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The map label for this gene is ilvC

Identifier: 183220120

GI number: 183220120

Start: 718620

End: 719621

Strand: Reverse

Name: ilvC

Synonym: LEPBI_I0708

Alternate gene names: 183220120

Gene position: 719621-718620 (Counterclockwise)

Preceding gene: 183220125

Following gene: 183220119

Centisome position: 19.99

GC content: 44.51

Gene sequence:

>1002_bases
ATGGCAAATATCTATTACGACGACAGTTGCGATCTCAATCTCCTTAAAGGTAAAACCATTGCAGTGATTGGCTACGGAAG
CCAAGGTCACGCCCAAGCTCAAAACATGAAAGATTCTGGTTTGAAAGTCATCATTGGACTTCGCGATGGATCCAAATCAG
TCAAAGAAGCAAAAGAAGCTGGTTTCGAAGTTTATAATGTAGCAGAAGCTTCCAAAAAAGCGGACATCATCCAAATCCTT
GCTCCAGATACCATCCAAGCTGACATGTATAAGGCGGACATTGAACCAAACCTGTCAGAAGGGAAAGCTCTTGTTTTCTC
TCATGGATTTAACATCCACTACGATCTCATCACTCCTCCAAAAAACGTAGACGTGTATATGGTGGCTCCTAAAGGACCTG
GACATTTAGTTCGCCGTGTGTATACAGAAGGTGGTGGAGTGCCTTGCCTTATCGCCATCTACCAAGATGCAACAGGCCAA
GCAAAAGCTCGTGCACTCGCACACGCAAGTGGAGTTGGTGGAGGAAGAGCAGGAATTTTAGAAACCTCTTTCCGTGAAGA
AACAGAAACAGACCTTTTCGGAGAACAAGCAGTTCTTTGTGGTGGTGTGGCAAACCTCATCATGAGTGGATTTGAAACTC
TTACCGAAGCTGGATACGATCCAGAGATCGCTTACTTTGAATGTTTGCATGAAGTGAAACTCATCACGGACCTGATCTAT
GAAGGTGGCCTTGCTCGTATGCGTTTCTCTATCTCTGACACAGCAGAGTATGGAGACTATATCAGTGGACCACGTGTGAT
TGATGCTGGTGTGAAAGCTCGCATGAAAGATGTTCTCACTGACATCCAAAAAGACAAGGGAGCAGCGTTTGCAAAACGTT
GGATGGCCGATACAAAAGCTGGATACCCTGAATACAAAAAACTCAAAGAAAAAAATGCGGCACACCCAATTGAAGCAGTA
GGAACTAAACTACGTTCCATGATGAAGTGGCTCGCAAAGTAA

Upstream 100 bases:

>100_bases
GCAAGCAAGGAAAGGCGCCCTAATTCGTTCTTGTTTCCCTCGTTATAGTTCAAAATGATGGAAAAATCAGTTAAATTTTC
CGCAGGAAGTGTGCCCATCC

Downstream 100 bases:

>100_bases
TTGTTTAGGTAACTTTAGTTAAAAGAAAGAAAGGAAGAAGGATTATATATGAAAGTAACACAAAAGATTGTACTCGCAGC
ACCTGCACGAACTCCTTTTG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MANIYYDDSCDLNLLKGKTIAVIGYGSQGHAQAQNMKDSGLKVIIGLRDGSKSVKEAKEAGFEVYNVAEASKKADIIQIL
APDTIQADMYKADIEPNLSEGKALVFSHGFNIHYDLITPPKNVDVYMVAPKGPGHLVRRVYTEGGGVPCLIAIYQDATGQ
AKARALAHASGVGGGRAGILETSFREETETDLFGEQAVLCGGVANLIMSGFETLTEAGYDPEIAYFECLHEVKLITDLIY
EGGLARMRFSISDTAEYGDYISGPRVIDAGVKARMKDVLTDIQKDKGAAFAKRWMADTKAGYPEYKKLKEKNAAHPIEAV
GTKLRSMMKWLAK

Sequences:

>Translated_333_residues
MANIYYDDSCDLNLLKGKTIAVIGYGSQGHAQAQNMKDSGLKVIIGLRDGSKSVKEAKEAGFEVYNVAEASKKADIIQIL
APDTIQADMYKADIEPNLSEGKALVFSHGFNIHYDLITPPKNVDVYMVAPKGPGHLVRRVYTEGGGVPCLIAIYQDATGQ
AKARALAHASGVGGGRAGILETSFREETETDLFGEQAVLCGGVANLIMSGFETLTEAGYDPEIAYFECLHEVKLITDLIY
EGGLARMRFSISDTAEYGDYISGPRVIDAGVKARMKDVLTDIQKDKGAAFAKRWMADTKAGYPEYKKLKEKNAAHPIEAV
GTKLRSMMKWLAK
>Mature_332_residues
ANIYYDDSCDLNLLKGKTIAVIGYGSQGHAQAQNMKDSGLKVIIGLRDGSKSVKEAKEAGFEVYNVAEASKKADIIQILA
PDTIQADMYKADIEPNLSEGKALVFSHGFNIHYDLITPPKNVDVYMVAPKGPGHLVRRVYTEGGGVPCLIAIYQDATGQA
KARALAHASGVGGGRAGILETSFREETETDLFGEQAVLCGGVANLIMSGFETLTEAGYDPEIAYFECLHEVKLITDLIYE
GGLARMRFSISDTAEYGDYISGPRVIDAGVKARMKDVLTDIQKDKGAAFAKRWMADTKAGYPEYKKLKEKNAAHPIEAVG
TKLRSMMKWLAK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=255, Percent_Identity=39.2156862745098, Blast_Score=150, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6323387, Length=255, Percent_Identity=38.0392156862745, Blast_Score=148, Evalue=1e-36,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_LEPBA (B0SCQ5)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001961795.1
- ProteinModelPortal:   B0SCQ5
- SMR:   B0SCQ5
- GeneID:   6390155
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_0685
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- BioCyc:   LBIF355278:LBF_0685-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36157; Mature: 36026

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANIYYDDSCDLNLLKGKTIAVIGYGSQGHAQAQNMKDSGLKVIIGLRDGSKSVKEAKEA
CCCEEECCCCCEEEECCCEEEEEEECCCCCHHHHCCCCCCCEEEEEECCCCHHHHHHHHC
GFEVYNVAEASKKADIIQILAPDTIQADMYKADIEPNLSEGKALVFSHGFNIHYDLITPP
CCEEEEHHHHHCCCCEEEEECCCCHHHHHEEECCCCCCCCCCEEEEECCCEEEEEEECCC
KNVDVYMVAPKGPGHLVRRVYTEGGGVPCLIAIYQDATGQAKARALAHASGVGGGRAGIL
CCCEEEEECCCCHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCE
ETSFREETETDLFGEQAVLCGGVANLIMSGFETLTEAGYDPEIAYFECLHEVKLITDLIY
ECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGLARMRFSISDTAEYGDYISGPRVIDAGVKARMKDVLTDIQKDKGAAFAKRWMADTKA
CCCCEEEEEECCCHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
GYPEYKKLKEKNAAHPIEAVGTKLRSMMKWLAK
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ANIYYDDSCDLNLLKGKTIAVIGYGSQGHAQAQNMKDSGLKVIIGLRDGSKSVKEAKEA
CCEEECCCCCEEEECCCEEEEEEECCCCCHHHHCCCCCCCEEEEEECCCCHHHHHHHHC
GFEVYNVAEASKKADIIQILAPDTIQADMYKADIEPNLSEGKALVFSHGFNIHYDLITPP
CCEEEEHHHHHCCCCEEEEECCCCHHHHHEEECCCCCCCCCCEEEEECCCEEEEEEECCC
KNVDVYMVAPKGPGHLVRRVYTEGGGVPCLIAIYQDATGQAKARALAHASGVGGGRAGIL
CCCEEEEECCCCHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCE
ETSFREETETDLFGEQAVLCGGVANLIMSGFETLTEAGYDPEIAYFECLHEVKLITDLIY
ECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGLARMRFSISDTAEYGDYISGPRVIDAGVKARMKDVLTDIQKDKGAAFAKRWMADTKA
CCCCEEEEEECCCHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
GYPEYKKLKEKNAAHPIEAVGTKLRSMMKWLAK
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA