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The map label for this gene is folK [H]

Identifier: 17547347

GI number: 17547347

Start: 2831376

End: 2831885

Strand: Direct

Name: folK [H]

Synonym: RSc2628

Alternate gene names: 17547347

Gene position: 2831376-2831885 (Clockwise)

Preceding gene: 17547346

Following gene: 17547348

Centisome position: 76.19

GC content: 68.24

Gene sequence:

>510_bases
ATGACAGTGGCGTATATCGGCATCGGCGCCAACCTCGGCGACGCGCGCCAGGCCGTCAAAGACGCCGTGGTCTGCCTCGC
GCAGCAGGTGGGCATCAGCATCACCGGCAAGTCCAGCCTGTACCGCAGTGCCCCGGTGGACGCCACCGGCGACGACTACA
TCAATGCCGTGGTGCGCATCGATACGCACTTCACCGCCGGCCAGCTGCTGCGCATCTGCCACCATATCGAAGACCAGTTC
GGCCGCGAACGCCCGTTCCGCAACGCACCGCGCACGCTGGACCTGGACCTGCTGCTGTACGGCGACCAGACCCTCACCTC
GCCCGAGCTGACCGTGCCGCATCCGCGCGTCGGACAGCGTGCCTTTACCCTGCTGCCGCTGCACGAACTGGCGCCGGATC
TCGTCATCCCCGGCATCGGCGCCGTGGCGGCACTGCTGCCGGGCGTCGCCGACCAGGTCATCGAGAAGATGACGCTGTGC
CAGTGCATGCGCGCCAAGCCGGCCGCCTGA

Upstream 100 bases:

>100_bases
CCGGGGGCGCCCCCGCGGGCGCCAAGCGCCGCCGCCGGCGTGGTCCGGCAAAATCGGATACAGTCGCCGACGTGAACCCG
GGCAGTTCGGAGGGAACGTG

Downstream 100 bases:

>100_bases
CACCTCTTTTCCACTCTCCCGAATCCAGACGCGATGGCACTCGATCATCTGCGCCGCATCGTCGTCGAAGGGCCGATCGG
CGCCGGCAAGACGGCATTGG

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 169; Mature: 168

Protein sequence:

>169_residues
MTVAYIGIGANLGDARQAVKDAVVCLAQQVGISITGKSSLYRSAPVDATGDDYINAVVRIDTHFTAGQLLRICHHIEDQF
GRERPFRNAPRTLDLDLLLYGDQTLTSPELTVPHPRVGQRAFTLLPLHELAPDLVIPGIGAVAALLPGVADQVIEKMTLC
QCMRAKPAA

Sequences:

>Translated_169_residues
MTVAYIGIGANLGDARQAVKDAVVCLAQQVGISITGKSSLYRSAPVDATGDDYINAVVRIDTHFTAGQLLRICHHIEDQF
GRERPFRNAPRTLDLDLLLYGDQTLTSPELTVPHPRVGQRAFTLLPLHELAPDLVIPGIGAVAALLPGVADQVIEKMTLC
QCMRAKPAA
>Mature_168_residues
TVAYIGIGANLGDARQAVKDAVVCLAQQVGISITGKSSLYRSAPVDATGDDYINAVVRIDTHFTAGQLLRICHHIEDQFG
RERPFRNAPRTLDLDLLLYGDQTLTSPELTVPHPRVGQRAFTLLPLHELAPDLVIPGIGAVAALLPGVADQVIEKMTLCQ
CMRAKPAA

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=139, Percent_Identity=42.4460431654676, Blast_Score=102, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324073, Length=136, Percent_Identity=33.0882352941176, Blast_Score=87, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18179; Mature: 18048

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVAYIGIGANLGDARQAVKDAVVCLAQQVGISITGKSSLYRSAPVDATGDDYINAVVRI
CEEEEEEECCCCCHHHHHHHHHHHHHHHHHCEEEECCCHHHCCCCCCCCCHHHEEEEEEE
DTHFTAGQLLRICHHIEDQFGRERPFRNAPRTLDLDLLLYGDQTLTSPELTVPHPRVGQR
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCH
AFTLLPLHELAPDLVIPGIGAVAALLPGVADQVIEKMTLCQCMRAKPAA
HHHEEEHHHHCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TVAYIGIGANLGDARQAVKDAVVCLAQQVGISITGKSSLYRSAPVDATGDDYINAVVRI
EEEEEEECCCCCHHHHHHHHHHHHHHHHHCEEEECCCHHHCCCCCCCCCHHHEEEEEEE
DTHFTAGQLLRICHHIEDQFGRERPFRNAPRTLDLDLLLYGDQTLTSPELTVPHPRVGQR
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCH
AFTLLPLHELAPDLVIPGIGAVAALLPGVADQVIEKMTLCQCMRAKPAA
HHHEEEHHHHCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9168622 [H]