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The map label for this gene is 183220518

Identifier: 183220518

GI number: 183220518

Start: 1166359

End: 1168377

Strand: Direct

Name: 183220518

Synonym: LEPBI_I1119

Alternate gene names: NA

Gene position: 1166359-1168377 (Clockwise)

Preceding gene: 183220516

Following gene: 183220533

Centisome position: 32.4

GC content: 34.42

Gene sequence:

>2019_bases
ATGACTGGAATTTCAATTTGGAACCAAGTTTCAGTTTTGGAAGATTCCAAACAATCGATCCCCGCTGAATCCATCATTCA
TGGTGAAAGGGACCTTGAATTCAAATCTCTCAAATCCCCCAATTTAGGATTTTCGCAATCGGTGTATTGGGTGAGGTTCG
AGATTTTCAATCCGACATCTCAATTGATTCGATGGAATTTGGCTTATGATTTCCCGCTCATCGATGAAATCCAATTGTTT
GGAAGTCCCCTCCCTAAAGATTCCGTACGAACGCTGGGAGATTCATTTCCCTTTTCTCAAAGAAATGTAGATTATCGCAA
TCCAGTGTTCCCTATGGAGACACCTCCTAACACTACGAATGTATATTATTTAAAGATAAAATCAGAATCAACAATTCCTT
TGATTTTGGAACTTTGGACGGAAAAGGAATTCTATGAAAAGTTAAATAAAGAACAAATGATTTTCGGCATATTTTATGGA
ATTTTATTTGTGATGATTGCTTATAATTTTTTCATTTATATTTTTACTTACGAAAAAAGTTATTTGTTATATCTATTTTT
TATCAGTTCGATCTTTTTCTTCCATTTGGTTAACAATGGATTTGCGTTTCAATACATTTGGCCAAATTGGGTTTTTTGGG
CGAATTATTCCTTGCCGTTTTTTATTTGTTTGTCTTGTATTACAGGAATTATTTTTACTAACAACTACTTAAGTTTAAAA
AAGCATCTACCTAAGGTTTCGAAATTGATGTGGATTTGGGTTGGTATGCTGATTCTTTTTGTTGGGGTTTCCTTCTTCTT
GCGATACCGAGTGGCGATGGTGGCTTCCATTTTAATGACGGTACCAACAGCGTTATTACTCGTATATAGTGGGACATATA
CTTATCTTTCCAAGGTGAGAACTGCAAGGTATTATTTAATATCTTGGGCGTTTTTCCTCTTAGGAGTTTTATTATACTCT
TTAAAAAGTTTAGGTTTTTTATCAGACAATCATATCACACGATGGACCATTCAAATTGGAACAGCACTACAGACGATTTT
GTTATCACTTGGTCTTGCTGACAGAATCAATTTTTTAACTAGAAGCCTTCGAGAAAATTTACGTGATTTGTCACATGCAA
AGGTGAAGATTGAGGAATCAGAAAAAAGATTCCGTGAAATTTTCCAAGGTTCTGACGAAGTCATTTTAATGATGAATGAA
AATTTTGAAATCATCAATGCAAATCGGTCTTTGTCCAAACATTTAGGTTATCGATTGGATGATCTTAAATTCAAAAAAAT
TACAGAGATTCTTTATACAGGCCGGGACCAAAAGTCAGATTATAATGTGATGTTTGTGAATGATAAACTGACTGATTTAA
AAATGACAGGATCCGCCATCAATTTTAAGACAGAACTTTCTCAAAAGTATGTGAAAGAACCAAAGGAGATGGTATGCCGT
ATCCAATACATTGACTTTGATGAGACAAGAGAAGTTCTCATGACCTTGTCACCTGAGTATGAAGATACCATCATCCAATT
GATTGATTCCGAAAAAATAGAACTTTCGATGAATAATTACCTTCGAAATGCAGAACTTGTCTCCCAAAAAATCACAGCAC
AATTAGCAAAATATCTCACTACAATTGAACAAACTGAAGTTAGGTCATCTGTAAGGGAGATCATCATCAATGCGGTGGAA
CATGGAAATTTAAATATTAGTTTTGATGAAAAATCAAAAGCTCTTTTGGAAGGAAATTATTTAGAGTTTTTGCAAAAAAG
GCAAGAAGACCCTAGATATCGCAATAAAAAGGTGAAAATCGAATATTCGTTTAGCAGTGAATATGTGGCGTTTCGCATCA
CAGATGAAGGAAAGGGCTTTGATCATAAAAAACATATGGAGAAATCCATCGAAGAAATGAATGAAGCGCACGTGCAACAT
GGACGTGGGATTCTTATGACAAAATCTGTTTTTGATCGGATTGAATACAATGACAAAGGAAATCAAGTCAGTTTGATTAA
GTTTTTAAACCGAGATTAA

Upstream 100 bases:

>100_bases
CATTGTTTTCTCTTCCTTTTCCTCCCTATGTACACTTGGATTCCTACTCTTTGTCCCAGGATTTTTGTCTGCCGCACCTA
AAATCAATTTGGCTGCGGAA

Downstream 100 bases:

>100_bases
TTTCTTTGCCAATCAAGAACCCACCACTCGTTCCATTCTTTGGAATAGAGGAGTTTACCAGGCAAGTGACTCTGTAATAA
ACTTAAAAAATCATCTTTTT

Product: putative chemotaxis protein histidine kinase

Products: 3',5'-cyclic AMP; diphosphate

Alternate protein names: Sensor Histidine Kinase; Response Regulator; GGDEF Domain-Containing Protein; Diverse 7TM Receptor Transmembrane Region; Signal Transduction Histidine Kinase; Response Regulator Receiver Protein; Periplasmic/7TM Domain Sensor Diguanylate Cyclase; Sensor Histidine Kinase/Response Regulator; Response Regulator Receiver Domain-Containing Protein; Two-Component Response Regulator; Phosphoserine Phosphatase; Response Regulator Receiver; Signal Transduction Protein; Adenylate/Guanylate Cyclase; Histidine Kinase; Multi-Sensor Hybrid Histidine Kinase; Diguanylate Cyclase/Phosphodiesterase; Multi-Sensor Signal Transduction Multi-Kinase; Signal Protein; Two-Component Sensor; Integral Membrane Sensor Hybrid Histidine Kinase; 7TM Diverse Intracellular Signalling Domain Protein; Protein Serine/Threonine Phosphatase; Serine Phosphatase; Response Regulator With ATPase Domain; Response Regulator Receiver Modulated Serine Phosphatase; PAS Sensor Protein; Aerobic Respiration Sensor-Response Protein; Phosphoserine Phosphatase RsbP; Two-Component Sensor Histidine Kinase; Sensor Protein; Sensor/Response Regulator Hybrid; 7TM Receptor Family Protein; 7TM Domain Sensor Diguanylate Cyclase; AraC Family Transcriptional Regulator; Lost Adherence Sensor LadS; Periplasmic Sensor Signal Transduction Histidine Kinase; Two-Component System Sensor Kinase; Integral Membrane Hybrid Histidine Protein Kinase; Sensory Transduction Histidine Kinase; Sensor/Response Regulator Hybrid Protein; Phosphoglycerate Transport; Transmembrane Signal Transduction Protein; Sensor Protein For Response Regulator AtoC; Signaling Protein With A Acyltransferase And GGDEF Domains; Periplasmic Sensor Hybrid Histidine Kinase; Diverse 7tm Receptor Transmembrane Region; Methyl-Accepting Chemotaxis Sensory Transducer; Chromosome Segregation ATPase; ATPase Histidine Kinase- DNA Gyrase B- And

Number of amino acids: Translated: 672; Mature: 671

Protein sequence:

>672_residues
MTGISIWNQVSVLEDSKQSIPAESIIHGERDLEFKSLKSPNLGFSQSVYWVRFEIFNPTSQLIRWNLAYDFPLIDEIQLF
GSPLPKDSVRTLGDSFPFSQRNVDYRNPVFPMETPPNTTNVYYLKIKSESTIPLILELWTEKEFYEKLNKEQMIFGIFYG
ILFVMIAYNFFIYIFTYEKSYLLYLFFISSIFFFHLVNNGFAFQYIWPNWVFWANYSLPFFICLSCITGIIFTNNYLSLK
KHLPKVSKLMWIWVGMLILFVGVSFFLRYRVAMVASILMTVPTALLLVYSGTYTYLSKVRTARYYLISWAFFLLGVLLYS
LKSLGFLSDNHITRWTIQIGTALQTILLSLGLADRINFLTRSLRENLRDLSHAKVKIEESEKRFREIFQGSDEVILMMNE
NFEIINANRSLSKHLGYRLDDLKFKKITEILYTGRDQKSDYNVMFVNDKLTDLKMTGSAINFKTELSQKYVKEPKEMVCR
IQYIDFDETREVLMTLSPEYEDTIIQLIDSEKIELSMNNYLRNAELVSQKITAQLAKYLTTIEQTEVRSSVREIIINAVE
HGNLNISFDEKSKALLEGNYLEFLQKRQEDPRYRNKKVKIEYSFSSEYVAFRITDEGKGFDHKKHMEKSIEEMNEAHVQH
GRGILMTKSVFDRIEYNDKGNQVSLIKFLNRD

Sequences:

>Translated_672_residues
MTGISIWNQVSVLEDSKQSIPAESIIHGERDLEFKSLKSPNLGFSQSVYWVRFEIFNPTSQLIRWNLAYDFPLIDEIQLF
GSPLPKDSVRTLGDSFPFSQRNVDYRNPVFPMETPPNTTNVYYLKIKSESTIPLILELWTEKEFYEKLNKEQMIFGIFYG
ILFVMIAYNFFIYIFTYEKSYLLYLFFISSIFFFHLVNNGFAFQYIWPNWVFWANYSLPFFICLSCITGIIFTNNYLSLK
KHLPKVSKLMWIWVGMLILFVGVSFFLRYRVAMVASILMTVPTALLLVYSGTYTYLSKVRTARYYLISWAFFLLGVLLYS
LKSLGFLSDNHITRWTIQIGTALQTILLSLGLADRINFLTRSLRENLRDLSHAKVKIEESEKRFREIFQGSDEVILMMNE
NFEIINANRSLSKHLGYRLDDLKFKKITEILYTGRDQKSDYNVMFVNDKLTDLKMTGSAINFKTELSQKYVKEPKEMVCR
IQYIDFDETREVLMTLSPEYEDTIIQLIDSEKIELSMNNYLRNAELVSQKITAQLAKYLTTIEQTEVRSSVREIIINAVE
HGNLNISFDEKSKALLEGNYLEFLQKRQEDPRYRNKKVKIEYSFSSEYVAFRITDEGKGFDHKKHMEKSIEEMNEAHVQH
GRGILMTKSVFDRIEYNDKGNQVSLIKFLNRD
>Mature_671_residues
TGISIWNQVSVLEDSKQSIPAESIIHGERDLEFKSLKSPNLGFSQSVYWVRFEIFNPTSQLIRWNLAYDFPLIDEIQLFG
SPLPKDSVRTLGDSFPFSQRNVDYRNPVFPMETPPNTTNVYYLKIKSESTIPLILELWTEKEFYEKLNKEQMIFGIFYGI
LFVMIAYNFFIYIFTYEKSYLLYLFFISSIFFFHLVNNGFAFQYIWPNWVFWANYSLPFFICLSCITGIIFTNNYLSLKK
HLPKVSKLMWIWVGMLILFVGVSFFLRYRVAMVASILMTVPTALLLVYSGTYTYLSKVRTARYYLISWAFFLLGVLLYSL
KSLGFLSDNHITRWTIQIGTALQTILLSLGLADRINFLTRSLRENLRDLSHAKVKIEESEKRFREIFQGSDEVILMMNEN
FEIINANRSLSKHLGYRLDDLKFKKITEILYTGRDQKSDYNVMFVNDKLTDLKMTGSAINFKTELSQKYVKEPKEMVCRI
QYIDFDETREVLMTLSPEYEDTIIQLIDSEKIELSMNNYLRNAELVSQKITAQLAKYLTTIEQTEVRSSVREIIINAVEH
GNLNISFDEKSKALLEGNYLEFLQKRQEDPRYRNKKVKIEYSFSSEYVAFRITDEGKGFDHKKHMEKSIEEMNEAHVQHG
RGILMTKSVFDRIEYNDKGNQVSLIKFLNRD

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.6.1.1

Molecular weight: Translated: 78955; Mature: 78824

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS50112 PAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGISIWNQVSVLEDSKQSIPAESIIHGERDLEFKSLKSPNLGFSQSVYWVRFEIFNPTS
CCCCCHHHHHHHHHCHHHCCCHHHHHCCCCCCCHHHCCCCCCCCCCCEEEEEEEEECCHH
QLIRWNLAYDFPLIDEIQLFGSPLPKDSVRTLGDSFPFSQRNVDYRNPVFPMETPPNTTN
HHEEEEEEECCCCHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCE
VYYLKIKSESTIPLILELWTEKEFYEKLNKEQMIFGIFYGILFVMIAYNFFIYIFTYEKS
EEEEEEECCCCCEEHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEEEEEECCH
YLLYLFFISSIFFFHLVNNGFAFQYIWPNWVFWANYSLPFFICLSCITGIIFTNNYLSLK
HHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHCCCCHHHH
KHLPKVSKLMWIWVGMLILFVGVSFFLRYRVAMVASILMTVPTALLLVYSGTYTYLSKVR
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
TARYYLISWAFFLLGVLLYSLKSLGFLSDNHITRWTIQIGTALQTILLSLGLADRINFLT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHHHHHCHHHHHHHHH
RSLRENLRDLSHAKVKIEESEKRFREIFQGSDEVILMMNENFEIINANRSLSKHLGYRLD
HHHHHHHHHHHHHEEEEHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCHHHHHCCCCCC
DLKFKKITEILYTGRDQKSDYNVMFVNDKLTDLKMTGSAINFKTELSQKYVKEPKEMVCR
CCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEECCCEEEHHHHHHHHHHHCHHHHEEE
IQYIDFDETREVLMTLSPEYEDTIIQLIDSEKIELSMNNYLRNAELVSQKITAQLAKYLT
EEECCCHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
TIEQTEVRSSVREIIINAVEHGNLNISFDEKSKALLEGNYLEFLQKRQEDPRYRNKKVKI
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHCCHHHHHHHHHCCCCCCCCCEEEE
EYSFSSEYVAFRITDEGKGFDHKKHMEKSIEEMNEAHVQHGRGILMTKSVFDRIEYNDKG
EEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHCCCCCC
NQVSLIKFLNRD
CEEEEHHHHCCC
>Mature Secondary Structure 
TGISIWNQVSVLEDSKQSIPAESIIHGERDLEFKSLKSPNLGFSQSVYWVRFEIFNPTS
CCCCHHHHHHHHHCHHHCCCHHHHHCCCCCCCHHHCCCCCCCCCCCEEEEEEEEECCHH
QLIRWNLAYDFPLIDEIQLFGSPLPKDSVRTLGDSFPFSQRNVDYRNPVFPMETPPNTTN
HHEEEEEEECCCCHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCE
VYYLKIKSESTIPLILELWTEKEFYEKLNKEQMIFGIFYGILFVMIAYNFFIYIFTYEKS
EEEEEEECCCCCEEHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEEEEEECCH
YLLYLFFISSIFFFHLVNNGFAFQYIWPNWVFWANYSLPFFICLSCITGIIFTNNYLSLK
HHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHCCCCHHHH
KHLPKVSKLMWIWVGMLILFVGVSFFLRYRVAMVASILMTVPTALLLVYSGTYTYLSKVR
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
TARYYLISWAFFLLGVLLYSLKSLGFLSDNHITRWTIQIGTALQTILLSLGLADRINFLT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHHHHHCHHHHHHHHH
RSLRENLRDLSHAKVKIEESEKRFREIFQGSDEVILMMNENFEIINANRSLSKHLGYRLD
HHHHHHHHHHHHHEEEEHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCHHHHHCCCCCC
DLKFKKITEILYTGRDQKSDYNVMFVNDKLTDLKMTGSAINFKTELSQKYVKEPKEMVCR
CCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEECCCEEEHHHHHHHHHHHCHHHHEEE
IQYIDFDETREVLMTLSPEYEDTIIQLIDSEKIELSMNNYLRNAELVSQKITAQLAKYLT
EEECCCHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
TIEQTEVRSSVREIIINAVEHGNLNISFDEKSKALLEGNYLEFLQKRQEDPRYRNKKVKI
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHCCHHHHHHHHHCCCCCCCCCEEEE
EYSFSSEYVAFRITDEGKGFDHKKHMEKSIEEMNEAHVQHGRGILMTKSVFDRIEYNDKG
EEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHCCCCCC
NQVSLIKFLNRD
CEEEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP

Specific reaction: ATP = 3',5'-cyclic AMP + diphosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA