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The map label for this gene is rnc

Identifier: 182681907

GI number: 182681907

Start: 1522437

End: 1523120

Strand: Direct

Name: rnc

Synonym: XfasM23_1375

Alternate gene names: 182681907

Gene position: 1522437-1523120 (Clockwise)

Preceding gene: 182681906

Following gene: 182681908

Centisome position: 60.04

GC content: 55.12

Gene sequence:

>684_bases
GTGATATCAAGTAAGGCCAGCGATTACCAACAGCGGATCGGCTATGTGTTTACCGATCCATCTCTGCTGCTGCAAGCACT
GCGTCACCGTAGTGCCGGCACCCCGCACAATGAGCGCCTGGAGTTCCTCGGCGACAGCGTGGTTAACTTGCTGATCGCCG
AAGCGCTTTTCCAACGCTGGCCACGTGCTGACGAAGGAGCATTAACCCGTGCCCGTTCCGAACTGGTGCGTGAAACATCT
CTGGCCTCGATTGCACGCACCATGCAATTAGGGGAGCAACTCATCCTTGGACCAGGTGAACTCAAATCTGGAGGACACCG
CCGCGACTCCATCCTCGCCGATGCAGTAGAAGCAGTGATTGCAGCCATTTATCTCGACGCCGATTTAGCAACGTGCCGTA
CTGTGGTGTTACCGTGGTTTGAAACAGCACTCACCGCATTGCCTGTTGGCAAACCCGAAAAAGACCCGAAAACTCGACTC
CAAGAATGGCTACAAGCACGCCAGTGGTCATTACCCGTGTATGAATTGATCTTCGAGAGCGGCGATCCTCATACCAAGCA
CTTCCGAGTGAGTTGCACTCTGGGTGAACTAAAACTGCGCACCGAAGGCGAAGGCAGCTCACGCCGTCTCGCCGAGCAAG
ACGCTGCCTCTCACGCCATCGACCAACTGGATTCAAACAAGTGA

Upstream 100 bases:

>100_bases
GATGGCTGGAAAATGAAGGTCAACTTTGAAATCCTCCGCAAGCGGATTGGGAATATGGACCTGGTCGGCACATTCGATAG
CGAGCAGGACTTGACATCAC

Downstream 100 bases:

>100_bases
CTCAGACTGTCCCGTATCGTTGCGGCCGCATCGCCGTGATAGGCCGCCCCAACGTCGGCAAGTCCACACTGACCAATGCA
CTGGTCGGAACGAAAATCAG

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MISSKASDYQQRIGYVFTDPSLLLQALRHRSAGTPHNERLEFLGDSVVNLLIAEALFQRWPRADEGALTRARSELVRETS
LASIARTMQLGEQLILGPGELKSGGHRRDSILADAVEAVIAAIYLDADLATCRTVVLPWFETALTALPVGKPEKDPKTRL
QEWLQARQWSLPVYELIFESGDPHTKHFRVSCTLGELKLRTEGEGSSRRLAEQDAASHAIDQLDSNK

Sequences:

>Translated_227_residues
MISSKASDYQQRIGYVFTDPSLLLQALRHRSAGTPHNERLEFLGDSVVNLLIAEALFQRWPRADEGALTRARSELVRETS
LASIARTMQLGEQLILGPGELKSGGHRRDSILADAVEAVIAAIYLDADLATCRTVVLPWFETALTALPVGKPEKDPKTRL
QEWLQARQWSLPVYELIFESGDPHTKHFRVSCTLGELKLRTEGEGSSRRLAEQDAASHAIDQLDSNK
>Mature_227_residues
MISSKASDYQQRIGYVFTDPSLLLQALRHRSAGTPHNERLEFLGDSVVNLLIAEALFQRWPRADEGALTRARSELVRETS
LASIARTMQLGEQLILGPGELKSGGHRRDSILADAVEAVIAAIYLDADLATCRTVVLPWFETALTALPVGKPEKDPKTRL
QEWLQARQWSLPVYELIFESGDPHTKHFRVSCTLGELKLRTEGEGSSRRLAEQDAASHAIDQLDSNK

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=233, Percent_Identity=30.0429184549356, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI155030236, Length=233, Percent_Identity=30.0429184549356, Blast_Score=100, Evalue=9e-22,
Organism=Escherichia coli, GI1788920, Length=200, Percent_Identity=51.5, Blast_Score=215, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI193202651, Length=230, Percent_Identity=28.2608695652174, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17506883, Length=230, Percent_Identity=28.2608695652174, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17137682, Length=241, Percent_Identity=28.2157676348548, Blast_Score=85, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_XYLF2 (B2I604)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830067.1
- ProteinModelPortal:   B2I604
- SMR:   B2I604
- GeneID:   6202289
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_1375
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- ProtClustDB:   PRK00102
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 25243; Mature: 25243

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISSKASDYQQRIGYVFTDPSLLLQALRHRSAGTPHNERLEFLGDSVVNLLIAEALFQRW
CCCCCHHHHHHHCCEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
PRADEGALTRARSELVRETSLASIARTMQLGEQLILGPGELKSGGHRRDSILADAVEAVI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHH
AAIYLDADLATCRTVVLPWFETALTALPVGKPEKDPKTRLQEWLQARQWSLPVYELIFES
HHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHC
GDPHTKHFRVSCTLGELKLRTEGEGSSRRLAEQDAASHAIDQLDSNK
CCCCCEEEEEEEEECCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MISSKASDYQQRIGYVFTDPSLLLQALRHRSAGTPHNERLEFLGDSVVNLLIAEALFQRW
CCCCCHHHHHHHCCEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
PRADEGALTRARSELVRETSLASIARTMQLGEQLILGPGELKSGGHRRDSILADAVEAVI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHH
AAIYLDADLATCRTVVLPWFETALTALPVGKPEKDPKTRLQEWLQARQWSLPVYELIFES
HHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHC
GDPHTKHFRVSCTLGELKLRTEGEGSSRRLAEQDAASHAIDQLDSNK
CCCCCEEEEEEEEECCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA