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The map label for this gene is mtnA

Identifier: 182682555

GI number: 182682555

Start: 2291949

End: 2293013

Strand: Reverse

Name: mtnA

Synonym: XfasM23_2043

Alternate gene names: 182682555

Gene position: 2293013-2291949 (Counterclockwise)

Preceding gene: 182682556

Following gene: 182682554

Centisome position: 90.43

GC content: 58.03

Gene sequence:

>1065_bases
ATGCACCATCCCTTGCCCCCTGATGACACACTTTACGACCAGGTTCGTCCCATCCTTTGGACCGGCCATTTCCTGAAATT
ACTTGATCAGCGCAAATTGCCGTTTGTGGTCGAATATGTGGAGTGCCACAGTAGCGAAGATGTCACACAGGCCATCCGCA
CCCTGATCGTTCGTGGTGCACCGGCCATTGGCATTGTTGCAGGGTGGGGCGCCGTCCTTGCAGCGCGTGAGATTGAAGCG
GTCGATGGCATTGAAGCACTTTGCAAGCTAGAACCCGCATTACAACGTCTCCATGCCGCACGCCCAACCGCGGTCAACCT
TGCTTGGGTCCTGGCCCGCATGCGCCGGACCCTGAGCGCTGCCCACGCTGATTGGCGCCAAGTGATGGAGTGCGAAGCGG
AGTCCATTGCGAGGGAGGACCTCACCGCCAACCGTTGCATGGGTGCCTACGGTGCCGCACTCATTCCAATCGGCAGTGGC
GTGTTGACCCATTGCAATACCGGTTCTTTGGCGACTGCAGGGTTCGGGACTGCCTTGGGAGTCATCCGTGATGGCATCGC
CCAAGGGCGCATCGCACGCGTATTCGTAGGAGAGACCCGTCCCTGGCTACAGGGTGCACGTCTCACCGTGTGGGAATTGC
AGCAAGACGGGATCGACGCCACCTTGATTGCCGACTCCGCCGCTGCCCACCTCATGAAATCTGGCCAGGTGCAATGGGTC
ATTGTTGGCGCTGACAGAATCTGTGCCAATGGGGATACTGCCAACAAAATTGGCACCTACCAACTGGCTATTACCGCTCG
CCATCATGGAGTTAAATTCATGGTGGTTGCCTCCGCTGCGACTGTCGATATGGACACCGTCGCTGGAGAGGCGATCGAGA
TTGAACAGCGCGATCCGGAGGAACTGCTTGGAGTGAGTGGTGTGCGTACCGTGGCCGAAGGTATTGCTGCTTGGAATCCA
GTCTTTGACGTCACACCGGGTGCCCTGATTGACGCCATTGTCACGGAGCGCGGTGTGATTCAATCTCCAGATGCGGCACA
GATGCGTGCCACATTCGGCAACTGA

Upstream 100 bases:

>100_bases
CCGACACCAACACCTGTGTAGCGTCACCTGATCGCACACACCGACCTTTCCTATTCTCGACAGGCCTCAATGTCTATCAA
CGGATGCGTACAATGCTCCA

Downstream 100 bases:

>100_bases
ATGCGCCTGGGAACCACCTTCTTTCCATCCTCACACTCCCATCAAGTGTTTGTTTCTTTGGGGTAAGCATCAGCGGCCGT
AGTGCCTTCATGATAAAATC

Product: methylthioribose-1-phosphate isomerase

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MHHPLPPDDTLYDQVRPILWTGHFLKLLDQRKLPFVVEYVECHSSEDVTQAIRTLIVRGAPAIGIVAGWGAVLAAREIEA
VDGIEALCKLEPALQRLHAARPTAVNLAWVLARMRRTLSAAHADWRQVMECEAESIAREDLTANRCMGAYGAALIPIGSG
VLTHCNTGSLATAGFGTALGVIRDGIAQGRIARVFVGETRPWLQGARLTVWELQQDGIDATLIADSAAAHLMKSGQVQWV
IVGADRICANGDTANKIGTYQLAITARHHGVKFMVVASAATVDMDTVAGEAIEIEQRDPEELLGVSGVRTVAEGIAAWNP
VFDVTPGALIDAIVTERGVIQSPDAAQMRATFGN

Sequences:

>Translated_354_residues
MHHPLPPDDTLYDQVRPILWTGHFLKLLDQRKLPFVVEYVECHSSEDVTQAIRTLIVRGAPAIGIVAGWGAVLAAREIEA
VDGIEALCKLEPALQRLHAARPTAVNLAWVLARMRRTLSAAHADWRQVMECEAESIAREDLTANRCMGAYGAALIPIGSG
VLTHCNTGSLATAGFGTALGVIRDGIAQGRIARVFVGETRPWLQGARLTVWELQQDGIDATLIADSAAAHLMKSGQVQWV
IVGADRICANGDTANKIGTYQLAITARHHGVKFMVVASAATVDMDTVAGEAIEIEQRDPEELLGVSGVRTVAEGIAAWNP
VFDVTPGALIDAIVTERGVIQSPDAAQMRATFGN
>Mature_354_residues
MHHPLPPDDTLYDQVRPILWTGHFLKLLDQRKLPFVVEYVECHSSEDVTQAIRTLIVRGAPAIGIVAGWGAVLAAREIEA
VDGIEALCKLEPALQRLHAARPTAVNLAWVLARMRRTLSAAHADWRQVMECEAESIAREDLTANRCMGAYGAALIPIGSG
VLTHCNTGSLATAGFGTALGVIRDGIAQGRIARVFVGETRPWLQGARLTVWELQQDGIDATLIADSAAAHLMKSGQVQWV
IVGADRICANGDTANKIGTYQLAITARHHGVKFMVVASAATVDMDTVAGEAIEIEQRDPEELLGVSGVRTVAEGIAAWNP
VFDVTPGALIDAIVTERGVIQSPDAAQMRATFGN

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=342, Percent_Identity=45.6140350877193, Blast_Score=233, Evalue=1e-61,
Organism=Homo sapiens, GI23943880, Length=338, Percent_Identity=39.0532544378698, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI78000158, Length=270, Percent_Identity=25.9259259259259, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI78000156, Length=270, Percent_Identity=25.9259259259259, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI187607323, Length=270, Percent_Identity=25.9259259259259, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17557462, Length=344, Percent_Identity=37.7906976744186, Blast_Score=211, Evalue=5e-55,
Organism=Saccharomyces cerevisiae, GI6325375, Length=393, Percent_Identity=37.1501272264631, Blast_Score=216, Evalue=4e-57,
Organism=Drosophila melanogaster, GI21357667, Length=351, Percent_Identity=41.8803418803419, Blast_Score=238, Evalue=7e-63,
Organism=Drosophila melanogaster, GI24651647, Length=351, Percent_Identity=41.8803418803419, Blast_Score=238, Evalue=7e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_XYLF2 (B2I9S0)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830715.1
- ProteinModelPortal:   B2I9S0
- SMR:   B2I9S0
- GeneID:   6203390
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_2043
- HOGENOM:   HBG682649
- OMA:   RPRNQGA
- ProtClustDB:   PRK05720
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 37928; Mature: 37928

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: ACT_SITE 245-245 BINDING 101-101 BINDING 204-204

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHHPLPPDDTLYDQVRPILWTGHFLKLLDQRKLPFVVEYVECHSSEDVTQAIRTLIVRGA
CCCCCCCCCCHHHHCCHHHHHHHHHHHHHCCCCCCEEHHHHHCCCCHHHHHHHHHHHCCC
PAIGIVAGWGAVLAAREIEAVDGIEALCKLEPALQRLHAARPTAVNLAWVLARMRRTLSA
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
AHADWRQVMECEAESIAREDLTANRCMGAYGAALIPIGSGVLTHCNTGSLATAGFGTALG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEECCCCCEECCCHHHHHH
VIRDGIAQGRIARVFVGETRPWLQGARLTVWELQQDGIDATLIADSAAAHLMKSGQVQWV
HHHHHHHCCCEEEEEECCCCCCCCCCEEEEEEECCCCCCEEEEEHHHHHHHHHCCCEEEE
IVGADRICANGDTANKIGTYQLAITARHHGVKFMVVASAATVDMDTVAGEAIEIEQRDPE
EEECCEEECCCCCCCCCEEEEEEEEEECCCEEEEEEECCCEECHHHHCCCEEEECCCCHH
ELLGVSGVRTVAEGIAAWNPVFDVTPGALIDAIVTERGVIQSPDAAQMRATFGN
HHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MHHPLPPDDTLYDQVRPILWTGHFLKLLDQRKLPFVVEYVECHSSEDVTQAIRTLIVRGA
CCCCCCCCCCHHHHCCHHHHHHHHHHHHHCCCCCCEEHHHHHCCCCHHHHHHHHHHHCCC
PAIGIVAGWGAVLAAREIEAVDGIEALCKLEPALQRLHAARPTAVNLAWVLARMRRTLSA
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
AHADWRQVMECEAESIAREDLTANRCMGAYGAALIPIGSGVLTHCNTGSLATAGFGTALG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEECCCCCEECCCHHHHHH
VIRDGIAQGRIARVFVGETRPWLQGARLTVWELQQDGIDATLIADSAAAHLMKSGQVQWV
HHHHHHHCCCEEEEEECCCCCCCCCCEEEEEEECCCCCCEEEEEHHHHHHHHHCCCEEEE
IVGADRICANGDTANKIGTYQLAITARHHGVKFMVVASAATVDMDTVAGEAIEIEQRDPE
EEECCEEECCCCCCCCCEEEEEEEEEECCCEEEEEEECCCEECHHHHCCCEEEECCCCHH
ELLGVSGVRTVAEGIAAWNPVFDVTPGALIDAIVTERGVIQSPDAAQMRATFGN
HHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA