Click here to switch to the map view.

The map label for this gene is folP [H]

Identifier: 182680631

GI number: 182680631

Start: 89271

End: 90167

Strand: Reverse

Name: folP [H]

Synonym: XfasM23_0060

Alternate gene names: 182680631

Gene position: 90167-89271 (Counterclockwise)

Preceding gene: 182680633

Following gene: 182680630

Centisome position: 3.56

GC content: 54.96

Gene sequence:

>897_bases
ATGTTTGACACTATCCCCACCCTGCACTGCGCCGGACGCACCTTGCGTCTAGACAGTCCATTGGTCATGGGTATCCTCAA
CGTGACTCCTGATTCCTTTTCCGACGGAGGCCTGTATGACTCTGTGGATGCAGCAGTGGCGCATGGATTACGCCTGATTG
CTGAGGGTGCAGACATCATTGATATTGGCGGGGAATCCACCCGTCCCGGCGCAGCGCCGGTACCGCTGGAGGAGGAACTA
CTCCGAGTGGTGCCGGTCATCAAGGCATTAGCTGCCTACGATAAAGCTGTCATCAGCGTAGACACCTTCAAACCTGAGGT
AATGCGTGCGGCAGTCGCTGCCGGTGCCGGCTTGATCAATGACATCTATGCACTACGCACTCCCGGAGCGCTGAAAGCAG
CAGCAGAACTGGCTGTACCAGTGATATTGATGCATATGAAAGGTGAGCCGCACTCAACGCAAACACCACAGTACGATCAT
GTGGTTGATGAAGTGTACCGTTTCCTGGCCGAGCGGATTTTTGCCGCCGAGATAGCAGGTATCGAACGACACCGACTGCT
GATCGATCCTGGTTTCAGTTTCAGCAAGACCACGGAACATAACATTGCACTGTTAGCGGCACTGGAACGTTTCACCAATC
TCGGCATCCCATTGTTGGCCGGATTGTCACGCAAGCGTAGCTTGGGCGAACTGACAGGACGTCAGTTACCAATCGAACGC
GTGTACGCCTCCGTCGCTGCACATCTCATTGCGGTACAACGCGGCGCGTTAATCGTACGGGTGCATGATGTGGCAGCTAT
GGTCGATGCCCTCAAAGTTTGGCAGGCAGTTTCAGCAGCGGCTGCACCTGCAACACATACCAAAACTACAGTGGCTCGTT
CGCCCCATGACGACTGA

Upstream 100 bases:

>100_bases
TGTTGCTAGTGAATCTATCGGCTTTTAACGATCAGCCATACCATGCTGGTTACCTTACAACGCTCATCCACCATCACAGC
AACAGGAAAGGAAGTTTCCG

Downstream 100 bases:

>100_bases
TGCCGGCCGACACGAGACCAGCCGCAATTGTACTCATGGGGCCAACCGCAAGCGGCAAAAGCCAACTGGCCATTGATATT
GCCAAGCGTTGGGGAGGGGA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MFDTIPTLHCAGRTLRLDSPLVMGILNVTPDSFSDGGLYDSVDAAVAHGLRLIAEGADIIDIGGESTRPGAAPVPLEEEL
LRVVPVIKALAAYDKAVISVDTFKPEVMRAAVAAGAGLINDIYALRTPGALKAAAELAVPVILMHMKGEPHSTQTPQYDH
VVDEVYRFLAERIFAAEIAGIERHRLLIDPGFSFSKTTEHNIALLAALERFTNLGIPLLAGLSRKRSLGELTGRQLPIER
VYASVAAHLIAVQRGALIVRVHDVAAMVDALKVWQAVSAAAAPATHTKTTVARSPHDD

Sequences:

>Translated_298_residues
MFDTIPTLHCAGRTLRLDSPLVMGILNVTPDSFSDGGLYDSVDAAVAHGLRLIAEGADIIDIGGESTRPGAAPVPLEEEL
LRVVPVIKALAAYDKAVISVDTFKPEVMRAAVAAGAGLINDIYALRTPGALKAAAELAVPVILMHMKGEPHSTQTPQYDH
VVDEVYRFLAERIFAAEIAGIERHRLLIDPGFSFSKTTEHNIALLAALERFTNLGIPLLAGLSRKRSLGELTGRQLPIER
VYASVAAHLIAVQRGALIVRVHDVAAMVDALKVWQAVSAAAAPATHTKTTVARSPHDD
>Mature_298_residues
MFDTIPTLHCAGRTLRLDSPLVMGILNVTPDSFSDGGLYDSVDAAVAHGLRLIAEGADIIDIGGESTRPGAAPVPLEEEL
LRVVPVIKALAAYDKAVISVDTFKPEVMRAAVAAGAGLINDIYALRTPGALKAAAELAVPVILMHMKGEPHSTQTPQYDH
VVDEVYRFLAERIFAAEIAGIERHRLLIDPGFSFSKTTEHNIALLAALERFTNLGIPLLAGLSRKRSLGELTGRQLPIER
VYASVAAHLIAVQRGALIVRVHDVAAMVDALKVWQAVSAAAAPATHTKTTVARSPHDD

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=274, Percent_Identity=52.1897810218978, Blast_Score=268, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6324073, Length=327, Percent_Identity=29.3577981651376, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31789; Mature: 31789

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDTIPTLHCAGRTLRLDSPLVMGILNVTPDSFSDGGLYDSVDAAVAHGLRLIAEGADII
CCCCCCCHHHCCCEEECCCCHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEE
DIGGESTRPGAAPVPLEEELLRVVPVIKALAAYDKAVISVDTFKPEVMRAAVAAGAGLIN
ECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHCCHHHH
DIYALRTPGALKAAAELAVPVILMHMKGEPHSTQTPQYDHVVDEVYRFLAERIFAAEIAG
HHHHHCCCHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
IERHRLLIDPGFSFSKTTEHNIALLAALERFTNLGIPLLAGLSRKRSLGELTGRQLPIER
CCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHCCCCCCHHH
VYASVAAHLIAVQRGALIVRVHDVAAMVDALKVWQAVSAAAAPATHTKTTVARSPHDD
HHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCC
>Mature Secondary Structure
MFDTIPTLHCAGRTLRLDSPLVMGILNVTPDSFSDGGLYDSVDAAVAHGLRLIAEGADII
CCCCCCCHHHCCCEEECCCCHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEE
DIGGESTRPGAAPVPLEEELLRVVPVIKALAAYDKAVISVDTFKPEVMRAAVAAGAGLIN
ECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHCCHHHH
DIYALRTPGALKAAAELAVPVILMHMKGEPHSTQTPQYDHVVDEVYRFLAERIFAAEIAG
HHHHHCCCHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
IERHRLLIDPGFSFSKTTEHNIALLAALERFTNLGIPLLAGLSRKRSLGELTGRQLPIER
CCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHCCCCCCHHH
VYASVAAHLIAVQRGALIVRVHDVAAMVDALKVWQAVSAAAAPATHTKTTVARSPHDD
HHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]