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The map label for this gene is mtnP [H]

Identifier: 182677159

GI number: 182677159

Start: 188182

End: 189057

Strand: Direct

Name: mtnP [H]

Synonym: Bind_0158

Alternate gene names: 182677159

Gene position: 188182-189057 (Clockwise)

Preceding gene: 182677157

Following gene: 182677160

Centisome position: 4.51

GC content: 58.11

Gene sequence:

>876_bases
ATGTCCAAAGCCGTGGTCGGTATTATTGGCGGTTCCGGTGTCTATGACCTGCCGGGTCTCAAGGATTTGCGGGAAGAGCG
GGTCAAGACGCCCTGGGGCGAGCCTTCCGATGCTTTGCGCTTCGGCCGTATTGGGGACACCGAGGCGGTGTTTTTGCCGA
GGCATGGGCGTGGTCATGTCTATTCCCCTTCCGGCATCAACTATCGCGCCAATATCGATGCGATGAAACGTGTGGGCGTG
ACCGATATTGTTTCGGTCTCGGCCTGTGGCTCGTTCAAGCAGGAACTCTACCCGGGGCTTTTCGTCCTGGTCGATCAATT
TGTCGATCGCACGCAGGGGCGTGAGAGCTCCTTCTTCGGCAATGGCTGCGTCGTGCATGTCTCCATGGCGCATCCGGTTG
CGCCTTTGCTGCAAAAAAGGATCGCCGCTGCCGCGACGGCGGAAGAGATTCCCTTTGTCAGCGGCGGCACTTATGTGTGC
ATGGAGGGACCGCAATTTTCCTCAGGCGCCGAATCCCTTGGTTATAAAAGTCAAAATTTCGATGTGATCGGAATGACCGC
CATGCCCGAGGCCAAGCTCGCGCGCGAGGCGGAAATTTCCTATGCGACCATCGCCATGGTCACGGATTTCGATTGCTGGC
ACCCAGACCATGATCATGTCGATGTCGCCTCGGTAATCAAGGTTGTGCAGGCCAATGCCGCCAATGCCGCGCGCCTTCTG
GCGCGGCTCCTGGCCGATTTTCCAGATCAGCACGAGCCCTGTCCGATCGGCTCCGATCGCGCGCTTGATAATGCCTTTTT
GACGGCGCCCGACGCGCGCGACCCGGATCTTCTGCAAAAGCTCGATGCCATCATGCAACGGATCAATGCGAAATGA

Upstream 100 bases:

>100_bases
CTTTCTGGCCTCTCTTTCCGCTCTTCTGCCTCTACGGTTGATCGGAAGCTGACGTTACGCAAGAAGGCCGGAAAAATGTG
CGAGCCCGAGAGGGGTGCTG

Downstream 100 bases:

>100_bases
ACAAGCCCATCGATTTGAAAAGCGCGATCCGTACGATCTCCAATTATCCCAAGCCAGGCATAGAATTTCGCGACATCACC
ACTTTGCTTGGTGATGCTCG

Product: 5'-methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MSKAVVGIIGGSGVYDLPGLKDLREERVKTPWGEPSDALRFGRIGDTEAVFLPRHGRGHVYSPSGINYRANIDAMKRVGV
TDIVSVSACGSFKQELYPGLFVLVDQFVDRTQGRESSFFGNGCVVHVSMAHPVAPLLQKRIAAAATAEEIPFVSGGTYVC
MEGPQFSSGAESLGYKSQNFDVIGMTAMPEAKLAREAEISYATIAMVTDFDCWHPDHDHVDVASVIKVVQANAANAARLL
ARLLADFPDQHEPCPIGSDRALDNAFLTAPDARDPDLLQKLDAIMQRINAK

Sequences:

>Translated_291_residues
MSKAVVGIIGGSGVYDLPGLKDLREERVKTPWGEPSDALRFGRIGDTEAVFLPRHGRGHVYSPSGINYRANIDAMKRVGV
TDIVSVSACGSFKQELYPGLFVLVDQFVDRTQGRESSFFGNGCVVHVSMAHPVAPLLQKRIAAAATAEEIPFVSGGTYVC
MEGPQFSSGAESLGYKSQNFDVIGMTAMPEAKLAREAEISYATIAMVTDFDCWHPDHDHVDVASVIKVVQANAANAARLL
ARLLADFPDQHEPCPIGSDRALDNAFLTAPDARDPDLLQKLDAIMQRINAK
>Mature_290_residues
SKAVVGIIGGSGVYDLPGLKDLREERVKTPWGEPSDALRFGRIGDTEAVFLPRHGRGHVYSPSGINYRANIDAMKRVGVT
DIVSVSACGSFKQELYPGLFVLVDQFVDRTQGRESSFFGNGCVVHVSMAHPVAPLLQKRIAAAATAEEIPFVSGGTYVCM
EGPQFSSGAESLGYKSQNFDVIGMTAMPEAKLAREAEISYATIAMVTDFDCWHPDHDHVDVASVIKVVQANAANAARLLA
RLLADFPDQHEPCPIGSDRALDNAFLTAPDARDPDLLQKLDAIMQRINAK

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=240, Percent_Identity=44.5833333333333, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI71980569, Length=249, Percent_Identity=42.1686746987952, Blast_Score=177, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6323045, Length=296, Percent_Identity=33.7837837837838, Blast_Score=153, Evalue=4e-38,
Organism=Drosophila melanogaster, GI20130079, Length=241, Percent_Identity=40.6639004149378, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI221459247, Length=240, Percent_Identity=32.0833333333333, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 31461; Mature: 31330

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAVVGIIGGSGVYDLPGLKDLREERVKTPWGEPSDALRFGRIGDTEAVFLPRHGRGHV
CCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCHHHHEECCCCCCCEEEEECCCCCCE
YSPSGINYRANIDAMKRVGVTDIVSVSACGSFKQELYPGLFVLVDQFVDRTQGRESSFFG
ECCCCCCEEECHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCC
NGCVVHVSMAHPVAPLLQKRIAAAATAEEIPFVSGGTYVCMEGPQFSSGAESLGYKSQNF
CCEEEEEECCCCHHHHHHHHHHHHHHHHHCCEECCCEEEEECCCCCCCCHHHHCCCCCCC
DVIGMTAMPEAKLAREAEISYATIAMVTDFDCWHPDHDHVDVASVIKVVQANAANAARLL
EEEEECCCCHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHH
ARLLADFPDQHEPCPIGSDRALDNAFLTAPDARDPDLLQKLDAIMQRINAK
HHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKAVVGIIGGSGVYDLPGLKDLREERVKTPWGEPSDALRFGRIGDTEAVFLPRHGRGHV
CCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCHHHHEECCCCCCCEEEEECCCCCCE
YSPSGINYRANIDAMKRVGVTDIVSVSACGSFKQELYPGLFVLVDQFVDRTQGRESSFFG
ECCCCCCEEECHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCC
NGCVVHVSMAHPVAPLLQKRIAAAATAEEIPFVSGGTYVCMEGPQFSSGAESLGYKSQNF
CCEEEEEECCCCHHHHHHHHHHHHHHHHHCCEECCCEEEEECCCCCCCCHHHHCCCCCCC
DVIGMTAMPEAKLAREAEISYATIAMVTDFDCWHPDHDHVDVASVIKVVQANAANAARLL
EEEEECCCCHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHH
ARLLADFPDQHEPCPIGSDRALDNAFLTAPDARDPDLLQKLDAIMQRINAK
HHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA