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The map label for this gene is folK [H]

Identifier: 182680743

GI number: 182680743

Start: 236138

End: 236635

Strand: Direct

Name: folK [H]

Synonym: XfasM23_0172

Alternate gene names: 182680743

Gene position: 236138-236635 (Clockwise)

Preceding gene: 182680742

Following gene: 182680744

Centisome position: 9.31

GC content: 54.62

Gene sequence:

>498_bases
GTGACCAGTGGCAATGTGGTGGCTTATGTTGGGTTGGGCGCCAATCTCGGCCCGGCTGAGATGACGTTGCGAGCCGCAAT
TGCTGCGTTGGATCAGTTGCCGTTCACCCGTCTACGCATTGCTTCCAGTTTGTATCGCACCCCTCCCTGGGGACGTCAGG
ATCAGGCGGAGTTTGTTAATGCGGTTGCAGCGTTGGAAACAAGGTTAGCGCCTTTAGCCTTGTTGGATGCATTGTTGGAG
GTGGAATGTCTCCATGGGAGAGTGCGTCTTCCCGGCGACCGTTGGGGGCCGCGTACACTTGATCTGGATTTGTTGCTTTA
TGGGGAGCATGTTTTGGATCTGCCGCGACTGAGGGTGCCTCATCCTCATCTACATGAGCGCACTTTTGTAGTGGTGCCTT
TGGCCGAAATTGCTGCGGAGTTGGTGCTTCCTCGTCATGGGATGGTATGTGAGCTATTGGAGCATATGGATACCTTGGGC
TTGGTACCAATCAGGTAG

Upstream 100 bases:

>100_bases
CTTCTGAAGACTCTCTGGCGTCAGCCATTGATGCTGTGCGGTTTGAATCGGAGGAAGTGGGTGTGTCGCGTCAGCGGTAA
TGCCAAGGTGGTCAAGTAGA

Downstream 100 bases:

>100_bases
ATAATGTTCACTGGTTAGATTTTCATGAATTTATGAGCATATATACCAATAGCAAACCTTGGACGGTGCCTGCTTTGGCG
GAGGCCAAGCGAAACGGTTC

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 165; Mature: 164

Protein sequence:

>165_residues
MTSGNVVAYVGLGANLGPAEMTLRAAIAALDQLPFTRLRIASSLYRTPPWGRQDQAEFVNAVAALETRLAPLALLDALLE
VECLHGRVRLPGDRWGPRTLDLDLLLYGEHVLDLPRLRVPHPHLHERTFVVVPLAEIAAELVLPRHGMVCELLEHMDTLG
LVPIR

Sequences:

>Translated_165_residues
MTSGNVVAYVGLGANLGPAEMTLRAAIAALDQLPFTRLRIASSLYRTPPWGRQDQAEFVNAVAALETRLAPLALLDALLE
VECLHGRVRLPGDRWGPRTLDLDLLLYGEHVLDLPRLRVPHPHLHERTFVVVPLAEIAAELVLPRHGMVCELLEHMDTLG
LVPIR
>Mature_164_residues
TSGNVVAYVGLGANLGPAEMTLRAAIAALDQLPFTRLRIASSLYRTPPWGRQDQAEFVNAVAALETRLAPLALLDALLEV
ECLHGRVRLPGDRWGPRTLDLDLLLYGEHVLDLPRLRVPHPHLHERTFVVVPLAEIAAELVLPRHGMVCELLEHMDTLGL
VPIR

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=148, Percent_Identity=46.6216216216216, Blast_Score=132, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6324073, Length=158, Percent_Identity=31.6455696202532, Blast_Score=79, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18224; Mature: 18092

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSGNVVAYVGLGANLGPAEMTLRAAIAALDQLPFTRLRIASSLYRTPPWGRQDQAEFVN
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHH
AVAALETRLAPLALLDALLEVECLHGRVRLPGDRWGPRTLDLDLLLYGEHVLDLPRLRVP
HHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCEEEEEEEEEECCHHHCCCCCCCC
HPHLHERTFVVVPLAEIAAELVLPRHGMVCELLEHMDTLGLVPIR
CCCCCCCEEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TSGNVVAYVGLGANLGPAEMTLRAAIAALDQLPFTRLRIASSLYRTPPWGRQDQAEFVN
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHH
AVAALETRLAPLALLDALLEVECLHGRVRLPGDRWGPRTLDLDLLLYGEHVLDLPRLRVP
HHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCEEEEEEEEEECCHHHCCCCCCCC
HPHLHERTFVVVPLAEIAAELVLPRHGMVCELLEHMDTLGLVPIR
CCCCCCCEEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10080886 [H]