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The map label for this gene is lpd [H]

Identifier: 182682425

GI number: 182682425

Start: 2128479

End: 2130290

Strand: Direct

Name: lpd [H]

Synonym: XfasM23_1911

Alternate gene names: 182682425

Gene position: 2128479-2130290 (Clockwise)

Preceding gene: 182682424

Following gene: 182682430

Centisome position: 83.94

GC content: 55.57

Gene sequence:

>1812_bases
ATGACGGTGATTGAAATCAAAGTTCCCGATATCGGCGATTACAGCAAGGTCCCAGTCATCGAAGTGCTGGTTACCGTTGG
CGACCACTTGGTCAAAAACCAAGGGATCCTCACACTAGAATCAGACAAAGCCACCTTGGAAGTGCCATCGATGAATAATG
GCATTGTCAAAGAACTGAAAGTCAACGTCGGCGATTTGCTTTCACAAGGCGACGTGATCCTCCTGCTGGAGACCGAAGAC
ACCACCGCCCCCCCCTCACCAAGCAACGCGGCGACATCCGACACCACCTCACCGCCCCCGCCATCCCCCCAACCAGCCGC
TTCCAAGCCGACAGCACCCGATCAACAACACTCCGACATCAAGTGCCGCATGGTCGTACTCGGTGCCGGTCCCGGCGGCT
ACACCGCAGCATTCCGCGCCGCTGACCTCGGCTTGGATACAGTGCTCGTTGAACGCTATCCCAACCTAGGTGGCGTCTGC
CTCAATGTCGGCTGCATTCCTTCCAAAGCATTACTGCACGCAGCCGCCGTCATCGACGAAGCTGCACATGCCAGCACCTT
TGGAATTGATTTTGGCAAACCCAAAATCACCCTAGACACACTGCGCGAATACAAACAAAACGTAGTCAACAAACTGACTG
CCGGCTTGGCCGGGATGGCCAAACAACGCAAGGTACGCACCGTCACCGGCATCGCGCACTTCGTCTCTCCCAACACACTG
GACATTACCGCTGCTGACGGCAGCACCCAACGACTCCATTTCCAACAATGCATCATTGCTACCGGCTCACACCCAGTGAA
GCTACCAAACTTCCCTTGGGACGACCCGCGCATCATGGACTCCACTGACGCACTGGAACTGGCCGAAGTGCCAAAAAAAC
TGCTTGTCGTTGGTGGCGGCATCATCGGCCTAGAAATGGCTACCGTGTACAACGCCCTGGGCAGCCACGTCACCATTGTC
GAATTCATGGACCAGATCATCCCCGGCACCGACAAAGATCTAGTGAAGCCACTGGCGGACCGCATGAAAAAACAGGGCAT
TGAAATACACCTGAACACCAAAGCAAGCCACGTCAAAGCCGACAAAAAAGGCATCACCGTCTCATTCGAAGCACCCACCC
AAGGCACACAACCCGCATTAAAAACATCGACCTATGATCGCGTCCTTGTTGCCGTCGGCCGTACACCGACAGGCAACAAC
ATCGGCGCTGAAAAAGCAGGCGTCAACGTCACCGAACGCGGCTTCATCCCGGTTGATCGCCAAATGCGCAGCAACGTACC
CCATATCTTTGCCATTGGAGACATTGTTGGTAACCCAATGCTGGCGCACAAAGCCACACATGAAGGCAAACTGGCCGCCG
AAGTCGCCGCTGCTGAAACAGAATCAGGCAAACATCGGGAATGGGTTGCCCGCGTGATCCCATCCGTGGCCTACACCAAC
CCGGAAATTGCCTGGATCGGTATCACTGAAACCGAAGCCAAAGCGAAAGGACTCAACATCGGCGTCGCCAAATTCCCCTG
GGTTGCCAGCGGTCGCGCCATAGGCATCGGACGCACTGAAGGCTTCACTAAACTCATCTTCGACGAAGACACACACCGCA
TCATTGGCGGAGCGATCGTCGGCGTCCACGCAGGCGACCTCTTGGCTGAAATCGGACTCGCCATCGAAATGGGTGCCGAA
GCCGAAGACATCAGCCACACAATCCACGCACACCCCACACTGAGCGAATCGATTGCCATGAGCGCCGAAGTCTACGACGG
CACCATCACCGACTTGTATCTCCCCAAAAAATCCGCTACTTCAGCAAAGTAA

Upstream 100 bases:

>100_bases
CTTCACCACTTATCTCAGCCAGATACTCGCCGACATGCGGCGCGTACTGCTGTGACAAAGACGCTGACCAACACAAACCA
CCGAGCGACAGGAGACACCT

Downstream 100 bases:

>100_bases
AGCAACATAGCCAACTAGCCTATCGACATTCAGACAACACCATCCAGTGTAGCCAGCGCTGAACTGGATGCTACGGTCAC
CGTACAACATAGGAAATGCA

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of 2-oxoglutarate dehydrogenase complex [H]

Number of amino acids: Translated: 603; Mature: 602

Protein sequence:

>603_residues
MTVIEIKVPDIGDYSKVPVIEVLVTVGDHLVKNQGILTLESDKATLEVPSMNNGIVKELKVNVGDLLSQGDVILLLETED
TTAPPSPSNAATSDTTSPPPPSPQPAASKPTAPDQQHSDIKCRMVVLGAGPGGYTAAFRAADLGLDTVLVERYPNLGGVC
LNVGCIPSKALLHAAAVIDEAAHASTFGIDFGKPKITLDTLREYKQNVVNKLTAGLAGMAKQRKVRTVTGIAHFVSPNTL
DITAADGSTQRLHFQQCIIATGSHPVKLPNFPWDDPRIMDSTDALELAEVPKKLLVVGGGIIGLEMATVYNALGSHVTIV
EFMDQIIPGTDKDLVKPLADRMKKQGIEIHLNTKASHVKADKKGITVSFEAPTQGTQPALKTSTYDRVLVAVGRTPTGNN
IGAEKAGVNVTERGFIPVDRQMRSNVPHIFAIGDIVGNPMLAHKATHEGKLAAEVAAAETESGKHREWVARVIPSVAYTN
PEIAWIGITETEAKAKGLNIGVAKFPWVASGRAIGIGRTEGFTKLIFDEDTHRIIGGAIVGVHAGDLLAEIGLAIEMGAE
AEDISHTIHAHPTLSESIAMSAEVYDGTITDLYLPKKSATSAK

Sequences:

>Translated_603_residues
MTVIEIKVPDIGDYSKVPVIEVLVTVGDHLVKNQGILTLESDKATLEVPSMNNGIVKELKVNVGDLLSQGDVILLLETED
TTAPPSPSNAATSDTTSPPPPSPQPAASKPTAPDQQHSDIKCRMVVLGAGPGGYTAAFRAADLGLDTVLVERYPNLGGVC
LNVGCIPSKALLHAAAVIDEAAHASTFGIDFGKPKITLDTLREYKQNVVNKLTAGLAGMAKQRKVRTVTGIAHFVSPNTL
DITAADGSTQRLHFQQCIIATGSHPVKLPNFPWDDPRIMDSTDALELAEVPKKLLVVGGGIIGLEMATVYNALGSHVTIV
EFMDQIIPGTDKDLVKPLADRMKKQGIEIHLNTKASHVKADKKGITVSFEAPTQGTQPALKTSTYDRVLVAVGRTPTGNN
IGAEKAGVNVTERGFIPVDRQMRSNVPHIFAIGDIVGNPMLAHKATHEGKLAAEVAAAETESGKHREWVARVIPSVAYTN
PEIAWIGITETEAKAKGLNIGVAKFPWVASGRAIGIGRTEGFTKLIFDEDTHRIIGGAIVGVHAGDLLAEIGLAIEMGAE
AEDISHTIHAHPTLSESIAMSAEVYDGTITDLYLPKKSATSAK
>Mature_602_residues
TVIEIKVPDIGDYSKVPVIEVLVTVGDHLVKNQGILTLESDKATLEVPSMNNGIVKELKVNVGDLLSQGDVILLLETEDT
TAPPSPSNAATSDTTSPPPPSPQPAASKPTAPDQQHSDIKCRMVVLGAGPGGYTAAFRAADLGLDTVLVERYPNLGGVCL
NVGCIPSKALLHAAAVIDEAAHASTFGIDFGKPKITLDTLREYKQNVVNKLTAGLAGMAKQRKVRTVTGIAHFVSPNTLD
ITAADGSTQRLHFQQCIIATGSHPVKLPNFPWDDPRIMDSTDALELAEVPKKLLVVGGGIIGLEMATVYNALGSHVTIVE
FMDQIIPGTDKDLVKPLADRMKKQGIEIHLNTKASHVKADKKGITVSFEAPTQGTQPALKTSTYDRVLVAVGRTPTGNNI
GAEKAGVNVTERGFIPVDRQMRSNVPHIFAIGDIVGNPMLAHKATHEGKLAAEVAAAETESGKHREWVARVIPSVAYTNP
EIAWIGITETEAKAKGLNIGVAKFPWVASGRAIGIGRTEGFTKLIFDEDTHRIIGGAIVGVHAGDLLAEIGLAIEMGAEA
EDISHTIHAHPTLSESIAMSAEVYDGTITDLYLPKKSATSAK

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransfer

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=474, Percent_Identity=40.7172995780591, Blast_Score=338, Evalue=9e-93,
Organism=Homo sapiens, GI50301238, Length=451, Percent_Identity=26.1640798226164, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI291045266, Length=437, Percent_Identity=28.8329519450801, Blast_Score=152, Evalue=9e-37,
Organism=Homo sapiens, GI148277065, Length=431, Percent_Identity=28.0742459396752, Blast_Score=147, Evalue=4e-35,
Organism=Homo sapiens, GI33519430, Length=431, Percent_Identity=28.0742459396752, Blast_Score=147, Evalue=4e-35,
Organism=Homo sapiens, GI33519428, Length=431, Percent_Identity=28.0742459396752, Blast_Score=147, Evalue=4e-35,
Organism=Homo sapiens, GI33519426, Length=431, Percent_Identity=28.0742459396752, Blast_Score=147, Evalue=4e-35,
Organism=Homo sapiens, GI148277071, Length=430, Percent_Identity=28.1395348837209, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI22035672, Length=438, Percent_Identity=29.4520547945205, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI291045268, Length=430, Percent_Identity=27.4418604651163, Blast_Score=136, Evalue=5e-32,
Organism=Escherichia coli, GI1786307, Length=479, Percent_Identity=58.8726513569937, Blast_Score=564, Evalue=1e-162,
Organism=Escherichia coli, GI87082354, Length=464, Percent_Identity=28.8793103448276, Blast_Score=196, Evalue=5e-51,
Organism=Escherichia coli, GI87081717, Length=462, Percent_Identity=28.3549783549784, Blast_Score=172, Evalue=8e-44,
Organism=Escherichia coli, GI1789915, Length=445, Percent_Identity=28.314606741573, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1786305, Length=77, Percent_Identity=50.6493506493506, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI32565766, Length=457, Percent_Identity=41.3566739606127, Blast_Score=340, Evalue=9e-94,
Organism=Caenorhabditis elegans, GI17557007, Length=488, Percent_Identity=29.7131147540984, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71982272, Length=440, Percent_Identity=24.0909090909091, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71983419, Length=450, Percent_Identity=26.4444444444444, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI71983429, Length=450, Percent_Identity=26.4444444444444, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17559934, Length=212, Percent_Identity=25.4716981132075, Blast_Score=67, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321091, Length=477, Percent_Identity=41.2997903563941, Blast_Score=324, Evalue=3e-89,
Organism=Saccharomyces cerevisiae, GI6325240, Length=484, Percent_Identity=28.5123966942149, Blast_Score=181, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6325166, Length=455, Percent_Identity=28.1318681318681, Blast_Score=164, Evalue=3e-41,
Organism=Drosophila melanogaster, GI21358499, Length=459, Percent_Identity=41.6122004357298, Blast_Score=343, Evalue=2e-94,
Organism=Drosophila melanogaster, GI24640551, Length=515, Percent_Identity=26.7961165048544, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24640549, Length=489, Percent_Identity=27.8118609406953, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24640553, Length=493, Percent_Identity=26.9776876267748, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17737741, Length=475, Percent_Identity=27.1578947368421, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 63881; Mature: 63750

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00076 PYRIDINE_REDOX_1 ; PS50968 BIOTINYL_LIPOYL ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVIEIKVPDIGDYSKVPVIEVLVTVGDHLVKNQGILTLESDKATLEVPSMNNGIVKELK
CEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCHHHHH
VNVGDLLSQGDVILLLETEDTTAPPSPSNAATSDTTSPPPPSPQPAASKPTAPDQQHSDI
CCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
KCRMVVLGAGPGGYTAAFRAADLGLDTVLVERYPNLGGVCLNVGCIPSKALLHAAAVIDE
EEEEEEEECCCCCCHHHHHHHHCCHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHH
AAHASTFGIDFGKPKITLDTLREYKQNVVNKLTAGLAGMAKQRKVRTVTGIAHFVSPNTL
HHCCEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
DITAADGSTQRLHFQQCIIATGSHPVKLPNFPWDDPRIMDSTDALELAEVPKKLLVVGGG
EEEECCCCCCEEEEEEHEEECCCCCEECCCCCCCCCCEECCCCCHHHHHCCCEEEEECCC
IIGLEMATVYNALGSHVTIVEFMDQIIPGTDKDLVKPLADRMKKQGIEIHLNTKASHVKA
CHHHHHHHHHHHHCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCCHHHEEC
DKKGITVSFEAPTQGTQPALKTSTYDRVLVAVGRTPTGNNIGAEKAGVNVTERGFIPVDR
CCCCEEEEEECCCCCCCCCHHCCCCCEEEEEECCCCCCCCCCCHHCCCCEECCCCCCCCH
QMRSNVPHIFAIGDIVGNPMLAHKATHEGKLAAEVAAAETESGKHREWVARVIPSVAYTN
HHHCCCCEEEEEHHHHCCCHHEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
PEIAWIGITETEAKAKGLNIGVAKFPWVASGRAIGIGRTEGFTKLIFDEDTHRIIGGAIV
CCEEEEEEECCCHHHCCCEECCEECCEEECCCEEEECCCCCCEEEEECCCCCEEECEEEE
GVHAGDLLAEIGLAIEMGAEAEDISHTIHAHPTLSESIAMSAEVYDGTITDLYLPKKSAT
EEEHHHHHHHHCCEEECCCCHHHHCEEEECCCCCHHHHEEEEEECCCCEEEEEECCCCCC
SAK
CCC
>Mature Secondary Structure 
TVIEIKVPDIGDYSKVPVIEVLVTVGDHLVKNQGILTLESDKATLEVPSMNNGIVKELK
EEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCHHHHH
VNVGDLLSQGDVILLLETEDTTAPPSPSNAATSDTTSPPPPSPQPAASKPTAPDQQHSDI
CCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
KCRMVVLGAGPGGYTAAFRAADLGLDTVLVERYPNLGGVCLNVGCIPSKALLHAAAVIDE
EEEEEEEECCCCCCHHHHHHHHCCHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHH
AAHASTFGIDFGKPKITLDTLREYKQNVVNKLTAGLAGMAKQRKVRTVTGIAHFVSPNTL
HHCCEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
DITAADGSTQRLHFQQCIIATGSHPVKLPNFPWDDPRIMDSTDALELAEVPKKLLVVGGG
EEEECCCCCCEEEEEEHEEECCCCCEECCCCCCCCCCEECCCCCHHHHHCCCEEEEECCC
IIGLEMATVYNALGSHVTIVEFMDQIIPGTDKDLVKPLADRMKKQGIEIHLNTKASHVKA
CHHHHHHHHHHHHCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCCHHHEEC
DKKGITVSFEAPTQGTQPALKTSTYDRVLVAVGRTPTGNNIGAEKAGVNVTERGFIPVDR
CCCCEEEEEECCCCCCCCCHHCCCCCEEEEEECCCCCCCCCCCHHCCCCEECCCCCCCCH
QMRSNVPHIFAIGDIVGNPMLAHKATHEGKLAAEVAAAETESGKHREWVARVIPSVAYTN
HHHCCCCEEEEEHHHHCCCHHEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
PEIAWIGITETEAKAKGLNIGVAKFPWVASGRAIGIGRTEGFTKLIFDEDTHRIIGGAIV
CCEEEEEEECCCHHHCCCEECCEECCEEECCCEEEECCCCCCEEEEECCCCCEEECEEEE
GVHAGDLLAEIGLAIEMGAEAEDISHTIHAHPTLSESIAMSAEVYDGTITDLYLPKKSAT
EEEHHHHHHHHCCEEECCCCHHHHCEEEECCCCCHHHHEEEEEECCCCEEEEEECCCCCC
SAK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]