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The map label for this gene is xseA

Identifier: 182682519

GI number: 182682519

Start: 2245824

End: 2247158

Strand: Direct

Name: xseA

Synonym: XfasM23_2006

Alternate gene names: 182682519

Gene position: 2245824-2247158 (Clockwise)

Preceding gene: 182682513

Following gene: 182682522

Centisome position: 88.57

GC content: 59.33

Gene sequence:

>1335_bases
ATGCAGCACCGCGACGAGATCCTGACACCCAGCCAGCTCAATACTCTCGCCCGCGATCTGCTTGAAAGCGCGTTTCCGCT
GGTGTGGATTGAGGGCGAACTCGGCAATGTCAGCCGCCCGTCTTCAGGCCATCTGTATGTCACGCTGAAGGACGCGCAGG
CGCAGGTACGCTGTGCGATGTTTAAACCCAAGAGCCAGTGGCTCACGTTTCAGCCGCGCGAAGGTTTGCGGGTGCTCGCA
CGGGGGCGGCTGACGTTGTATGAAGCGCGCGGTGATTACCAAATCGTCCTGGACCATCTCGAAGAGTCCGGTGAAGGGGC
GCTGCGTCGGGCCTTTGAACAACTACGTATCCGGCTCGAAGCCGAAGGCCTGTTCGATCCTGCACGCAAACAGCCTCTAC
CTGTCCATCCCCGCCGCATCGCAGTGATTACCTCGCCCAGCGGCGCTGTAATACGTGACATTCTCAGCGTGCTGATGCGG
CGCTTTCCACTGGTCGAAATCGAATTACTGCCCTCGTTGGTGCAGGGTGATACAGCGGCGGCACAAATCACCCATTTGCT
GGGCGGCGCAGACAGCAGCGGCCGTTACGACGCCATTCTGATCGCGCGCGGCGGCGGGTCACTTGAGGACCTTTGGGCAT
TTAATAACGAGCAGCTGGCACGTACAATCGCTGCCGCACACACGCCGGTGATCTCGGCGATTGGTCATGAAACTGATTTC
ACTCTTGCGGATTTTGCCGCAGATATCCGAGCACCCACTCCATCTGTTGCGGCTGAATTGCTGGTCCCCGACCAACGCGC
ACTGCGCCAGCACTTAGGCCAGTTGCAGCAGCGCTTGCTGCATTTGCAGCAACACCGTCTGGACCAAGCCATCCAACGGG
CCGACCAACTGGGGCTGCGCTTGCAGGCACGCAATCCTGAGATGCACTTGCGTCTGTTGGCGCAACGCCAAGCCGAAGCT
GGACGCCGCCTTCAACAATGCCTGCATCACGTGCTTGACCGCGCCCAAGGGCAACTACGCAATCACCACACCCGACTGTA
TGCACTCAACCCAAGACAGCAGATTGCGGGATTGCAAAAGCACCTAAAGCATTTAAATCCACAGCAACCGCTACAGCGAC
GTCTGCAACAAGAGCAACTGCGTCTGCATGGGCTGGTACGTGCTTTGGAGGCGGTCAACCCTTTGGCCACGGTGGCGCGC
GGCTATGCGCTGGTACGTCGCGCCGACAACAATACGTTGGTACGCGACAGCGCTCAGGTCTGTGTGGGCGATGTTCTAGA
CACCAAGCTGGCACATGGCCAGCTCCGGGTCAGGGTCGAAATCAGCAGCACATGA

Upstream 100 bases:

>100_bases
GGTCCGTGATTTGCATCACCGAGGGGAGCGATATACCGTGCGTCGGCTCTGGAGACAGAAGTACACTGCATCCTGCCTGA
CCAAGTCATCACATGCACAG

Downstream 100 bases:

>100_bases
ACTAAAAACATCGCAATCGGTTATGGTGCGCAGCAGCTACTCACGGCTGCGAACGGCTGGTGCCCTCAACGATGGCTGCT
CCCCCCGTTGCGTGGTTCCC

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MQHRDEILTPSQLNTLARDLLESAFPLVWIEGELGNVSRPSSGHLYVTLKDAQAQVRCAMFKPKSQWLTFQPREGLRVLA
RGRLTLYEARGDYQIVLDHLEESGEGALRRAFEQLRIRLEAEGLFDPARKQPLPVHPRRIAVITSPSGAVIRDILSVLMR
RFPLVEIELLPSLVQGDTAAAQITHLLGGADSSGRYDAILIARGGGSLEDLWAFNNEQLARTIAAAHTPVISAIGHETDF
TLADFAADIRAPTPSVAAELLVPDQRALRQHLGQLQQRLLHLQQHRLDQAIQRADQLGLRLQARNPEMHLRLLAQRQAEA
GRRLQQCLHHVLDRAQGQLRNHHTRLYALNPRQQIAGLQKHLKHLNPQQPLQRRLQQEQLRLHGLVRALEAVNPLATVAR
GYALVRRADNNTLVRDSAQVCVGDVLDTKLAHGQLRVRVEISST

Sequences:

>Translated_444_residues
MQHRDEILTPSQLNTLARDLLESAFPLVWIEGELGNVSRPSSGHLYVTLKDAQAQVRCAMFKPKSQWLTFQPREGLRVLA
RGRLTLYEARGDYQIVLDHLEESGEGALRRAFEQLRIRLEAEGLFDPARKQPLPVHPRRIAVITSPSGAVIRDILSVLMR
RFPLVEIELLPSLVQGDTAAAQITHLLGGADSSGRYDAILIARGGGSLEDLWAFNNEQLARTIAAAHTPVISAIGHETDF
TLADFAADIRAPTPSVAAELLVPDQRALRQHLGQLQQRLLHLQQHRLDQAIQRADQLGLRLQARNPEMHLRLLAQRQAEA
GRRLQQCLHHVLDRAQGQLRNHHTRLYALNPRQQIAGLQKHLKHLNPQQPLQRRLQQEQLRLHGLVRALEAVNPLATVAR
GYALVRRADNNTLVRDSAQVCVGDVLDTKLAHGQLRVRVEISST
>Mature_444_residues
MQHRDEILTPSQLNTLARDLLESAFPLVWIEGELGNVSRPSSGHLYVTLKDAQAQVRCAMFKPKSQWLTFQPREGLRVLA
RGRLTLYEARGDYQIVLDHLEESGEGALRRAFEQLRIRLEAEGLFDPARKQPLPVHPRRIAVITSPSGAVIRDILSVLMR
RFPLVEIELLPSLVQGDTAAAQITHLLGGADSSGRYDAILIARGGGSLEDLWAFNNEQLARTIAAAHTPVISAIGHETDF
TLADFAADIRAPTPSVAAELLVPDQRALRQHLGQLQQRLLHLQQHRLDQAIQRADQLGLRLQARNPEMHLRLLAQRQAEA
GRRLQQCLHHVLDRAQGQLRNHHTRLYALNPRQQIAGLQKHLKHLNPQQPLQRRLQQEQLRLHGLVRALEAVNPLATVAR
GYALVRRADNNTLVRDSAQVCVGDVLDTKLAHGQLRVRVEISST

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=440, Percent_Identity=42.2727272727273, Blast_Score=324, Evalue=8e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_XYLF2 (B2I9F0)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830679.1
- GeneID:   6203360
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_2006
- HOGENOM:   HBG634411
- OMA:   EISNFTR
- ProtClustDB:   PRK00286
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 49783; Mature: 49783

Theoretical pI: Translated: 10.36; Mature: 10.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHRDEILTPSQLNTLARDLLESAFPLVWIEGELGNVSRPSSGHLYVTLKDAQAQVRCAM
CCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCEEHEE
FKPKSQWLTFQPREGLRVLARGRLTLYEARGDYQIVLDHLEESGEGALRRAFEQLRIRLE
ECCCCCCEEECCCHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHEEEE
AEGLFDPARKQPLPVHPRRIAVITSPSGAVIRDILSVLMRRFPLVEIELLPSLVQGDTAA
ECCCCCCHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEHHHHHHHCCCHHH
AQITHLLGGADSSGRYDAILIARGGGSLEDLWAFNNEQLARTIAAAHTPVISAIGHETDF
HHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCC
TLADFAADIRAPTPSVAAELLVPDQRALRQHLGQLQQRLLHLQQHRLDQAIQRADQLGLR
HHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
LQARNPEMHLRLLAQRQAEAGRRLQQCLHHVLDRAQGQLRNHHTRLYALNPRQQIAGLQK
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHH
HLKHLNPQQPLQRRLQQEQLRLHGLVRALEAVNPLATVARGYALVRRADNNTLVRDSAQV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHEEECCCCCEEECCHHH
CVGDVLDTKLAHGQLRVRVEISST
HHHHHHHHHHCCCEEEEEEEECCC
>Mature Secondary Structure
MQHRDEILTPSQLNTLARDLLESAFPLVWIEGELGNVSRPSSGHLYVTLKDAQAQVRCAM
CCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCEEHEE
FKPKSQWLTFQPREGLRVLARGRLTLYEARGDYQIVLDHLEESGEGALRRAFEQLRIRLE
ECCCCCCEEECCCHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHEEEE
AEGLFDPARKQPLPVHPRRIAVITSPSGAVIRDILSVLMRRFPLVEIELLPSLVQGDTAA
ECCCCCCHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEHHHHHHHCCCHHH
AQITHLLGGADSSGRYDAILIARGGGSLEDLWAFNNEQLARTIAAAHTPVISAIGHETDF
HHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCC
TLADFAADIRAPTPSVAAELLVPDQRALRQHLGQLQQRLLHLQQHRLDQAIQRADQLGLR
HHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
LQARNPEMHLRLLAQRQAEAGRRLQQCLHHVLDRAQGQLRNHHTRLYALNPRQQIAGLQK
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHH
HLKHLNPQQPLQRRLQQEQLRLHGLVRALEAVNPLATVARGYALVRRADNNTLVRDSAQV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHEEECCCCCEEECCHHH
CVGDVLDTKLAHGQLRVRVEISST
HHHHHHHHHHCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA