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The map label for this gene is yggV [C]

Identifier: 18311235

GI number: 18311235

Start: 2586484

End: 2587098

Strand: Reverse

Name: yggV [C]

Synonym: CPE2253

Alternate gene names: 18311235

Gene position: 2587098-2586484 (Counterclockwise)

Preceding gene: 18311236

Following gene: 18311234

Centisome position: 85.34

GC content: 27.64

Gene sequence:

>615_bases
ATGAAAAAATTTATACTAGCAAGTAATAATGCACATAAGGTAAAAGAAATAAAAGAAATATTAAAAGATTTTAATTTAAA
CATATTATCTTTAAATGAAGCAGGAATAGACATAGATGTTGAAGAGGACGGAAAAACATTTGAAGAAAATTCTTTTAAGA
AAGCTAATGAAATAAGAAAGTATTTACTTAGTAAAGGTGAAAGTGATTTTATTGTAATGGCTGACGATTCAGGATTAGAA
GTAGATTATTTAAATGGAGCGCCAGGTATATATTCTGCTAGATATGCAGGGGAACATGGAAATGATTCTAAAAATAATGA
AAAGTTATTAGAGGAATTAAAAAATGTTAAAGATGATGAAAGAAAAGCTAATTTTATATGTGTAATAGTTGCAGTTACAG
ATAAAGGAGAAAAAATAGTAGCAGAGGGAAAAAGTTATGGATTAATTTTAGAAGCTTTAAGTGGAAATGAAGGTTTTGGA
TATGATCCTTTATTTTTCGTACCAGAATACAAAAAAACTTTCGCAGAAATGACTTCAGATGAAAAGAATGCTATTAGCCA
TAGGGGAAGAGCTTTAGAAAAACTAAAGGATAATTTAAAAGGGATACTTAAATAG

Upstream 100 bases:

>100_bases
TTATTAAATCTTGCTGAAAAAGGAGCAAAACAAATGATACAAGCACAAAAAGATGCTTTAAAGACAGATTCTTTATGGAT
CGGAACAGGGAGAGAGTAAA

Downstream 100 bases:

>100_bases
GAGGAGAAGAAATGAAAGTAGCTATAGTCAGTGATACACATGGAGTTACTCATGTTATTGAATATATAAAAACTTTACTA
AATGATTCAGATGTTCTTAT

Product: putative deoxyribonucleotide triphosphate pyrophosphatase

Products: NA

Alternate protein names: Nucleoside triphosphate phosphohydrolase; NTPase

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MKKFILASNNAHKVKEIKEILKDFNLNILSLNEAGIDIDVEEDGKTFEENSFKKANEIRKYLLSKGESDFIVMADDSGLE
VDYLNGAPGIYSARYAGEHGNDSKNNEKLLEELKNVKDDERKANFICVIVAVTDKGEKIVAEGKSYGLILEALSGNEGFG
YDPLFFVPEYKKTFAEMTSDEKNAISHRGRALEKLKDNLKGILK

Sequences:

>Translated_204_residues
MKKFILASNNAHKVKEIKEILKDFNLNILSLNEAGIDIDVEEDGKTFEENSFKKANEIRKYLLSKGESDFIVMADDSGLE
VDYLNGAPGIYSARYAGEHGNDSKNNEKLLEELKNVKDDERKANFICVIVAVTDKGEKIVAEGKSYGLILEALSGNEGFG
YDPLFFVPEYKKTFAEMTSDEKNAISHRGRALEKLKDNLKGILK
>Mature_204_residues
MKKFILASNNAHKVKEIKEILKDFNLNILSLNEAGIDIDVEEDGKTFEENSFKKANEIRKYLLSKGESDFIVMADDSGLE
VDYLNGAPGIYSARYAGEHGNDSKNNEKLLEELKNVKDDERKANFICVIVAVTDKGEKIVAEGKSYGLILEALSGNEGFG
YDPLFFVPEYKKTFAEMTSDEKNAISHRGRALEKLKDNLKGILK

Specific function: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions

COG id: COG0127

COG function: function code F; Xanthosine triphosphate pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAM1 NTPase family

Homologues:

Organism=Homo sapiens, GI15626999, Length=199, Percent_Identity=29.6482412060301, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1789324, Length=202, Percent_Identity=47.5247524752475, Blast_Score=184, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17556833, Length=201, Percent_Identity=30.3482587064677, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322529, Length=201, Percent_Identity=31.3432835820896, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NTPA_CLOPE (Q8XI68)

Other databases:

- EMBL:   BA000016
- RefSeq:   NP_563169.1
- ProteinModelPortal:   Q8XI68
- GeneID:   990606
- GenomeReviews:   BA000016_GR
- KEGG:   cpe:CPE2253
- NMPDR:   fig|195102.1.peg.2316
- HOGENOM:   HBG697237
- OMA:   VYTADWA
- PhylomeDB:   Q8XI68
- ProtClustDB:   PRK00120
- BioCyc:   CPER195102:CPE2253-MONOMER
- BRENDA:   3.6.1.15
- HAMAP:   MF_01405
- InterPro:   IPR002637
- InterPro:   IPR020922
- PANTHER:   PTHR11067
- TIGRFAMs:   TIGR00042

Pfam domain/function: PF01725 Ham1p_like

EC number: =3.6.1.15

Molecular weight: Translated: 22847; Mature: 22847

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFILASNNAHKVKEIKEILKDFNLNILSLNEAGIDIDVEEDGKTFEENSFKKANEIRK
CCCEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHH
YLLSKGESDFIVMADDSGLEVDYLNGAPGIYSARYAGEHGNDSKNNEKLLEELKNVKDDE
HHHHCCCCCEEEEECCCCCEEEEECCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCC
RKANFICVIVAVTDKGEKIVAEGKSYGLILEALSGNEGFGYDPLFFVPEYKKTFAEMTSD
CCCCEEEEEEEEECCCCEEEECCCCCEEEEEEECCCCCCCCCCEEECCHHHHHHHHHCCC
EKNAISHRGRALEKLKDNLKGILK
HHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKFILASNNAHKVKEIKEILKDFNLNILSLNEAGIDIDVEEDGKTFEENSFKKANEIRK
CCCEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHH
YLLSKGESDFIVMADDSGLEVDYLNGAPGIYSARYAGEHGNDSKNNEKLLEELKNVKDDE
HHHHCCCCCEEEEECCCCCEEEEECCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCC
RKANFICVIVAVTDKGEKIVAEGKSYGLILEALSGNEGFGYDPLFFVPEYKKTFAEMTSD
CCCCEEEEEEEEECCCCEEEECCCCCEEEEEEECCCCCCCCCCEEECCHHHHHHHHHCCC
EKNAISHRGRALEKLKDNLKGILK
HHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792842