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The map label for this gene is era

Identifier: 182681908

GI number: 182681908

Start: 1523117

End: 1524013

Strand: Direct

Name: era

Synonym: XfasM23_1376

Alternate gene names: 182681908

Gene position: 1523117-1524013 (Clockwise)

Preceding gene: 182681907

Following gene: 182681909

Centisome position: 60.07

GC content: 50.95

Gene sequence:

>897_bases
GTGACTCAGACTGTCCCGTATCGTTGCGGCCGCATCGCCGTGATAGGCCGCCCCAACGTCGGCAAGTCCACACTGACCAA
TGCACTGGTCGGAACGAAAATCAGCATCGTCTCCAACCGTCCGCAAACGACCCGGCACCGGTTACTTGGCATCGCAACCT
TTCCTGAGGGCCAAATCATCCTGGTCGATACACCAGGCTTACACCGTGAACAAAAGCATCCAATGAACCGGCTCATGAAC
AGAACCGCACGCGGCTCGCTCGAAGACGTGGATGCAGCACTGTTAGTAACCGAATCCACACACTGGAATGAAGAAGACAC
CCTGGCTTACAACCTACTCAATGACACGGGTATTCCTGTCGTACTCGTCATCAACAAAATTGACCGCTTTAAAGACAAGA
GCGCATTGTTACCCTTCCTCACACACATCAATGAAAACCATACCTTCGCCACAATACATCCAGTTTCAGCACTGAAACGG
AAGGGACTGAAAACACTGGTGAGCGACCTACTCGCACTGTTGCCCGAAGGTGGCCCCATGTTCAGCGAAGACGAGATCAC
CGACCGAAGCCAGCGTTTCCTGGCCAGCGAACTCGTCCGCGAACAAGTCATGCGCCAACTGGGTAAAGAATTGCCCTACG
CAACCACCGTAGAGATCGAGTACTTCACTGAAAATACCGGATTATTTCGCATTGGTGCACTCATCTGGGTTGAACGCGAA
AGTCAAAAAGCAATCGTCATCGGCAAAGGCGGTGTCCGGCTCAAAGAGATTGGCGTTAAAGCAAGACAACAGATGGAACG
CTTATTCCAAACCAAAGTATTCCTAGAAACATGGGTACGTGTCCGTAAAGACTGGTCCAATAATGAAGCAGCACTAAAAA
CATTCGGCTACGAATAA

Upstream 100 bases:

>100_bases
TGGGTGAACTAAAACTGCGCACCGAAGGCGAAGGCAGCTCACGCCGTCTCGCCGAGCAAGACGCTGCCTCTCACGCCATC
GACCAACTGGATTCAAACAA

Downstream 100 bases:

>100_bases
CCCCATCGCAACAAACAACAGTTTGAATTGACCCAATGTGGCTCATCATTCCGTTTTACACTCCCCCGGATACCTAATCG
CATCCTGAAATCACAAAACG

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MTQTVPYRCGRIAVIGRPNVGKSTLTNALVGTKISIVSNRPQTTRHRLLGIATFPEGQIILVDTPGLHREQKHPMNRLMN
RTARGSLEDVDAALLVTESTHWNEEDTLAYNLLNDTGIPVVLVINKIDRFKDKSALLPFLTHINENHTFATIHPVSALKR
KGLKTLVSDLLALLPEGGPMFSEDEITDRSQRFLASELVREQVMRQLGKELPYATTVEIEYFTENTGLFRIGALIWVERE
SQKAIVIGKGGVRLKEIGVKARQQMERLFQTKVFLETWVRVRKDWSNNEAALKTFGYE

Sequences:

>Translated_298_residues
MTQTVPYRCGRIAVIGRPNVGKSTLTNALVGTKISIVSNRPQTTRHRLLGIATFPEGQIILVDTPGLHREQKHPMNRLMN
RTARGSLEDVDAALLVTESTHWNEEDTLAYNLLNDTGIPVVLVINKIDRFKDKSALLPFLTHINENHTFATIHPVSALKR
KGLKTLVSDLLALLPEGGPMFSEDEITDRSQRFLASELVREQVMRQLGKELPYATTVEIEYFTENTGLFRIGALIWVERE
SQKAIVIGKGGVRLKEIGVKARQQMERLFQTKVFLETWVRVRKDWSNNEAALKTFGYE
>Mature_297_residues
TQTVPYRCGRIAVIGRPNVGKSTLTNALVGTKISIVSNRPQTTRHRLLGIATFPEGQIILVDTPGLHREQKHPMNRLMNR
TARGSLEDVDAALLVTESTHWNEEDTLAYNLLNDTGIPVVLVINKIDRFKDKSALLPFLTHINENHTFATIHPVSALKRK
GLKTLVSDLLALLPEGGPMFSEDEITDRSQRFLASELVREQVMRQLGKELPYATTVEIEYFTENTGLFRIGALIWVERES
QKAIVIGKGGVRLKEIGVKARQQMERLFQTKVFLETWVRVRKDWSNNEAALKTFGYE

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain

Homologues:

Organism=Homo sapiens, GI24307899, Length=326, Percent_Identity=26.0736196319018, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1788919, Length=290, Percent_Identity=48.9655172413793, Blast_Score=287, Evalue=6e-79,
Organism=Escherichia coli, GI87082120, Length=161, Percent_Identity=27.9503105590062, Blast_Score=61, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24646434, Length=303, Percent_Identity=26.0726072607261, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ERA_XYLF2 (B2I605)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830068.1
- ProteinModelPortal:   B2I605
- SMR:   B2I605
- GeneID:   6202293
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_1376
- HOGENOM:   HBG561652
- OMA:   AKDWQRD
- ProtClustDB:   PRK00089
- GO:   GO:0005737
- HAMAP:   MF_00367
- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PRINTS:   PR00326
- TIGRFAMs:   TIGR00436
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1; SSF54814 KH_prok

EC number: NA

Molecular weight: Translated: 33686; Mature: 33555

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTVPYRCGRIAVIGRPNVGKSTLTNALVGTKISIVSNRPQTTRHRLLGIATFPEGQII
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCEEEEECCCCCHHHHHEEEEEECCCCCEE
LVDTPGLHREQKHPMNRLMNRTARGSLEDVDAALLVTESTHWNEEDTLAYNLLNDTGIPV
EEECCCCCCHHCCHHHHHHHHHCCCCHHHCCEEEEEEECCCCCCCCCEEEEEECCCCCEE
VLVINKIDRFKDKSALLPFLTHINENHTFATIHPVSALKRKGLKTLVSDLLALLPEGGPM
EEEEEHHHHHCCHHHHHHHHHHCCCCCEEEEECHHHHHHHCCHHHHHHHHHHHCCCCCCC
FSEDEITDRSQRFLASELVREQVMRQLGKELPYATTVEIEYFTENTGLFRIGALIWVERE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCEEEEEEEEEEEEC
SQKAIVIGKGGVRLKEIGVKARQQMERLFQTKVFLETWVRVRKDWSNNEAALKTFGYE
CCCEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCC
>Mature Secondary Structure 
TQTVPYRCGRIAVIGRPNVGKSTLTNALVGTKISIVSNRPQTTRHRLLGIATFPEGQII
CCCCCCCCCEEEEEECCCCCHHHHHHHHHCCEEEEECCCCCHHHHHEEEEEECCCCCEE
LVDTPGLHREQKHPMNRLMNRTARGSLEDVDAALLVTESTHWNEEDTLAYNLLNDTGIPV
EEECCCCCCHHCCHHHHHHHHHCCCCHHHCCEEEEEEECCCCCCCCCEEEEEECCCCCEE
VLVINKIDRFKDKSALLPFLTHINENHTFATIHPVSALKRKGLKTLVSDLLALLPEGGPM
EEEEEHHHHHCCHHHHHHHHHHCCCCCEEEEECHHHHHHHCCHHHHHHHHHHHCCCCCCC
FSEDEITDRSQRFLASELVREQVMRQLGKELPYATTVEIEYFTENTGLFRIGALIWVERE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCEEEEEEEEEEEEC
SQKAIVIGKGGVRLKEIGVKARQQMERLFQTKVFLETWVRVRKDWSNNEAALKTFGYE
CCCEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA