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The map label for this gene is fadA [H]

Identifier: 17546480

GI number: 17546480

Start: 1887189

End: 1888367

Strand: Direct

Name: fadA [H]

Synonym: RSc1761

Alternate gene names: 17546480

Gene position: 1887189-1888367 (Clockwise)

Preceding gene: 17546479

Following gene: 17546481

Centisome position: 50.78

GC content: 68.53

Gene sequence:

>1179_bases
ATGACCGAAGCAGTGATCGTTTCCACCGCACGTACGGGCCTGGCCAAGAGCTGGAAGGGCGCCTTCAACATGACGCACGG
CGCCACCATGGGCGGCCACGTGGTCAAGCACGCCATCGAGCGCGCCAAGCTCGAGCCGGGCGAAGTTGAGGACGTGCTGA
TGGGCTGCGCCAACCCGGAAGGCGCGACCGGCGCCAATATCGCGCGCCAGATCGCGCTGCGCGCCGGCTGTCCCGTCACC
GTGCCGGGCGCGACCGTCAACCGTTTCTGCTCGTCGGGCCTGCAGACCATCGCCATGGCCGCGCAGCGCGTGATCGCCGA
TGAAGGCGACATCTTCGTGGCCGGCGGCGTGGAATCCATCTCGTGCGTGCAGCAGGAGATGAACCGCCACATGATGACCG
AGGGCTGGCTCAACCGGCACAAGCCCGAGATCTACTGGAGCATGCTGCAGACGGCCGAGACCGTCGCTAAGCGCTACAAC
ATTTCGAAGGCGCGCCAGGACGAATACGGCGTGCAGAGCCAGCTGCGCGCCGCCGCCGCTGCCGCCGCGGGCAAGTTCAA
CGACGAAATCGTGCCGATCACGGTGACGATGGGCGTGGCCGACGCCAAGACCGGCCAGCTCGGCACGCGCGAGGTGACCC
TCTCCGCCGACGAAGGCATCCGCCCGGACACCACGCTCGAAGGCGTGTCCAAGATCCGCACGGCCATGCCGGGCGGCGTC
GTCACCGCCGGCAATGCCAGCCAGTTCTCCGACGGTGCCTCGGCGGCCGTGGTGATGAACGGCAAGGTGGCGGCCGCCCG
CGGCCTGCAGCCGCTGGGTGTGTTCCGCGGTTTCGCCGTGGCCGGCTGCGAGCCGGATGAAATGGGGATCGGCCCGGTGT
TCGCCGTGCCCAAGCTGCTCAGGAAGGCGGGCCTGAAGGTCGAGGACATCGGCCTGTGGGAGCTGAACGAGGCGTTCGCC
GTGCAGGTGCTGTATTGCGCCGACACGCTCGGCATTCCGATGGATCGCCTGAACGTCAACGGCGGCGCCATTGCCGTGGG
CCATCCTTACGGCGTGTCGGGCGCGCGCCTGGTCGGCCACGCCCTGATCGAAGGCAAGCGCCGCGGCGTCAAGTACGTGG
TCGTGACCATGTGCATCGGCGGTGGCCAGGGCGCGGCGGGCCTGTTCGAGGTGCTCTGA

Upstream 100 bases:

>100_bases
ATCGCGCGATTGCAGTCGCGCGACGTCTTGAACGGATAACGGAATACCAGAGCGCGCCTGCGAACGCAGCGCGCCGCCAC
CAGATACGAGGAGCACCACC

Downstream 100 bases:

>100_bases
GGCCCCAGGCTCCCGCGCCGCGCGGGAGCCCGCTTCGCTTCGTCGCCCCGTGCGCGGCCGCTCGGCGCAGGGGCGGCATG
GATCGCCTGTCCGGAACCCA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MTEAVIVSTARTGLAKSWKGAFNMTHGATMGGHVVKHAIERAKLEPGEVEDVLMGCANPEGATGANIARQIALRAGCPVT
VPGATVNRFCSSGLQTIAMAAQRVIADEGDIFVAGGVESISCVQQEMNRHMMTEGWLNRHKPEIYWSMLQTAETVAKRYN
ISKARQDEYGVQSQLRAAAAAAAGKFNDEIVPITVTMGVADAKTGQLGTREVTLSADEGIRPDTTLEGVSKIRTAMPGGV
VTAGNASQFSDGASAAVVMNGKVAAARGLQPLGVFRGFAVAGCEPDEMGIGPVFAVPKLLRKAGLKVEDIGLWELNEAFA
VQVLYCADTLGIPMDRLNVNGGAIAVGHPYGVSGARLVGHALIEGKRRGVKYVVVTMCIGGGQGAAGLFEVL

Sequences:

>Translated_392_residues
MTEAVIVSTARTGLAKSWKGAFNMTHGATMGGHVVKHAIERAKLEPGEVEDVLMGCANPEGATGANIARQIALRAGCPVT
VPGATVNRFCSSGLQTIAMAAQRVIADEGDIFVAGGVESISCVQQEMNRHMMTEGWLNRHKPEIYWSMLQTAETVAKRYN
ISKARQDEYGVQSQLRAAAAAAAGKFNDEIVPITVTMGVADAKTGQLGTREVTLSADEGIRPDTTLEGVSKIRTAMPGGV
VTAGNASQFSDGASAAVVMNGKVAAARGLQPLGVFRGFAVAGCEPDEMGIGPVFAVPKLLRKAGLKVEDIGLWELNEAFA
VQVLYCADTLGIPMDRLNVNGGAIAVGHPYGVSGARLVGHALIEGKRRGVKYVVVTMCIGGGQGAAGLFEVL
>Mature_391_residues
TEAVIVSTARTGLAKSWKGAFNMTHGATMGGHVVKHAIERAKLEPGEVEDVLMGCANPEGATGANIARQIALRAGCPVTV
PGATVNRFCSSGLQTIAMAAQRVIADEGDIFVAGGVESISCVQQEMNRHMMTEGWLNRHKPEIYWSMLQTAETVAKRYNI
SKARQDEYGVQSQLRAAAAAAAGKFNDEIVPITVTMGVADAKTGQLGTREVTLSADEGIRPDTTLEGVSKIRTAMPGGVV
TAGNASQFSDGASAAVVMNGKVAAARGLQPLGVFRGFAVAGCEPDEMGIGPVFAVPKLLRKAGLKVEDIGLWELNEAFAV
QVLYCADTLGIPMDRLNVNGGAIAVGHPYGVSGARLVGHALIEGKRRGVKYVVVTMCIGGGQGAAGLFEVL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=42.8571428571429, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI167614485, Length=367, Percent_Identity=38.9645776566758, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI4557237, Length=403, Percent_Identity=36.7245657568238, Blast_Score=235, Evalue=6e-62,
Organism=Homo sapiens, GI148539872, Length=394, Percent_Identity=34.7715736040609, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI4504327, Length=412, Percent_Identity=30.0970873786408, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI194353979, Length=390, Percent_Identity=31.7948717948718, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1787663, Length=409, Percent_Identity=38.8753056234719, Blast_Score=246, Evalue=1e-66,
Organism=Escherichia coli, GI48994986, Length=396, Percent_Identity=39.1414141414141, Blast_Score=242, Evalue=3e-65,
Organism=Escherichia coli, GI1788554, Length=409, Percent_Identity=40.3422982885086, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI87082165, Length=409, Percent_Identity=35.9413202933985, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1788683, Length=420, Percent_Identity=28.5714285714286, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI133906874, Length=397, Percent_Identity=37.27959697733, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17535921, Length=405, Percent_Identity=36.7901234567901, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17551802, Length=437, Percent_Identity=30.2059496567506, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI25147385, Length=398, Percent_Identity=31.1557788944724, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17535917, Length=391, Percent_Identity=26.3427109974425, Blast_Score=133, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=37.3737373737374, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6325229, Length=403, Percent_Identity=30.5210918114144, Blast_Score=169, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24655093, Length=405, Percent_Identity=40, Blast_Score=254, Evalue=6e-68,
Organism=Drosophila melanogaster, GI17648125, Length=358, Percent_Identity=38.5474860335196, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24640423, Length=403, Percent_Identity=34.7394540942928, Blast_Score=217, Evalue=9e-57,
Organism=Drosophila melanogaster, GI17137578, Length=417, Percent_Identity=30.2158273381295, Blast_Score=171, Evalue=6e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 40906; Mature: 40774

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAVIVSTARTGLAKSWKGAFNMTHGATMGGHVVKHAIERAKLEPGEVEDVLMGCANPE
CCCEEEEECHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCC
GATGANIARQIALRAGCPVTVPGATVNRFCSSGLQTIAMAAQRVIADEGDIFVAGGVESI
CCCHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
SCVQQEMNRHMMTEGWLNRHKPEIYWSMLQTAETVAKRYNISKARQDEYGVQSQLRAAAA
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AAAGKFNDEIVPITVTMGVADAKTGQLGTREVTLSADEGIRPDTTLEGVSKIRTAMPGGV
HHCCCCCCCEEEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCE
VTAGNASQFSDGASAAVVMNGKVAAARGLQPLGVFRGFAVAGCEPDEMGIGPVFAVPKLL
EECCCCHHCCCCCCEEEEECCCCHHHCCCCHHHHHCCCEEECCCCCCCCCCHHHHHHHHH
RKAGLKVEDIGLWELNEAFAVQVLYCADTLGIPMDRLNVNGGAIAVGHPYGVSGARLVGH
HHCCCCEEECCCEECCHHHEEEEEEEHHHHCCCHHHEECCCCEEEECCCCCCCHHHHHHH
ALIEGKRRGVKYVVVTMCIGGGQGAAGLFEVL
HHHHHCCCCCEEEEEEEEECCCCCCCHHHHCC
>Mature Secondary Structure 
TEAVIVSTARTGLAKSWKGAFNMTHGATMGGHVVKHAIERAKLEPGEVEDVLMGCANPE
CCEEEEECHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCC
GATGANIARQIALRAGCPVTVPGATVNRFCSSGLQTIAMAAQRVIADEGDIFVAGGVESI
CCCHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
SCVQQEMNRHMMTEGWLNRHKPEIYWSMLQTAETVAKRYNISKARQDEYGVQSQLRAAAA
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AAAGKFNDEIVPITVTMGVADAKTGQLGTREVTLSADEGIRPDTTLEGVSKIRTAMPGGV
HHCCCCCCCEEEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCE
VTAGNASQFSDGASAAVVMNGKVAAARGLQPLGVFRGFAVAGCEPDEMGIGPVFAVPKLL
EECCCCHHCCCCCCEEEEECCCCHHHCCCCHHHHHCCCEEECCCCCCCCCCHHHHHHHHH
RKAGLKVEDIGLWELNEAFAVQVLYCADTLGIPMDRLNVNGGAIAVGHPYGVSGARLVGH
HHCCCCEEECCCEECCHHHEEEEEEEHHHHCCCHHHEECCCCEEEECCCCCCCHHHHHHH
ALIEGKRRGVKYVVVTMCIGGGQGAAGLFEVL
HHHHHCCCCCEEEEEEEEECCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]