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The map label for this gene is nuoL [H]

Identifier: 182680816

GI number: 182680816

Start: 327248

End: 329389

Strand: Direct

Name: nuoL [H]

Synonym: XfasM23_0251

Alternate gene names: 182680816

Gene position: 327248-329389 (Clockwise)

Preceding gene: 182680815

Following gene: 182680817

Centisome position: 12.91

GC content: 50.33

Gene sequence:

>2142_bases
ATGGATATTACTCTCTCCAAGAATATGCTGATTGCTGTTGTCCTTGCCCCACTGTTCGGCAGCATTATTGCCGGATTGTT
AGGGCGCCAGGTCGGCCGCAAGGGGGCGCATTGTGTGACCCTTCTGGGTGTTGCTGTCAGTTGCGCGATGTCGTGTTGGA
CGCTTTACCAGCTCGTTGGACAAGGAGCGGCACCGTTTAATCAGAATCTTTATACCTTCTTCCAGGTGGGTGAGTATTCT
GCCCATGTCGGCTTCATGATTGATCGTCTCACTGCGGTAATGATGGTTGTGGTGACGTTTGTGTCGCTGTTGGTCCATCT
GTATACCATCGGCTACATGGAAGAAGACCCGGGGTATCAGCGCTTTTTTAGTTATATCTCTCTATTCACCTTCTCGATGC
TCACTTTGGTGATGAGCAACAACTTTTTACAGTTGTTTTTCGGTTGGGAGGCAGTGGGATTGGTGTCTTACCTCTTGATC
GGTTTTTGGTTCAAGCGGCCGAGTGCGATATTTGCCAACATGAAGGCGTTTTTGGTGAATCGCGTTGGTGACTTCGGTTT
CTTGCTTGGCATTAGTTTGGTTCTGTACACGTTTGGCACATTGGATTATTCAGTGGTCTTTGCCAACGTGGGTAGCTTGG
TGGGACAAACCACTAACGTGTGGAGCGGTAATGTCGACGTGTTTGGCAGCATCATCCACGTCATGGGGCCGCTGAGTTGG
TCAACGGCGACGTTGGTGTGTATTTGTTTGTTTATCGGTGCGATGGGTAAGTCCGCACAGGTTCCGTTGCACGTGTGGTT
GCCTGATTCCATGGAAGGGCCAACTCCTATTTCAGCGTTAATCCATGCGGCCACGATGGTGACGGCAGGCATTTTTATGG
TTGCACGCATGTCACCGTTGTTCCAACTCAGTGAGGTTGCGTTGCAGTTCGTGTTGTTCGTTGGTGCCACGACCGCATTT
TTTACGGGGTTGATCGGCATGGTGCAGAATGACATTAAGCGTGTCGTGGCGTATTCCACCTTATCGCAGTTGGGTTATAT
GACAGTGGCACTGGGTGTGTCGGCGTATTCGGCGGCTGTGTTCCACCTGATGACGCACGCGTTCTTTAAAGCATTGCTAT
TTCTTGCGGCTGGCTCAGTCATTATTGGCATGCATCATGAGCAAGATATGCGCAAGATGGGCGGGCTACGTAAGTACATG
CCAATAACCTATATCACCAGTGTGATTGGTACGTTGGCTTTGGTGGGGACGCCGTTCTTTTCTGGATTCTATTCCAAGGA
CACCATCATTGAGGCAGCGGCTTATCATGCTGAGCATGCACACAGTTGGGTAGCGACTTACGGTTACTGGGCGGTGCTCG
GCGGTGTACTGGTGACGAGTTTCTACAGCTTCCGCTTGTTGTTTCTGACCTTTCATGGTGAGGAGCGTTTCCGCCGTGTT
GGAGGCGGACATGATGCTGATGACCATGTAAATACACACACGTCAAATGATGAACATGCGCATGGTGTGCATGAGCCGCA
AGAATCGCCATGGGTAGTGACATTGCCGCTAATTTTTCTGGCAATCCCTTCTATTGCGTTGGGCTTCTTCACGATTGGTC
CGATGCTGTTTGGTACGGACTGGGCAGGCCATCATGCCGTTGAGGTGATCTGGGGTCAGACTGTCTCATTCTTTACAGGC
ATCATTGATTTTTATGATCCGGCACAGAATACAGTTGCTGTTTTGGGTGAGGAATTCCGCGGCCCGGTGGCTTTTGCGCT
GCATGGGATGATGTCGGCACCATTCTTTTTAACGGTTGCCGGCTTCTTGCTTGCCGTGTTGCTGTATCTATGGAAACCGC
AATGGCCAGTGAAAATACGTGAAACCTTCTCGTTGCCGGTGCGTATTCTGGAGAACAAGTACGGTTTTGATGCGTTGTGG
ATCGGTGGTTTTTCCGGATGGGGCCTCAAGCTTGGTAATGTTTCCCGCGCGATTGATACCCATGTGGTGGATGGTGTTTT
GGTGAATGGTTCGGCACGCCTGATTGATGTGGTGGCGAATGTGTTACGTCGCACGCAATCTGGTTTTGTCTATCACTATG
CCTTCGCAATGATCATTGGTTTGATCGCTTTGTTGGCAGTGCTGATGTGTTTTTGGCGTTGA

Upstream 100 bases:

>100_bases
GCAGAGGCTGCCATTGGCCTCGCGATCCTGGTCACCCTGTTCCGTACCCACCACACGATTAATGTGGCCGAAGTCGATGC
TCTGAAGGGCTGATCTGCAG

Downstream 100 bases:

>100_bases
TCTGTTACGGAATAAAAATACGTGTCGAATTGGCCTCTACTGTCTGTCTTAATTTGGCTGCCGATCATTGGTGGCCTCTT
GATTATGGGGTTGCGCAACG

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 713; Mature: 713

Protein sequence:

>713_residues
MDITLSKNMLIAVVLAPLFGSIIAGLLGRQVGRKGAHCVTLLGVAVSCAMSCWTLYQLVGQGAAPFNQNLYTFFQVGEYS
AHVGFMIDRLTAVMMVVVTFVSLLVHLYTIGYMEEDPGYQRFFSYISLFTFSMLTLVMSNNFLQLFFGWEAVGLVSYLLI
GFWFKRPSAIFANMKAFLVNRVGDFGFLLGISLVLYTFGTLDYSVVFANVGSLVGQTTNVWSGNVDVFGSIIHVMGPLSW
STATLVCICLFIGAMGKSAQVPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFQLSEVALQFVLFVGATTAF
FTGLIGMVQNDIKRVVAYSTLSQLGYMTVALGVSAYSAAVFHLMTHAFFKALLFLAAGSVIIGMHHEQDMRKMGGLRKYM
PITYITSVIGTLALVGTPFFSGFYSKDTIIEAAAYHAEHAHSWVATYGYWAVLGGVLVTSFYSFRLLFLTFHGEERFRRV
GGGHDADDHVNTHTSNDEHAHGVHEPQESPWVVTLPLIFLAIPSIALGFFTIGPMLFGTDWAGHHAVEVIWGQTVSFFTG
IIDFYDPAQNTVAVLGEEFRGPVAFALHGMMSAPFFLTVAGFLLAVLLYLWKPQWPVKIRETFSLPVRILENKYGFDALW
IGGFSGWGLKLGNVSRAIDTHVVDGVLVNGSARLIDVVANVLRRTQSGFVYHYAFAMIIGLIALLAVLMCFWR

Sequences:

>Translated_713_residues
MDITLSKNMLIAVVLAPLFGSIIAGLLGRQVGRKGAHCVTLLGVAVSCAMSCWTLYQLVGQGAAPFNQNLYTFFQVGEYS
AHVGFMIDRLTAVMMVVVTFVSLLVHLYTIGYMEEDPGYQRFFSYISLFTFSMLTLVMSNNFLQLFFGWEAVGLVSYLLI
GFWFKRPSAIFANMKAFLVNRVGDFGFLLGISLVLYTFGTLDYSVVFANVGSLVGQTTNVWSGNVDVFGSIIHVMGPLSW
STATLVCICLFIGAMGKSAQVPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFQLSEVALQFVLFVGATTAF
FTGLIGMVQNDIKRVVAYSTLSQLGYMTVALGVSAYSAAVFHLMTHAFFKALLFLAAGSVIIGMHHEQDMRKMGGLRKYM
PITYITSVIGTLALVGTPFFSGFYSKDTIIEAAAYHAEHAHSWVATYGYWAVLGGVLVTSFYSFRLLFLTFHGEERFRRV
GGGHDADDHVNTHTSNDEHAHGVHEPQESPWVVTLPLIFLAIPSIALGFFTIGPMLFGTDWAGHHAVEVIWGQTVSFFTG
IIDFYDPAQNTVAVLGEEFRGPVAFALHGMMSAPFFLTVAGFLLAVLLYLWKPQWPVKIRETFSLPVRILENKYGFDALW
IGGFSGWGLKLGNVSRAIDTHVVDGVLVNGSARLIDVVANVLRRTQSGFVYHYAFAMIIGLIALLAVLMCFWR
>Mature_713_residues
MDITLSKNMLIAVVLAPLFGSIIAGLLGRQVGRKGAHCVTLLGVAVSCAMSCWTLYQLVGQGAAPFNQNLYTFFQVGEYS
AHVGFMIDRLTAVMMVVVTFVSLLVHLYTIGYMEEDPGYQRFFSYISLFTFSMLTLVMSNNFLQLFFGWEAVGLVSYLLI
GFWFKRPSAIFANMKAFLVNRVGDFGFLLGISLVLYTFGTLDYSVVFANVGSLVGQTTNVWSGNVDVFGSIIHVMGPLSW
STATLVCICLFIGAMGKSAQVPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFQLSEVALQFVLFVGATTAF
FTGLIGMVQNDIKRVVAYSTLSQLGYMTVALGVSAYSAAVFHLMTHAFFKALLFLAAGSVIIGMHHEQDMRKMGGLRKYM
PITYITSVIGTLALVGTPFFSGFYSKDTIIEAAAYHAEHAHSWVATYGYWAVLGGVLVTSFYSFRLLFLTFHGEERFRRV
GGGHDADDHVNTHTSNDEHAHGVHEPQESPWVVTLPLIFLAIPSIALGFFTIGPMLFGTDWAGHHAVEVIWGQTVSFFTG
IIDFYDPAQNTVAVLGEEFRGPVAFALHGMMSAPFFLTVAGFLLAVLLYLWKPQWPVKIRETFSLPVRILENKYGFDALW
IGGFSGWGLKLGNVSRAIDTHVVDGVLVNGSARLIDVVANVLRRTQSGFVYHYAFAMIIGLIALLAVLMCFWR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=406, Percent_Identity=39.4088669950739, Blast_Score=287, Evalue=2e-77,
Organism=Escherichia coli, GI1788614, Length=532, Percent_Identity=40.2255639097744, Blast_Score=347, Evalue=1e-96,
Organism=Escherichia coli, GI1788829, Length=436, Percent_Identity=28.2110091743119, Blast_Score=147, Evalue=3e-36,
Organism=Escherichia coli, GI1788831, Length=374, Percent_Identity=28.6096256684492, Blast_Score=125, Evalue=1e-29,
Organism=Escherichia coli, GI1788827, Length=368, Percent_Identity=29.3478260869565, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1788613, Length=474, Percent_Identity=23.6286919831224, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI2367154, Length=136, Percent_Identity=33.0882352941176, Blast_Score=80, Evalue=6e-16,
Organism=Escherichia coli, GI145693160, Length=394, Percent_Identity=23.8578680203046, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 78341; Mature: 78341

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHCCEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure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HHHCCEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]