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The map label for this gene is nuoM [H]

Identifier: 182680817

GI number: 182680817

Start: 329411

End: 330916

Strand: Direct

Name: nuoM [H]

Synonym: XfasM23_0252

Alternate gene names: 182680817

Gene position: 329411-330916 (Clockwise)

Preceding gene: 182680816

Following gene: 182680818

Centisome position: 12.99

GC content: 50.27

Gene sequence:

>1506_bases
GTGTCGAATTGGCCTCTACTGTCTGTCTTAATTTGGCTGCCGATCATTGGTGGCCTCTTGATTATGGGGTTGCGCAACGC
CCATGTTGCTCGTTGGGCAGCGTTAGCGGTCGCGCTGGTTACCTTCGGATTCAGTCTGCACTTGTTGGGTGGTTACGATA
TTGCTAAAGATGCGTTGCAGTTTGTTGAGCAGCATGTCTGGATCCAGACGTACAGTATTGGTTACAACCTTGGTGTGGAT
GGCATCGCGATCGCGCTGGTGCTGTTGACAACGTTGGTGACTGTATTGGTATTGATCGGTTCCTGGGGGTCGATCCAGCA
GCGTGTTCCCCAATACGTGGCGGCGTTTCTCATTCTTGAAGGGGTGACAATCGGTATCTTCGCTGCGACGGACGCAATGC
TTTTCTATGTGTTCTTCGAGGCGATGTTGATTCCGATGTTCTTGATCATCGGTGTCTGGGGTGGTCCACGTCGTATCTAT
GCAGCGATCAAGTTTTTTCTTTATACCTTTCTCGGTTCGGTGTTGATGTTGGTTGGCTTGATCTACCTGTATTTGAAGGG
GGGGAGCTTTCAGCTGGCTGATTTGTATGCAATGCAGCTCAGTGCCAAAGAGCAGACGTGGTTGTTCTTTGCCTTCTTGA
TTGCTTTTGCGGTCAAGGTCCCAATGTTCCCGGTGCATACATGGTTGCCGGATGCTCACGTGGAAGCGCCGACTGCAGGT
TCAGTGATCCTGGCGGCGATTGCGTTGAAGATTGGTGGCTACGGTTTCTTGCGTTTCAATCTGCCGATTGTCCCGGATGC
GAGCCACGAGTTTGCTTGGGTGGTTATTGCGTTGTCCTTAATTGCGGTGATCTATGTCGGCTTGGTTGCGCTGGTACAGG
AGGATATGAAGAAACTGATTGCCTATTCTTCAATTGCGCATATGGGCTTCGTGACATTGGGGATCTTCATTGCCTTCACC
TTGGTACGTGACTTTGGTAATACAGATGCTGCGCGTCTTGGATTACAGGGGGCCATGGTGCAAATGATTTCGCACGGTTT
CGTCTCTGGTGCAATGTTCACTTGTATTGGTGTGCTGTACGATCGCATGCATACCCGCCGTATCGCTGATTACGGTGGGG
TGGTGAATGTGATGCCGTGGTTTGCGACGTTTGCCATATTGTTCTATATGGCAAATGCGGGCTTGCCGGGAACCAGTGGT
TTTGTTGGTGAATTCATGGTGATCCTTGCCAGTTTTCAAAAGCACCCACTGGTGGCATTCGGTGCAGGGACGACGCTAGT
GATTACCGCTGCCTACACGCTGTGGCTCTATAAACGTGTGTTTTTTGGAGAGGTTGCTAATACGCATGTCGCCGCATTGA
AAGACATTAATTTTCGGGAAGCTTCCGTACTCGTGTTGTTCGCGATTGGTGTGTTGGTGTTGGGGCTGTATCCTAAGCCG
CTTATTGATTTGATGGATTCTTCCATTGTCAAGCTCACTACTCAGATTGCCGTGAGCAAGCTGTGA

Upstream 100 bases:

>100_bases
TTTTGTCTATCACTATGCCTTCGCAATGATCATTGGTTTGATCGCTTTGTTGGCAGTGCTGATGTGTTTTTGGCGTTGAT
CTGTTACGGAATAAAAATAC

Downstream 100 bases:

>100_bases
TCGGCTGCGGCACAATTGATTTCAGGATTCGATAATGACCATGCCGACATCTGGGTTAAACATTGCCGATCTGGCTCCCT
TGTTGCCGGAGCTAGTCCTT

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 501; Mature: 500

Protein sequence:

>501_residues
MSNWPLLSVLIWLPIIGGLLIMGLRNAHVARWAALAVALVTFGFSLHLLGGYDIAKDALQFVEQHVWIQTYSIGYNLGVD
GIAIALVLLTTLVTVLVLIGSWGSIQQRVPQYVAAFLILEGVTIGIFAATDAMLFYVFFEAMLIPMFLIIGVWGGPRRIY
AAIKFFLYTFLGSVLMLVGLIYLYLKGGSFQLADLYAMQLSAKEQTWLFFAFLIAFAVKVPMFPVHTWLPDAHVEAPTAG
SVILAAIALKIGGYGFLRFNLPIVPDASHEFAWVVIALSLIAVIYVGLVALVQEDMKKLIAYSSIAHMGFVTLGIFIAFT
LVRDFGNTDAARLGLQGAMVQMISHGFVSGAMFTCIGVLYDRMHTRRIADYGGVVNVMPWFATFAILFYMANAGLPGTSG
FVGEFMVILASFQKHPLVAFGAGTTLVITAAYTLWLYKRVFFGEVANTHVAALKDINFREASVLVLFAIGVLVLGLYPKP
LIDLMDSSIVKLTTQIAVSKL

Sequences:

>Translated_501_residues
MSNWPLLSVLIWLPIIGGLLIMGLRNAHVARWAALAVALVTFGFSLHLLGGYDIAKDALQFVEQHVWIQTYSIGYNLGVD
GIAIALVLLTTLVTVLVLIGSWGSIQQRVPQYVAAFLILEGVTIGIFAATDAMLFYVFFEAMLIPMFLIIGVWGGPRRIY
AAIKFFLYTFLGSVLMLVGLIYLYLKGGSFQLADLYAMQLSAKEQTWLFFAFLIAFAVKVPMFPVHTWLPDAHVEAPTAG
SVILAAIALKIGGYGFLRFNLPIVPDASHEFAWVVIALSLIAVIYVGLVALVQEDMKKLIAYSSIAHMGFVTLGIFIAFT
LVRDFGNTDAARLGLQGAMVQMISHGFVSGAMFTCIGVLYDRMHTRRIADYGGVVNVMPWFATFAILFYMANAGLPGTSG
FVGEFMVILASFQKHPLVAFGAGTTLVITAAYTLWLYKRVFFGEVANTHVAALKDINFREASVLVLFAIGVLVLGLYPKP
LIDLMDSSIVKLTTQIAVSKL
>Mature_500_residues
SNWPLLSVLIWLPIIGGLLIMGLRNAHVARWAALAVALVTFGFSLHLLGGYDIAKDALQFVEQHVWIQTYSIGYNLGVDG
IAIALVLLTTLVTVLVLIGSWGSIQQRVPQYVAAFLILEGVTIGIFAATDAMLFYVFFEAMLIPMFLIIGVWGGPRRIYA
AIKFFLYTFLGSVLMLVGLIYLYLKGGSFQLADLYAMQLSAKEQTWLFFAFLIAFAVKVPMFPVHTWLPDAHVEAPTAGS
VILAAIALKIGGYGFLRFNLPIVPDASHEFAWVVIALSLIAVIYVGLVALVQEDMKKLIAYSSIAHMGFVTLGIFIAFTL
VRDFGNTDAARLGLQGAMVQMISHGFVSGAMFTCIGVLYDRMHTRRIADYGGVVNVMPWFATFAILFYMANAGLPGTSGF
VGEFMVILASFQKHPLVAFGAGTTLVITAAYTLWLYKRVFFGEVANTHVAALKDINFREASVLVLFAIGVLVLGLYPKPL
IDLMDSSIVKLTTQIAVSKL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=379, Percent_Identity=35.0923482849604, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI251831117, Length=362, Percent_Identity=22.9281767955801, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1788613, Length=505, Percent_Identity=37.8217821782178, Blast_Score=310, Evalue=2e-85,
Organism=Escherichia coli, GI1788827, Length=364, Percent_Identity=25.2747252747253, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788831, Length=373, Percent_Identity=24.6648793565684, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788829, Length=426, Percent_Identity=26.056338028169, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI145693160, Length=374, Percent_Identity=26.2032085561497, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788614, Length=520, Percent_Identity=24.8076923076923, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI2367154, Length=308, Percent_Identity=26.6233766233766, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 54756; Mature: 54625

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNWPLLSVLIWLPIIGGLLIMGLRNAHVARWAALAVALVTFGFSLHLLGGYDIAKDALQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEECCHHHHHHHHH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HHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8566820 [H]