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The map label for this gene is uppS [H]

Identifier: 182680888

GI number: 182680888

Start: 423596

End: 424363

Strand: Reverse

Name: uppS [H]

Synonym: XfasM23_0326

Alternate gene names: 182680888

Gene position: 424363-423596 (Counterclockwise)

Preceding gene: 182680889

Following gene: 182680887

Centisome position: 16.74

GC content: 54.69

Gene sequence:

>768_bases
ATGCAGATCAACACCATACCAGTCAATCCCACACTTCCCCGCCACATAGCCATCATCATGGATGGTAACGGGCGCTGGGC
AGAACGCCGATCACGGCCGCGCACCACAGGCCATCGCGCCGGCGTAAAAGCAGCCATGCGCACCGTGGATTTCTGTCTGG
AGAAGGGAATCAAGATGCTGACATTGTTCGCATTCTCCAGCGAAAATTGGAACCGGCCAGCCGATGAAGTCAACTTTTTG
ATGGAAATGTCAATCAAGTTATTTGGCCGCGGCATCGAAGAACTGCACCGACGCGGTGTACAAGTACGCTTTATAGGGGA
ACGTAAACGCTTTGATATCGCGCTCGTCGAACATATGACCAAGGCGGAACACCTGACAGCCAGCAACCAACGCTTAATAC
TGTCACTCGCCGTCAGCTACGGTGGACGCCAGGACATTACGATGGCTGCACGCGCTCTGGCCCAGGATGTGGCTGCCGGA
CGATTGAAACCAGAGCAGATTGATGAAGATTTGCTTGGACAACACATGGCGCTCGCTGATCTGCCGCCGCCCGACATGTT
CATCCGCACCAGCGGTGTTATTCGAATTAGTAACTTCTTGCTGTGGCAGATCGCCTATACCGAGCTGTGGTTCACCGACG
TGATGTGGCCAGAATTCAACTCGACCGTATTGCAGCAAGCGTTGGACGACTACGCCAGCCGGGAGCGTCGCTTCGGTCTA
ACAAATGCACAAATCGCCAGCCGGGGGAAAGGAAGCATACCCGCATGA

Upstream 100 bases:

>100_bases
GCCACGGTGAAGAAGACATCCAGAAGCTGACCGATAAAGCAATCAAAAGCGTGGATGAGGTAGTCAAGTCCAAAGAACAG
GAATTGATGACGGTCTGAAG

Downstream 100 bases:

>100_bases
CCCGAACCCGTGTCATTGCCGCGCTGGTCATGGCACCCGTCGCAATGTGTTCGATCCTGTTTTTACCAACGGCCTGGTTA
GCCTCATTGACAGCAATCAT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MQINTIPVNPTLPRHIAIIMDGNGRWAERRSRPRTTGHRAGVKAAMRTVDFCLEKGIKMLTLFAFSSENWNRPADEVNFL
MEMSIKLFGRGIEELHRRGVQVRFIGERKRFDIALVEHMTKAEHLTASNQRLILSLAVSYGGRQDITMAARALAQDVAAG
RLKPEQIDEDLLGQHMALADLPPPDMFIRTSGVIRISNFLLWQIAYTELWFTDVMWPEFNSTVLQQALDDYASRERRFGL
TNAQIASRGKGSIPA

Sequences:

>Translated_255_residues
MQINTIPVNPTLPRHIAIIMDGNGRWAERRSRPRTTGHRAGVKAAMRTVDFCLEKGIKMLTLFAFSSENWNRPADEVNFL
MEMSIKLFGRGIEELHRRGVQVRFIGERKRFDIALVEHMTKAEHLTASNQRLILSLAVSYGGRQDITMAARALAQDVAAG
RLKPEQIDEDLLGQHMALADLPPPDMFIRTSGVIRISNFLLWQIAYTELWFTDVMWPEFNSTVLQQALDDYASRERRFGL
TNAQIASRGKGSIPA
>Mature_255_residues
MQINTIPVNPTLPRHIAIIMDGNGRWAERRSRPRTTGHRAGVKAAMRTVDFCLEKGIKMLTLFAFSSENWNRPADEVNFL
MEMSIKLFGRGIEELHRRGVQVRFIGERKRFDIALVEHMTKAEHLTASNQRLILSLAVSYGGRQDITMAARALAQDVAAG
RLKPEQIDEDLLGQHMALADLPPPDMFIRTSGVIRISNFLLWQIAYTELWFTDVMWPEFNSTVLQQALDDYASRERRFGL
TNAQIASRGKGSIPA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=258, Percent_Identity=36.4341085271318, Blast_Score=164, Evalue=8e-41,
Organism=Homo sapiens, GI45580742, Length=251, Percent_Identity=36.2549800796813, Blast_Score=161, Evalue=4e-40,
Organism=Escherichia coli, GI1786371, Length=241, Percent_Identity=51.8672199170125, Blast_Score=259, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI71993029, Length=225, Percent_Identity=32.4444444444444, Blast_Score=131, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6319474, Length=220, Percent_Identity=35, Blast_Score=132, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6323748, Length=265, Percent_Identity=26.4150943396226, Blast_Score=105, Evalue=7e-24,
Organism=Drosophila melanogaster, GI18857969, Length=261, Percent_Identity=31.8007662835249, Blast_Score=134, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28906; Mature: 28906

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQINTIPVNPTLPRHIAIIMDGNGRWAERRSRPRTTGHRAGVKAAMRTVDFCLEKGIKML
CCCEEECCCCCCCCEEEEEECCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEE
TLFAFSSENWNRPADEVNFLMEMSIKLFGRGIEELHRRGVQVRFIGERKRFDIALVEHMT
EEEEECCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEECCCCHHHHHHHHHHH
KAEHLTASNQRLILSLAVSYGGRQDITMAARALAQDVAAGRLKPEQIDEDLLGQHMALAD
HHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHCCHHHHHCHHHHCC
LPPPDMFIRTSGVIRISNFLLWQIAYTELWFTDVMWPEFNSTVLQQALDDYASRERRFGL
CCCCCEEEECCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCC
TNAQIASRGKGSIPA
CCHHHHCCCCCCCCC
>Mature Secondary Structure
MQINTIPVNPTLPRHIAIIMDGNGRWAERRSRPRTTGHRAGVKAAMRTVDFCLEKGIKML
CCCEEECCCCCCCCEEEEEECCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEE
TLFAFSSENWNRPADEVNFLMEMSIKLFGRGIEELHRRGVQVRFIGERKRFDIALVEHMT
EEEEECCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEECCCCHHHHHHHHHHH
KAEHLTASNQRLILSLAVSYGGRQDITMAARALAQDVAAGRLKPEQIDEDLLGQHMALAD
HHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHCCHHHHHCHHHHCC
LPPPDMFIRTSGVIRISNFLLWQIAYTELWFTDVMWPEFNSTVLQQALDDYASRERRFGL
CCCCCEEEECCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCC
TNAQIASRGKGSIPA
CCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]