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The map label for this gene is groEL [H]

Identifier: 18311271

GI number: 18311271

Start: 2633990

End: 2635609

Strand: Reverse

Name: groEL [H]

Synonym: CPE2289

Alternate gene names: 18311271

Gene position: 2635609-2633990 (Counterclockwise)

Preceding gene: 18311272

Following gene: 18311270

Centisome position: 86.94

GC content: 33.7

Gene sequence:

>1620_bases
ATGGCTAAAACATTATTATTCGGTGAAGAAGCAAGAAGATCTATGCAAGCGGGTGTAGATAAATTAGCTAACACTGTTAA
GGTTACATTAGGACCAAAAGGAAGAAATGTTATTTTAGATAAAAAATTTGGATCACCATTAATAACAAATGATGGGGTTA
CAATAGCAAGAGAAATTGAACTTGAAGATGCTTATGAAAATATGGGAGCTCAACTTGTAAAAGAAGTAGCTACAAAGACT
AATGATGTGGCAGGAGATGGAACTACTACAGCTACCTTATTAGCTCAAGCAATTATAAGAGAAGGATTAAAAAATGTAAC
AGCAGGGGCAAATCCTATATTAATAAGAAATGGAATTAAAACTGCAGTTGAAAAAGCTGTAGAGGAAATACAAAAAATTT
CTAAGCCTGTAAATGGAAAAGAAGACATAGCTAGAGTTGCTGCAATTTCAGCGGCTGATGAAAAAATTGGTAAGCTAATT
GCAGATGCTATGGAAAAGGTAGGAAATGAAGGCGTTATAACTGTAGAAGAATCTAAATCAATGGGAACTGAGTTAGATGT
TGTTGAAGGTATGCAATTTGATAGAGGATATGTATCAGCTTATATGGTTACTGATACTGAAAAAATGGAAGCTGTTTTAG
ATAATCCATTAGTATTAATAACAGATAAGAAAATAAGCAATATACAAGATTTATTACCATTACTTGAGCAAATAGTTCAA
GCAGGTAAAAAACTTTTAATAATAGCTGATGATATAGAAGGCGAAGCTATGACAACATTAGTTGTTAATAAATTAAGAGG
AACATTTACTTGTGTTGGAGTTAAAGCACCTGGATTTGGTGATAGAAGAAAAGAAATGTTACAAGATATAGCTACTTTAA
CAGGTGGCGTTGTTATATCTGATGAAGTAGGCGGAGATTTAAAAGAAGCTACATTAGATATGCTTGGAGAAGCTGAAAGT
GTTAAGGTAACTAAAGAAAGTACTACAATAGTTAATGGAAGAGGAAACTCAGAAGAGATTAAAAATAGAGTTAACCAAAT
AAAATTACAATTAGAAGCTACTACTTCTGAATTTGACAAAGAAAAATTACAAGAAAGATTAGCTAAATTAGCAGGTGGGG
TTGCAGTAGTTAAGGTTGGAGCTGCCACTGAAACAGAGCTTAAGGAAAGTAAGCTAAGAATAGAGGATGCTTTAGCAGCT
ACAAAGGCAGCTGTTGAAGAAGGAATAGTTCCAGGTGGTGGAACAGCTTACGTAAATGTAATAAATGAAGTTGCAAAATT
AACCTCTGATATTCAAGATGAACAAGTTGGTATAAATATAATTGTAAGATCTTTAGAAGAACCTATGAGACAAATAGCTC
ATAATGCAGGACTAGAAGGTTCAGTTATAATAGAAAAAGTTAAAAATAGTGATGCAGGTGTAGGATTTGATGCTTTAAGA
GGAGAATATAAAGATATGATTAAAGCTGGAATAGTTGATCCAACTAAGGTTACAAGATCAGCTCTTCAAAATGCAGCATC
AGTAGCATCAACATTCTTAACAACAGAGGCTGCTGTAGCAGATATTCCAGAAAAAGAAATGCCTCAAGGCGCAGGTATGG
GAATGGACGGAATGTACTAA

Upstream 100 bases:

>100_bases
ATATACTATTTTAAGACAAGACGATATACTAGCAATAGTTGAATAGTTTTAAAATATAAGTGATTTAGATATTCATAATA
TATTTGGGAGGTAAATTAAT

Downstream 100 bases:

>100_bases
TAAAAGAATAAAAAGGATGACAGTTAAGTCATCCTTTTTTTATTTAATTCTTATTGAAAATAATTACATAATATGATTAA
AATGGTTTAAATGTCGAAAA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 539; Mature: 538

Protein sequence:

>539_residues
MAKTLLFGEEARRSMQAGVDKLANTVKVTLGPKGRNVILDKKFGSPLITNDGVTIAREIELEDAYENMGAQLVKEVATKT
NDVAGDGTTTATLLAQAIIREGLKNVTAGANPILIRNGIKTAVEKAVEEIQKISKPVNGKEDIARVAAISAADEKIGKLI
ADAMEKVGNEGVITVEESKSMGTELDVVEGMQFDRGYVSAYMVTDTEKMEAVLDNPLVLITDKKISNIQDLLPLLEQIVQ
AGKKLLIIADDIEGEAMTTLVVNKLRGTFTCVGVKAPGFGDRRKEMLQDIATLTGGVVISDEVGGDLKEATLDMLGEAES
VKVTKESTTIVNGRGNSEEIKNRVNQIKLQLEATTSEFDKEKLQERLAKLAGGVAVVKVGAATETELKESKLRIEDALAA
TKAAVEEGIVPGGGTAYVNVINEVAKLTSDIQDEQVGINIIVRSLEEPMRQIAHNAGLEGSVIIEKVKNSDAGVGFDALR
GEYKDMIKAGIVDPTKVTRSALQNAASVASTFLTTEAAVADIPEKEMPQGAGMGMDGMY

Sequences:

>Translated_539_residues
MAKTLLFGEEARRSMQAGVDKLANTVKVTLGPKGRNVILDKKFGSPLITNDGVTIAREIELEDAYENMGAQLVKEVATKT
NDVAGDGTTTATLLAQAIIREGLKNVTAGANPILIRNGIKTAVEKAVEEIQKISKPVNGKEDIARVAAISAADEKIGKLI
ADAMEKVGNEGVITVEESKSMGTELDVVEGMQFDRGYVSAYMVTDTEKMEAVLDNPLVLITDKKISNIQDLLPLLEQIVQ
AGKKLLIIADDIEGEAMTTLVVNKLRGTFTCVGVKAPGFGDRRKEMLQDIATLTGGVVISDEVGGDLKEATLDMLGEAES
VKVTKESTTIVNGRGNSEEIKNRVNQIKLQLEATTSEFDKEKLQERLAKLAGGVAVVKVGAATETELKESKLRIEDALAA
TKAAVEEGIVPGGGTAYVNVINEVAKLTSDIQDEQVGINIIVRSLEEPMRQIAHNAGLEGSVIIEKVKNSDAGVGFDALR
GEYKDMIKAGIVDPTKVTRSALQNAASVASTFLTTEAAVADIPEKEMPQGAGMGMDGMY
>Mature_538_residues
AKTLLFGEEARRSMQAGVDKLANTVKVTLGPKGRNVILDKKFGSPLITNDGVTIAREIELEDAYENMGAQLVKEVATKTN
DVAGDGTTTATLLAQAIIREGLKNVTAGANPILIRNGIKTAVEKAVEEIQKISKPVNGKEDIARVAAISAADEKIGKLIA
DAMEKVGNEGVITVEESKSMGTELDVVEGMQFDRGYVSAYMVTDTEKMEAVLDNPLVLITDKKISNIQDLLPLLEQIVQA
GKKLLIIADDIEGEAMTTLVVNKLRGTFTCVGVKAPGFGDRRKEMLQDIATLTGGVVISDEVGGDLKEATLDMLGEAESV
KVTKESTTIVNGRGNSEEIKNRVNQIKLQLEATTSEFDKEKLQERLAKLAGGVAVVKVGAATETELKESKLRIEDALAAT
KAAVEEGIVPGGGTAYVNVINEVAKLTSDIQDEQVGINIIVRSLEEPMRQIAHNAGLEGSVIIEKVKNSDAGVGFDALRG
EYKDMIKAGIVDPTKVTRSALQNAASVASTFLTTEAAVADIPEKEMPQGAGMGMDGMY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=527, Percent_Identity=49.146110056926, Blast_Score=497, Evalue=1e-140,
Organism=Homo sapiens, GI31542947, Length=527, Percent_Identity=49.146110056926, Blast_Score=497, Evalue=1e-140,
Organism=Homo sapiens, GI24307939, Length=135, Percent_Identity=34.0740740740741, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI38455427, Length=552, Percent_Identity=22.1014492753623, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1790586, Length=526, Percent_Identity=59.3155893536122, Blast_Score=608, Evalue=1e-175,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=48.5822306238185, Blast_Score=502, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI193210679, Length=210, Percent_Identity=48.5714285714286, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI25144674, Length=187, Percent_Identity=31.0160427807487, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=51.1450381679389, Blast_Score=512, Evalue=1e-146,
Organism=Saccharomyces cerevisiae, GI6322524, Length=515, Percent_Identity=24.6601941747573, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322446, Length=543, Percent_Identity=23.2044198895028, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320418, Length=590, Percent_Identity=23.2203389830508, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=48.7666034155598, Blast_Score=507, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=48.7666034155598, Blast_Score=507, Evalue=1e-144,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=46.8690702087287, Blast_Score=482, Evalue=1e-136,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=46.8690702087287, Blast_Score=482, Evalue=1e-136,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=46.8690702087287, Blast_Score=482, Evalue=1e-136,
Organism=Drosophila melanogaster, GI17864606, Length=541, Percent_Identity=42.1441774491682, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24584129, Length=531, Percent_Identity=36.346516007533, Blast_Score=302, Evalue=3e-82,
Organism=Drosophila melanogaster, GI19921262, Length=531, Percent_Identity=36.346516007533, Blast_Score=302, Evalue=3e-82,
Organism=Drosophila melanogaster, GI17647245, Length=535, Percent_Identity=23.1775700934579, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24652903, Length=131, Percent_Identity=30.5343511450382, Blast_Score=66, Evalue=8e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57368; Mature: 57236

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTLLFGEEARRSMQAGVDKLANTVKVTLGPKGRNVILDKKFGSPLITNDGVTIAREIE
CCCCEECCHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEECCCCCCEEECCCCEEEEEEE
LEDAYENMGAQLVKEVATKTNDVAGDGTTTATLLAQAIIREGLKNVTAGANPILIRNGIK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHH
TAVEKAVEEIQKISKPVNGKEDIARVAAISAADEKIGKLIADAMEKVGNEGVITVEESKS
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
MGTELDVVEGMQFDRGYVSAYMVTDTEKMEAVLDNPLVLITDKKISNIQDLLPLLEQIVQ
CCCCCHHHHCCCCCCCEEEEEEEECHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
AGKKLLIIADDIEGEAMTTLVVNKLRGTFTCVGVKAPGFGDRRKEMLQDIATLTGGVVIS
CCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCEEEE
DEVGGDLKEATLDMLGEAESVKVTKESTTIVNGRGNSEEIKNRVNQIKLQLEATTSEFDK
CCCCCCHHHHHHHHHCCCCCEEEEECCCEEEECCCCHHHHHHHHHHEEEEEECCHHHHHH
EKLQERLAKLAGGVAVVKVGAATETELKESKLRIEDALAATKAAVEEGIVPGGGTAYVNV
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
INEVAKLTSDIQDEQVGINIIVRSLEEPMRQIAHNAGLEGSVIIEKVKNSDAGVGFDALR
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEECCCCCCCCCHHHHH
GEYKDMIKAGIVDPTKVTRSALQNAASVASTFLTTEAAVADIPEKEMPQGAGMGMDGMY
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
AKTLLFGEEARRSMQAGVDKLANTVKVTLGPKGRNVILDKKFGSPLITNDGVTIAREIE
CCCEECCHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEECCCCCCEEECCCCEEEEEEE
LEDAYENMGAQLVKEVATKTNDVAGDGTTTATLLAQAIIREGLKNVTAGANPILIRNGIK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHH
TAVEKAVEEIQKISKPVNGKEDIARVAAISAADEKIGKLIADAMEKVGNEGVITVEESKS
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
MGTELDVVEGMQFDRGYVSAYMVTDTEKMEAVLDNPLVLITDKKISNIQDLLPLLEQIVQ
CCCCCHHHHCCCCCCCEEEEEEEECHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
AGKKLLIIADDIEGEAMTTLVVNKLRGTFTCVGVKAPGFGDRRKEMLQDIATLTGGVVIS
CCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCEEEE
DEVGGDLKEATLDMLGEAESVKVTKESTTIVNGRGNSEEIKNRVNQIKLQLEATTSEFDK
CCCCCCHHHHHHHHHCCCCCEEEEECCCEEEECCCCHHHHHHHHHHEEEEEECCHHHHHH
EKLQERLAKLAGGVAVVKVGAATETELKESKLRIEDALAATKAAVEEGIVPGGGTAYVNV
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
INEVAKLTSDIQDEQVGINIIVRSLEEPMRQIAHNAGLEGSVIIEKVKNSDAGVGFDALR
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEECCCCCCCCCHHHHH
GEYKDMIKAGIVDPTKVTRSALQNAASVASTFLTTEAAVADIPEKEMPQGAGMGMDGMY
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA