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The map label for this gene is manC [H]

Identifier: 18311290

GI number: 18311290

Start: 2653069

End: 2654139

Strand: Reverse

Name: manC [H]

Synonym: CPE2308

Alternate gene names: 18311290

Gene position: 2654139-2653069 (Counterclockwise)

Preceding gene: 18311291

Following gene: 18311289

Centisome position: 87.55

GC content: 31.75

Gene sequence:

>1071_bases
ATGCTTTACTCATTAATTTTAGCAGGAGGAAAGGGTACTAGACTTTATCCACTTTCAAGAAGTTCAAACCCTAAACAATT
TCTTAGCATACACAATAATGGGAAGAGTTTTTTAAGTAATACTGTGGATAGAATTAGACCTATAATCCATAAAGATAATA
TTTATGTAGTGACAAACCAGGAGTATGAAGACAAAACAAGAGATGAACTTAAAGACATAAGAGAGGAAAATATCTTTACT
GAACCTGCTAATAAAGAAACTGCAACCTGTATAGGTCTTTCAGCAGCTAAGCTTTTAAAGAAAGATAAGGATGCAGTTAT
GATTGTATTGCCTTCAGACCATTATATAGAAGGAGATAAAAGTTATCTTCAAACTCTGGAACAAGCCGTAGAGATTGCGG
ATAAGAAGAGAGCTATTGTTACCATAGGAATAGAGCCAACTAGACCAGAGACAGGTTATGGCTATATAGAAATGGGAGAT
AGAGTCAATGGACACATTCCTACCTTCAAGATAGCAAGGTTTACAGAGAAACCTAATTTAGAAGTAGCAAAGGACTTCTT
ATTAAAGGGGACTTATTTATGGAATAGTGGAATGTTCATATTTAGAGCTGATGTTATATTGAGAGAAATTGAAAAATATA
TTCCTAAGATGTATAAATGTTTAATGGAGATATATCAACACATTGGAGAAGATGATGAGGAAGAAATAATAAAAGAGCAG
TATTCTTTAATTGATGGAATATCTATAGATTTTGGAGTAATGCAAAAAACAAGAAGATCCTTTGTTATAAAATGTGATTT
TTCTTGGGATGATATAGGTACTTTCTCAGCTCTAAGTAGATTTTTGGGACATAATGGAAATAATAGAACTTCAGATAATG
TTTTTTTAGAGGAATGTGAGAATTGTTCCGTTTTTGGAAAGGAAAAATTAATAATAGGATTTGGAATAAAAGATCTAGTA
TTAGTTGATGCAGGAGATGTTATTTTGGTCATGGACAAAGGTAGAGACCAAGAGATTAAGCATCTATTAAATTCTATTAG
TGGTAAGAAGGAATTTAAAGAATATCTATAA

Upstream 100 bases:

>100_bases
TATTTTTGCTTAAACTAAAGCCTTAAATTTTTTTAATACTCACATAATGGGATATTTTCACATAAAATACACTATAACAA
TTAACGGAGTTGAAGGCAAC

Downstream 100 bases:

>100_bases
GTTTATAAACTTATGTAAAAAAAGTCCTATATCATATACTTTAGGTGTATGATATAGGACTTTTTAGTTACTTTTAATAT
CTACAATTTAGTTAAGAAAA

Product: mannose-1-phosphate guanylyltransferase

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MLYSLILAGGKGTRLYPLSRSSNPKQFLSIHNNGKSFLSNTVDRIRPIIHKDNIYVVTNQEYEDKTRDELKDIREENIFT
EPANKETATCIGLSAAKLLKKDKDAVMIVLPSDHYIEGDKSYLQTLEQAVEIADKKRAIVTIGIEPTRPETGYGYIEMGD
RVNGHIPTFKIARFTEKPNLEVAKDFLLKGTYLWNSGMFIFRADVILREIEKYIPKMYKCLMEIYQHIGEDDEEEIIKEQ
YSLIDGISIDFGVMQKTRRSFVIKCDFSWDDIGTFSALSRFLGHNGNNRTSDNVFLEECENCSVFGKEKLIIGFGIKDLV
LVDAGDVILVMDKGRDQEIKHLLNSISGKKEFKEYL

Sequences:

>Translated_356_residues
MLYSLILAGGKGTRLYPLSRSSNPKQFLSIHNNGKSFLSNTVDRIRPIIHKDNIYVVTNQEYEDKTRDELKDIREENIFT
EPANKETATCIGLSAAKLLKKDKDAVMIVLPSDHYIEGDKSYLQTLEQAVEIADKKRAIVTIGIEPTRPETGYGYIEMGD
RVNGHIPTFKIARFTEKPNLEVAKDFLLKGTYLWNSGMFIFRADVILREIEKYIPKMYKCLMEIYQHIGEDDEEEIIKEQ
YSLIDGISIDFGVMQKTRRSFVIKCDFSWDDIGTFSALSRFLGHNGNNRTSDNVFLEECENCSVFGKEKLIIGFGIKDLV
LVDAGDVILVMDKGRDQEIKHLLNSISGKKEFKEYL
>Mature_356_residues
MLYSLILAGGKGTRLYPLSRSSNPKQFLSIHNNGKSFLSNTVDRIRPIIHKDNIYVVTNQEYEDKTRDELKDIREENIFT
EPANKETATCIGLSAAKLLKKDKDAVMIVLPSDHYIEGDKSYLQTLEQAVEIADKKRAIVTIGIEPTRPETGYGYIEMGD
RVNGHIPTFKIARFTEKPNLEVAKDFLLKGTYLWNSGMFIFRADVILREIEKYIPKMYKCLMEIYQHIGEDDEEEIIKEQ
YSLIDGISIDFGVMQKTRRSFVIKCDFSWDDIGTFSALSRFLGHNGNNRTSDNVFLEECENCSVFGKEKLIIGFGIKDLV
LVDAGDVILVMDKGRDQEIKHLLNSISGKKEFKEYL

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=362, Percent_Identity=33.1491712707182, Blast_Score=199, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR018247
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 40709; Mature: 40709

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYSLILAGGKGTRLYPLSRSSNPKQFLSIHNNGKSFLSNTVDRIRPIIHKDNIYVVTNQ
CCEEEEEECCCCCEEEECCCCCCHHHHEEEECCCHHHHHHHHHHHHHHEECCCEEEEECC
EYEDKTRDELKDIREENIFTEPANKETATCIGLSAAKLLKKDKDAVMIVLPSDHYIEGDK
CCCHHHHHHHHHHHHHCCCCCCCCCCCCEEECHHHHHHHHCCCCEEEEEECCCCEECCCH
SYLQTLEQAVEIADKKRAIVTIGIEPTRPETGYGYIEMGDRVNGHIPTFKIARFTEKPNL
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCCH
EVAKDFLLKGTYLWNSGMFIFRADVILREIEKYIPKMYKCLMEIYQHIGEDDEEEIIKEQ
HHHHHHHHCCEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
YSLIDGISIDFGVMQKTRRSFVIKCDFSWDDIGTFSALSRFLGHNGNNRTSDNVFLEECE
HHHHCCCCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHCC
NCSVFGKEKLIIGFGIKDLVLVDAGDVILVMDKGRDQEIKHLLNSISGKKEFKEYL
CCCEECCCEEEEEECCCEEEEEECCCEEEEEECCCCHHHHHHHHHCCCHHHHHHCC
>Mature Secondary Structure
MLYSLILAGGKGTRLYPLSRSSNPKQFLSIHNNGKSFLSNTVDRIRPIIHKDNIYVVTNQ
CCEEEEEECCCCCEEEECCCCCCHHHHEEEECCCHHHHHHHHHHHHHHEECCCEEEEECC
EYEDKTRDELKDIREENIFTEPANKETATCIGLSAAKLLKKDKDAVMIVLPSDHYIEGDK
CCCHHHHHHHHHHHHHCCCCCCCCCCCCEEECHHHHHHHHCCCCEEEEEECCCCEECCCH
SYLQTLEQAVEIADKKRAIVTIGIEPTRPETGYGYIEMGDRVNGHIPTFKIARFTEKPNL
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCCH
EVAKDFLLKGTYLWNSGMFIFRADVILREIEKYIPKMYKCLMEIYQHIGEDDEEEIIKEQ
HHHHHHHHCCEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
YSLIDGISIDFGVMQKTRRSFVIKCDFSWDDIGTFSALSRFLGHNGNNRTSDNVFLEECE
HHHHCCCCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHCC
NCSVFGKEKLIIGFGIKDLVLVDAGDVILVMDKGRDQEIKHLLNSISGKKEFKEYL
CCCEECCCEEEEEECCCEEEEEECCCEEEEEECCCCHHHHHHHHHCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1383393 [H]