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The map label for this gene is yfhM [H]

Identifier: 182677273

GI number: 182677273

Start: 317656

End: 318960

Strand: Direct

Name: yfhM [H]

Synonym: Bind_0276

Alternate gene names: 182677273

Gene position: 317656-318960 (Clockwise)

Preceding gene: 182677267

Following gene: 182677276

Centisome position: 7.62

GC content: 60.84

Gene sequence:

>1305_bases
ATGCCTCTCTACAAAATCAAACCATCGCCGTCTCGACGCGCCGTCTTAGCGATGGGCGCGGCCAGCCTGGTTGCGGCTTC
ACTTCGACCGGCCCACGCAAACCCCATGGGAGGAACTGATTTGACGATATGGACATATGGCGAGGGAACGCTTCCCACGG
GGGTCCGCTCGCGCATGATCCATGGGGTCAACGGCCTCAATGTCCATATTCTGGAGGCCGGTTACGAAAGCCCCAGCCGG
CCGCTCGCGCTGCTTCTGCACGGCTTTCCGGATTTGGCTTACGGCTGGCGACACTTGATTCCAATTCTGGCTGAAGCCGG
GTACCATGTCGTGGCGCCCGACCAGCGGGGCTTTGGCCGCACAACCGGTTGGGTGAACGACTATGACGCCCCGTTAGAGC
CCTTCAGCTTCTTGAATATGGCGCGTGACGCCCTCGGACTGGTTGCGGCGTTGGGGTATCGCCGTACGGCAATGCTCGTC
GGGCACGACCTCGGCTCACCCGTAGCAGCCTATTGTGCGCTAGCCCGACCTGACGTCTTTCCCTCGGTGGTGCTGATGAG
CGCACCGTTCCCTGGTCCGCCGGCGTTTCCATTCGATACCGCGAAAAACGAGGCATCGTCGGTTCAACCGAACACTGAAA
ATCAAAAGCTAGCGGCCGCGCTGGCCGCGCTCGATCCGCCCAGAGAGTATTATCAACAATACTTGAGCACGCGGGCGGCG
AACGATGACATGTGGCACCCCCCTCAAGGCTTGCATGCGTTTCTGCGTGCATTCTTCTACGTCAAGAGCGCCGACTGGCC
GGGAAACAAGCCCCATCCGTTGAAGGCGCGAACCGCCGCGGAACTTGCACGAATGCCCACTTATTACGTCATGGATCTCG
GCAGGACGATGCCCCAGACCGTCGCTCCATTCCAACCTTCCGCCACCGAGGTCCTGGCCTGCAAATGGCTCACCGAGCCA
GAACTTGGAGTGTATACAGAGGAGTACGACCGCACCGGGTTTCAAGGTGCCCTGCAGGCTTATCGCGTCTTTTCCGATCC
TGACCTAAACGCTGAGTTGCGCCTGTTTTCGGGCAAGACGATCGATGTCCCGTCGCTCTTCATCGGCGGGAAGAGCGATT
GGGGCACCTATTCGGCGCCAGGCGCGCTCGATCTCATGAGGACGAAGGCGGCGACGAGGATGGGTGGCATGGAGCTGATC
GACGGTGCCGGTCACTGGATCCAACAGGAGCAGCCGGTTCGGCTCGGCGCGCTCCTGCTTGCCTTCATTAAGGAGGTTGG
TGGGGCGGGTCGTACCAGCCGTTAG

Upstream 100 bases:

>100_bases
CGTCAGTCTTACGTGTCATGCCGCGAACATACCACGCTTTGCTTGACGCTTCTATGGTGGTCACTATACTATGGTGATCA
CCATATAGCGGAGTTCGGCG

Downstream 100 bases:

>100_bases
GCCGGGGAATGCCTATCGCCGCTCTTGAAATATTGCCCGGCGACCTGATCACCGTCCCGACAGGTCCGTCACATTCAATG
AAGCGCTTCGGTTTGGTGGT

Product: alpha/beta hydrolase fold protein

Products: glycol

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MPLYKIKPSPSRRAVLAMGAASLVAASLRPAHANPMGGTDLTIWTYGEGTLPTGVRSRMIHGVNGLNVHILEAGYESPSR
PLALLLHGFPDLAYGWRHLIPILAEAGYHVVAPDQRGFGRTTGWVNDYDAPLEPFSFLNMARDALGLVAALGYRRTAMLV
GHDLGSPVAAYCALARPDVFPSVVLMSAPFPGPPAFPFDTAKNEASSVQPNTENQKLAAALAALDPPREYYQQYLSTRAA
NDDMWHPPQGLHAFLRAFFYVKSADWPGNKPHPLKARTAAELARMPTYYVMDLGRTMPQTVAPFQPSATEVLACKWLTEP
ELGVYTEEYDRTGFQGALQAYRVFSDPDLNAELRLFSGKTIDVPSLFIGGKSDWGTYSAPGALDLMRTKAATRMGGMELI
DGAGHWIQQEQPVRLGALLLAFIKEVGGAGRTSR

Sequences:

>Translated_434_residues
MPLYKIKPSPSRRAVLAMGAASLVAASLRPAHANPMGGTDLTIWTYGEGTLPTGVRSRMIHGVNGLNVHILEAGYESPSR
PLALLLHGFPDLAYGWRHLIPILAEAGYHVVAPDQRGFGRTTGWVNDYDAPLEPFSFLNMARDALGLVAALGYRRTAMLV
GHDLGSPVAAYCALARPDVFPSVVLMSAPFPGPPAFPFDTAKNEASSVQPNTENQKLAAALAALDPPREYYQQYLSTRAA
NDDMWHPPQGLHAFLRAFFYVKSADWPGNKPHPLKARTAAELARMPTYYVMDLGRTMPQTVAPFQPSATEVLACKWLTEP
ELGVYTEEYDRTGFQGALQAYRVFSDPDLNAELRLFSGKTIDVPSLFIGGKSDWGTYSAPGALDLMRTKAATRMGGMELI
DGAGHWIQQEQPVRLGALLLAFIKEVGGAGRTSR
>Mature_433_residues
PLYKIKPSPSRRAVLAMGAASLVAASLRPAHANPMGGTDLTIWTYGEGTLPTGVRSRMIHGVNGLNVHILEAGYESPSRP
LALLLHGFPDLAYGWRHLIPILAEAGYHVVAPDQRGFGRTTGWVNDYDAPLEPFSFLNMARDALGLVAALGYRRTAMLVG
HDLGSPVAAYCALARPDVFPSVVLMSAPFPGPPAFPFDTAKNEASSVQPNTENQKLAAALAALDPPREYYQQYLSTRAAN
DDMWHPPQGLHAFLRAFFYVKSADWPGNKPHPLKARTAAELARMPTYYVMDLGRTMPQTVAPFQPSATEVLACKWLTEPE
LGVYTEEYDRTGFQGALQAYRVFSDPDLNAELRLFSGKTIDVPSLFIGGKSDWGTYSAPGALDLMRTKAATRMGGMELID
GAGHWIQQEQPVRLGALLLAFIKEVGGAGRTSR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily. Epoxide hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI27597073, Length=381, Percent_Identity=24.1469816272966, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI218777837, Length=131, Percent_Identity=32.824427480916, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: 3.3.2.3

Molecular weight: Translated: 47210; Mature: 47078

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLYKIKPSPSRRAVLAMGAASLVAASLRPAHANPMGGTDLTIWTYGEGTLPTGVRSRMI
CCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHH
HGVNGLNVHILEAGYESPSRPLALLLHGFPDLAYGWRHLIPILAEAGYHVVAPDQRGFGR
HCCCCCEEEEEECCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCC
TTGWVNDYDAPLEPFSFLNMARDALGLVAALGYRRTAMLVGHDLGSPVAAYCALARPDVF
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHCCCCCC
PSVVLMSAPFPGPPAFPFDTAKNEASSVQPNTENQKLAAALAALDPPREYYQQYLSTRAA
CCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCC
NDDMWHPPQGLHAFLRAFFYVKSADWPGNKPHPLKARTAAELARMPTYYVMDLGRTMPQT
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCCHH
VAPFQPSATEVLACKWLTEPELGVYTEEYDRTGFQGALQAYRVFSDPDLNAELRLFSGKT
CCCCCCCCCCEEEEEECCCCCCCCCHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEECCCE
IDVPSLFIGGKSDWGTYSAPGALDLMRTKAATRMGGMELIDGAGHWIQQEQPVRLGALLL
ECCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCHHEECCCCCCCCCCCCHHHHHHHH
AFIKEVGGAGRTSR
HHHHHHCCCCCCCC
>Mature Secondary Structure 
PLYKIKPSPSRRAVLAMGAASLVAASLRPAHANPMGGTDLTIWTYGEGTLPTGVRSRMI
CCCCCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHH
HGVNGLNVHILEAGYESPSRPLALLLHGFPDLAYGWRHLIPILAEAGYHVVAPDQRGFGR
HCCCCCEEEEEECCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCC
TTGWVNDYDAPLEPFSFLNMARDALGLVAALGYRRTAMLVGHDLGSPVAAYCALARPDVF
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHCCCCCC
PSVVLMSAPFPGPPAFPFDTAKNEASSVQPNTENQKLAAALAALDPPREYYQQYLSTRAA
CCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCC
NDDMWHPPQGLHAFLRAFFYVKSADWPGNKPHPLKARTAAELARMPTYYVMDLGRTMPQT
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCCHH
VAPFQPSATEVLACKWLTEPELGVYTEEYDRTGFQGALQAYRVFSDPDLNAELRLFSGKT
CCCCCCCCCCEEEEEECCCCCCCCCHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEECCCE
IDVPSLFIGGKSDWGTYSAPGALDLMRTKAATRMGGMELIDGAGHWIQQEQPVRLGALLL
ECCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCHHEECCCCCCCCCCCCHHHHHHHH
AFIKEVGGAGRTSR
HHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O; epoxide

Specific reaction: H2O + an epoxide = a glycol

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]