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The map label for this gene is 183220590

Identifier: 183220590

GI number: 183220590

Start: 1244375

End: 1246348

Strand: Direct

Name: 183220590

Synonym: LEPBI_I1194

Alternate gene names: NA

Gene position: 1244375-1246348 (Clockwise)

Preceding gene: 183220589

Following gene: 183220591

Centisome position: 34.57

GC content: 36.07

Gene sequence:

>1974_bases
GTGAGCCAATCTTCGGATTTCAAATACATCATCACGGATGACCCCTTTTTTGAAGGTAAAATTGCCGATTATTCTAAAAA
ACTAAAAACGAATGTTCTTTCTTTATCGGAACTGCTAACAACGGATTTTGATTCACAAGGAAAAATCATCAAAGTATTAT
TTTACATCTCGCGATTCGAGTTGGAAAATAAACACAAAGAGATCCATCAATTTTTAAAAGTACATCCAACCATTATGTCG
AACATCATCGTTCGTGCACCTATCGACTACACTGGTTATATGGCACTCTCAATCGAGGAAGACTTATTTTTTACCAATGT
CCCTGACGATGCACCTTTGGTATTCCTTATCAAAAATTTGATCAATGCCTTTACCAGCTTACAAATGATCGTTGATAAGT
TTGAACTTCAAAAACGGATTAATGTCTCTACAAATGAAATTTCGAAATTAACAAAAATTGGAATCAGTCTTGCGAACGAA
AAAGATTTCACAAAACTACTCCGTGATATTTTGAATTCTGCTCGTGAAATTTCCAACTCGGATTCAGGGTCATTGTATTT
GGTTGAAAAAGATGAAAGAGGTAATCCCAGAAATTTAAGATTTAAAATTTCAGCCTTGGATCTGAATAGTGATGAATTCA
TTTTACCAATTAATAAAAAAAGTATCGCGGGATACGTTGCATTTACTGGGAAACAATTAAACATCCCGAATGTTTATGAA
CTTTCAGGAAAGGAAGAATATAAATTCAATAGCGATTTTGATCGAATGAGTAATTATTACTCCAAATCAATGTTAGTGGT
TCCAATGAAAGACCACCATGATGAAGTTGTTGGTGTTATCCAACTCATCAATCGCAAAAAAAACTTCCAAACCAAACTTA
GTTTAGAAGAGATGAAAACCAATTCAGTATTGGAATATGATAAATATTCGGAAGAATTGGTGATGGCAGTGGCGGGTCAA
GCGGCCGTTGCCATCCAAAACAATAATTTGGTTCATGACATCGAAACTTTGTTTGAAGGGTTTGTGACCGCAAGTGTTTC
GGCCATTGAATCGAGGGATCCCACTACCTCAGGTCATTCGTTTCGAGTGGCACAATATACAGTGGGTCTTGCTGAATCAG
TTAATAGTGTACAAGTAGGCCGATTCAAAGATGTCAATTTTAATGAATCTCAAATCAAAGAAATTCGTTATGCATCATTA
TTACATGATTTTGGAAAAGTTGGAGTTAGGGAAAAAGTTTTAGTCAAAGCCAAAAAATTGGAAGACTATGAAATGGATCT
CATCCGATGGAGATTCCAATTCATTTTAAAAGATGTCGAAGCAAAACTATCTCAAAAGAAAATTGATTACTTAAAAAAAC
ACGGTAACAATGGTTACCCACAATTTGAAAAATCCATCCAATTGGAATATGCCTTAGAAAAAGGAAAATTGGAAGAGATG
GTACGTGTCATTACTGATTCCAACGAACCAACCATTTTAGAAGAAGGAAACTCAAACTTTTTAGAAGAAATTTCAAAGAT
GAGTTACCATACAACTGATGGAAACCAATTGAGTTTACTTTTGCCAAAAGAGTTCGGTTTTTTATCGATCAGACGTGGAT
CTCTCGATTTTGAAGAAAGAAGGGAAATTGAATCCCACGTTGAACATACATTCCAATTTTTATCCAAAATCCCATGGACA
CGTGAATTAAAAATGGTTCCAAGCATAGCGCATGGTCACCATGAAAAATTGAATGGTTCTGGTTACCCTCGTGGTTTGTC
TGCTGTCGAAATTCCAGTGCAGGCAAAAATGATGGCCATTGCCGATATTTTTGATGCTCTCACGGACCAAGATCGACCTT
ATAAAAAAGCAGTGCCCTTGGACCGTGCATTTGATATCCTCAAAATGGAAGTGAGGGACCAACACATCGATGGTGACCTT
CTCGATCTATTCATTGAAAGTCGTGCTTACGAAAAAATTCAGCACAAACGATAA

Upstream 100 bases:

>100_bases
AAGTTTGGTTTTTGGGGTTCTACTTCTCTTCAAACCAAAGTCAGAGTAAATTTTTGAAAAAACAATCGACAGTGAATTTT
TTGCTGTCGATAGTATATCC

Downstream 100 bases:

>100_bases
AAAAAACCTGAAAAAAAGTTCGTCTTTTAAAGCACCTCCGAAACTTCTGTGTCTAAGCACTAGGAGGAGATATGAACCAA
ACTCTAAAAGGTCGTACTGT

Product: hypothetical protein

Products: nucleoside 5'-phosphate

Alternate protein names: Metal-Dependent Phosphohydrolase; Response Regulator; Chemotaxis Sensory Transducer Family Protein; HAMP Domain Protein; GAF Domain-Containing Protein; HD-GYP Domain-Containing Protein; Response Regulator Receiver; Methyl-Accepting Chemotaxis Protein; PAS/PAC Sensor Protein; HD-Domain-Containing Protein; GAF Domain/HD Domain-Containing Protein; GAF Domain Protein; Chemotactic Transducer-Related Protein; Response Regulator Receiver Protein; Sensor Histidine Kinase; Response Regulator CheB; HD Domain-Containing Protein; Pas/Pac Sensor Protein; Two-Component Response Regulator; ABC-Type Amino Acid Transport Signal Transduction Systems; HAMP Domain/GAF Domain/HD Domain-Containing Protein; Metal Dependent Phosphohydrolase With Gaf Sensor; HD-GYP/GAF Domain-Containing Protein; Hamp Domain/Gaf Domain/Hd Domain Protein; 3 5'-Cyclic-Nucleotide Phosphodiesterase; GAF Domain/HD Domain Protein; GAF Containing Protein; Diguanylate Cyclase; Replicative DNA Helicase; HD_GYP Domain-Containing Response Regulator; Metal Dependent Phophohydrolase; Two-Component System Response Regulator Protein; Two-Component Regulatory System Response Regulator; Sensor Histidine Kinase/GAF Domain-Containing Protein; Metal-Dependent Phosphohydrolase HD Region; Metal-Dependent Phosphohydrolase Hd Subdomain; Diguanylate Cyclase And Metal Dependent Phosphohydrolase; HD-Hydrolase Domain-Containing Protein; Integral Membrane Protein Two-Component Signal Transducer; HAMP Domain-Containing Protein; Fused HD-GYP/HD-Hydrolase Domain-Containing Protein; Two-Component System Response Regulator; HD Domain Protein; Response Regulator/Phosphatase; Two-Component Hybrid Sensor And Regulator Protein; Signaling Protein; Chemotaxis Protein; Response Regulator With HD-GYP Domain; Metal Dependent Phosphohydrolase HD Region; Diguanylate Cyclase With GAF Sensor; Two-Component Response Regulator Fusion Protein; Response Regulator Containing A CheY-Like Receiver Domain; Multi-Sensor Signal Transduction Histidine Kinase

Number of amino acids: Translated: 657; Mature: 656

Protein sequence:

>657_residues
MSQSSDFKYIITDDPFFEGKIADYSKKLKTNVLSLSELLTTDFDSQGKIIKVLFYISRFELENKHKEIHQFLKVHPTIMS
NIIVRAPIDYTGYMALSIEEDLFFTNVPDDAPLVFLIKNLINAFTSLQMIVDKFELQKRINVSTNEISKLTKIGISLANE
KDFTKLLRDILNSAREISNSDSGSLYLVEKDERGNPRNLRFKISALDLNSDEFILPINKKSIAGYVAFTGKQLNIPNVYE
LSGKEEYKFNSDFDRMSNYYSKSMLVVPMKDHHDEVVGVIQLINRKKNFQTKLSLEEMKTNSVLEYDKYSEELVMAVAGQ
AAVAIQNNNLVHDIETLFEGFVTASVSAIESRDPTTSGHSFRVAQYTVGLAESVNSVQVGRFKDVNFNESQIKEIRYASL
LHDFGKVGVREKVLVKAKKLEDYEMDLIRWRFQFILKDVEAKLSQKKIDYLKKHGNNGYPQFEKSIQLEYALEKGKLEEM
VRVITDSNEPTILEEGNSNFLEEISKMSYHTTDGNQLSLLLPKEFGFLSIRRGSLDFEERREIESHVEHTFQFLSKIPWT
RELKMVPSIAHGHHEKLNGSGYPRGLSAVEIPVQAKMMAIADIFDALTDQDRPYKKAVPLDRAFDILKMEVRDQHIDGDL
LDLFIESRAYEKIQHKR

Sequences:

>Translated_657_residues
MSQSSDFKYIITDDPFFEGKIADYSKKLKTNVLSLSELLTTDFDSQGKIIKVLFYISRFELENKHKEIHQFLKVHPTIMS
NIIVRAPIDYTGYMALSIEEDLFFTNVPDDAPLVFLIKNLINAFTSLQMIVDKFELQKRINVSTNEISKLTKIGISLANE
KDFTKLLRDILNSAREISNSDSGSLYLVEKDERGNPRNLRFKISALDLNSDEFILPINKKSIAGYVAFTGKQLNIPNVYE
LSGKEEYKFNSDFDRMSNYYSKSMLVVPMKDHHDEVVGVIQLINRKKNFQTKLSLEEMKTNSVLEYDKYSEELVMAVAGQ
AAVAIQNNNLVHDIETLFEGFVTASVSAIESRDPTTSGHSFRVAQYTVGLAESVNSVQVGRFKDVNFNESQIKEIRYASL
LHDFGKVGVREKVLVKAKKLEDYEMDLIRWRFQFILKDVEAKLSQKKIDYLKKHGNNGYPQFEKSIQLEYALEKGKLEEM
VRVITDSNEPTILEEGNSNFLEEISKMSYHTTDGNQLSLLLPKEFGFLSIRRGSLDFEERREIESHVEHTFQFLSKIPWT
RELKMVPSIAHGHHEKLNGSGYPRGLSAVEIPVQAKMMAIADIFDALTDQDRPYKKAVPLDRAFDILKMEVRDQHIDGDL
LDLFIESRAYEKIQHKR
>Mature_656_residues
SQSSDFKYIITDDPFFEGKIADYSKKLKTNVLSLSELLTTDFDSQGKIIKVLFYISRFELENKHKEIHQFLKVHPTIMSN
IIVRAPIDYTGYMALSIEEDLFFTNVPDDAPLVFLIKNLINAFTSLQMIVDKFELQKRINVSTNEISKLTKIGISLANEK
DFTKLLRDILNSAREISNSDSGSLYLVEKDERGNPRNLRFKISALDLNSDEFILPINKKSIAGYVAFTGKQLNIPNVYEL
SGKEEYKFNSDFDRMSNYYSKSMLVVPMKDHHDEVVGVIQLINRKKNFQTKLSLEEMKTNSVLEYDKYSEELVMAVAGQA
AVAIQNNNLVHDIETLFEGFVTASVSAIESRDPTTSGHSFRVAQYTVGLAESVNSVQVGRFKDVNFNESQIKEIRYASLL
HDFGKVGVREKVLVKAKKLEDYEMDLIRWRFQFILKDVEAKLSQKKIDYLKKHGNNGYPQFEKSIQLEYALEKGKLEEMV
RVITDSNEPTILEEGNSNFLEEISKMSYHTTDGNQLSLLLPKEFGFLSIRRGSLDFEERREIESHVEHTFQFLSKIPWTR
ELKMVPSIAHGHHEKLNGSGYPRGLSAVEIPVQAKMMAIADIFDALTDQDRPYKKAVPLDRAFDILKMEVRDQHIDGDLL
DLFIESRAYEKIQHKR

Specific function: Unknown

COG id: COG2206

COG function: function code T; HD-GYP domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI61744435, Length=152, Percent_Identity=31.5789473684211, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI61744432, Length=152, Percent_Identity=31.5789473684211, Blast_Score=70, Evalue=9e-12,
Organism=Homo sapiens, GI61744430, Length=152, Percent_Identity=31.5789473684211, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161076955, Length=160, Percent_Identity=28.125, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161076953, Length=139, Percent_Identity=28.7769784172662, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281361762, Length=187, Percent_Identity=26.2032085561497, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.1.4.17

Molecular weight: Translated: 75483; Mature: 75352

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSSDFKYIITDDPFFEGKIADYSKKLKTNVLSLSELLTTDFDSQGKIIKVLFYISRFE
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LENKHKEIHQFLKVHPTIMSNIIVRAPIDYTGYMALSIEEDLFFTNVPDDAPLVFLIKNL
HHHHHHHHHHHHHHCHHHHHCEEEECCCCCCCEEEEEEECCEEEECCCCCCHHHHHHHHH
INAFTSLQMIVDKFELQKRINVSTNEISKLTKIGISLANEKDFTKLLRDILNSAREISNS
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
DSGSLYLVEKDERGNPRNLRFKISALDLNSDEFILPINKKSIAGYVAFTGKQLNIPNVYE
CCCEEEEEEECCCCCCCCEEEEEEEEECCCCCEEEEECCCCCEEEEEEECCCCCCCCEEE
LSGKEEYKFNSDFDRMSNYYSKSMLVVPMKDHHDEVVGVIQLINRKKNFQTKLSLEEMKT
CCCCCCCCCCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCHHHEEHHHHCC
NSVLEYDKYSEELVMAVAGQAAVAIQNNNLVHDIETLFEGFVTASVSAIESRDPTTSGHS
CCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
FRVAQYTVGLAESVNSVQVGRFKDVNFNESQIKEIRYASLLHDFGKVGVREKVLVKAKKL
EEEHHHHHHHHHCCCCEECCCEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHC
EDYEMDLIRWRFQFILKDVEAKLSQKKIDYLKKHGNNGYPQFEKSIQLEYALEKGKLEEM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEEEHHHHCCHHHH
VRVITDSNEPTILEEGNSNFLEEISKMSYHTTDGNQLSLLLPKEFGFLSIRRGSLDFEER
HHHHHCCCCCEEEECCCCHHHHHHHHCEEECCCCCEEEEEECCCCCEEEEECCCCCHHHH
REIESHVEHTFQFLSKIPWTRELKMVPSIAHGHHEKLNGSGYPRGLSAVEIPVQAKMMAI
HHHHHHHHHHHHHHHHCCCCHHHHHCCHHHCCCCCCCCCCCCCCCCCEEECCHHHHHHHH
ADIFDALTDQDRPYKKAVPLDRAFDILKMEVRDQHIDGDLLDLFIESRAYEKIQHKR
HHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SQSSDFKYIITDDPFFEGKIADYSKKLKTNVLSLSELLTTDFDSQGKIIKVLFYISRFE
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LENKHKEIHQFLKVHPTIMSNIIVRAPIDYTGYMALSIEEDLFFTNVPDDAPLVFLIKNL
HHHHHHHHHHHHHHCHHHHHCEEEECCCCCCCEEEEEEECCEEEECCCCCCHHHHHHHHH
INAFTSLQMIVDKFELQKRINVSTNEISKLTKIGISLANEKDFTKLLRDILNSAREISNS
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
DSGSLYLVEKDERGNPRNLRFKISALDLNSDEFILPINKKSIAGYVAFTGKQLNIPNVYE
CCCEEEEEEECCCCCCCCEEEEEEEEECCCCCEEEEECCCCCEEEEEEECCCCCCCCEEE
LSGKEEYKFNSDFDRMSNYYSKSMLVVPMKDHHDEVVGVIQLINRKKNFQTKLSLEEMKT
CCCCCCCCCCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCHHHEEHHHHCC
NSVLEYDKYSEELVMAVAGQAAVAIQNNNLVHDIETLFEGFVTASVSAIESRDPTTSGHS
CCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
FRVAQYTVGLAESVNSVQVGRFKDVNFNESQIKEIRYASLLHDFGKVGVREKVLVKAKKL
EEEHHHHHHHHHCCCCEECCCEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHC
EDYEMDLIRWRFQFILKDVEAKLSQKKIDYLKKHGNNGYPQFEKSIQLEYALEKGKLEEM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEEEHHHHCCHHHH
VRVITDSNEPTILEEGNSNFLEEISKMSYHTTDGNQLSLLLPKEFGFLSIRRGSLDFEER
HHHHHCCCCCEEEECCCCHHHHHHHHCEEECCCCCEEEEEECCCCCEEEEECCCCCHHHH
REIESHVEHTFQFLSKIPWTRELKMVPSIAHGHHEKLNGSGYPRGLSAVEIPVQAKMMAI
HHHHHHHHHHHHHHHHCCCCHHHHHCCHHHCCCCCCCCCCCCCCCCCEEECCHHHHHHHH
ADIFDALTDQDRPYKKAVPLDRAFDILKMEVRDQHIDGDLLDLFIESRAYEKIQHKR
HHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: nucleoside 3',5'-cyclic phosphate; H2O

Specific reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA