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The map label for this gene is fbiC [H]

Identifier: 183221187

GI number: 183221187

Start: 1878686

End: 1879789

Strand: Reverse

Name: fbiC [H]

Synonym: LEPBI_I1801

Alternate gene names: 183221187

Gene position: 1879789-1878686 (Counterclockwise)

Preceding gene: 183221192

Following gene: 183221183

Centisome position: 52.22

GC content: 45.92

Gene sequence:

>1104_bases
ATGAATTTAGCCTCCTTTTCCCTGAACCCGAATGATCCAGTCGATTCCGTCCTTTTGAAGGCTACGGAAGGCAAACGCAT
CTCACCAAAAGAGGGACTCCTTCTCTACAAAGAAGGAGACTTTCTGAAAATCCAAATGGTGGCACGTTTCCTCCGAGAGA
AGATACGTCCTCATTCCGAGGCAAGTTACACCATGTTTCGGGTGGTGAACTATACCAATTATTGTAATGTTGAATGTAGT
TTTTGTTCCTTCATGGATGAAATTGGGAATGGGAAGGGATATGTCCTCTCCAAAGAAGACATCCTGCAAAAGATGGACTA
TGCCATGGAAGAAGGGGCCGACCAAATGTTCTTACAGGGAGGGGTGTATCCAGAGCTTCCTTTTGATTATTATTTGGACG
TGATTCGCACCGTAAAAGCCAAATACCCTAAAATGCATATCCGAGCCTTTTCCCCGGTAGAGGTAATCAACCTGGAGACC
ATTACAGGAAAACCACTCCGTGAAGTTTTAGAAATTTTAAAAGAAGCAGGACTTGATTCAGTCCCGGGTGCCGGGGCAGA
AATCCTCACAGAAAGGATGCGCCAAATCATCTCTCCGAAGAAAGCAACGGTGGCGGAGTGGGTTCGAGCCATGGAAACCT
GCCACGAAGTGGGACTCAAAGGCTCTGCCAATATCGTATTTGGATCGGAAGAAACAGAAGAGGAAGTGATGGAACACTTG
CAGGTGGTGCGAGATTTACAAGATCGTACCGGTGGGTTTTTGTCTTTTATCCCTTGGACCTTCCAACCCCAAACCAAACG
GTTCAAAGTGAGGCCTGTTCCGACACATGAGTATTTGAAGGTGCTTGGGATCTGCCGAATTTTCCTCGATAATATCCAAC
ACATTGAAACTTCTGTGATGGTGCTAGGGAAAGGGGTTGGACAACTGGCACTCTATTCAGGAGCCGATGATATATCTTCT
GTTGTGATTGAAGAAAATGTCCTCCGTTCATTTGGACTGAAAACGGAGAAGGAAGCGAGAAAATTCCTTAAGGAAGGTGG
GTTTCGACCCGTCCGCCGTGATCTCAATTATGAAGAAGTGCCAACGAATTTGGAGCTGGTATAA

Upstream 100 bases:

>100_bases
TTTGGTATTTCCTAGGATTTCTATAGAAAAATGAATGTCCAGGAAAATTCGGTTTTTACAGGGATATGTCAGAAGATTTC
CTGTCCAAGTAGGTAGAGAT

Downstream 100 bases:

>100_bases
ACTAACTGATCGATCGGTTGTGATGACAGAGTCGTAAAAGGATTCTGAAATCTGGTCGCATTCGATTCTCTTCGAGTCGG
CAGCGAAACAAACAAAACAT

Product: hypothetical protein

Products: NA

Alternate protein names: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase [H]

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MNLASFSLNPNDPVDSVLLKATEGKRISPKEGLLLYKEGDFLKIQMVARFLREKIRPHSEASYTMFRVVNYTNYCNVECS
FCSFMDEIGNGKGYVLSKEDILQKMDYAMEEGADQMFLQGGVYPELPFDYYLDVIRTVKAKYPKMHIRAFSPVEVINLET
ITGKPLREVLEILKEAGLDSVPGAGAEILTERMRQIISPKKATVAEWVRAMETCHEVGLKGSANIVFGSEETEEEVMEHL
QVVRDLQDRTGGFLSFIPWTFQPQTKRFKVRPVPTHEYLKVLGICRIFLDNIQHIETSVMVLGKGVGQLALYSGADDISS
VVIEENVLRSFGLKTEKEARKFLKEGGFRPVRRDLNYEEVPTNLELV

Sequences:

>Translated_367_residues
MNLASFSLNPNDPVDSVLLKATEGKRISPKEGLLLYKEGDFLKIQMVARFLREKIRPHSEASYTMFRVVNYTNYCNVECS
FCSFMDEIGNGKGYVLSKEDILQKMDYAMEEGADQMFLQGGVYPELPFDYYLDVIRTVKAKYPKMHIRAFSPVEVINLET
ITGKPLREVLEILKEAGLDSVPGAGAEILTERMRQIISPKKATVAEWVRAMETCHEVGLKGSANIVFGSEETEEEVMEHL
QVVRDLQDRTGGFLSFIPWTFQPQTKRFKVRPVPTHEYLKVLGICRIFLDNIQHIETSVMVLGKGVGQLALYSGADDISS
VVIEENVLRSFGLKTEKEARKFLKEGGFRPVRRDLNYEEVPTNLELV
>Mature_367_residues
MNLASFSLNPNDPVDSVLLKATEGKRISPKEGLLLYKEGDFLKIQMVARFLREKIRPHSEASYTMFRVVNYTNYCNVECS
FCSFMDEIGNGKGYVLSKEDILQKMDYAMEEGADQMFLQGGVYPELPFDYYLDVIRTVKAKYPKMHIRAFSPVEVINLET
ITGKPLREVLEILKEAGLDSVPGAGAEILTERMRQIISPKKATVAEWVRAMETCHEVGLKGSANIVFGSEETEEEVMEHL
QVVRDLQDRTGGFLSFIPWTFQPQTKRFKVRPVPTHEYLKVLGICRIFLDNIQHIETSVMVLGKGVGQLALYSGADDISS
VVIEENVLRSFGLKTEKEARKFLKEGGFRPVRRDLNYEEVPTNLELV

Specific function: Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) [H]

COG id: COG1060

COG function: function code HR; Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the radical SAM superfamily. CofH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR019940
- InterPro:   IPR006638
- InterPro:   IPR019939
- InterPro:   IPR020050
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 41666; Mature: 41666

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLASFSLNPNDPVDSVLLKATEGKRISPKEGLLLYKEGDFLKIQMVARFLREKIRPHSE
CCCCCCCCCCCCCHHHHHEECCCCCCCCCCCCEEEEECCCEEEHHHHHHHHHHHCCCCCC
ASYTMFRVVNYTNYCNVECSFCSFMDEIGNGKGYVLSKEDILQKMDYAMEEGADQMFLQG
CCEEEEEEEECCCCCCCEEHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHCCCHHHHHCC
GVYPELPFDYYLDVIRTVKAKYPKMHIRAFSPVEVINLETITGKPLREVLEILKEAGLDS
CCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEEECCCHHHHHHHHHHHHCCCCC
VPGAGAEILTERMRQIISPKKATVAEWVRAMETCHEVGLKGSANIVFGSEETEEEVMEHL
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHH
QVVRDLQDRTGGFLSFIPWTFQPQTKRFKVRPVPTHEYLKVLGICRIFLDNIQHIETSVM
HHHHHHHHHCCCEEEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VLGKGVGQLALYSGADDISSVVIEENVLRSFGLKTEKEARKFLKEGGFRPVRRDLNYEEV
HHHCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHCCCHHHC
PTNLELV
CCCCCCC
>Mature Secondary Structure
MNLASFSLNPNDPVDSVLLKATEGKRISPKEGLLLYKEGDFLKIQMVARFLREKIRPHSE
CCCCCCCCCCCCCHHHHHEECCCCCCCCCCCCEEEEECCCEEEHHHHHHHHHHHCCCCCC
ASYTMFRVVNYTNYCNVECSFCSFMDEIGNGKGYVLSKEDILQKMDYAMEEGADQMFLQG
CCEEEEEEEECCCCCCCEEHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHCCCHHHHHCC
GVYPELPFDYYLDVIRTVKAKYPKMHIRAFSPVEVINLETITGKPLREVLEILKEAGLDS
CCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEEECCCHHHHHHHHHHHHCCCCC
VPGAGAEILTERMRQIISPKKATVAEWVRAMETCHEVGLKGSANIVFGSEETEEEVMEHL
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHH
QVVRDLQDRTGGFLSFIPWTFQPQTKRFKVRPVPTHEYLKVLGICRIFLDNIQHIETSVM
HHHHHHHHHCCCEEEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VLGKGVGQLALYSGADDISSVVIEENVLRSFGLKTEKEARKFLKEGGFRPVRRDLNYEEV
HHHCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHCCCHHHC
PTNLELV
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]