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The map label for this gene is ispH [H]

Identifier: 183220975

GI number: 183220975

Start: 1663810

End: 1664757

Strand: Reverse

Name: ispH [H]

Synonym: LEPBI_I1588

Alternate gene names: 183220975

Gene position: 1664757-1663810 (Counterclockwise)

Preceding gene: 183220978

Following gene: 183220974

Centisome position: 46.25

GC content: 41.88

Gene sequence:

>948_bases
GTGCTAGAAACGATTTATTTAGCAAACCCACGCGGTTTTTGTGCAGGTGTCAAATATGCAATTTCGTATGTGGAACAAGC
CTTCCAAGAAAATCCAGACACGCCACTTTATGTACGAAAAGAAATTGTCCATAACCAAAGAGTTGTGGAAGAAATGAAAA
AAAAGGGAATTCGCTTCATAAGCGAACTCTCTGAAGTTCCCGATGGTGCCACAGTCGTTTTTTCTGCACACGGGGTTTCA
CCCGAAGTCGTCAAGGAAGCAACCGAACGAAAGATGAAAATCGGTGATGCCACCTGCCCCCTTGTGACTCGAGTCCATAA
AAAGGCACGTAACATTCGTGATACGCATCAAATCATTTACATTGGTCATAGAGGCCATGATGAAGCGATTGGTACCATGG
GGGAAGCAGAGATGTTTCTCGTAGAATCACCAGAAGATGTTGAGAATCTGAAAGGGAAAATCTCAACTGAAAAAGCACTC
ACCTATTTGATGCAGACCACTCTCTCTGTTGAAGATACAAAAAACATTGTCAAAAAAATTGAGGAAGTTTTCCCTTTTGT
CGAGCACCCCCAAAAAGATGACATCTGTTATGCGACAACAGAACGCCAAGATGCTGTTCAGAAAATGTTAGGATCCGTTG
ATGCCATGCTCGTCATTGGTGCGGAAAATTCTTCCAACTCCGTAAGACTCTGTCAACTAGCGAAAAAAACAAGACCCGCT
AGTTTTCAAATTTCAAAAAAGGATGATGTAAACCCCAAACATATCATCGAATCGGGGATTAAAATTTTGGGGATCACGGC
AGGGGCATCTAGCCCACAAGTTCTCGTGGACGAAATTGTGGAAGAGATCCTAAAACATTTTCCAAATGCAAAAGTATCCC
TATTTCCGGAAAGCAGGGAAGATACCATGAGTTTCAAACTTCCCAAAGAACTACTAAAACAATATTAA

Upstream 100 bases:

>100_bases
AAAATGAAATAAAATTTGAATAAAAATAGAACTTCCCCTTTTCTAAAATATGTCCTAGGAATTCTATGGAAATGGATCCT
AGTGAAAAGGAAGGTTTTTC

Downstream 100 bases:

>100_bases
TATGATAGAAGACCCGATGTCATTATTTCAGGCCTCGCTTGAGGGAAATGACTCGGGAATCGCCATCTTAGTCATTGACG
TTTCTCAAAAAAAGTATGAA

Product: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MLETIYLANPRGFCAGVKYAISYVEQAFQENPDTPLYVRKEIVHNQRVVEEMKKKGIRFISELSEVPDGATVVFSAHGVS
PEVVKEATERKMKIGDATCPLVTRVHKKARNIRDTHQIIYIGHRGHDEAIGTMGEAEMFLVESPEDVENLKGKISTEKAL
TYLMQTTLSVEDTKNIVKKIEEVFPFVEHPQKDDICYATTERQDAVQKMLGSVDAMLVIGAENSSNSVRLCQLAKKTRPA
SFQISKKDDVNPKHIIESGIKILGITAGASSPQVLVDEIVEEILKHFPNAKVSLFPESREDTMSFKLPKELLKQY

Sequences:

>Translated_315_residues
MLETIYLANPRGFCAGVKYAISYVEQAFQENPDTPLYVRKEIVHNQRVVEEMKKKGIRFISELSEVPDGATVVFSAHGVS
PEVVKEATERKMKIGDATCPLVTRVHKKARNIRDTHQIIYIGHRGHDEAIGTMGEAEMFLVESPEDVENLKGKISTEKAL
TYLMQTTLSVEDTKNIVKKIEEVFPFVEHPQKDDICYATTERQDAVQKMLGSVDAMLVIGAENSSNSVRLCQLAKKTRPA
SFQISKKDDVNPKHIIESGIKILGITAGASSPQVLVDEIVEEILKHFPNAKVSLFPESREDTMSFKLPKELLKQY
>Mature_315_residues
MLETIYLANPRGFCAGVKYAISYVEQAFQENPDTPLYVRKEIVHNQRVVEEMKKKGIRFISELSEVPDGATVVFSAHGVS
PEVVKEATERKMKIGDATCPLVTRVHKKARNIRDTHQIIYIGHRGHDEAIGTMGEAEMFLVESPEDVENLKGKISTEKAL
TYLMQTTLSVEDTKNIVKKIEEVFPFVEHPQKDDICYATTERQDAVQKMLGSVDAMLVIGAENSSNSVRLCQLAKKTRPA
SFQISKKDDVNPKHIIESGIKILGITAGASSPQVLVDEIVEEILKHFPNAKVSLFPESREDTMSFKLPKELLKQY

Specific function: Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) [H]

COG id: COG0761

COG function: function code IM; Penicillin tolerance protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispH family [H]

Homologues:

Organism=Escherichia coli, GI1786212, Length=313, Percent_Identity=46.3258785942492, Blast_Score=271, Evalue=3e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003451 [H]

Pfam domain/function: PF02401 LYTB [H]

EC number: =1.17.1.2 [H]

Molecular weight: Translated: 35316; Mature: 35316

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLETIYLANPRGFCAGVKYAISYVEQAFQENPDTPLYVRKEIVHNQRVVEEMKKKGIRFI
CCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SELSEVPDGATVVFSAHGVSPEVVKEATERKMKIGDATCPLVTRVHKKARNIRDTHQIIY
HHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEE
IGHRGHDEAIGTMGEAEMFLVESPEDVENLKGKISTEKALTYLMQTTLSVEDTKNIVKKI
EECCCCCHHHCCCCCCEEEEEECCHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHH
EEVFPFVEHPQKDDICYATTERQDAVQKMLGSVDAMLVIGAENSSNSVRLCQLAKKTRPA
HHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCCC
SFQISKKDDVNPKHIIESGIKILGITAGASSPQVLVDEIVEEILKHFPNAKVSLFPESRE
CEEECCCCCCCHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCC
DTMSFKLPKELLKQY
CCHHHHCHHHHHHCC
>Mature Secondary Structure
MLETIYLANPRGFCAGVKYAISYVEQAFQENPDTPLYVRKEIVHNQRVVEEMKKKGIRFI
CCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SELSEVPDGATVVFSAHGVSPEVVKEATERKMKIGDATCPLVTRVHKKARNIRDTHQIIY
HHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEE
IGHRGHDEAIGTMGEAEMFLVESPEDVENLKGKISTEKALTYLMQTTLSVEDTKNIVKKI
EECCCCCHHHCCCCCCEEEEEECCHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHH
EEVFPFVEHPQKDDICYATTERQDAVQKMLGSVDAMLVIGAENSSNSVRLCQLAKKTRPA
HHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCCC
SFQISKKDDVNPKHIIESGIKILGITAGASSPQVLVDEIVEEILKHFPNAKVSLFPESRE
CEEECCCCCCCHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCC
DTMSFKLPKELLKQY
CCHHHHCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA