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The map label for this gene is pepD [H]

Identifier: 18311233

GI number: 18311233

Start: 2582494

End: 2583945

Strand: Reverse

Name: pepD [H]

Synonym: CPE2251

Alternate gene names: 18311233

Gene position: 2583945-2582494 (Counterclockwise)

Preceding gene: 18311234

Following gene: 18311231

Centisome position: 85.24

GC content: 30.65

Gene sequence:

>1452_bases
ATGAGAGTATTAGAAAAACTAGAGCCTAAAAGTGTATTTAGATTTTTTGAAGATTTAACAAGAATACCACATGATTCTGG
AAATGAAAAAGAACTTAGTGATTATCTTGTTAAGTTTGCAAAGGATAGAAATCTTGAAGTTATTCAGGATGAGGCACTAA
ATGTAATAATTAAAAAGCCTGCTACTAAGGGGTATGAAAATGTACCAGGAGTTATAATTCAAGGGCATATGGATATGGTA
TGTGAAAAATTAAAGAGTAGTAATCACGATTTTAAAAAAGATCCTTTAAAATTAAGAATTATTGATGATAAATTTGTTTA
TGCTACAGATACTACTTTAGGAGCAGATGATGGTATTTCCTTAGCCTATGGATTAGCTATTTTAGATTCTAATAATATAG
AACATCCAGCAATAGAGTTTGTAGCAACTACAGAGGAAGAAACAGTTATGGGGGGAGCTACTGCTTTAGATACTTCACTT
TTAAAAGGAAAGGTTTTATTAAACATAGATGCTGAAGAAGAAGGAGTATTTATTGTAGGGTGTGCTGGAGGAATTATGGT
TTATCCAGAAATAAATGCTGAATTTGAAGATTTTAATGGAGAAGCTTTAAAATTAGAGATTTTAGGTTTTAAGGGTGGAC
ACTCAGGAATGGAAATCCATAAACAAAGAGGAAATGCCAATAAGTTAATGGGAAGAATCTTATATGATTTAAGCAAAGAA
GTTGACTTTAATATTGCATCAATTAAGGGTGGATCAAAACATAATGCAATACCACAATATTGTCAAAGCATAATTGCAGT
TAAGAAAGAAGAGGTAGAGAAGGTTAAAGAAATTTGTACTGCCTTAGAAAAAGATTTAAAGGCAGAATACAGAATTGGAG
AGCCAGATGTGAATCTTTCTGTTAAAAGCATTGGAGGAGTAGAAAAACAATTAACTAAAAAGGTTACAGATGATATAACT
AGATTTTTAGTTTTAGTTCCAGACGGATTACAATCTATGAGTCAAGAGATAAATGGATTAGTTGAAAGTAGCTTAAATCT
TGGAATAGTAGAAATGGTAGAGGATAAAATTAAATTTATTATTGATATAAGAAGTGCAGTTAAGAGTAAAAAGATAGAAA
TTACAAATAGAGTAGAGGCTCTTTGTAAGGTTATAGGAGCTAATATGACTAAAGATGGAGATTATCCAGAGTGGGAATAT
GAAGCAGAATCAAAAATAAAAGATTTAAGTATTAAAACTTACAGTGATTTATTTGGAATTGAGCCTCAAATAACAGCTTT
ACATGCAGGTCTTGAGTGTGGAATCTTTAAAGAAAAGATGGGACAAGAGGTAGAAATGATAAGTTTTGGTCCAGATATAT
TTGATGTGCATACAGCAAATGAGCATTTTAAAATAGAATCTGTTGGAAGATGCTATAGATTCTTAACTGAATTATTAAAG
AACATGAAATAA

Upstream 100 bases:

>100_bases
ATTATAGGTAATATATAATATTTACAATATAGATAAAACTAAATTAGTAATTATAAAGTTTAAATTGATTATTAATTATT
TAGTTAGAGGAGGAAGTAAA

Downstream 100 bases:

>100_bases
TGATTAAAAACTTTATAATAAATTCTATAGTTTAAAGATATTAGTTAAATAAGAATTTAAATTTATGAAAGGTGCATAGG
TTAGAATTTATATATAGAAA

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MRVLEKLEPKSVFRFFEDLTRIPHDSGNEKELSDYLVKFAKDRNLEVIQDEALNVIIKKPATKGYENVPGVIIQGHMDMV
CEKLKSSNHDFKKDPLKLRIIDDKFVYATDTTLGADDGISLAYGLAILDSNNIEHPAIEFVATTEEETVMGGATALDTSL
LKGKVLLNIDAEEEGVFIVGCAGGIMVYPEINAEFEDFNGEALKLEILGFKGGHSGMEIHKQRGNANKLMGRILYDLSKE
VDFNIASIKGGSKHNAIPQYCQSIIAVKKEEVEKVKEICTALEKDLKAEYRIGEPDVNLSVKSIGGVEKQLTKKVTDDIT
RFLVLVPDGLQSMSQEINGLVESSLNLGIVEMVEDKIKFIIDIRSAVKSKKIEITNRVEALCKVIGANMTKDGDYPEWEY
EAESKIKDLSIKTYSDLFGIEPQITALHAGLECGIFKEKMGQEVEMISFGPDIFDVHTANEHFKIESVGRCYRFLTELLK
NMK

Sequences:

>Translated_483_residues
MRVLEKLEPKSVFRFFEDLTRIPHDSGNEKELSDYLVKFAKDRNLEVIQDEALNVIIKKPATKGYENVPGVIIQGHMDMV
CEKLKSSNHDFKKDPLKLRIIDDKFVYATDTTLGADDGISLAYGLAILDSNNIEHPAIEFVATTEEETVMGGATALDTSL
LKGKVLLNIDAEEEGVFIVGCAGGIMVYPEINAEFEDFNGEALKLEILGFKGGHSGMEIHKQRGNANKLMGRILYDLSKE
VDFNIASIKGGSKHNAIPQYCQSIIAVKKEEVEKVKEICTALEKDLKAEYRIGEPDVNLSVKSIGGVEKQLTKKVTDDIT
RFLVLVPDGLQSMSQEINGLVESSLNLGIVEMVEDKIKFIIDIRSAVKSKKIEITNRVEALCKVIGANMTKDGDYPEWEY
EAESKIKDLSIKTYSDLFGIEPQITALHAGLECGIFKEKMGQEVEMISFGPDIFDVHTANEHFKIESVGRCYRFLTELLK
NMK
>Mature_483_residues
MRVLEKLEPKSVFRFFEDLTRIPHDSGNEKELSDYLVKFAKDRNLEVIQDEALNVIIKKPATKGYENVPGVIIQGHMDMV
CEKLKSSNHDFKKDPLKLRIIDDKFVYATDTTLGADDGISLAYGLAILDSNNIEHPAIEFVATTEEETVMGGATALDTSL
LKGKVLLNIDAEEEGVFIVGCAGGIMVYPEINAEFEDFNGEALKLEILGFKGGHSGMEIHKQRGNANKLMGRILYDLSKE
VDFNIASIKGGSKHNAIPQYCQSIIAVKKEEVEKVKEICTALEKDLKAEYRIGEPDVNLSVKSIGGVEKQLTKKVTDDIT
RFLVLVPDGLQSMSQEINGLVESSLNLGIVEMVEDKIKFIIDIRSAVKSKKIEITNRVEALCKVIGANMTKDGDYPEWEY
EAESKIKDLSIKTYSDLFGIEPQITALHAGLECGIFKEKMGQEVEMISFGPDIFDVHTANEHFKIESVGRCYRFLTELLK
NMK

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=482, Percent_Identity=39.0041493775934, Blast_Score=338, Evalue=4e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 53883; Mature: 53883

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLEKLEPKSVFRFFEDLTRIPHDSGNEKELSDYLVKFAKDRNLEVIQDEALNVIIKKP
CCCHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEHHCCCEEEEECC
ATKGYENVPGVIIQGHMDMVCEKLKSSNHDFKKDPLKLRIIDDKFVYATDTTLGADDGIS
CCCCCCCCCCEEEECCHHHHHHHHHCCCCCCCCCCEEEEEEECCEEEEECCCCCCCCCCC
LAYGLAILDSNNIEHPAIEFVATTEEETVMGGATALDTSLLKGKVLLNIDAEEEGVFIVG
CEEEEEEEECCCCCCCCEEEEEECCCHHHCCCCHHHHHHHHCCEEEEEECCCCCCEEEEE
CAGGIMVYPEINAEFEDFNGEALKLEILGFKGGHSGMEIHKQRGNANKLMGRILYDLSKE
ECCCEEEEECCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHHHHC
VDFNIASIKGGSKHNAIPQYCQSIIAVKKEEVEKVKEICTALEKDLKAEYRIGEPDVNLS
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCEE
VKSIGGVEKQLTKKVTDDITRFLVLVPDGLQSMSQEINGLVESSLNLGIVEMVEDKIKFI
EHHCCCHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
IDIRSAVKSKKIEITNRVEALCKVIGANMTKDGDYPEWEYEAESKIKDLSIKTYSDLFGI
HHHHHHHHHCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCHHHCEEEHHHHHHCC
EPQITALHAGLECGIFKEKMGQEVEMISFGPDIFDVHTANEHFKIESVGRCYRFLTELLK
CCCHHHHHCCCCCCCHHHHCCCCEEEEEECCCEEEEECCCCCEEHHHHHHHHHHHHHHHH
NMK
HCC
>Mature Secondary Structure
MRVLEKLEPKSVFRFFEDLTRIPHDSGNEKELSDYLVKFAKDRNLEVIQDEALNVIIKKP
CCCHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEHHCCCEEEEECC
ATKGYENVPGVIIQGHMDMVCEKLKSSNHDFKKDPLKLRIIDDKFVYATDTTLGADDGIS
CCCCCCCCCCEEEECCHHHHHHHHHCCCCCCCCCCEEEEEEECCEEEEECCCCCCCCCCC
LAYGLAILDSNNIEHPAIEFVATTEEETVMGGATALDTSLLKGKVLLNIDAEEEGVFIVG
CEEEEEEEECCCCCCCCEEEEEECCCHHHCCCCHHHHHHHHCCEEEEEECCCCCCEEEEE
CAGGIMVYPEINAEFEDFNGEALKLEILGFKGGHSGMEIHKQRGNANKLMGRILYDLSKE
ECCCEEEEECCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHHHHC
VDFNIASIKGGSKHNAIPQYCQSIIAVKKEEVEKVKEICTALEKDLKAEYRIGEPDVNLS
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCEE
VKSIGGVEKQLTKKVTDDITRFLVLVPDGLQSMSQEINGLVESSLNLGIVEMVEDKIKFI
EHHCCCHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
IDIRSAVKSKKIEITNRVEALCKVIGANMTKDGDYPEWEYEAESKIKDLSIKTYSDLFGI
HHHHHHHHHCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCHHHCEEEHHHHHHCC
EPQITALHAGLECGIFKEKMGQEVEMISFGPDIFDVHTANEHFKIESVGRCYRFLTELLK
CCCHHHHHCCCCCCCHHHHCCCCEEEEEECCCEEEEECCCCCEEHHHHHHHHHHHHHHHH
NMK
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]