Click here to switch to the map view.

The map label for this gene is modD [H]

Identifier: 182677276

GI number: 182677276

Start: 320330

End: 321190

Strand: Direct

Name: modD [H]

Synonym: Bind_0279

Alternate gene names: 182677276

Gene position: 320330-321190 (Clockwise)

Preceding gene: 182677273

Following gene: 182677277

Centisome position: 7.68

GC content: 62.37

Gene sequence:

>861_bases
GTGATTCTTCCTATTTTGCCCGACCATGTGCTCGACCAATTGCTGGCCGATGATAGTCCACTTCTCGATCTGACAACCCA
TGTCCTCGCCCTTGATGCTCACGCCGGGGAGATGCATTTCGCCGCGCGCGACCCCATGGTGGCAGCCTGCGTGGAGGAGG
CTGCCCGGATCATCGAACGGGCGGGCGCCAAAGTTGTGCGGCACGCCGCGTCCGGCGACAGACTGGTGCCGAAGGCTCCG
ATCCTGACCGCGCAAGGGCCCGCCCCGGTTTTGTTGCGCGCCTGGAAGGTCAGCCAGAATCTGATTGAAGTGGCCTCCGG
CATAGCCACGGCCACCGCCGCTCTCGTCGATGCGGCCCGCGCGGTTCGCCCCAATATTGCGGTCACCTGCACCCGCAAGG
CGGTGCCAGGCACCAAGCTGATCTCGCTCAAGGCCATTCTCGCCGGCGGGGCTTTGCCGCATCGTCTCGGCCTCTCCGAA
ACCATTTTGATCTTTGCCGAGCATCGCGCCTTTCTGAGCGGTCAGTCGGAACAGGCTTTGGTCGAACAGGTTCGCCGCGA
GGCGGCCGAGAAGAAAATTGTCGTGGAGGTAGCCTCGGTCGAAGAAGCTCTGGCCTGGGCCAAGGCGGGGGCCGATGTGA
TTCAGGCGGAAAAATTTTCTCCTGCGGCCATTATATCCTTGGTCGAGGCCGTGGGATCGCTGCAACCAAAGCCGGTGATC
GCCGCAGCGGGGGGAATTAATGCTGAAAATGCAGGCCTTTATGCGGCGGCAGGGGCGGATGTTCTCGTGACCTCCTCACC
TTATTGGGGCAAGCCGCGCGATGTCGCGGTCACGCTTGGTCCAGCCATCCTCGGTCAATGA

Upstream 100 bases:

>100_bases
AGCTTTGTGACAAAGCTCTTACACTCCCTCTTAAGAGTCCCAGGCTGGTTCATTTTTTTGTTTTTTCTTGGTCGGTAAAA
GGATCCAGCGGAGTGATGAT

Downstream 100 bases:

>100_bases
CCAGCACCTCCGACTTGCGACATTTGAAAATTAAGGCATGTTCGTCATGTTTACGCTTATATCAAAAGGCGGAGCCTCTT
CGAGGTTTTGAAAATCAATT

Product: modD protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MILPILPDHVLDQLLADDSPLLDLTTHVLALDAHAGEMHFAARDPMVAACVEEAARIIERAGAKVVRHAASGDRLVPKAP
ILTAQGPAPVLLRAWKVSQNLIEVASGIATATAALVDAARAVRPNIAVTCTRKAVPGTKLISLKAILAGGALPHRLGLSE
TILIFAEHRAFLSGQSEQALVEQVRREAAEKKIVVEVASVEEALAWAKAGADVIQAEKFSPAAIISLVEAVGSLQPKPVI
AAAGGINAENAGLYAAAGADVLVTSSPYWGKPRDVAVTLGPAILGQ

Sequences:

>Translated_286_residues
MILPILPDHVLDQLLADDSPLLDLTTHVLALDAHAGEMHFAARDPMVAACVEEAARIIERAGAKVVRHAASGDRLVPKAP
ILTAQGPAPVLLRAWKVSQNLIEVASGIATATAALVDAARAVRPNIAVTCTRKAVPGTKLISLKAILAGGALPHRLGLSE
TILIFAEHRAFLSGQSEQALVEQVRREAAEKKIVVEVASVEEALAWAKAGADVIQAEKFSPAAIISLVEAVGSLQPKPVI
AAAGGINAENAGLYAAAGADVLVTSSPYWGKPRDVAVTLGPAILGQ
>Mature_286_residues
MILPILPDHVLDQLLADDSPLLDLTTHVLALDAHAGEMHFAARDPMVAACVEEAARIIERAGAKVVRHAASGDRLVPKAP
ILTAQGPAPVLLRAWKVSQNLIEVASGIATATAALVDAARAVRPNIAVTCTRKAVPGTKLISLKAILAGGALPHRLGLSE
TILIFAEHRAFLSGQSEQALVEQVRREAAEKKIVVEVASVEEALAWAKAGADVIQAEKFSPAAIISLVEAVGSLQPKPVI
AAAGGINAENAGLYAAAGADVLVTSSPYWGKPRDVAVTLGPAILGQ

Specific function: NAD biosynthesis; aspartate to NaMN; third (last) step. [C]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=266, Percent_Identity=30.8270676691729, Blast_Score=79, Evalue=3e-15,
Organism=Escherichia coli, GI1786299, Length=217, Percent_Identity=29.9539170506912, Blast_Score=73, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321162, Length=269, Percent_Identity=26.0223048327138, Blast_Score=82, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006242
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: 2.4.2.-

Molecular weight: Translated: 29627; Mature: 29627

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILPILPDHVLDQLLADDSPLLDLTTHVLALDAHAGEMHFAARDPMVAACVEEAARIIER
CCCCCCCHHHHHHHHCCCCCHHHHHHHHHEEECCCCCEEECCCCCHHHHHHHHHHHHHHH
AGAKVVRHAASGDRLVPKAPILTAQGPAPVLLRAWKVSQNLIEVASGIATATAALVDAAR
HHHHHHHHHCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVRPNIAVTCTRKAVPGTKLISLKAILAGGALPHRLGLSETILIFAEHRAFLSGQSEQAL
HHCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCHHCCCCCEEEEEEEHHHHHCCCCHHHH
VEQVRREAAEKKIVVEVASVEEALAWAKAGADVIQAEKFSPAAIISLVEAVGSLQPKPVI
HHHHHHHHHHHEEEEEHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCEE
AAAGGINAENAGLYAAAGADVLVTSSPYWGKPRDVAVTLGPAILGQ
EECCCCCCCCCCEEEECCCCEEEECCCCCCCCCEEEEEECCHHHCC
>Mature Secondary Structure
MILPILPDHVLDQLLADDSPLLDLTTHVLALDAHAGEMHFAARDPMVAACVEEAARIIER
CCCCCCCHHHHHHHHCCCCCHHHHHHHHHEEECCCCCEEECCCCCHHHHHHHHHHHHHHH
AGAKVVRHAASGDRLVPKAPILTAQGPAPVLLRAWKVSQNLIEVASGIATATAALVDAAR
HHHHHHHHHCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVRPNIAVTCTRKAVPGTKLISLKAILAGGALPHRLGLSETILIFAEHRAFLSGQSEQAL
HHCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCHHCCCCCEEEEEEEHHHHHCCCCHHHH
VEQVRREAAEKKIVVEVASVEEALAWAKAGADVIQAEKFSPAAIISLVEAVGSLQPKPVI
HHHHHHHHHHHEEEEEHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCEE
AAAGGINAENAGLYAAAGADVLVTSSPYWGKPRDVAVTLGPAILGQ
EECCCCCCCCCCEEEECCCCEEEECCCCCCCCCEEEEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA