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The map label for this gene is apt

Identifier: 182677160

GI number: 182677160

Start: 189054

End: 189593

Strand: Direct

Name: apt

Synonym: Bind_0159

Alternate gene names: 182677160

Gene position: 189054-189593 (Clockwise)

Preceding gene: 182677159

Following gene: 182677161

Centisome position: 4.53

GC content: 58.7

Gene sequence:

>540_bases
ATGAACAAGCCCATCGATTTGAAAAGCGCGATCCGTACGATCTCCAATTATCCCAAGCCAGGCATAGAATTTCGCGACAT
CACCACTTTGCTTGGTGATGCTCGCGCCTTTCGCCGCGCGGTCGATGAATTGGTCCAGCCTTGGGCCGGGACCAAGGTCG
ACAAGATCGCCGGCATGGAGGCGCGCGGCTTCATTCTGGGCGGCGCGGTGGCGCATCAGCTTTCCGCCGGCTTCGTGCCG
ATCCGCAAGAAAGGCAAGCTGCCTCATACCACTGTCTCGATCGCCTATTCATTGGAATATGGTCTCGACGAGATGGAGAT
TCATGCCGATGCTGTGGTGAAGGGCGAGAAGGTCATCCTTGTCGATGATTTGATCGCCACCGGCGGCACGGCGACCGGCG
CTGTCGGTTTGTTGCAGAAGCTCGGCGCGGAAGTCATCGCCGCCTGTTTCGTGATCGACCTGCCCGATCTTGGCGGAGCC
AAGAAGATCGAGGCGCTCGGCGTGCCGGTGCGCAGCCTGATCTCTTTTGAAGGGCATTAA

Upstream 100 bases:

>100_bases
CCGATCGCGCGCTTGATAATGCCTTTTTGACGGCGCCCGACGCGCGCGACCCGGATCTTCTGCAAAAGCTCGATGCCATC
ATGCAACGGATCAATGCGAA

Downstream 100 bases:

>100_bases
ACAGCTTCGGGAATGTCGCGCGCCAATCCAAACAATCGGAGGTCAGGATGGATATGCGGCCGGTCTTTCTCTTCGACCTT
GATGGAACGCTTGTCGATAG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MNKPIDLKSAIRTISNYPKPGIEFRDITTLLGDARAFRRAVDELVQPWAGTKVDKIAGMEARGFILGGAVAHQLSAGFVP
IRKKGKLPHTTVSIAYSLEYGLDEMEIHADAVVKGEKVILVDDLIATGGTATGAVGLLQKLGAEVIAACFVIDLPDLGGA
KKIEALGVPVRSLISFEGH

Sequences:

>Translated_179_residues
MNKPIDLKSAIRTISNYPKPGIEFRDITTLLGDARAFRRAVDELVQPWAGTKVDKIAGMEARGFILGGAVAHQLSAGFVP
IRKKGKLPHTTVSIAYSLEYGLDEMEIHADAVVKGEKVILVDDLIATGGTATGAVGLLQKLGAEVIAACFVIDLPDLGGA
KKIEALGVPVRSLISFEGH
>Mature_179_residues
MNKPIDLKSAIRTISNYPKPGIEFRDITTLLGDARAFRRAVDELVQPWAGTKVDKIAGMEARGFILGGAVAHQLSAGFVP
IRKKGKLPHTTVSIAYSLEYGLDEMEIHADAVVKGEKVILVDDLIATGGTATGAVGLLQKLGAEVIAACFVIDLPDLGGA
KKIEALGVPVRSLISFEGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=174, Percent_Identity=42.5287356321839, Blast_Score=139, Evalue=9e-34,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=44.8, Blast_Score=113, Evalue=8e-26,
Organism=Escherichia coli, GI1786675, Length=173, Percent_Identity=50.8670520231214, Blast_Score=186, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI17509087, Length=174, Percent_Identity=41.9540229885057, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323619, Length=174, Percent_Identity=38.5057471264368, Blast_Score=108, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6320649, Length=173, Percent_Identity=34.6820809248555, Blast_Score=95, Evalue=8e-21,
Organism=Drosophila melanogaster, GI17136334, Length=172, Percent_Identity=40.1162790697674, Blast_Score=115, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_BEII9 (B2IBU5)

Other databases:

- EMBL:   CP001016
- RefSeq:   YP_001831306.1
- ProteinModelPortal:   B2IBU5
- GeneID:   6201455
- GenomeReviews:   CP001016_GR
- KEGG:   bid:Bind_0159
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18972; Mature: 18972

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKPIDLKSAIRTISNYPKPGIEFRDITTLLGDARAFRRAVDELVQPWAGTKVDKIAGME
CCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCC
ARGFILGGAVAHQLSAGFVPIRKKGKLPHTTVSIAYSLEYGLDEMEIHADAVVKGEKVIL
CCCEEEHHHHHHHHHCCCCEECCCCCCCCEEEEEEEEECCCCCHHHHHHHHEECCCEEEE
VDDLIATGGTATGAVGLLQKLGAEVIAACFVIDLPDLGGAKKIEALGVPVRSLISFEGH
EECHHHCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHCCCHHHHHCCCCC
>Mature Secondary Structure
MNKPIDLKSAIRTISNYPKPGIEFRDITTLLGDARAFRRAVDELVQPWAGTKVDKIAGME
CCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCC
ARGFILGGAVAHQLSAGFVPIRKKGKLPHTTVSIAYSLEYGLDEMEIHADAVVKGEKVIL
CCCEEEHHHHHHHHHCCCCEECCCCCCCCEEEEEEEEECCCCCHHHHHHHHEECCCEEEE
VDDLIATGGTATGAVGLLQKLGAEVIAACFVIDLPDLGGAKKIEALGVPVRSLISFEGH
EECHHHCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA