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The map label for this gene is norM [H]

Identifier: 182682656

GI number: 182682656

Start: 2423418

End: 2424779

Strand: Reverse

Name: norM [H]

Synonym: XfasM23_2146

Alternate gene names: 182682656

Gene position: 2424779-2423418 (Counterclockwise)

Preceding gene: 182682657

Following gene: 182682655

Centisome position: 95.63

GC content: 51.03

Gene sequence:

>1362_bases
ATGGCAGTCTCGTTTGTGATATCCCGCTTTGGTTCCGAAGTTCGTCCTACTCTTTTGCTTGCGCTGCCGCTCGTTTTGGG
TCACGTTTCCACTGGTCTGATCGGCTTTGTACTTAACGTTATTGCTGGTCATCACTCTACCGTCACTCTAGCGGCATCGA
CTATCGGCACTGCATTGCTTTGGTTGCCGATGTTGGTACCCATGGGTACGTTGATTTCGTTAACGGTGTTGGTATCGCAA
TTGCATGGTGCTGAGCGTGAACGGGACATTGGGCCTTTGTTCCGCCAAGCGTTGTGGCTGGCCATGCTGTTGGGGTTGGT
GATGTTCACTTTCCTCAGTGTGGTGCCAGCCTTGTTGCCGCTCTTTGGTATCGTCCCGGATATCGTTCCGGGTGCTGCTA
AGTTTTTGCATGTAGTGCGTTGGGGGAGTTTGGCATTCCCTCTTTACTTCTGTATGCGTTATTTCTGTGAGGGAATGCAC
TGTACTTTTCCAACGATGCTTCTGGGTTTTGGTGGGTTGCTAGTGCTGGTGCCATTGAGTTATGCGTTGACATACGGTCG
TTTTGGTTTTGCCGAGTATGGTGTTGAGGGCTTGGGGATCGCAACAGTGACGGTCATGTGGCTACAGGCGGTTGTATTTG
CGTTGTACTTGTGGAGATCACGTCGCTTCGCCCATCTGCAGCTATTTGCGCATCTGGAATTGCCGTGCTGGGCACGTATC
CGTGATCTGTTGAATATAGGATTACCCATCGGCATTAGTATTTTGATGGAGGGCGGATTATTTATTGTCACCACGTTGCT
GATTGGTCGGTTTGGTACTGATGAAATTGCCGCGCATCAAATTGCCCTAAGTGTTGCTCAATTGTGCTTCATGATCCCGA
TGGGTGTAGCTGAGGCAACCACGGTGCGAATCGGCCATGCTGTGGGTCGTTGCGATCTTTTGGTGATGCGCCGTGTCGCT
TGGGCTGGTTATGCAATCGTGATCGGGACGCAGACACTCTCAGCAAGTGTGCTTTTGCTCGGATATGACGTGATTGTAGC
CGCTTATACGGATGATTTGGTGGTGGCGTCTCTGGCTTCTAAATTACTGTTGTTTGCGGCTATATTCCAGTTCCCGGATG
GTCTCCAGATGCTTTCGTCCGGTGTATTACGTGGGATGAAGGACACCCGGGTGCCGATGCTGCTGGCGATGATCTCGTAT
TGGGGTTTAGGTATGCCGCTTGGTCTTGGCCTTGGTTTTGCCTTGGAATGGAATTCTCGCGGTATGTGGATCGGCTTAAT
CATTGGCTTGACTGCAGCTGCATTGTTGCTTGGTTGGCGATTTCGTGTGGTTAGCGAGCGCATGTTTGCCGGTATTCCCT
AA

Upstream 100 bases:

>100_bases
GAATTGTGATATTTTCCATAAATTGCGCCTTTACGCGCATCCTAAATGCCTAGTGTTTTTACCTAGGCCCGATTTCAGGA
TCGCTCTTTCTATTTGCTTT

Downstream 100 bases:

>100_bases
TTGTCAGTCACAGCGCGGTTATGCTGACACCCGCTGCGCTGATTCGCGTTCAAAATGATGTCAGTTTTTCAAGGAGCGTT
TCATGAACCAGTCTGTGCCT

Product: multidrug efflux protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MAVSFVISRFGSEVRPTLLLALPLVLGHVSTGLIGFVLNVIAGHHSTVTLAASTIGTALLWLPMLVPMGTLISLTVLVSQ
LHGAERERDIGPLFRQALWLAMLLGLVMFTFLSVVPALLPLFGIVPDIVPGAAKFLHVVRWGSLAFPLYFCMRYFCEGMH
CTFPTMLLGFGGLLVLVPLSYALTYGRFGFAEYGVEGLGIATVTVMWLQAVVFALYLWRSRRFAHLQLFAHLELPCWARI
RDLLNIGLPIGISILMEGGLFIVTTLLIGRFGTDEIAAHQIALSVAQLCFMIPMGVAEATTVRIGHAVGRCDLLVMRRVA
WAGYAIVIGTQTLSASVLLLGYDVIVAAYTDDLVVASLASKLLLFAAIFQFPDGLQMLSSGVLRGMKDTRVPMLLAMISY
WGLGMPLGLGLGFALEWNSRGMWIGLIIGLTAAALLLGWRFRVVSERMFAGIP

Sequences:

>Translated_453_residues
MAVSFVISRFGSEVRPTLLLALPLVLGHVSTGLIGFVLNVIAGHHSTVTLAASTIGTALLWLPMLVPMGTLISLTVLVSQ
LHGAERERDIGPLFRQALWLAMLLGLVMFTFLSVVPALLPLFGIVPDIVPGAAKFLHVVRWGSLAFPLYFCMRYFCEGMH
CTFPTMLLGFGGLLVLVPLSYALTYGRFGFAEYGVEGLGIATVTVMWLQAVVFALYLWRSRRFAHLQLFAHLELPCWARI
RDLLNIGLPIGISILMEGGLFIVTTLLIGRFGTDEIAAHQIALSVAQLCFMIPMGVAEATTVRIGHAVGRCDLLVMRRVA
WAGYAIVIGTQTLSASVLLLGYDVIVAAYTDDLVVASLASKLLLFAAIFQFPDGLQMLSSGVLRGMKDTRVPMLLAMISY
WGLGMPLGLGLGFALEWNSRGMWIGLIIGLTAAALLLGWRFRVVSERMFAGIP
>Mature_452_residues
AVSFVISRFGSEVRPTLLLALPLVLGHVSTGLIGFVLNVIAGHHSTVTLAASTIGTALLWLPMLVPMGTLISLTVLVSQL
HGAERERDIGPLFRQALWLAMLLGLVMFTFLSVVPALLPLFGIVPDIVPGAAKFLHVVRWGSLAFPLYFCMRYFCEGMHC
TFPTMLLGFGGLLVLVPLSYALTYGRFGFAEYGVEGLGIATVTVMWLQAVVFALYLWRSRRFAHLQLFAHLELPCWARIR
DLLNIGLPIGISILMEGGLFIVTTLLIGRFGTDEIAAHQIALSVAQLCFMIPMGVAEATTVRIGHAVGRCDLLVMRRVAW
AGYAIVIGTQTLSASVLLLGYDVIVAAYTDDLVVASLASKLLLFAAIFQFPDGLQMLSSGVLRGMKDTRVPMLLAMISYW
GLGMPLGLGLGFALEWNSRGMWIGLIIGLTAAALLLGWRFRVVSERMFAGIP

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI153792564, Length=460, Percent_Identity=25.2173913043478, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI22907060, Length=423, Percent_Identity=24.113475177305, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI38261960, Length=496, Percent_Identity=24.5967741935484, Blast_Score=93, Evalue=6e-19,
Organism=Escherichia coli, GI48994890, Length=442, Percent_Identity=34.841628959276, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI226510954, Length=296, Percent_Identity=25, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320545, Length=439, Percent_Identity=21.6400911161731, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49197; Mature: 49066

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSFVISRFGSEVRPTLLLALPLVLGHVSTGLIGFVLNVIAGHHSTVTLAASTIGTALL
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHH
WLPMLVPMGTLISLTVLVSQLHGAERERDIGPLFRQALWLAMLLGLVMFTFLSVVPALLP
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFGIVPDIVPGAAKFLHVVRWGSLAFPLYFCMRYFCEGMHCTFPTMLLGFGGLLVLVPLS
HHHHHHHHCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
YALTYGRFGFAEYGVEGLGIATVTVMWLQAVVFALYLWRSRRFAHLQLFAHLELPCWARI
HHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHH
RDLLNIGLPIGISILMEGGLFIVTTLLIGRFGTDEIAAHQIALSVAQLCFMIPMGVAEAT
HHHHHCCCCHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHH
TVRIGHAVGRCDLLVMRRVAWAGYAIVIGTQTLSASVLLLGYDVIVAAYTDDLVVASLAS
HHHHHHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLLLFAAIFQFPDGLQMLSSGVLRGMKDTRVPMLLAMISYWGLGMPLGLGLGFALEWNSR
HHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHCCCCEEEEECCC
GMWIGLIIGLTAAALLLGWRFRVVSERMFAGIP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AVSFVISRFGSEVRPTLLLALPLVLGHVSTGLIGFVLNVIAGHHSTVTLAASTIGTALL
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHH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CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]