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The map label for this gene is trpE [H]

Identifier: 183219455

GI number: 183219455

Start: 28640

End: 30073

Strand: Direct

Name: trpE [H]

Synonym: LEPBI_I0028

Alternate gene names: 183219455

Gene position: 28640-30073 (Clockwise)

Preceding gene: 183219454

Following gene: 183219456

Centisome position: 0.8

GC content: 40.1

Gene sequence:

>1434_bases
TTGGTAACAAACATTGAGTACACTATGAGCGAATCACTTCCGAAAATCTCCATTCCTAAAAAACCAAATTATACATCCTT
AAGTTTGCCGGAAGGAATTGAGTTTTGGGAACTCTTTCGGGAGATAGAAGAGAAATATGAAAATTGTTTTCTCTTGGAAT
CAGCAGGCGACAACCAATATGACTCAAGATACTCTGTGATTGGATTTGATCCATCACACCTGATTACTGGTGAACCCGGA
GTGTTGGAAATTGATGGAAAACTATATAAAGTCAAAAATCCATATTTTGCTCTTCGCGATATCACAGATTATAATTCGCT
AAGCATTAGTTATGCGGGTGGGCTCGTTGGTTACTTGGGTTACCAAAGTATGCAGTTTTTTGAACCCAAATTACACTTAA
AACCACATCCAGATTTCCCAGCAATGATCTTTGGAATGTACCTTGATGGACTCATATACGATAAATTTACAGGGGAACTC
ATTTACTTTGATAATGGAACCAATCGGATTGATGTTGTAAAATCGATCCTTACTTCCATTCAAAATCCAGTTTCTAAAAA
ACCGGAAGCCAGTGTGACCGTTTTACAAGAGGGACTTTCCAAAGATGTCCACAAACAAATGGTAGATGAAGCATTAGAAG
AGGTGAAAGCTGGAAATACATTTCAATGCCAAATTGGTTTTGAAGAAACGTATTCAGTGGATGGGAATCCTCTTGCTATC
TACGAAACCTTACGAGAAATCAATCCTTCACCTCATATGTACTATGTGAAATTCGGGAAACGTGTGATCCTAGGTGCCAG
CCCAGAGCTTTTGTTTCGTTTGAGACAAGGGGAGATGGAATCATTTCCCCTGGCAGGAACCACAAAACGAGGAGTTGATG
CTAAGGAAGATACGTTGCTTGCACGTAAACTTCTCACGGATCCAAAGGAAATCGCAGAACACAATATGCTCATCGATCTA
CATCGAAATGACATTGGCCGTGTGGCAAAATTTGGCACTGTCAAAGTGAGAAGGAGATTTGATATCAAACGGTTTTCGCA
TGTCCAACATATCTCAAGCGAAGTAGTGGGTATACTTTCTTCCAAAGAAGATATGTTTTCGGGACTTGCTTCTTCCTTCC
CTGCTGGAACCTTGTCAGGCGCTCCCAAAATTGAATCGATGAAGATCATTGAACGTATTGAGAAGTCACCACGAGGGCCT
TATGGTGGAGCTGTAGGAAGTTTTGGATTGAATGGAGATTGTACTTTTGCGATTCCCATTCGTAGTTTTTTTGTTCATAA
TGGAAAGGGATTTGTTCGAGCATCTGGTGGGATTGTGTATGATTCAAAACCTGACGACGAATACCAAGAAATCATCAATA
AAATGGCTTCTGTGAGAAAGGCTTTGGACTTACACCAACTGCCTCAAGAAAAAAATACAAAGGCAAAAGGGTAA

Upstream 100 bases:

>100_bases
AAAAATCTTTAAAATCGGATTCTAATCTGAAACCAGAAAAGGCAGGTTCCGGAATCCGGCGCCTGCCTTTTTTATTTCTA
AAATAGATTCAAAATGAATC

Downstream 100 bases:

>100_bases
GTGGGTCAATCATGAAAGTTCTCATCTTAGATAATTACGATTCCTTCACTTATAATTTATACCAAATCGTGGGAGAAATT
TTAGAAGAACAGGAAAAACT

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MVTNIEYTMSESLPKISIPKKPNYTSLSLPEGIEFWELFREIEEKYENCFLLESAGDNQYDSRYSVIGFDPSHLITGEPG
VLEIDGKLYKVKNPYFALRDITDYNSLSISYAGGLVGYLGYQSMQFFEPKLHLKPHPDFPAMIFGMYLDGLIYDKFTGEL
IYFDNGTNRIDVVKSILTSIQNPVSKKPEASVTVLQEGLSKDVHKQMVDEALEEVKAGNTFQCQIGFEETYSVDGNPLAI
YETLREINPSPHMYYVKFGKRVILGASPELLFRLRQGEMESFPLAGTTKRGVDAKEDTLLARKLLTDPKEIAEHNMLIDL
HRNDIGRVAKFGTVKVRRRFDIKRFSHVQHISSEVVGILSSKEDMFSGLASSFPAGTLSGAPKIESMKIIERIEKSPRGP
YGGAVGSFGLNGDCTFAIPIRSFFVHNGKGFVRASGGIVYDSKPDDEYQEIINKMASVRKALDLHQLPQEKNTKAKG

Sequences:

>Translated_477_residues
MVTNIEYTMSESLPKISIPKKPNYTSLSLPEGIEFWELFREIEEKYENCFLLESAGDNQYDSRYSVIGFDPSHLITGEPG
VLEIDGKLYKVKNPYFALRDITDYNSLSISYAGGLVGYLGYQSMQFFEPKLHLKPHPDFPAMIFGMYLDGLIYDKFTGEL
IYFDNGTNRIDVVKSILTSIQNPVSKKPEASVTVLQEGLSKDVHKQMVDEALEEVKAGNTFQCQIGFEETYSVDGNPLAI
YETLREINPSPHMYYVKFGKRVILGASPELLFRLRQGEMESFPLAGTTKRGVDAKEDTLLARKLLTDPKEIAEHNMLIDL
HRNDIGRVAKFGTVKVRRRFDIKRFSHVQHISSEVVGILSSKEDMFSGLASSFPAGTLSGAPKIESMKIIERIEKSPRGP
YGGAVGSFGLNGDCTFAIPIRSFFVHNGKGFVRASGGIVYDSKPDDEYQEIINKMASVRKALDLHQLPQEKNTKAKG
>Mature_477_residues
MVTNIEYTMSESLPKISIPKKPNYTSLSLPEGIEFWELFREIEEKYENCFLLESAGDNQYDSRYSVIGFDPSHLITGEPG
VLEIDGKLYKVKNPYFALRDITDYNSLSISYAGGLVGYLGYQSMQFFEPKLHLKPHPDFPAMIFGMYLDGLIYDKFTGEL
IYFDNGTNRIDVVKSILTSIQNPVSKKPEASVTVLQEGLSKDVHKQMVDEALEEVKAGNTFQCQIGFEETYSVDGNPLAI
YETLREINPSPHMYYVKFGKRVILGASPELLFRLRQGEMESFPLAGTTKRGVDAKEDTLLARKLLTDPKEIAEHNMLIDL
HRNDIGRVAKFGTVKVRRRFDIKRFSHVQHISSEVVGILSSKEDMFSGLASSFPAGTLSGAPKIESMKIIERIEKSPRGP
YGGAVGSFGLNGDCTFAIPIRSFFVHNGKGFVRASGGIVYDSKPDDEYQEIINKMASVRKALDLHQLPQEKNTKAKG

Specific function: Catalyzes The Biosynthesis Of 4-Amino-4-Deoxychorismate (Adc) From Chorismate And Glutamine. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1788114, Length=430, Percent_Identity=28.6046511627907, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI1787518, Length=265, Percent_Identity=37.7358490566038, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI87082077, Length=226, Percent_Identity=28.3185840707965, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786809, Length=227, Percent_Identity=25.9911894273128, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320935, Length=464, Percent_Identity=32.7586206896552, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6324361, Length=250, Percent_Identity=29.2, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 53496; Mature: 53496

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTNIEYTMSESLPKISIPKKPNYTSLSLPEGIEFWELFREIEEKYENCFLLESAGDNQY
CCCCEEEHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEECCCCCCC
DSRYSVIGFDPSHLITGEPGVLEIDGKLYKVKNPYFALRDITDYNSLSISYAGGLVGYLG
CCEEEEEECCCCCEECCCCCEEEECCEEEEECCCEEEEEECCCCCCEEEEECCHHHHHHH
YQSMQFFEPKLHLKPHPDFPAMIFGMYLDGLIYDKFTGELIYFDNGTNRIDVVKSILTSI
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHEECCCCEEEEEECCCCHHHHHHHHHHHH
QNPVSKKPEASVTVLQEGLSKDVHKQMVDEALEEVKAGNTFQCQIGFEETYSVDGNPLAI
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEECCCCCCCHH
YETLREINPSPHMYYVKFGKRVILGASPELLFRLRQGEMESFPLAGTTKRGVDAKEDTLL
HHHHHHCCCCCCEEEEEECCEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
ARKLLTDPKEIAEHNMLIDLHRNDIGRVAKFGTVKVRRRFDIKRFSHVQHISSEVVGILS
HHHHHCCHHHHHHCCEEEEECCCCHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHC
SKEDMFSGLASSFPAGTLSGAPKIESMKIIERIEKSPRGPYGGAVGSFGLNGDCTFAIPI
CHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEE
RSFFVHNGKGFVRASGGIVYDSKPDDEYQEIINKMASVRKALDLHQLPQEKNTKAKG
HEEEEECCCEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MVTNIEYTMSESLPKISIPKKPNYTSLSLPEGIEFWELFREIEEKYENCFLLESAGDNQY
CCCCEEEHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEECCCCCCC
DSRYSVIGFDPSHLITGEPGVLEIDGKLYKVKNPYFALRDITDYNSLSISYAGGLVGYLG
CCEEEEEECCCCCEECCCCCEEEECCEEEEECCCEEEEEECCCCCCEEEEECCHHHHHHH
YQSMQFFEPKLHLKPHPDFPAMIFGMYLDGLIYDKFTGELIYFDNGTNRIDVVKSILTSI
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHEECCCCEEEEEECCCCHHHHHHHHHHHH
QNPVSKKPEASVTVLQEGLSKDVHKQMVDEALEEVKAGNTFQCQIGFEETYSVDGNPLAI
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEECCCCCCCHH
YETLREINPSPHMYYVKFGKRVILGASPELLFRLRQGEMESFPLAGTTKRGVDAKEDTLL
HHHHHHCCCCCCEEEEEECCEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
ARKLLTDPKEIAEHNMLIDLHRNDIGRVAKFGTVKVRRRFDIKRFSHVQHISSEVVGILS
HHHHHCCHHHHHHCCEEEEECCCCHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHC
SKEDMFSGLASSFPAGTLSGAPKIESMKIIERIEKSPRGPYGGAVGSFGLNGDCTFAIPI
CHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEE
RSFFVHNGKGFVRASGGIVYDSKPDDEYQEIINKMASVRKALDLHQLPQEKNTKAKG
HEEEEECCCEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2703466 [H]