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The map label for this gene is zntA [H]

Identifier: 182677267

GI number: 182677267

Start: 309554

End: 311695

Strand: Direct

Name: zntA [H]

Synonym: Bind_0269

Alternate gene names: 182677267

Gene position: 309554-311695 (Clockwise)

Preceding gene: 182677265

Following gene: 182677273

Centisome position: 7.42

GC content: 61.06

Gene sequence:

>2142_bases
ATGGCGAGCGCCAGCATCTTGAAGCTGCGGGTCGAAGGCATGGATTGCGGGGCCTGCGCCTTGAAGATCGAGGCCGCAAT
GCGGTCCTTGCCAGGTGTCGCGGATATTGCGGTCGATTATCACAAAGCCTCGCTCTCTCTCACGCTTGACGAAGACCGCT
CTTCCCGCGCCGTAATCGAGGCCAGGATCAGGGCGCTCGGCTATACACCGATCGGTGACGGCGTGGCGGTGGCTTGTGAG
ACGGATCGTGATCATGGTCCAAGGCAAGACGCCTGGTGGGCCTCGCGCAAGGGACGGTTGGTCATCACGACGGGTGTTGT
GCTGAGCCTTGCGACTATCATCGCCTATCGCGCGCCGGAATGGTCATATTGGGCCTATGGCGTGGCGACACTGGCGGGCC
TTTTACCGCTCAGCCGGCGGGCTTTGGCGGGAGCACGCTCGGGAGTTCCGTTCAGCATTGAGACGTTGATGACAATCGCC
ACGGCTGGCGCCATCGCCATCGGCGAGGCGCAAGAAGCCGCCGTGATCGTGTTCCTGTTTGCCGTGGGGGAATTATTGGA
AGGCATCGCGGCTGATCGCGCGCGGACCGGCATCAAGGCGCTGACCAAGCTTTTGCCACGCCAAGCGCTCCGCCTACACG
GGGCAAATGTCGAGATGGTGTCCGTCGAGACATTGGCCGTCGGAGATCATGTGGTGGTTCGGCCGGGCGACAGGATTCCT
TCCGATGGCTTCGTCGTCGAGGGGATGTCGGAGGTCGATGAAGCGCCTGTGACGGGGGAATCCATGCCTGTCGCCAAAGA
GACCGGCGCGATTGTCTATGCGGGAAGCATCAATGCCAATGGCGAGTTGCGTGTCGAAATTACCCGGACAGCGGCTGATA
ATACGATCGCGCGCATCATTCATAAGGTCGAGGAGGCCCAGGCCTCGAAAGCACCGACAGCCCGTTTGATCGACCGTTTC
AGCCGATTGTATACGCCTTTTGCCATGGCGGCGGCAGGCTTTGTGGTCCTGATGCCGCCGCTGTTCTTTGGGGCTGACTG
GTTCCTCTCGATCTATCGCGGTCTGGCCGTGCTGCTGATCGCCTGTCCCTGTGCTCTCGTCGTTTCCACACCCACCGCCA
TTGCCTCGGGGCTTGCGAGCGGTGCCCGGCATGGCCTGCTCATCAAAGGAGGCGCGGCGCTCGAGACACTGAGCCGGGTC
CAGACGATCGCCTTCGACAAGACGGGCACGCTGACCTTGGGTCATCCGCAAGTCACGGATGTTTTGCCAATCCATGGGAG
CGTAGCCGAAATCCTCGTCAAGGCCGCGGCCGTCGAGCGGGGTTCCAGCCATCCGCTGGGAGTGGCGATTGTCGCGGAAG
CCGAGAAACGGCATCTCGCACTGCCCGAATGTTTCGGTGGTGGGATCGCCATTCCTGGCAAGGCGATGATGGGTCGATTG
AAATCGGGTTTTGTCTGGGTGGAATCACCGCGCCATGCCGCCGCGCAAACCGCCCTGGCCGATAACAATGACGATGACAT
TGCGGCCAGGATCGCGGCCTTGGAAGGGGAAGGCAAGACCGTTGTCGTCATCAGGGAAAACAAGACGATACTCGGATTGA
TTGCTTTGCGTGATGCGCCGCGATCGGATGCGGCCGAAGGCCTTGCGCGGCTTCGTGCCCTGGGCCTTCGCCTGGTGATG
CTCACGGGGGATAATGGACGCGCCGCGACAACGCTTGGTCATGTACTTGGCCTTGAGGTGAAAGCTGAACTTCTGCCTGA
CGCCAAACTCGACGCGATTTTGACCTATAAAGCCGAGGCGCCGATCGCCATGGTCGGCGATGGCATCAATGATGCGCCGG
CGCTCGCCGCCGCCTCGGTCGGTATTGCAATGGGCTGCGGGACCGATGTCGCCTTGGAAACGGCCGATGCTGCGCTTTTG
AAGAATCGTGTGACCGGGGTCGCCGAACTGGTCGCTTTATCGCGCGCGACGCTTGCCATTGTCTGGCAGAATATCGCGCT
GGCTCTTGGGTTCAAAAGCGTCTTTCTCGCAACCACTTTGTGGGGAGCGACGCCGCTTTGGACAGCGATTCTCGCCGATA
CTGGAGCCATGGTTCTCGTGACCGGCAACGCTCTGCGTCTGCTCCGTTTCAAAGTCAGTTGA

Upstream 100 bases:

>100_bases
GTCATGCCTTGACCCTGTAGTCACTACAGGGCCCATGTGTGGAACCATGCTGAATTTGTCTATGGTGAATTTATCCTGGT
GACTTTGGCGAGGTGAGGTC

Downstream 100 bases:

>100_bases
GCAGGGGGCTCCAGGCAGGGTCGGAGGCGAAACTCGGCGTTGGCACGGGGAATTCGCCGCGACCGTAGAGATCGACCATG
AACAGCCGTGGACCGCCCTG

Product: heavy metal translocating P-type ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 713; Mature: 712

Protein sequence:

>713_residues
MASASILKLRVEGMDCGACALKIEAAMRSLPGVADIAVDYHKASLSLTLDEDRSSRAVIEARIRALGYTPIGDGVAVACE
TDRDHGPRQDAWWASRKGRLVITTGVVLSLATIIAYRAPEWSYWAYGVATLAGLLPLSRRALAGARSGVPFSIETLMTIA
TAGAIAIGEAQEAAVIVFLFAVGELLEGIAADRARTGIKALTKLLPRQALRLHGANVEMVSVETLAVGDHVVVRPGDRIP
SDGFVVEGMSEVDEAPVTGESMPVAKETGAIVYAGSINANGELRVEITRTAADNTIARIIHKVEEAQASKAPTARLIDRF
SRLYTPFAMAAAGFVVLMPPLFFGADWFLSIYRGLAVLLIACPCALVVSTPTAIASGLASGARHGLLIKGGAALETLSRV
QTIAFDKTGTLTLGHPQVTDVLPIHGSVAEILVKAAAVERGSSHPLGVAIVAEAEKRHLALPECFGGGIAIPGKAMMGRL
KSGFVWVESPRHAAAQTALADNNDDDIAARIAALEGEGKTVVVIRENKTILGLIALRDAPRSDAAEGLARLRALGLRLVM
LTGDNGRAATTLGHVLGLEVKAELLPDAKLDAILTYKAEAPIAMVGDGINDAPALAAASVGIAMGCGTDVALETADAALL
KNRVTGVAELVALSRATLAIVWQNIALALGFKSVFLATTLWGATPLWTAILADTGAMVLVTGNALRLLRFKVS

Sequences:

>Translated_713_residues
MASASILKLRVEGMDCGACALKIEAAMRSLPGVADIAVDYHKASLSLTLDEDRSSRAVIEARIRALGYTPIGDGVAVACE
TDRDHGPRQDAWWASRKGRLVITTGVVLSLATIIAYRAPEWSYWAYGVATLAGLLPLSRRALAGARSGVPFSIETLMTIA
TAGAIAIGEAQEAAVIVFLFAVGELLEGIAADRARTGIKALTKLLPRQALRLHGANVEMVSVETLAVGDHVVVRPGDRIP
SDGFVVEGMSEVDEAPVTGESMPVAKETGAIVYAGSINANGELRVEITRTAADNTIARIIHKVEEAQASKAPTARLIDRF
SRLYTPFAMAAAGFVVLMPPLFFGADWFLSIYRGLAVLLIACPCALVVSTPTAIASGLASGARHGLLIKGGAALETLSRV
QTIAFDKTGTLTLGHPQVTDVLPIHGSVAEILVKAAAVERGSSHPLGVAIVAEAEKRHLALPECFGGGIAIPGKAMMGRL
KSGFVWVESPRHAAAQTALADNNDDDIAARIAALEGEGKTVVVIRENKTILGLIALRDAPRSDAAEGLARLRALGLRLVM
LTGDNGRAATTLGHVLGLEVKAELLPDAKLDAILTYKAEAPIAMVGDGINDAPALAAASVGIAMGCGTDVALETADAALL
KNRVTGVAELVALSRATLAIVWQNIALALGFKSVFLATTLWGATPLWTAILADTGAMVLVTGNALRLLRFKVS
>Mature_712_residues
ASASILKLRVEGMDCGACALKIEAAMRSLPGVADIAVDYHKASLSLTLDEDRSSRAVIEARIRALGYTPIGDGVAVACET
DRDHGPRQDAWWASRKGRLVITTGVVLSLATIIAYRAPEWSYWAYGVATLAGLLPLSRRALAGARSGVPFSIETLMTIAT
AGAIAIGEAQEAAVIVFLFAVGELLEGIAADRARTGIKALTKLLPRQALRLHGANVEMVSVETLAVGDHVVVRPGDRIPS
DGFVVEGMSEVDEAPVTGESMPVAKETGAIVYAGSINANGELRVEITRTAADNTIARIIHKVEEAQASKAPTARLIDRFS
RLYTPFAMAAAGFVVLMPPLFFGADWFLSIYRGLAVLLIACPCALVVSTPTAIASGLASGARHGLLIKGGAALETLSRVQ
TIAFDKTGTLTLGHPQVTDVLPIHGSVAEILVKAAAVERGSSHPLGVAIVAEAEKRHLALPECFGGGIAIPGKAMMGRLK
SGFVWVESPRHAAAQTALADNNDDDIAARIAALEGEGKTVVVIRENKTILGLIALRDAPRSDAAEGLARLRALGLRLVML
TGDNGRAATTLGHVLGLEVKAELLPDAKLDAILTYKAEAPIAMVGDGINDAPALAAASVGIAMGCGTDVALETADAALLK
NRVTGVAELVALSRATLAIVWQNIALALGFKSVFLATTLWGATPLWTAILADTGAMVLVTGNALRLLRFKVS

Specific function: Involved in export of lead, cadmium, zinc and mercury [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI115529486, Length=586, Percent_Identity=34.1296928327645, Blast_Score=270, Evalue=3e-72,
Organism=Homo sapiens, GI55743071, Length=573, Percent_Identity=34.3804537521815, Blast_Score=263, Evalue=5e-70,
Organism=Homo sapiens, GI55743073, Length=500, Percent_Identity=33.8, Blast_Score=239, Evalue=9e-63,
Organism=Homo sapiens, GI118498343, Length=625, Percent_Identity=23.36, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI22748667, Length=227, Percent_Identity=27.3127753303965, Blast_Score=78, Evalue=4e-14,
Organism=Homo sapiens, GI4502271, Length=227, Percent_Identity=27.3127753303965, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI153946397, Length=226, Percent_Identity=26.5486725663717, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI237681111, Length=227, Percent_Identity=26.431718061674, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI21361181, Length=227, Percent_Identity=26.431718061674, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI237681109, Length=227, Percent_Identity=26.431718061674, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI48762687, Length=254, Percent_Identity=23.2283464566929, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI48762691, Length=254, Percent_Identity=23.2283464566929, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI48762689, Length=254, Percent_Identity=23.2283464566929, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI48762685, Length=254, Percent_Identity=23.2283464566929, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI209413709, Length=216, Percent_Identity=28.2407407407407, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI24638454, Length=216, Percent_Identity=28.2407407407407, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI4502285, Length=216, Percent_Identity=28.2407407407407, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI51944966, Length=228, Percent_Identity=25.4385964912281, Blast_Score=67, Evalue=8e-11,
Organism=Escherichia coli, GI1789879, Length=705, Percent_Identity=46.241134751773, Blast_Score=519, Evalue=1e-148,
Organism=Escherichia coli, GI1786691, Length=557, Percent_Identity=36.983842010772, Blast_Score=259, Evalue=4e-70,
Organism=Escherichia coli, GI1786914, Length=518, Percent_Identity=31.6602316602317, Blast_Score=163, Evalue=4e-41,
Organism=Escherichia coli, GI2367363, Length=617, Percent_Identity=25.1215559157212, Blast_Score=107, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17556548, Length=583, Percent_Identity=32.0754716981132, Blast_Score=230, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71997262, Length=256, Percent_Identity=26.5625, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71997275, Length=256, Percent_Identity=26.5625, Blast_Score=83, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71997269, Length=256, Percent_Identity=26.5625, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17559224, Length=226, Percent_Identity=27.4336283185841, Blast_Score=78, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320475, Length=542, Percent_Identity=30.9963099630996, Blast_Score=230, Evalue=6e-61,
Organism=Saccharomyces cerevisiae, GI6319772, Length=578, Percent_Identity=28.0276816608997, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6321271, Length=249, Percent_Identity=24.4979919678715, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221329854, Length=518, Percent_Identity=29.7297297297297, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24668708, Length=570, Percent_Identity=22.4561403508772, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281366617, Length=570, Percent_Identity=22.4561403508772, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24668704, Length=570, Percent_Identity=22.8070175438596, Blast_Score=92, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24668696, Length=570, Percent_Identity=22.4561403508772, Blast_Score=92, Evalue=2e-18,
Organism=Drosophila melanogaster, GI161085803, Length=570, Percent_Identity=22.4561403508772, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI281366676, Length=271, Percent_Identity=24.7232472324723, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006404
- InterPro:   IPR000695
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3; =3.6.3.5 [H]

Molecular weight: Translated: 74383; Mature: 74252

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00626 RCC1_2 ; PS00154 ATPASE_E1_E2 ; PS50846 HMA_2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASASILKLRVEGMDCGACALKIEAAMRSLPGVADIAVDYHKASLSLTLDEDRSSRAVIE
CCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHEEEEEEEEEEEEEECCCCCCHHHHH
ARIRALGYTPIGDGVAVACETDRDHGPRQDAWWASRKGRLVITTGVVLSLATIIAYRAPE
HHHHHHCCCCCCCCEEEEEECCCCCCCCCCCHHHCCCCCEEEEHHHHHHHHHHHHHCCCC
WSYWAYGVATLAGLLPLSRRALAGARSGVPFSIETLMTIATAGAIAIGEAQEAAVIVFLF
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCCEEECCCCCHHHHHHHH
AVGELLEGIAADRARTGIKALTKLLPRQALRLHGANVEMVSVETLAVGDHVVVRPGDRIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCEEEECCCCCCC
SDGFVVEGMSEVDEAPVTGESMPVAKETGAIVYAGSINANGELRVEITRTAADNTIARII
CCCEEECCHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCHHHHHHH
HKVEEAQASKAPTARLIDRFSRLYTPFAMAAAGFVVLMPPLFFGADWFLSIYRGLAVLLI
HHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHCCHHEECCHHHHCHHHHHHHHHHHHHHHH
ACPCALVVSTPTAIASGLASGARHGLLIKGGAALETLSRVQTIAFDKTGTLTLGHPQVTD
HHCHHHEECCHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHEECCCCCEEECCCCCCE
VLPIHGSVAEILVKAAAVERGSSHPLGVAIVAEAEKRHLALPECFGGGIAIPGKAMMGRL
EEECCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHHCCCCEECCCHHHHHHH
KSGFVWVESPRHAAAQTALADNNDDDIAARIAALEGEGKTVVVIRENKTILGLIALRDAP
HCCEEEEECCCHHHHHHHHCCCCCCHHEEEEEEEECCCCEEEEEECCCEEEEEEEECCCC
RSDAAEGLARLRALGLRLVMLTGDNGRAATTLGHVLGLEVKAELLPDAKLDAILTYKAEA
CCHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHCCEEEHHHCCCCCCCEEEEEECCC
PIAMVGDGINDAPALAAASVGIAMGCGTDVALETADAALLKNRVTGVAELVALSRATLAI
CEEEECCCCCCCHHHHHHHCCEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VWQNIALALGFKSVFLATTLWGATPLWTAILADTGAMVLVTGNALRLLRFKVS
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCEEEEEEEECC
>Mature Secondary Structure 
ASASILKLRVEGMDCGACALKIEAAMRSLPGVADIAVDYHKASLSLTLDEDRSSRAVIE
CCCEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHEEEEEEEEEEEEEECCCCCCHHHHH
ARIRALGYTPIGDGVAVACETDRDHGPRQDAWWASRKGRLVITTGVVLSLATIIAYRAPE
HHHHHHCCCCCCCCEEEEEECCCCCCCCCCCHHHCCCCCEEEEHHHHHHHHHHHHHCCCC
WSYWAYGVATLAGLLPLSRRALAGARSGVPFSIETLMTIATAGAIAIGEAQEAAVIVFLF
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCCEEECCCCCHHHHHHHH
AVGELLEGIAADRARTGIKALTKLLPRQALRLHGANVEMVSVETLAVGDHVVVRPGDRIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCEEEECCCCCCC
SDGFVVEGMSEVDEAPVTGESMPVAKETGAIVYAGSINANGELRVEITRTAADNTIARII
CCCEEECCHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCHHHHHHH
HKVEEAQASKAPTARLIDRFSRLYTPFAMAAAGFVVLMPPLFFGADWFLSIYRGLAVLLI
HHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHCCHHEECCHHHHCHHHHHHHHHHHHHHHH
ACPCALVVSTPTAIASGLASGARHGLLIKGGAALETLSRVQTIAFDKTGTLTLGHPQVTD
HHCHHHEECCHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHEECCCCCEEECCCCCCE
VLPIHGSVAEILVKAAAVERGSSHPLGVAIVAEAEKRHLALPECFGGGIAIPGKAMMGRL
EEECCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHHCCCCEECCCHHHHHHH
KSGFVWVESPRHAAAQTALADNNDDDIAARIAALEGEGKTVVVIRENKTILGLIALRDAP
HCCEEEEECCCHHHHHHHHCCCCCCHHEEEEEEEECCCCEEEEEECCCEEEEEEEECCCC
RSDAAEGLARLRALGLRLVMLTGDNGRAATTLGHVLGLEVKAELLPDAKLDAILTYKAEA
CCHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHCCEEEHHHCCCCCCCEEEEEECCC
PIAMVGDGINDAPALAAASVGIAMGCGTDVALETADAALLKNRVTGVAELVALSRATLAI
CEEEECCCCCCCHHHHHHHCCEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VWQNIALALGFKSVFLATTLWGATPLWTAILADTGAMVLVTGNALRLLRFKVS
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 9405611; 9364914; 10660539; 12417201 [H]