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The map label for this gene is ilvA [H]

Identifier: 183220977

GI number: 183220977

Start: 1666115

End: 1667392

Strand: Direct

Name: ilvA [H]

Synonym: LEPBI_I1590

Alternate gene names: 183220977

Gene position: 1666115-1667392 (Clockwise)

Preceding gene: 183220976

Following gene: 183220981

Centisome position: 46.29

GC content: 38.97

Gene sequence:

>1278_bases
ATGAGTTCCTTGGGAAACTTGAGACAAACTGGAACGTACCTCCCCATGAAATTAGATATCGATTCTGCTTATAAAATCTT
AGAACCTATTGTGAAAAAAACTCCCTTAGAGTATCATTCTAGGTTATCCGACCTTTATGGTGCCAAGGTATTCATCAAAC
GTGAAGACCTCCAAGTGGTTCGATCTTACAAAATCCGCGGTGCGTATCATATGATCCAAAGTTTACCCATGGAAACAAGA
TCACATGGTGTTGTTTGTGCGAGTGCCGGAAACCATGCGCAAGGCGTCGCTTATTCCTGTAATCTTTTGAAACTATATGG
TAAAATTTATATGCCAGAAGTGACACCAAAACAAAAAATCAACCAGGTACGTATGTTTGGTGGTGAATTCATCGAAATTA
GATTAGTCGGTGATACATTTGATGAATGCCAAAAAGAAGCAATAGACTATGCGAATACAAACAAAATGTCATTTATCCCT
CCCTTTGATCATAATAAGATTATGGAGGGTCAGGGGACGGTTGCAAAGGAAATTCTTTTCGAATTGGATCGTATCGACTA
CCTATTTTTGCCGATTGGAGGTGGTGGACTTTGTGCCGGAGTGGGAACCTATTTTAAAATTCATTCCCCACAAACAAAAA
TCATTGGAGCTGAGCCGATGGGGGCTCCTTCCATGAAAGAAGCTTTCCACTCAGGCAAGCCAATTGTCTTGGAGAAAATT
GATAAATTTGTCGATGGAGCTGCTGTAAAAAAAGTGGGTGAGTTTACGTTTCCAATTTGCCAATCAGTTTTGCATGACCT
TTGCCTCGTGCCAGAAGGAAAGGTTTGTACCACCATATTAAATTTATATAATCTTGATGCGATCGTAAGTGAGCCAGCGG
GAGCATTGAGTATCGCTGCCTTAGACGATTATAAAGAATCCATACGTGGCAAAACGGTTGTTTGTATTCTCAGTGGAGGG
AATAACGATATTGATCGTATGCAAGAGATCAAGGAGAGATCGTTACTCTATGAAGGTCTTAAACAATACTTCATTGTTCG
GTTTGCTCAGAAGCCAGGAGCCCTCAAACAATTTGTAAATGAAATATTAGGACCCAATGATGACATCGTGAGATTCGAAT
TCATTCAAAAAAATAATAAAGAATCTGGGCCAGCGCTCATTGGAATTGAACTCAAATCAAAAGATGATTTCCAAAATTTA
CTCATCCGTATGCAAGAATATCGATTGAATTTTACGTTGATCAACCAAGATGAAAATTTATTTGAATATCTCATTTGA

Upstream 100 bases:

>100_bases
AAAATAGAAACCTGGTTTTAACTGAGAACATTTGAATTTTTAATTGTATGCTGATCGTAATTATCGGTTCTCTAGTGAAT
ATATTTTTCATTGGTAAAGA

Downstream 100 bases:

>100_bases
GACTTAAGTTAAATTAAAAACTTGTTTTTGTTTTTCCTATCTTTTCGTTGAAATTCTTTGATTTGTCTAAAGGAAAATGA
ATTTTGATCGATATTGGTAT

Product: threonine dehydratase biosynthetic

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSSLGNLRQTGTYLPMKLDIDSAYKILEPIVKKTPLEYHSRLSDLYGAKVFIKREDLQVVRSYKIRGAYHMIQSLPMETR
SHGVVCASAGNHAQGVAYSCNLLKLYGKIYMPEVTPKQKINQVRMFGGEFIEIRLVGDTFDECQKEAIDYANTNKMSFIP
PFDHNKIMEGQGTVAKEILFELDRIDYLFLPIGGGGLCAGVGTYFKIHSPQTKIIGAEPMGAPSMKEAFHSGKPIVLEKI
DKFVDGAAVKKVGEFTFPICQSVLHDLCLVPEGKVCTTILNLYNLDAIVSEPAGALSIAALDDYKESIRGKTVVCILSGG
NNDIDRMQEIKERSLLYEGLKQYFIVRFAQKPGALKQFVNEILGPNDDIVRFEFIQKNNKESGPALIGIELKSKDDFQNL
LIRMQEYRLNFTLINQDENLFEYLI

Sequences:

>Translated_425_residues
MSSLGNLRQTGTYLPMKLDIDSAYKILEPIVKKTPLEYHSRLSDLYGAKVFIKREDLQVVRSYKIRGAYHMIQSLPMETR
SHGVVCASAGNHAQGVAYSCNLLKLYGKIYMPEVTPKQKINQVRMFGGEFIEIRLVGDTFDECQKEAIDYANTNKMSFIP
PFDHNKIMEGQGTVAKEILFELDRIDYLFLPIGGGGLCAGVGTYFKIHSPQTKIIGAEPMGAPSMKEAFHSGKPIVLEKI
DKFVDGAAVKKVGEFTFPICQSVLHDLCLVPEGKVCTTILNLYNLDAIVSEPAGALSIAALDDYKESIRGKTVVCILSGG
NNDIDRMQEIKERSLLYEGLKQYFIVRFAQKPGALKQFVNEILGPNDDIVRFEFIQKNNKESGPALIGIELKSKDDFQNL
LIRMQEYRLNFTLINQDENLFEYLI
>Mature_424_residues
SSLGNLRQTGTYLPMKLDIDSAYKILEPIVKKTPLEYHSRLSDLYGAKVFIKREDLQVVRSYKIRGAYHMIQSLPMETRS
HGVVCASAGNHAQGVAYSCNLLKLYGKIYMPEVTPKQKINQVRMFGGEFIEIRLVGDTFDECQKEAIDYANTNKMSFIPP
FDHNKIMEGQGTVAKEILFELDRIDYLFLPIGGGGLCAGVGTYFKIHSPQTKIIGAEPMGAPSMKEAFHSGKPIVLEKID
KFVDGAAVKKVGEFTFPICQSVLHDLCLVPEGKVCTTILNLYNLDAIVSEPAGALSIAALDDYKESIRGKTVVCILSGGN
NDIDRMQEIKERSLLYEGLKQYFIVRFAQKPGALKQFVNEILGPNDDIVRFEFIQKNNKESGPALIGIELKSKDDFQNLL
IRMQEYRLNFTLINQDENLFEYLI

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=313, Percent_Identity=27.4760383386581, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI19923959, Length=318, Percent_Identity=27.6729559748428, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI33469958, Length=326, Percent_Identity=27.9141104294479, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1790207, Length=348, Percent_Identity=37.0689655172414, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1789505, Length=326, Percent_Identity=34.9693251533742, Blast_Score=158, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71991565, Length=352, Percent_Identity=32.1022727272727, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17537387, Length=392, Percent_Identity=29.8469387755102, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17508781, Length=320, Percent_Identity=25.625, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320930, Length=345, Percent_Identity=36.8115942028986, Blast_Score=210, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6322631, Length=313, Percent_Identity=34.185303514377, Blast_Score=166, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6319788, Length=234, Percent_Identity=25.2136752136752, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355833, Length=341, Percent_Identity=32.8445747800587, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24645328, Length=249, Percent_Identity=31.3253012048193, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR001721
- InterPro:   IPR011820 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 47720; Mature: 47589

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLGNLRQTGTYLPMKLDIDSAYKILEPIVKKTPLEYHSRLSDLYGAKVFIKREDLQVV
CCCCCCHHHCCCCCEEEECHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEHHHHHHH
RSYKIRGAYHMIQSLPMETRSHGVVCASAGNHAQGVAYSCNLLKLYGKIYMPEVTPKQKI
HHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCEEEHHHHHHHHHHCCCCCCHHHHH
NQVRMFGGEFIEIRLVGDTFDECQKEAIDYANTNKMSFIPPFDHNKIMEGQGTVAKEILF
HHHHHCCCCEEEEEEECCCHHHHHHHHHCCCCCCCEEECCCCCCCCEECCCCHHHHHHHH
ELDRIDYLFLPIGGGGLCAGVGTYFKIHSPQTKIIGAEPMGAPSMKEAFHSGKPIVLEKI
HHHCCCEEEEEECCCCHHHCCCCEEEEECCCCEEEECCCCCCCHHHHHHHCCCCHHHHHH
DKFVDGAAVKKVGEFTFPICQSVLHDLCLVPEGKVCTTILNLYNLDAIVSEPAGALSIAA
HHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEE
LDDYKESIRGKTVVCILSGGNNDIDRMQEIKERSLLYEGLKQYFIVRFAQKPGALKQFVN
HHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
EILGPNDDIVRFEFIQKNNKESGPALIGIELKSKDDFQNLLIRMQEYRLNFTLINQDENL
HHCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHHHEEEEEEECCCCHH
FEYLI
HHHCC
>Mature Secondary Structure 
SSLGNLRQTGTYLPMKLDIDSAYKILEPIVKKTPLEYHSRLSDLYGAKVFIKREDLQVV
CCCCCHHHCCCCCEEEECHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEHHHHHHH
RSYKIRGAYHMIQSLPMETRSHGVVCASAGNHAQGVAYSCNLLKLYGKIYMPEVTPKQKI
HHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCEEEHHHHHHHHHHCCCCCCHHHHH
NQVRMFGGEFIEIRLVGDTFDECQKEAIDYANTNKMSFIPPFDHNKIMEGQGTVAKEILF
HHHHHCCCCEEEEEEECCCHHHHHHHHHCCCCCCCEEECCCCCCCCEECCCCHHHHHHHH
ELDRIDYLFLPIGGGGLCAGVGTYFKIHSPQTKIIGAEPMGAPSMKEAFHSGKPIVLEKI
HHHCCCEEEEEECCCCHHHCCCCEEEEECCCCEEEECCCCCCCHHHHHHHCCCCHHHHHH
DKFVDGAAVKKVGEFTFPICQSVLHDLCLVPEGKVCTTILNLYNLDAIVSEPAGALSIAA
HHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEE
LDDYKESIRGKTVVCILSGGNNDIDRMQEIKERSLLYEGLKQYFIVRFAQKPGALKQFVN
HHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
EILGPNDDIVRFEFIQKNNKESGPALIGIELKSKDDFQNLLIRMQEYRLNFTLINQDENL
HHCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHHHEEEEEEECCCCHH
FEYLI
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]