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The map label for this gene is cyaA [H]

Identifier: 183220533

GI number: 183220533

Start: 1183114

End: 1184466

Strand: Direct

Name: cyaA [H]

Synonym: LEPBI_I1136

Alternate gene names: 183220533

Gene position: 1183114-1184466 (Clockwise)

Preceding gene: 183220518

Following gene: 183220535

Centisome position: 32.87

GC content: 39.91

Gene sequence:

>1353_bases
ATGCCAATGTTCCGCTCCATTCGAAATGCCATCCATTCTGTTTATTGCATCCGTGACCAATTCCCAAGGTATATGTCGGA
ACTTTTATCGGAAGAAGAAGCAATGGGAGCTCTGTTTGCCGTACGGTTTCGTTATGTGATTGGAATTGCGCTTTTTGCCA
GTGCTCTTGCAAATCTCAGCAATATCGATACGATTTGGGGGTATTTAGTCAATTTCATTGCGATTGGTATTTATTTTATC
AATACATTTTTACATTTGCATATTCTAAAAAAACACAGTAGCAATTGGAAAACAAAATATGACTATATCAGTCTTTTTGT
AGATAATGTGCTCATCACCATGACCATTCTCAATTGGTATTGGATCAAAGGAAATGGGAATCCAAACTTTTTAGTCAAAA
CTCCACTTTTGATCTTTTATTTACTCCCACTTTCCTTGTGTTTGTTTCAATACAGGTTTTCACTTGTCGTGTTTTCTTTT
GTTTGTTTTTTACTCAGTTATTATTCATTCATCGCCGCAGCGTTACTTGACCCAGATGCCATTGTGAGTTTGGATTGGTT
TAGTTATGTGTTAGGTGACGAAATCATCCTATTAGATGCTCTCGTTTCCAAACCAGTGATTTATTTGATTTTGGTCTTTG
CCATTTCTTATGGAATCTTTCGTAGCCTTCGGATGCTTCTGAAATTTGCTGCTTCCGAAACACAAAAAACAACTCTCTCT
CGGTATTTTTCTCCCGATTTGGTTTCGGAAATTGTATCGGATCCGGAAGTACTTGGGAAAGGAAAACGCCAACAAGTAAC
AGTGCTTTTCAGTGATATCCGCGGGTTCACTCAGTTTTCCGAACTCCTCGACCCTGAAGAGTTATCGATTTTTTTAACGG
AATTTCGCAGACGAATGGTTCGTGTAATCTTCCAAAACAAAGGTAGTTTGGATAAGTTCATTGGGGATGCTGTGATGGTG
ACCTTTGGAACACCACTTCCTTCAGAAATACCCGGGGAGGATTCAAGGAATGCTGTGTCTGCCGCTAAATCAATGTTAGA
AGAGCTAAAGAACTGGAATGAAGAACGAAAATCCCTAGGTCAGGTGGAGATCCGAATTGGCATTGGTATCCATTCCGGTG
AGGTGTTTTGTGGGAGTATCGGTTCTGAAGAACGAATGGAATATACTGTGATTGGAGATACAGTGAATACGGCCTCACGG
ATTGAGTCGGCATGTAAGGAACTTCATTCATCCCTTCTCATCTCAGAAGTCGTATGGAGTGAAATTGGAAAACCAAACGA
GTGGGAACGATTCGAAGGGATTTTATTACCAGGAAGGGAACAAAAAATTAATTTGTATGCGATCCAACCTTAG

Upstream 100 bases:

>100_bases
GTATGTGCCTCTTTCGGTACATAGTTCATTGATCCAAACAAGGAATCCTATGGCAAAAAGAAAATTCCCTTGCCACAAAA
TCTGAAACGACAGGAACTGT

Downstream 100 bases:

>100_bases
GATTTAGGCATTCAGATTTAATTTATAAACTGCTTCGTGTAAGGCGGGGTTGAGTTCCGGATCAATGGTATAAATCACCC
TAGTGGTCCCTGCTTGTAAG

Product: putative adenylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; AC 1 [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MPMFRSIRNAIHSVYCIRDQFPRYMSELLSEEEAMGALFAVRFRYVIGIALFASALANLSNIDTIWGYLVNFIAIGIYFI
NTFLHLHILKKHSSNWKTKYDYISLFVDNVLITMTILNWYWIKGNGNPNFLVKTPLLIFYLLPLSLCLFQYRFSLVVFSF
VCFLLSYYSFIAAALLDPDAIVSLDWFSYVLGDEIILLDALVSKPVIYLILVFAISYGIFRSLRMLLKFAASETQKTTLS
RYFSPDLVSEIVSDPEVLGKGKRQQVTVLFSDIRGFTQFSELLDPEELSIFLTEFRRRMVRVIFQNKGSLDKFIGDAVMV
TFGTPLPSEIPGEDSRNAVSAAKSMLEELKNWNEERKSLGQVEIRIGIGIHSGEVFCGSIGSEERMEYTVIGDTVNTASR
IESACKELHSSLLISEVVWSEIGKPNEWERFEGILLPGREQKINLYAIQP

Sequences:

>Translated_450_residues
MPMFRSIRNAIHSVYCIRDQFPRYMSELLSEEEAMGALFAVRFRYVIGIALFASALANLSNIDTIWGYLVNFIAIGIYFI
NTFLHLHILKKHSSNWKTKYDYISLFVDNVLITMTILNWYWIKGNGNPNFLVKTPLLIFYLLPLSLCLFQYRFSLVVFSF
VCFLLSYYSFIAAALLDPDAIVSLDWFSYVLGDEIILLDALVSKPVIYLILVFAISYGIFRSLRMLLKFAASETQKTTLS
RYFSPDLVSEIVSDPEVLGKGKRQQVTVLFSDIRGFTQFSELLDPEELSIFLTEFRRRMVRVIFQNKGSLDKFIGDAVMV
TFGTPLPSEIPGEDSRNAVSAAKSMLEELKNWNEERKSLGQVEIRIGIGIHSGEVFCGSIGSEERMEYTVIGDTVNTASR
IESACKELHSSLLISEVVWSEIGKPNEWERFEGILLPGREQKINLYAIQP
>Mature_449_residues
PMFRSIRNAIHSVYCIRDQFPRYMSELLSEEEAMGALFAVRFRYVIGIALFASALANLSNIDTIWGYLVNFIAIGIYFIN
TFLHLHILKKHSSNWKTKYDYISLFVDNVLITMTILNWYWIKGNGNPNFLVKTPLLIFYLLPLSLCLFQYRFSLVVFSFV
CFLLSYYSFIAAALLDPDAIVSLDWFSYVLGDEIILLDALVSKPVIYLILVFAISYGIFRSLRMLLKFAASETQKTTLSR
YFSPDLVSEIVSDPEVLGKGKRQQVTVLFSDIRGFTQFSELLDPEELSIFLTEFRRRMVRVIFQNKGSLDKFIGDAVMVT
FGTPLPSEIPGEDSRNAVSAAKSMLEELKNWNEERKSLGQVEIRIGIGIHSGEVFCGSIGSEERMEYTVIGDTVNTASRI
ESACKELHSSLLISEVVWSEIGKPNEWERFEGILLPGREQKINLYAIQP

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain [H]

Homologues:

Organism=Homo sapiens, GI4557255, Length=211, Percent_Identity=29.8578199052133, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI134152694, Length=175, Percent_Identity=33.7142857142857, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI4504217, Length=141, Percent_Identity=36.1702127659575, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI222080083, Length=142, Percent_Identity=35.2112676056338, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71989822, Length=183, Percent_Identity=31.1475409836066, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71989805, Length=160, Percent_Identity=33.75, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17508769, Length=138, Percent_Identity=35.5072463768116, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI193206632, Length=142, Percent_Identity=35.2112676056338, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI28574512, Length=191, Percent_Identity=32.9842931937173, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI161076872, Length=191, Percent_Identity=32.9842931937173, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221330468, Length=184, Percent_Identity=30.4347826086957, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI221330470, Length=184, Percent_Identity=30.4347826086957, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054 [H]

Pfam domain/function: PF00211 Guanylate_cyc [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 51352; Mature: 51221

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMFRSIRNAIHSVYCIRDQFPRYMSELLSEEEAMGALFAVRFRYVIGIALFASALANLS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
NIDTIWGYLVNFIAIGIYFINTFLHLHILKKHSSNWKTKYDYISLFVDNVLITMTILNWY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEE
WIKGNGNPNFLVKTPLLIFYLLPLSLCLFQYRFSLVVFSFVCFLLSYYSFIAAALLDPDA
EEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
IVSLDWFSYVLGDEIILLDALVSKPVIYLILVFAISYGIFRSLRMLLKFAASETQKTTLS
EEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RYFSPDLVSEIVSDPEVLGKGKRQQVTVLFSDIRGFTQFSELLDPEELSIFLTEFRRRMV
HHCCHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RVIFQNKGSLDKFIGDAVMVTFGTPLPSEIPGEDSRNAVSAAKSMLEELKNWNEERKSLG
HHHHHCCCCHHHHHCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHCCC
QVEIRIGIGIHSGEVFCGSIGSEERMEYTVIGDTVNTASRIESACKELHSSLLISEVVWS
CEEEEEEEEEECCCEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EIGKPNEWERFEGILLPGREQKINLYAIQP
HCCCCCCCHHHCCEECCCCCCEEEEEEECC
>Mature Secondary Structure 
PMFRSIRNAIHSVYCIRDQFPRYMSELLSEEEAMGALFAVRFRYVIGIALFASALANLS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH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HCCCCCCCHHHCCEECCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]