiens, GI300116273, Length=277, Percent_Identity=36.8231046931408, Blast_Score=166, Evalue=2e-41, Organism=Homo sapiens, GI300116271, Length=276, Percent_Identity=35.5072463768116, Blast_Score=157, Evalue=1e-38, Organism=Homo sapiens, GI310109924, Length=154, Percent_Identity=40.9090909090909, Blast_Score=102, Evalue=3e-22, Organism=Homo sapiens, GI310109926, Length=110, Percent_Identity=43.6363636363636, Blast_Score=89, Evalue=3e-18, Organism=Homo sapiens, GI207028673, Length=110, Percent_Identity=43.6363636363636, Blast_Score=89, Evalue=3e-18, Organism=Escherichia coli, GI87082198, Length=258, Percent_Identity=44.9612403100775, Blast_Score=222, Evalue=2e-59, Organism=Escherichia coli, GI1786400, Length=253, Percent_Identity=35.5731225296443, Blast_Score=163, Evalue=1e-41, Organism=Escherichia coli, GI1788081, Length=261, Percent_Identity=32.5670498084291, Blast_Score=120, Evalue=9e-29, Organism=Escherichia coli, GI87081735, Length=289, Percent_Identity=24.9134948096886, Blast_Score=74, Evalue=8e-15, Organism=Escherichia coli, GI1788070, Length=219, Percent_Identity=31.0502283105023, Blast_Score=70, Evalue=2e-13, Organism=Escherichia coli, GI1787674, Length=246, Percent_Identity=24.7967479674797, Blast_Score=64, Evalue=1e-11, Organism=Caenorhabditis elegans, GI71998625, Length=269, Percent_Identity=43.4944237918216, Blast_Score=208, Evalue=2e-54, Organism=Caenorhabditis elegans, GI17537077, Length=296, Percent_Identity=36.1486486486487, Blast_Score=190, Evalue=5e-49, Organism=Caenorhabditis elegans, GI17537075, Length=305, Percent_Identity=35.7377049180328, Blast_Score=187, Evalue=4e-48, Organism=Caenorhabditis elegans, GI17561298, Length=264, Percent_Identity=38.6363636363636, Blast_Score=186, Evalue=1e-47, Organism=Caenorhabditis elegans, GI17552492, Length=277, Percent_Identity=35.3790613718412, Blast_Score=184, Evalue=6e-47, Organism=Caenorhabditis elegans, GI17564128, Length=298, Percent_Identity=37.9194630872483, Blast_Score=183, Evalue=7e-47, Organism=Caenorhabditis elegans, GI17566692, Length=310, Percent_Identity=34.5161290322581, Blast_Score=170, Evalue=7e-43, Organism=Caenorhabditis elegans, GI17561300, Length=272, Percent_Identity=38.2352941176471, Blast_Score=170, Evalue=9e-43, Organism=Caenorhabditis elegans, GI17550248, Length=286, Percent_Identity=33.9160839160839, Blast_Score=168, Evalue=3e-42, Organism=Caenorhabditis elegans, GI17538386, Length=265, Percent_Identity=35.0943396226415, Blast_Score=160, Evalue=1e-39, Organism=Caenorhabditis elegans, GI17562292, Length=269, Percent_Identity=34.5724907063197, Blast_Score=158, Evalue=3e-39, Organism=Caenorhabditis elegans, GI17537079, Length=303, Percent_Identity=29.7029702970297, Blast_Score=155, Evalue=3e-38, Organism=Saccharomyces cerevisiae, GI6320576, Length=286, Percent_Identity=40.9090909090909, Blast_Score=212, Evalue=5e-56, Organism=Saccharomyces cerevisiae, GI6324694, Length=286, Percent_Identity=40.5594405594406, Blast_Score=202, Evalue=5e-53, Organism=Saccharomyces cerevisiae, GI6322556, Length=255, Percent_Identity=37.6470588235294, Blast_Score=181, Evalue=9e-47, Organism=Saccharomyces cerevisiae, GI6319625, Length=293, Percent_Identity=36.518771331058, Blast_Score=172, Evalue=7e-44, Organism=Saccharomyces cerevisiae, GI6321896, Length=311, Percent_Identity=32.1543408360129, Blast_Score=161, Evalue=1e-40, Organism=Saccharomyces cerevisiae, GI6320079, Length=246, Percent_Identity=36.5853658536585, Blast_Score=152, Evalue=4e-38, Organism=Drosophila melanogaster, GI20129731, Length=291, Percent_Identity=40.893470790378, Blast_Score=215, Evalue=2e-56, Organism=Drosophila melanogaster, GI24657054, Length=288, Percent_Identity=39.5833333333333, Blast_Score=191, Evalue=5e-49, Organism=Drosophila melanogaster, GI24644950, Length=306, Percent_Identity=34.9673202614379, Blast_Score=189, Evalue=2e-48, Organism=Drosophila melanogaster, GI24663317, Length=297, Percent_Identity=36.7003367003367, Blast_Score=188, Evalue=3e-48, Organism=Drosophila melanogaster, GI45553081, Length=295, Percent_Identity=35.9322033898305, Blast_Score=185, Evalue=3e-47, Organism=Drosophila melanogaster, GI221378297, Length=326, Percent_Identity=32.8220858895706, Blast_Score=181, Evalue=3e-46, Organism=Drosophila melanogaster, GI24662789, Length=287, Percent_Identity=35.191637630662, Blast_Score=179, Evalue=3e-45, Organism=Drosophila melanogaster, GI21356425, Length=297, Percent_Identity=36.026936026936, Blast_Score=172, Evalue=2e-43, Organism=Drosophila melanogaster, GI24662781, Length=288, Percent_Identity=38.1944444444444, Blast_Score=164, Evalue=7e-41, Organism=Drosophila melanogaster, GI24662785, Length=284, Percent_Identity=37.6760563380282, Blast_Score=159, Evalue=2e-39, Organism=Drosophila melanogaster, GI281366140, Length=256, Percent_Identity=35.9375, Blast_Score=157, Evalue=1e-38,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: 1.1.1.2
Molecular weight: Translated: 31340; Mature: 31209
Theoretical pI: Translated: 6.41; Mature: 6.41
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.1 %Cys (Translated Protein) 1.8 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 1.1 %Cys (Mature Protein) 1.5 %Met (Mature Protein) 2.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSELNLTSTIPTNQSIDVPLLGLGVWKSRPKECYDAVKSALEFGYRHIDTAAIYGNEADV CCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCHHH GRALKESGIKRSDIFLVTKLWNADQGYDEAQKAIDISLKKLGTDYVDMYLIHFPVSGKRN HHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCHHEEEEEEEECCCCCCC DSWRALEKIKGEGKARSIGVSNFMVPHLEELLKETDIIPAMNQVEYHPFLQDLELKEYCI CHHHHHHHHCCCCCEEEECCHHCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH KKGIVLEAYSPLAHGQKLEDERITNLAKKYHKSNAQILIRWSLQNGNVVIPKSKNPIRIK HCCEEEEECCCHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEECCCCCEEEE ENADVFDFVLSPDDMKEIHSWNENFRTCWDPTTVD CCCCEEEEEECCHHHHHHHHHCCCCCEECCCCCCC >Mature Secondary Structure SELNLTSTIPTNQSIDVPLLGLGVWKSRPKECYDAVKSALEFGYRHIDTAAIYGNEADV CCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCHHH GRALKESGIKRSDIFLVTKLWNADQGYDEAQKAIDISLKKLGTDYVDMYLIHFPVSGKRN HHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCHHEEEEEEEECCCCCCC DSWRALEKIKGEGKARSIGVSNFMVPHLEELLKETDIIPAMNQVEYHPFLQDLELKEYCI CHHHHHHHHCCCCCEEEECCHHCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH KKGIVLEAYSPLAHGQKLEDERITNLAKKYHKSNAQILIRWSLQNGNVVIPKSKNPIRIK HCCEEEEECCCHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEECCCCCEEEE ENADVFDFVLSPDDMKEIHSWNENFRTCWDPTTVD CCCCEEEEEECCHHHHHHHHHCCCCCEECCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: alcohol; NADP+
Specific reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA