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The map label for this gene is phbA [H]

Identifier: 17546351

GI number: 17546351

Start: 1753213

End: 1754394

Strand: Direct

Name: phbA [H]

Synonym: RSc1632

Alternate gene names: 17546351

Gene position: 1753213-1754394 (Clockwise)

Preceding gene: 17546350

Following gene: 17546352

Centisome position: 47.17

GC content: 68.27

Gene sequence:

>1182_bases
ATGACCGATGTAGTGATCGTATCGGCGGTCCGTACCGCCGTGGGCAAGTTTGGCGGTTCGCTGGCGAAAATCCCCGCGCC
GGAGCTGGGTGCGGCCGTGATCCGCGAAGCGCTGTCGCGCGCCAAGGTGGCGCCGGATCAGGTCAGCGAAGTCATCATGG
GCCAGGTGCTGACCGCGGGTTCGGGCCAGAACCCGGCGCGCCAGGCGTTGATCAAGGCCGGCCTGCCCGACATGGTGCCG
GGCATGACCATCAACAAGGTGTGCGGCTCGGGCCTGAAGGCCGTGATGCTGGCCGCCAACGCCATCGTCGCCGGGGATGC
CGACATCGTCGTGGCCGGCGGGCAGGAGAACATGTCCGCCGCGCCGCACGTGCTGCCCGGCTCGCGCGACGGTTTCCGCA
TGGGCGACACCAAGCTCATCGACTCGATGATCGTGGATGGGCTGTGGGACGTCTACAACCAGTACCACATGGGCATCACC
GCCGAGAATGTCGCCAAGCAGTACGGCATCACGCGCGAGGCCCAGGACGCATTCGCCGTGGCTTCGCAGAACAAGGCGGA
AGCCGCGCAGAAGTCCGGTCGCTTCAATGACGAGATCGTTCCCATCCTGATTCCGCAGCGCAAGGGCGACCCGATCGCCT
TCGCGCAGGACGAGTTCGTCCGCCATGGCGCCACGCTGGAATCGATGACGGGCCTGAAGCCGGCATTCGACAAAGCCGGC
ACGGTGACGGCCGCCAATGCCTCGGGCCTCAACGACGGCGGCGCCGCCGTGGTGGTCATGTCGGCCGCCCGCGCCAAGGA
ACTGGGTCTGACCCCGCTGGCCACCATCCGCGCCTACGCCAATGCCGGCGTGGACCCGAAGGTGATGGGCATGGGCCCGG
TGCCGGCTTCCAAGCGCTGCCTGTCGCGCGCCGGCTGGTCGGTGGGCGACCTGGACCTGATGGAGATCAACGAGGCGTTT
GCCGCCCAGGCGCTGGCCGTGCACCAGCAGATGGGCTGGGATACCGCCAAGGTCAACGTCAACGGCGGCGCGATTGCCAT
CGGTCACCCCATCGGCGCGTCGGGCTGCCGCATCCTGGTGACGCTGCTGCACGAGATGCAGAAGCGCGACGCGAAGAAGG
GCCTGGCCTCGCTGTGCATCGGCGGCGGCATGGGCGTGGCGCTGGCGGTCGAGCGCCCGTGA

Upstream 100 bases:

>100_bases
ACGTCAAACAGAAAGCGTAATAGCGCGCGCGCCACGCCGTGGCGGATTGTGCGCGGACAGCGCTTCCCCCAACCTTTTTG
AGATCGTGGAAGGAAAGCAA

Downstream 100 bases:

>100_bases
GTTTTGCGTGAAGAACCGGCACGCGGTGGAATGAGCCCGCCGCGCGCCGGCCCCAGACACTGAAGCACCGCCATCCGGCA
AGCACCGGGCGGCGCCAACA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTDVVIVSAVRTAVGKFGGSLAKIPAPELGAAVIREALSRAKVAPDQVSEVIMGQVLTAGSGQNPARQALIKAGLPDMVP
GMTINKVCGSGLKAVMLAANAIVAGDADIVVAGGQENMSAAPHVLPGSRDGFRMGDTKLIDSMIVDGLWDVYNQYHMGIT
AENVAKQYGITREAQDAFAVASQNKAEAAQKSGRFNDEIVPILIPQRKGDPIAFAQDEFVRHGATLESMTGLKPAFDKAG
TVTAANASGLNDGGAAVVVMSAARAKELGLTPLATIRAYANAGVDPKVMGMGPVPASKRCLSRAGWSVGDLDLMEINEAF
AAQALAVHQQMGWDTAKVNVNGGAIAIGHPIGASGCRILVTLLHEMQKRDAKKGLASLCIGGGMGVALAVERP

Sequences:

>Translated_393_residues
MTDVVIVSAVRTAVGKFGGSLAKIPAPELGAAVIREALSRAKVAPDQVSEVIMGQVLTAGSGQNPARQALIKAGLPDMVP
GMTINKVCGSGLKAVMLAANAIVAGDADIVVAGGQENMSAAPHVLPGSRDGFRMGDTKLIDSMIVDGLWDVYNQYHMGIT
AENVAKQYGITREAQDAFAVASQNKAEAAQKSGRFNDEIVPILIPQRKGDPIAFAQDEFVRHGATLESMTGLKPAFDKAG
TVTAANASGLNDGGAAVVVMSAARAKELGLTPLATIRAYANAGVDPKVMGMGPVPASKRCLSRAGWSVGDLDLMEINEAF
AAQALAVHQQMGWDTAKVNVNGGAIAIGHPIGASGCRILVTLLHEMQKRDAKKGLASLCIGGGMGVALAVERP
>Mature_392_residues
TDVVIVSAVRTAVGKFGGSLAKIPAPELGAAVIREALSRAKVAPDQVSEVIMGQVLTAGSGQNPARQALIKAGLPDMVPG
MTINKVCGSGLKAVMLAANAIVAGDADIVVAGGQENMSAAPHVLPGSRDGFRMGDTKLIDSMIVDGLWDVYNQYHMGITA
ENVAKQYGITREAQDAFAVASQNKAEAAQKSGRFNDEIVPILIPQRKGDPIAFAQDEFVRHGATLESMTGLKPAFDKAGT
VTAANASGLNDGGAAVVVMSAARAKELGLTPLATIRAYANAGVDPKVMGMGPVPASKRCLSRAGWSVGDLDLMEINEAFA
AQALAVHQQMGWDTAKVNVNGGAIAIGHPIGASGCRILVTLLHEMQKRDAKKGLASLCIGGGMGVALAVERP

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=56.2659846547315, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI167614485, Length=390, Percent_Identity=44.1025641025641, Blast_Score=318, Evalue=7e-87,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=44.0203562340967, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI4501853, Length=397, Percent_Identity=41.8136020151133, Blast_Score=274, Evalue=1e-73,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=31.3679245283019, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI194353979, Length=394, Percent_Identity=31.2182741116751, Blast_Score=159, Evalue=6e-39,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=59.1836734693878, Blast_Score=474, Evalue=1e-135,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=60.559796437659, Blast_Score=449, Evalue=1e-127,
Organism=Escherichia coli, GI1787663, Length=400, Percent_Identity=44.25, Blast_Score=319, Evalue=2e-88,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=42.14463840399, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI1788683, Length=409, Percent_Identity=34.718826405868, Blast_Score=214, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=45.1282051282051, Blast_Score=323, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI25147385, Length=387, Percent_Identity=41.0852713178295, Blast_Score=289, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17535921, Length=397, Percent_Identity=40.8060453400504, Blast_Score=268, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI17551802, Length=428, Percent_Identity=31.0747663551402, Blast_Score=187, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI17535917, Length=397, Percent_Identity=31.4861460957179, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6325229, Length=394, Percent_Identity=41.6243654822335, Blast_Score=293, Evalue=4e-80,
Organism=Saccharomyces cerevisiae, GI6322031, Length=393, Percent_Identity=38.676844783715, Blast_Score=226, Evalue=5e-60,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=57.1428571428571, Blast_Score=446, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=46.3104325699746, Blast_Score=323, Evalue=9e-89,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=44.1025641025641, Blast_Score=303, Evalue=1e-82,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=30.1176470588235, Blast_Score=176, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40496; Mature: 40365

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDVVIVSAVRTAVGKFGGSLAKIPAPELGAAVIREALSRAKVAPDQVSEVIMGQVLTAG
CCCEEEHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
SGQNPARQALIKAGLPDMVPGMTINKVCGSGLKAVMLAANAIVAGDADIVVAGGQENMSA
CCCCHHHHHHHHCCCCHHCCCCCHHHHHCCCHHHHHHHHCEEEECCCCEEEECCCCCCCC
APHVLPGSRDGFRMGDTKLIDSMIVDGLWDVYNQYHMGITAENVAKQYGITREAQDAFAV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHH
ASQNKAEAAQKSGRFNDEIVPILIPQRKGDPIAFAQDEFVRHGATLESMTGLKPAFDKAG
HCCCHHHHHHHCCCCCCCEEEEEECCCCCCCCEECHHHHHHCCCCHHHHCCCCCCCCCCC
TVTAANASGLNDGGAAVVVMSAARAKELGLTPLATIRAYANAGVDPKVMGMGPVPASKRC
CEEECCCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHCCCCCCEEEECCCCCHHHHH
LSRAGWSVGDLDLMEINEAFAAQALAVHQQMGWDTAKVNVNGGAIAIGHPIGASGCRILV
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCHHHHHH
TLLHEMQKRDAKKGLASLCIGGGMGVALAVERP
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure 
TDVVIVSAVRTAVGKFGGSLAKIPAPELGAAVIREALSRAKVAPDQVSEVIMGQVLTAG
CCEEEHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
SGQNPARQALIKAGLPDMVPGMTINKVCGSGLKAVMLAANAIVAGDADIVVAGGQENMSA
CCCCHHHHHHHHCCCCHHCCCCCHHHHHCCCHHHHHHHHCEEEECCCCEEEECCCCCCCC
APHVLPGSRDGFRMGDTKLIDSMIVDGLWDVYNQYHMGITAENVAKQYGITREAQDAFAV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHH
ASQNKAEAAQKSGRFNDEIVPILIPQRKGDPIAFAQDEFVRHGATLESMTGLKPAFDKAG
HCCCHHHHHHHCCCCCCCEEEEEECCCCCCCCEECHHHHHHCCCCHHHHCCCCCCCCCCC
TVTAANASGLNDGGAAVVVMSAARAKELGLTPLATIRAYANAGVDPKVMGMGPVPASKRC
CEEECCCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHCCCCCCEEEECCCCCHHHHH
LSRAGWSVGDLDLMEINEAFAAQALAVHQQMGWDTAKVNVNGGAIAIGHPIGASGCRILV
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCHHHHHH
TLLHEMQKRDAKKGLASLCIGGGMGVALAVERP
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2670935; 2670936 [H]