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The map label for this gene is lpxD [H]

Identifier: 182681621

GI number: 182681621

Start: 1224003

End: 1224767

Strand: Direct

Name: lpxD [H]

Synonym: XfasM23_1079

Alternate gene names: 182681621

Gene position: 1224003-1224767 (Clockwise)

Preceding gene: 182681620

Following gene: 182681622

Centisome position: 48.27

GC content: 49.41

Gene sequence:

>765_bases
ATGCCCCCTATGAACAACACGTTTGAATACAAATTCTCAGATGACTTGATCGCAAAGGCGCGGCACTGGATTAATCCGGA
TGGAAGCCAAGGCGGGATTGTTTCTACTGAGGCCAATATTGCTTCCTCTGCAACGATCAGCAAAGGCGCCATTGTCTTTC
CTAATGCCGTCATCCATGAAGACGTCTTCGTTGGGCCAAGAAGCACCATTGGAGGATATTCCACCATCCAAGAAAGTTCC
TATATCGGCCCTGATTGCCACATTGGCGTACAGGCATCCATTGGTGCGCAATCATTTCTCCGCCAGGGGAACATCATTGG
GGAATACACCATCATCTTCAGCCAGGCAAATATTGGCGAAGGCTCCCAGATTGAAAGCCATTGCTACATTGGTAGTGAGT
TAAACGTTGCTGATTTCGTCATCATCAGAAAATGTGCGGACATCGGCAGCTCCGTTTCCATTGGTCGGCGCGTCACCATT
GGCGAGTATGCAACCATTAACAAGCGATGCATCATCGGTAATGAAGTCAACATTGGGCGCAGCGTCTCCATAGGGCGTTC
CGTCACCATTGATGACCAGATCACCATTGCTGCTTTGACATGCATTAGAGCGCATGTCATTGCGAGCAAGGAGATGGACA
GAAAGCTGTACGCGCATCTACTTGACGTCATCAATGACACCGCCACCAAGCGCACTGGCCATAGCAATTACAAACTTTTC
TTAACTCCTGAGAAAGCCGCGCATGTGCTGAAGGAGGCATCGTGA

Upstream 100 bases:

>100_bases
GTGATCTGTCATGCCTTGAAACAGGTGTTGTCCGACGCTTCATCCCGCACCGCCATCAAGCAGGCCGCGTGATGGAACGC
CCCATCAATATCAAAAGACA

Downstream 100 bases:

>100_bases
GCTTGACCCACATTCACCGCTGCGGTACCGTCTTCGGTAAGGAGTGTAAGAACTCCGTACATAGCGGTACCCGCATCCGA
AAACCATGCGGTTTTTTTAC

Product: UDP-3-O-(3-hydroxymyristoyl)-like protein

Products: N-Acetyl-D-glucosamine 1-phosphate; Coenzyme A; H+ [C]

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MPPMNNTFEYKFSDDLIAKARHWINPDGSQGGIVSTEANIASSATISKGAIVFPNAVIHEDVFVGPRSTIGGYSTIQESS
YIGPDCHIGVQASIGAQSFLRQGNIIGEYTIIFSQANIGEGSQIESHCYIGSELNVADFVIIRKCADIGSSVSIGRRVTI
GEYATINKRCIIGNEVNIGRSVSIGRSVTIDDQITIAALTCIRAHVIASKEMDRKLYAHLLDVINDTATKRTGHSNYKLF
LTPEKAAHVLKEAS

Sequences:

>Translated_254_residues
MPPMNNTFEYKFSDDLIAKARHWINPDGSQGGIVSTEANIASSATISKGAIVFPNAVIHEDVFVGPRSTIGGYSTIQESS
YIGPDCHIGVQASIGAQSFLRQGNIIGEYTIIFSQANIGEGSQIESHCYIGSELNVADFVIIRKCADIGSSVSIGRRVTI
GEYATINKRCIIGNEVNIGRSVSIGRSVTIDDQITIAALTCIRAHVIASKEMDRKLYAHLLDVINDTATKRTGHSNYKLF
LTPEKAAHVLKEAS
>Mature_253_residues
PPMNNTFEYKFSDDLIAKARHWINPDGSQGGIVSTEANIASSATISKGAIVFPNAVIHEDVFVGPRSTIGGYSTIQESSY
IGPDCHIGVQASIGAQSFLRQGNIIGEYTIIFSQANIGEGSQIESHCYIGSELNVADFVIIRKCADIGSSVSIGRRVTIG
EYATINKRCIIGNEVNIGRSVSIGRSVTIDDQITIAALTCIRAHVIASKEMDRKLYAHLLDVINDTATKRTGHSNYKLFL
TPEKAAHVLKEAS

Specific function: Bifunctional Enzyme Responsible For The Acetylation Of Glc-N-1-P To Give Glcnac-1-P And The Synthesis Of UDP-Glcnac. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.7.7.23; 2.3.1.157 [C]

Molecular weight: Translated: 27416; Mature: 27285

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPMNNTFEYKFSDDLIAKARHWINPDGSQGGIVSTEANIASSATISKGAIVFPNAVIHE
CCCCCCCEEEEECCHHHHHHHHCCCCCCCCCCEEEECCCCCCCCEECCCEEECCCHHEEC
DVFVGPRSTIGGYSTIQESSYIGPDCHIGVQASIGAQSFLRQGNIIGEYTIIFSQANIGE
CEEECCCCCCCCCHHHCCCCCCCCCCEEEEEECCCHHHHHHCCCCEEEEEEEEEECCCCC
GSQIESHCYIGSELNVADFVIIRKCADIGSSVSIGRRVTIGEYATINKRCIIGNEVNIGR
CCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCEECCCEEEECCCCCCCC
SVSIGRSVTIDDQITIAALTCIRAHVIASKEMDRKLYAHLLDVINDTATKRTGHSNYKLF
EEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
LTPEKAAHVLKEAS
ECCHHHHHHHHCCC
>Mature Secondary Structure 
PPMNNTFEYKFSDDLIAKARHWINPDGSQGGIVSTEANIASSATISKGAIVFPNAVIHE
CCCCCCEEEEECCHHHHHHHHCCCCCCCCCCEEEECCCCCCCCEECCCEEECCCHHEEC
DVFVGPRSTIGGYSTIQESSYIGPDCHIGVQASIGAQSFLRQGNIIGEYTIIFSQANIGE
CEEECCCCCCCCCHHHCCCCCCCCCCEEEEEECCCHHHHHHCCCCEEEEEEEEEECCCCC
GSQIESHCYIGSELNVADFVIIRKCADIGSSVSIGRRVTIGEYATINKRCIIGNEVNIGR
CCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCEECCCEEEECCCCCCCC
SVSIGRSVTIDDQITIAALTCIRAHVIASKEMDRKLYAHLLDVINDTATKRTGHSNYKLF
EEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
LTPEKAAHVLKEAS
ECCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Co2+; Mg2+; Mn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.79 {diphosphate}} 0.36 {uridine} [C]

Substrates: Acetyl-CoA; D-Glucosamine 1-phosphate [C]

Specific reaction: Acetyl-CoA + D-Glucosamine 1-phosphate --> N-Acetyl-D-glucosamine 1-phosphate + Coenzyme A + H+ [C]

General reaction: Nucleotidyl group transfer [C]

Inhibitor: EDTA; Ni2+; PCMB [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA