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The map label for this gene is murC

Identifier: 182682481

GI number: 182682481

Start: 2207487

End: 2208920

Strand: Reverse

Name: murC

Synonym: XfasM23_1968

Alternate gene names: 182682481

Gene position: 2208920-2207487 (Counterclockwise)

Preceding gene: 182682482

Following gene: 182682480

Centisome position: 87.11

GC content: 53.35

Gene sequence:

>1434_bases
GTGATTCGTCGTCTTCAAGACAATGGCGATTTGATCCGTGCTTTCCCACGTGTGCATTTTGTGGGTATTGGTGGTGCTGG
GATGACGGGTATTGCTGAGGTGATGTTGACGTTGGGTTACGAGGTATCCGGTTCTGATAATGCCGATAATGCCGCGACTC
GACGTTTAGCGACACTGGGTGCACGGGTGATGCGTGGTCATTCAGCAGCTAATGTGCTTGGTACAGATTGTGTGGTGGTA
TCAAGTGCGATTCGCGAAGATAACCCGGAGTTGATGGAGGCGCGTAGTCAGCGTATTCCAATTATGCCGCGTGCGGCGAT
GTTGGCTGAGTTGATGCGTTTTCGCCACGGTATTGCTGTTGCCGGTACACACGGTAAGACAACGACGACGAGTTTGATTG
CGGCAGTGCTCAGTGAGGGAGGGTTAGATCCGACGTTTGTCATTGGTGGTCAGTTGCTTGCTGCTGGTGCTAACGCCAAG
CTCGGCGCTGGTCAATGGTTGGTGGTCGAGGCGGATGAAAGCGATGGCAGTTTTCTGCGTTTGAATCCGCTTGTGGCGGT
GGTTACCAATATTGATGCTGATCATTTGGAAAATTATGGGAATGATTTTTCCAGGATAAAAGATGCGTTTACGGAGTTTT
TGCAGCGTCTGCCGTTTTATGGGTTGGCATTGTTGTGCCTTGATGATCCAGAGGTGGCCGAGTTGGTGGGCAAGGCGAGA
CGTCATGTGATGACTTATGGGATTGATGCTGCTGCTGATGTGCGTGCCGAAGATGTGGTTCAAGATGGTGCACGGATGTG
TTTCACGCTGTGTCTTCCTGAGGGCAAGGTTATTCCGGTGACGCTGGCGTTGCCGGGGCGTCATAACGTACTCAATGCGT
TGGCTGCTTCTGCGGTCGGGTGGCAGTTGGGTGTGCCGCCAGAGGTGATTGGGCGTGCATTGAAGAGTTTTGTTGGTATC
GGGCGTCGCTTCAATGATTTGGGGGATGTCGCTATTGGAAATGGTGCATGTGTTCGTTTGATTGATGATTACGGGCATCA
TCCGCGTGAGTTAGAGGCGGTGTTTGCAGCTGCGCGAGGGGGGTGGCCGGATAAGCGGTTGGTGGTTGCGTTTCAGCCGC
ATCGTTACAGTCGTACTCGCGATCAGTTTGATGCGTTTGCTGCGGTGTTGAGCAGTGTTGATGCGCTGGTATTGAGTGAG
GTTTATCCGGCTGGTGAAGTGCCGATCCCGGGGGCTGATGCTAAGGCGCTGGCGCGTGCGATCCGCGCGCGGGGACGCAG
TGAGCCTGTCGTGGTGGGTCAAGTGGCTAGTTTGATTGATGTGTTGCCGGATGTGTTACAGGAGGGGGATTTGCTGTTGA
TGATGGGTGCTGGCGATATTGGTTCCATCGCGCAGCGGATTGTTCATGATGGTTTTGTCTTTGGAGAGGTTTAA

Upstream 100 bases:

>100_bases
GCTGCCGAGTGTATTGCTGAAATTATTCTTAAGGAATCGATATGAGGCGTGGAGTCGTTTCCAAAATGGTTGGGTGTCGT
GCTCAAAGTGAGTGCTGTTT

Downstream 100 bases:

>100_bases
ATATGGGTATGAGCATATTTTCACTGTCTCCACGGTATACGGATCCGGCGGTGTTTGGTCGTGTTGCAGTGTTATTAGGG
GGGACGTCTGCTGAGCGTGA

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MIRRLQDNGDLIRAFPRVHFVGIGGAGMTGIAEVMLTLGYEVSGSDNADNAATRRLATLGARVMRGHSAANVLGTDCVVV
SSAIREDNPELMEARSQRIPIMPRAAMLAELMRFRHGIAVAGTHGKTTTTSLIAAVLSEGGLDPTFVIGGQLLAAGANAK
LGAGQWLVVEADESDGSFLRLNPLVAVVTNIDADHLENYGNDFSRIKDAFTEFLQRLPFYGLALLCLDDPEVAELVGKAR
RHVMTYGIDAAADVRAEDVVQDGARMCFTLCLPEGKVIPVTLALPGRHNVLNALAASAVGWQLGVPPEVIGRALKSFVGI
GRRFNDLGDVAIGNGACVRLIDDYGHHPRELEAVFAAARGGWPDKRLVVAFQPHRYSRTRDQFDAFAAVLSSVDALVLSE
VYPAGEVPIPGADAKALARAIRARGRSEPVVVGQVASLIDVLPDVLQEGDLLLMMGAGDIGSIAQRIVHDGFVFGEV

Sequences:

>Translated_477_residues
MIRRLQDNGDLIRAFPRVHFVGIGGAGMTGIAEVMLTLGYEVSGSDNADNAATRRLATLGARVMRGHSAANVLGTDCVVV
SSAIREDNPELMEARSQRIPIMPRAAMLAELMRFRHGIAVAGTHGKTTTTSLIAAVLSEGGLDPTFVIGGQLLAAGANAK
LGAGQWLVVEADESDGSFLRLNPLVAVVTNIDADHLENYGNDFSRIKDAFTEFLQRLPFYGLALLCLDDPEVAELVGKAR
RHVMTYGIDAAADVRAEDVVQDGARMCFTLCLPEGKVIPVTLALPGRHNVLNALAASAVGWQLGVPPEVIGRALKSFVGI
GRRFNDLGDVAIGNGACVRLIDDYGHHPRELEAVFAAARGGWPDKRLVVAFQPHRYSRTRDQFDAFAAVLSSVDALVLSE
VYPAGEVPIPGADAKALARAIRARGRSEPVVVGQVASLIDVLPDVLQEGDLLLMMGAGDIGSIAQRIVHDGFVFGEV
>Mature_477_residues
MIRRLQDNGDLIRAFPRVHFVGIGGAGMTGIAEVMLTLGYEVSGSDNADNAATRRLATLGARVMRGHSAANVLGTDCVVV
SSAIREDNPELMEARSQRIPIMPRAAMLAELMRFRHGIAVAGTHGKTTTTSLIAAVLSEGGLDPTFVIGGQLLAAGANAK
LGAGQWLVVEADESDGSFLRLNPLVAVVTNIDADHLENYGNDFSRIKDAFTEFLQRLPFYGLALLCLDDPEVAELVGKAR
RHVMTYGIDAAADVRAEDVVQDGARMCFTLCLPEGKVIPVTLALPGRHNVLNALAASAVGWQLGVPPEVIGRALKSFVGI
GRRFNDLGDVAIGNGACVRLIDDYGHHPRELEAVFAAARGGWPDKRLVVAFQPHRYSRTRDQFDAFAAVLSSVDALVLSE
VYPAGEVPIPGADAKALARAIRARGRSEPVVVGQVASLIDVLPDVLQEGDLLLMMGAGDIGSIAQRIVHDGFVFGEV

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=460, Percent_Identity=53.695652173913, Blast_Score=444, Evalue=1e-126,
Organism=Escherichia coli, GI1790680, Length=478, Percent_Identity=28.6610878661088, Blast_Score=148, Evalue=9e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_XYLF2 (B2I9B2)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830641.1
- ProteinModelPortal:   B2I9B2
- SMR:   B2I9B2
- GeneID:   6203322
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_1968
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 50736; Mature: 50736

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRRLQDNGDLIRAFPRVHFVGIGGAGMTGIAEVMLTLGYEVSGSDNADNAATRRLATLG
CCCCCCCCCCHHEECCCEEEEEECCCCHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHH
ARVMRGHSAANVLGTDCVVVSSAIREDNPELMEARSQRIPIMPRAAMLAELMRFRHGIAV
HHHHCCCCHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEE
AGTHGKTTTTSLIAAVLSEGGLDPTFVIGGQLLAAGANAKLGAGQWLVVEADESDGSFLR
EECCCCHHHHHHHHHHHHCCCCCCEEEECCCCEECCCCCCCCCCCEEEEEECCCCCCEEE
LNPLVAVVTNIDADHLENYGNDFSRIKDAFTEFLQRLPFYGLALLCLDDPEVAELVGKAR
ECCCEEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHCCHHCEEEEEECCHHHHHHHHHHH
RHVMTYGIDAAADVRAEDVVQDGARMCFTLCLPEGKVIPVTLALPGRHNVLNALAASAVG
HHHHHCCCCCHHCCCHHHHHHHHHHEEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHCC
WQLGVPPEVIGRALKSFVGIGRRFNDLGDVAIGNGACVRLIDDYGHHPRELEAVFAAARG
CCCCCCHHHHHHHHHHHHHHCHHHHCCCCEEECCCCEEEEEHHCCCCHHHHHHHHHHHCC
GWPDKRLVVAFQPHRYSRTRDQFDAFAAVLSSVDALVLSEVYPAGEVPIPGADAKALARA
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
IRARGRSEPVVVGQVASLIDVLPDVLQEGDLLLMMGAGDIGSIAQRIVHDGFVFGEV
HHHCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCEEECCC
>Mature Secondary Structure
MIRRLQDNGDLIRAFPRVHFVGIGGAGMTGIAEVMLTLGYEVSGSDNADNAATRRLATLG
CCCCCCCCCCHHEECCCEEEEEECCCCHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHH
ARVMRGHSAANVLGTDCVVVSSAIREDNPELMEARSQRIPIMPRAAMLAELMRFRHGIAV
HHHHCCCCHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEE
AGTHGKTTTTSLIAAVLSEGGLDPTFVIGGQLLAAGANAKLGAGQWLVVEADESDGSFLR
EECCCCHHHHHHHHHHHHCCCCCCEEEECCCCEECCCCCCCCCCCEEEEEECCCCCCEEE
LNPLVAVVTNIDADHLENYGNDFSRIKDAFTEFLQRLPFYGLALLCLDDPEVAELVGKAR
ECCCEEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHCCHHCEEEEEECCHHHHHHHHHHH
RHVMTYGIDAAADVRAEDVVQDGARMCFTLCLPEGKVIPVTLALPGRHNVLNALAASAVG
HHHHHCCCCCHHCCCHHHHHHHHHHEEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHCC
WQLGVPPEVIGRALKSFVGIGRRFNDLGDVAIGNGACVRLIDDYGHHPRELEAVFAAARG
CCCCCCHHHHHHHHHHHHHHCHHHHCCCCEEECCCCEEEEEHHCCCCHHHHHHHHHHHCC
GWPDKRLVVAFQPHRYSRTRDQFDAFAAVLSSVDALVLSEVYPAGEVPIPGADAKALARA
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
IRARGRSEPVVVGQVASLIDVLPDVLQEGDLLLMMGAGDIGSIAQRIVHDGFVFGEV
HHHCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA