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The map label for this gene is luxQ [H]

Identifier: 183220974

GI number: 183220974

Start: 1662186

End: 1663808

Strand: Reverse

Name: luxQ [H]

Synonym: LEPBI_I1587

Alternate gene names: 183220974

Gene position: 1663808-1662186 (Counterclockwise)

Preceding gene: 183220975

Following gene: 183220973

Centisome position: 46.22

GC content: 35.43

Gene sequence:

>1623_bases
ATGATAGAAGACCCGATGTCATTATTTCAGGCCTCGCTTGAGGGAAATGACTCGGGAATCGCCATCTTAGTCATTGACGT
TTCTCAAAAAAAGTATGAAATCCTTCTCAAAAACTCCATATTTACCTCATTAGAAACTGAATTTGAATTTTCTTTTTTTC
TAAAAAATAAAATTGAACGGAATGATTTTCAAACGGAAATCATTTATAAAACAGATGGTAAAATCTTAGAAACATCTTTT
GGTCACTTTGCTTTTCATGGAGATTCAGAAGGAAAACAATATTCCAAATTTTTTATCCGCGATATCACGATCAAACAAAA
ACAAGAAGAAGAAATCGCCTGGAGACTTCGTTTTGAATTAGGTGTTGCTTCTTCCATTCAAATCCTCATACAAAAACCAT
CCATTCGGGAAAGTTTGCCACAGGCTCTGTATCAATTATTGTATTTTACAGAAATGGATTCCATTTTTTTCTTAAAAAAC
ATTTCAAGTGGAGATAAAGACCTATTCGAAATTTGGGTGAACGAAAGGAAATCAACTGATTACCCACTGTTATCTGACAA
ATTCAAATCATTGGATTGGAAATCACAAGGTTTGAATCGTTGGATCCATAAGTTAAAAAATGGAAAAGTCATATACCTAA
AAAAAGAGAAAGCCTTACCAAAAGAATTATGGTACTTTGAAGAATCAAAAGCAGAAACGATTCTTTTTATTCCAGTCAAG
TTTGAAAATCATTTTTTAGGCATTATGGGTTTTCAAAAGTATACTCCCAATTTTGTCATCCATCATGAAAATTTACTGAT
TTACCAAACAGTCAGTCGATGGATGGGATTATTTGTACAAAGAGATTTAGACTTAACTGAACTCAATCGATATAAATCTA
CCTTAGAATCACTGATCTTAGAACGAACGTTAGACCTTAGCCGCACCAAAGAAGAATTAGAACGTGCTTATAAAGCCAAA
ACAGAATTTTTGGCCCATGTCAGCCACGAACTTCGCACTCCACTCAACTCCATCATTGGATTTTCGAAACTCATCCAATT
GCCTGAAAACGATATCACAGGAAAAGAATACTTACAATACATCTATTCTGGTGGAACAAGACTTCTCAAAATGATCAATG
AAATTCTGAGTTTAATGAAAATTGAATCAGGCCAACTCAACCTTCAAATTTCCGAATTCAAACCAGAAGAAATCGCTCGG
CAATCTTTAGAATTAATCCAACCTCAAGCTGATGCAAAAGGGATGGAAATCCGGTTCTTTCCTCCCATCCAGTCTAAAAA
CATTCGATCCGATGCTGGGAAAATCCAACAAATCCTACTCAATTTACTTTCTAATGCGATTAAATACGGAGACCATTCTT
ATGTCGAATTCCATTGCGAGTGGATAGAGGGTAGAGTTACCTTTTCTGTGCGAGATTTTGGACCAGGCATCACAGAAGAA
GACCAAAGTCGAATCTTTCATAGTTTCACAAGATTAAACGATGATGGAAAGATTGAAGGATCGGGTCTTGGTTTGTCAAT
TTCACAGGGATTGGCTGAAAAACTTGGTGGAAATATCGAACTCACATCGTTATGGGGGGAAGGTTCCACATTTATACTCA
AGATCCCTGAAAATATTAAATAA

Upstream 100 bases:

>100_bases
CTAAAACATTTTCCAAATGCAAAAGTATCCCTATTTCCGGAAAGCAGGGAAGATACCATGAGTTTCAAACTTCCCAAAGA
ACTACTAAAACAATATTAAT

Downstream 100 bases:

>100_bases
AGGTATTGAATGGATTAGAAATATCGAATAGAATTTCCGATATTCTATATGGTGGAACCAATCGAACCAACAAATCCGAC
TGTTTCAAAAACAGAACACT

Product: putative sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 540; Mature: 540

Protein sequence:

>540_residues
MIEDPMSLFQASLEGNDSGIAILVIDVSQKKYEILLKNSIFTSLETEFEFSFFLKNKIERNDFQTEIIYKTDGKILETSF
GHFAFHGDSEGKQYSKFFIRDITIKQKQEEEIAWRLRFELGVASSIQILIQKPSIRESLPQALYQLLYFTEMDSIFFLKN
ISSGDKDLFEIWVNERKSTDYPLLSDKFKSLDWKSQGLNRWIHKLKNGKVIYLKKEKALPKELWYFEESKAETILFIPVK
FENHFLGIMGFQKYTPNFVIHHENLLIYQTVSRWMGLFVQRDLDLTELNRYKSTLESLILERTLDLSRTKEELERAYKAK
TEFLAHVSHELRTPLNSIIGFSKLIQLPENDITGKEYLQYIYSGGTRLLKMINEILSLMKIESGQLNLQISEFKPEEIAR
QSLELIQPQADAKGMEIRFFPPIQSKNIRSDAGKIQQILLNLLSNAIKYGDHSYVEFHCEWIEGRVTFSVRDFGPGITEE
DQSRIFHSFTRLNDDGKIEGSGLGLSISQGLAEKLGGNIELTSLWGEGSTFILKIPENIK

Sequences:

>Translated_540_residues
MIEDPMSLFQASLEGNDSGIAILVIDVSQKKYEILLKNSIFTSLETEFEFSFFLKNKIERNDFQTEIIYKTDGKILETSF
GHFAFHGDSEGKQYSKFFIRDITIKQKQEEEIAWRLRFELGVASSIQILIQKPSIRESLPQALYQLLYFTEMDSIFFLKN
ISSGDKDLFEIWVNERKSTDYPLLSDKFKSLDWKSQGLNRWIHKLKNGKVIYLKKEKALPKELWYFEESKAETILFIPVK
FENHFLGIMGFQKYTPNFVIHHENLLIYQTVSRWMGLFVQRDLDLTELNRYKSTLESLILERTLDLSRTKEELERAYKAK
TEFLAHVSHELRTPLNSIIGFSKLIQLPENDITGKEYLQYIYSGGTRLLKMINEILSLMKIESGQLNLQISEFKPEEIAR
QSLELIQPQADAKGMEIRFFPPIQSKNIRSDAGKIQQILLNLLSNAIKYGDHSYVEFHCEWIEGRVTFSVRDFGPGITEE
DQSRIFHSFTRLNDDGKIEGSGLGLSISQGLAEKLGGNIELTSLWGEGSTFILKIPENIK
>Mature_540_residues
MIEDPMSLFQASLEGNDSGIAILVIDVSQKKYEILLKNSIFTSLETEFEFSFFLKNKIERNDFQTEIIYKTDGKILETSF
GHFAFHGDSEGKQYSKFFIRDITIKQKQEEEIAWRLRFELGVASSIQILIQKPSIRESLPQALYQLLYFTEMDSIFFLKN
ISSGDKDLFEIWVNERKSTDYPLLSDKFKSLDWKSQGLNRWIHKLKNGKVIYLKKEKALPKELWYFEESKAETILFIPVK
FENHFLGIMGFQKYTPNFVIHHENLLIYQTVSRWMGLFVQRDLDLTELNRYKSTLESLILERTLDLSRTKEELERAYKAK
TEFLAHVSHELRTPLNSIIGFSKLIQLPENDITGKEYLQYIYSGGTRLLKMINEILSLMKIESGQLNLQISEFKPEEIAR
QSLELIQPQADAKGMEIRFFPPIQSKNIRSDAGKIQQILLNLLSNAIKYGDHSYVEFHCEWIEGRVTFSVRDFGPGITEE
DQSRIFHSFTRLNDDGKIEGSGLGLSISQGLAEKLGGNIELTSLWGEGSTFILKIPENIK

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87081816, Length=279, Percent_Identity=32.258064516129, Blast_Score=133, Evalue=4e-32,
Organism=Escherichia coli, GI1789149, Length=252, Percent_Identity=34.5238095238095, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI48994928, Length=236, Percent_Identity=35.5932203389831, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI145693157, Length=234, Percent_Identity=34.1880341880342, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1788713, Length=241, Percent_Identity=31.1203319502075, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790436, Length=236, Percent_Identity=32.2033898305085, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786912, Length=253, Percent_Identity=27.2727272727273, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786783, Length=282, Percent_Identity=25.886524822695, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1787894, Length=226, Percent_Identity=30.0884955752212, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1788549, Length=245, Percent_Identity=27.3469387755102, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790346, Length=199, Percent_Identity=29.1457286432161, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1789403, Length=200, Percent_Identity=30.5, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1786600, Length=240, Percent_Identity=24.1666666666667, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788393, Length=233, Percent_Identity=24.4635193133047, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI87082128, Length=232, Percent_Identity=25.4310344827586, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1790300, Length=241, Percent_Identity=25.3112033195021, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 62612; Mature: 62612

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEDPMSLFQASLEGNDSGIAILVIDVSQKKYEILLKNSIFTSLETEFEFSFFLKNKIER
CCCCHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEEEHHHHHHHCCCEEEEEHHHHCCCC
NDFQTEIIYKTDGKILETSFGHFAFHGDSEGKQYSKFFIRDITIKQKQEEEIAWRLRFEL
CCCCEEEEEECCCCEEEECCCCEEEECCCCCCHHHHHHHEEEEECCCCHHHHEEEEEEEE
GVASSIQILIQKPSIRESLPQALYQLLYFTEMDSIFFLKNISSGDKDLFEIWVNERKSTD
CCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCCC
YPLLSDKFKSLDWKSQGLNRWIHKLKNGKVIYLKKEKALPKELWYFEESKAETILFIPVK
CCCHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHEEECCCCCEEEEEEEE
FENHFLGIMGFQKYTPNFVIHHENLLIYQTVSRWMGLFVQRDLDLTELNRYKSTLESLIL
ECCCEEEEEEHHCCCCCEEEEECCEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ERTLDLSRTKEELERAYKAKTEFLAHVSHELRTPLNSIIGFSKLIQLPENDITGKEYLQY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHH
IYSGGTRLLKMINEILSLMKIESGQLNLQISEFKPEEIARQSLELIQPQADAKGMEIRFF
HHHCHHHHHHHHHHHHHHHEECCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCEEEEE
PPIQSKNIRSDAGKIQQILLNLLSNAIKYGDHSYVEFHCEWIEGRVTFSVRDFGPGITEE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCEEEEEEECCCCCCCCC
DQSRIFHSFTRLNDDGKIEGSGLGLSISQGLAEKLGGNIELTSLWGEGSTFILKIPENIK
HHHHHHHHHHHCCCCCEEECCCCCEEHHHHHHHHCCCCEEEEEEECCCCEEEEECCCCCC
>Mature Secondary Structure
MIEDPMSLFQASLEGNDSGIAILVIDVSQKKYEILLKNSIFTSLETEFEFSFFLKNKIER
CCCCHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEEEHHHHHHHCCCEEEEEHHHHCCCC
NDFQTEIIYKTDGKILETSFGHFAFHGDSEGKQYSKFFIRDITIKQKQEEEIAWRLRFEL
CCCCEEEEEECCCCEEEECCCCEEEECCCCCCHHHHHHHEEEEECCCCHHHHEEEEEEEE
GVASSIQILIQKPSIRESLPQALYQLLYFTEMDSIFFLKNISSGDKDLFEIWVNERKSTD
CCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCCC
YPLLSDKFKSLDWKSQGLNRWIHKLKNGKVIYLKKEKALPKELWYFEESKAETILFIPVK
CCCHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHEEECCCCCEEEEEEEE
FENHFLGIMGFQKYTPNFVIHHENLLIYQTVSRWMGLFVQRDLDLTELNRYKSTLESLIL
ECCCEEEEEEHHCCCCCEEEEECCEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ERTLDLSRTKEELERAYKAKTEFLAHVSHELRTPLNSIIGFSKLIQLPENDITGKEYLQY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHH
IYSGGTRLLKMINEILSLMKIESGQLNLQISEFKPEEIARQSLELIQPQADAKGMEIRFF
HHHCHHHHHHHHHHHHHHHEECCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCEEEEE
PPIQSKNIRSDAGKIQQILLNLLSNAIKYGDHSYVEFHCEWIEGRVTFSVRDFGPGITEE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCEEEEEEECCCCCCCCC
DQSRIFHSFTRLNDDGKIEGSGLGLSISQGLAEKLGGNIELTSLWGEGSTFILKIPENIK
HHHHHHHHHHHCCCCCEEECCCCCEEHHHHHHHHCCCCEEEEEEECCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]