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The map label for this gene is lpxD

Identifier: 182680883

GI number: 182680883

Start: 416539

End: 417555

Strand: Reverse

Name: lpxD

Synonym: XfasM23_0321

Alternate gene names: 182680883

Gene position: 417555-416539 (Counterclockwise)

Preceding gene: 182680884

Following gene: 182680882

Centisome position: 16.47

GC content: 54.18

Gene sequence:

>1017_bases
ATGCCAATCTTTACTGCTCAAGAGCTCGCCGAACGCTTTAACCTGCAACTGTTTGGGGACGGCAACATCCGTATCCACGG
TGTCGCCACACTCACACAAGCAAGTCCGGAACAACTTAGCTTCCTCGCTAATCCACGCTACCTCACACAGCTACCCAATA
GTCGCGCGGGCGTCATTGTGCTGCATGCCGACGATGTCAAAGCAGCCTCTGGTGCAGTACTGATCGCCAAAGACCCTTAC
GTCACTTTCGCCAAGATCGCCACACTATTCGACATAAAACCAGCGCGTGAAGCAGGCATCCATCCTCTAGCAACCGTCGA
TCCAAGCGCGCATGTCTCACCAACCGCGCATGTCGGCGCATTTGTCAGCATTGGCGCACGCAGCAGCATCGGCGCAAGCT
GCATCATAGGAACCGGTAGTATCATCGGCGATGATTGCACCATTGATGACGGCAGTGAACTCATTGCACGTGTCACGTTG
ATCTCCAGAGTACGCTTGGGTAAACGGGTACGCATTCACCCTGGTGCAGTGCTGGGTGGTGAAGGCTTCGGACTTGCAAT
GGAAAGCGGACACTGGATCAAAATACCGCAGTTAGGTGGCGTTGTGATCGGCGATGATTGCGAGATAGGCGCCAACAGCT
GCATCGACCGCGGTGCACTTGACGACACTGTATTGGAAGAGGATGTGCATATCGACAATTTAGTGCAAATCGCACACAAC
TGCCGGATTGGAGCACATACCGCAATCGCCGGCTGTACAGGCATTGCTGGTAGCGCGAAAATTGGCCGCTACTGTCTGCT
TGGCGGCCACGTTGGCGTCGTTGGTCACCTCCAGATCTGTGACAACGTCGTGATCACCGGCAAATCGGTCGTACGTAACT
CAATTCACACCCCCGGCGAGTACTCATCAGGTACTCCATTGACCGACAATCGTACTTGGCGCAAAAACGCTGTACGGTTT
AAACAGCTGGATATGCTGGTGCGCCGCATGATGGCCGTCAGTAAGGAGAAAGCATGA

Upstream 100 bases:

>100_bases
GCACTACAATGCGCGCGGGGGCAGCATTCCGTCTGATTCACTGCCGCATGAGTGGTTATTCTTCGGACAGTCACCAGACA
TTAAAATTTTCAGCGTAAAC

Downstream 100 bases:

>100_bases
GCGATTCACCCACTACCGCTCACACTCGTCTGGAATTACCAATCGATATCATTAGAATCCAAGCATTGCTGCCACACCGC
TATCCCTTTCTATTGGTCGA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MPIFTAQELAERFNLQLFGDGNIRIHGVATLTQASPEQLSFLANPRYLTQLPNSRAGVIVLHADDVKAASGAVLIAKDPY
VTFAKIATLFDIKPAREAGIHPLATVDPSAHVSPTAHVGAFVSIGARSSIGASCIIGTGSIIGDDCTIDDGSELIARVTL
ISRVRLGKRVRIHPGAVLGGEGFGLAMESGHWIKIPQLGGVVIGDDCEIGANSCIDRGALDDTVLEEDVHIDNLVQIAHN
CRIGAHTAIAGCTGIAGSAKIGRYCLLGGHVGVVGHLQICDNVVITGKSVVRNSIHTPGEYSSGTPLTDNRTWRKNAVRF
KQLDMLVRRMMAVSKEKA

Sequences:

>Translated_338_residues
MPIFTAQELAERFNLQLFGDGNIRIHGVATLTQASPEQLSFLANPRYLTQLPNSRAGVIVLHADDVKAASGAVLIAKDPY
VTFAKIATLFDIKPAREAGIHPLATVDPSAHVSPTAHVGAFVSIGARSSIGASCIIGTGSIIGDDCTIDDGSELIARVTL
ISRVRLGKRVRIHPGAVLGGEGFGLAMESGHWIKIPQLGGVVIGDDCEIGANSCIDRGALDDTVLEEDVHIDNLVQIAHN
CRIGAHTAIAGCTGIAGSAKIGRYCLLGGHVGVVGHLQICDNVVITGKSVVRNSIHTPGEYSSGTPLTDNRTWRKNAVRF
KQLDMLVRRMMAVSKEKA
>Mature_337_residues
PIFTAQELAERFNLQLFGDGNIRIHGVATLTQASPEQLSFLANPRYLTQLPNSRAGVIVLHADDVKAASGAVLIAKDPYV
TFAKIATLFDIKPAREAGIHPLATVDPSAHVSPTAHVGAFVSIGARSSIGASCIIGTGSIIGDDCTIDDGSELIARVTLI
SRVRLGKRVRIHPGAVLGGEGFGLAMESGHWIKIPQLGGVVIGDDCEIGANSCIDRGALDDTVLEEDVHIDNLVQIAHNC
RIGAHTAIAGCTGIAGSAKIGRYCLLGGHVGVVGHLQICDNVVITGKSVVRNSIHTPGEYSSGTPLTDNRTWRKNAVRFK
QLDMLVRRMMAVSKEKA

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=336, Percent_Identity=41.3690476190476, Blast_Score=278, Evalue=4e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_XYLF2 (B2I7P1)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001829043.1
- ProteinModelPortal:   B2I7P1
- GeneID:   6201879
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_0321
- HOGENOM:   HBG469615
- OMA:   CFVGKNT
- ProtClustDB:   PRK00892
- HAMAP:   MF_00523
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 35716; Mature: 35584

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIFTAQELAERFNLQLFGDGNIRIHGVATLTQASPEQLSFLANPRYLTQLPNSRAGVIV
CCCCCHHHHHHHCCEEEEECCCEEEEEEEEECCCCHHHHHHHCCCHHHHHCCCCCCCEEE
LHADDVKAASGAVLIAKDPYVTFAKIATLFDIKPAREAGIHPLATVDPSAHVSPTAHVGA
EEECCCCCCCCEEEEECCCCCHHHHHHHHHCCCCHHHCCCCCEEECCCCCCCCCCHHHCE
FVSIGARSSIGASCIIGTGSIIGDDCTIDDGSELIARVTLISRVRLGKRVRIHPGAVLGG
EEEECCCCCCCCEEEEECCCEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCEEECC
EGFGLAMESGHWIKIPQLGGVVIGDDCEIGANSCIDRGALDDTVLEEDVHIDNLVQIAHN
CCCEEEECCCCEEEECCCCCEEECCCCCCCCCHHHCCCCCCCHHHHCCCCHHHHHHHHHC
CRIGAHTAIAGCTGIAGSAKIGRYCLLGGHVGVVGHLQICDNVVITGKSVVRNSIHTPGE
CCCCCCHHHHHCCCCCCCCCCCCEEEECCCCCEEEEEEECCCEEEECHHHHHHCCCCCCC
YSSGTPLTDNRTWRKNAVRFKQLDMLVRRMMAVSKEKA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PIFTAQELAERFNLQLFGDGNIRIHGVATLTQASPEQLSFLANPRYLTQLPNSRAGVIV
CCCCHHHHHHHCCEEEEECCCEEEEEEEEECCCCHHHHHHHCCCHHHHHCCCCCCCEEE
LHADDVKAASGAVLIAKDPYVTFAKIATLFDIKPAREAGIHPLATVDPSAHVSPTAHVGA
EEECCCCCCCCEEEEECCCCCHHHHHHHHHCCCCHHHCCCCCEEECCCCCCCCCCHHHCE
FVSIGARSSIGASCIIGTGSIIGDDCTIDDGSELIARVTLISRVRLGKRVRIHPGAVLGG
EEEECCCCCCCCEEEEECCCEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCEEECC
EGFGLAMESGHWIKIPQLGGVVIGDDCEIGANSCIDRGALDDTVLEEDVHIDNLVQIAHN
CCCEEEECCCCEEEECCCCCEEECCCCCCCCCHHHCCCCCCCHHHHCCCCHHHHHHHHHC
CRIGAHTAIAGCTGIAGSAKIGRYCLLGGHVGVVGHLQICDNVVITGKSVVRNSIHTPGE
CCCCCCHHHHHCCCCCCCCCCCCEEEECCCCCEEEEEEECCCEEEECHHHHHHCCCCCCC
YSSGTPLTDNRTWRKNAVRFKQLDMLVRRMMAVSKEKA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA