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The map label for this gene is hutC [H]

Identifier: 17547367

GI number: 17547367

Start: 2849841

End: 2850554

Strand: Direct

Name: hutC [H]

Synonym: RSc2648

Alternate gene names: 17547367

Gene position: 2849841-2850554 (Clockwise)

Preceding gene: 17547360

Following gene: 17547369

Centisome position: 76.68

GC content: 68.91

Gene sequence:

>714_bases
ATGCCCCCGCGTCAATCCGCCCCCACGCCCGCCTTCCAGCGCATCAAGGAAGACATCCTGTCGCGCATCCGCAGCGGCGA
ATGGCAGGAAGGCGAGATGATTCCTGGAGAGACCACGCTGGCGCAGACCTTCGACGTCTCGCGCATGACGGTCAACCGCG
CGCTGCGCGAGCTGACCGCCGATCAGATCCTCACGCGCGTGCAGGGCTCGGGAACGTTCGTCGCGCAGCAGAAGTACCAG
GCGACGCTGGTGGCGATCCGCAACATCGCCGAGGAGGTCGCCGCGCGCGGCCACCGGCACCGCGCCGAGCTGCACAAGCT
CGAACGCGTGCGCGCCACCGAGGGGATGGCCGCGCCGTTCGGCGTGCCGGCCGGGCGCACGCTGTTCCATTCGCTGATCG
TGCACTTCGAGAACGATGCGCCGATCCAGGTGGAAGACCGCTGGGTCAGCGCCGAGCTGGCGCCCGACTACATGGAACAG
GATTTCACGCAGACCACGCCCAATGCCTACCTGATGCGGGCCGCCCCGCTGCAGGGCGTGGAGTACCGGATCGAGGCGCG
GCTGCCGCCGCGCGAGATCGCCGAGATGCTGCGCATGGACGTGCGCGAGCCCTGCCTGATGCTGCGGCGCAAGACGCTGT
CGCAGGGCCAGGTCGCCTCGGTGGCGACCATGTGGCACCCGGGCGAGCGGTATCAGTTCACGGGGAGTTTCTGA

Upstream 100 bases:

>100_bases
CTATGTTGTATATACAAATAAATCAAGGCAACTTTACAACTCACCGGCAAACCCGGATCATGCTGCCAGCCATCCGCCAC
CTCCACCTTCCGGTCGCCCC

Downstream 100 bases:

>100_bases
GGCGGGCCGGGCCGGCCCCGGTCAATGCTGGCTGAGCGTGCTGGACAGCAGCTTGGCCGTGATGTCCACGATCGGGATCA
CGCGCTCGTAGGCCATCCGC

Product: histidine utilization repressor transcription regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MPPRQSAPTPAFQRIKEDILSRIRSGEWQEGEMIPGETTLAQTFDVSRMTVNRALRELTADQILTRVQGSGTFVAQQKYQ
ATLVAIRNIAEEVAARGHRHRAELHKLERVRATEGMAAPFGVPAGRTLFHSLIVHFENDAPIQVEDRWVSAELAPDYMEQ
DFTQTTPNAYLMRAAPLQGVEYRIEARLPPREIAEMLRMDVREPCLMLRRKTLSQGQVASVATMWHPGERYQFTGSF

Sequences:

>Translated_237_residues
MPPRQSAPTPAFQRIKEDILSRIRSGEWQEGEMIPGETTLAQTFDVSRMTVNRALRELTADQILTRVQGSGTFVAQQKYQ
ATLVAIRNIAEEVAARGHRHRAELHKLERVRATEGMAAPFGVPAGRTLFHSLIVHFENDAPIQVEDRWVSAELAPDYMEQ
DFTQTTPNAYLMRAAPLQGVEYRIEARLPPREIAEMLRMDVREPCLMLRRKTLSQGQVASVATMWHPGERYQFTGSF
>Mature_236_residues
PPRQSAPTPAFQRIKEDILSRIRSGEWQEGEMIPGETTLAQTFDVSRMTVNRALRELTADQILTRVQGSGTFVAQQKYQA
TLVAIRNIAEEVAARGHRHRAELHKLERVRATEGMAAPFGVPAGRTLFHSLIVHFENDAPIQVEDRWVSAELAPDYMEQD
FTQTTPNAYLMRAAPLQGVEYRIEARLPPREIAEMLRMDVREPCLMLRRKTLSQGQVASVATMWHPGERYQFTGSF

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082252, Length=152, Percent_Identity=29.6052631578947, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1788418, Length=211, Percent_Identity=27.0142180094787, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1786950, Length=228, Percent_Identity=25, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1790118, Length=225, Percent_Identity=23.5555555555556, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 26916; Mature: 26785

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPRQSAPTPAFQRIKEDILSRIRSGEWQEGEMIPGETTLAQTFDVSRMTVNRALRELTA
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DQILTRVQGSGTFVAQQKYQATLVAIRNIAEEVAARGHRHRAELHKLERVRATEGMAAPF
HHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCC
GVPAGRTLFHSLIVHFENDAPIQVEDRWVSAELAPDYMEQDFTQTTPNAYLMRAAPLQGV
CCCCHHHHHHHHHHHCCCCCCEEEECCEEECCCCHHHHHHHHHCCCCCCEEEECCCCCCC
EYRIEARLPPREIAEMLRMDVREPCLMLRRKTLSQGQVASVATMWHPGERYQFTGSF
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEECCCC
>Mature Secondary Structure 
PPRQSAPTPAFQRIKEDILSRIRSGEWQEGEMIPGETTLAQTFDVSRMTVNRALRELTA
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DQILTRVQGSGTFVAQQKYQATLVAIRNIAEEVAARGHRHRAELHKLERVRATEGMAAPF
HHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCC
GVPAGRTLFHSLIVHFENDAPIQVEDRWVSAELAPDYMEQDFTQTTPNAYLMRAAPLQGV
CCCCHHHHHHHHHHHCCCCCCEEEECCEEECCCCHHHHHHHHHCCCCCCEEEECCCCCCC
EYRIEARLPPREIAEMLRMDVREPCLMLRRKTLSQGQVASVATMWHPGERYQFTGSF
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]