Click here to switch to the map view.

The map label for this gene is relA [H]

Identifier: 17546295

GI number: 17546295

Start: 1689822

End: 1692062

Strand: Direct

Name: relA [H]

Synonym: RSc1576

Alternate gene names: 17546295

Gene position: 1689822-1692062 (Clockwise)

Preceding gene: 17546294

Following gene: 17546296

Centisome position: 45.47

GC content: 68.18

Gene sequence:

>2241_bases
ATGAACAGCAAGACCGACCGTCCGGCAGAGGGCGCCGGCGCGACGGCCGACAGGGCGGCGCGCGAGGCGGCCGTCGCGCG
CGCGCTCGAATGCCTGGCCGACCATGCCGGCGACCACCAGACGCTGACCGGCGAGCCGCTGGTGTCGCACGCGCGCGGCA
CGGTGGCGATCCTCGAGGGGCTGCGCGTCGACGCGCCGTCGTTGCAGGCGGCGGCGCTGTTCCTGCTGCCGATCCTGGCC
ACCGACAACGAGAAGGCGATCGAGCCGGCGTTCGGCGGCGAGGTGGCCCGGCTGGTGCACGACGTGCGGCAGCTGCTGCG
CATCGGCGCGATCGCCGGCATGGCCAGCCCGGCCGAGGCGGGCGTCACCCGCAAGAACGAAGCCGAGGCGCGCCGCGCCC
AGGTCGAGGCGCTGCGCAAGATGCTGCTGGCCTTCGCGCAGGACATCCGCGTGGTGCTGATCCGCCTGGCGTCGCGGCTG
CAGTCGCTGCGCTGGCTGGCCCAGAACAAGCTGCCCGCCCCTGAGGGCATGGCGCGCGAGACGCTCGACATCTACGCGCC
GCTCGCCAACCGGCTCGGCATCTGGCAGCTGAAGTGGGAGCTCGAAGACCTGGGCTTCCGCTTCGAAGACCCCGATACCT
ACAAGCGCATCGCGCGCCTGCTGGACGAAAAGCGCATCGAGCGCGAGCAGTTCATCGGCGAGGCGATCGCCAGGCTGCAG
CAGACACTGCGCGACGCGGGCATCCACGCCGAGGTCAGCGGCCGCCCCAAGCACATCTACAGCATCTGGCGGAAGATGCG
CGGCAAGGACCTCGACTTCGCCGATCTGTACGATGTGCGCGCCTTCCGCGTCATCGTCGACGACATCAAGGACTGCTACA
CCGTGCTCGGCTTCGTGCACCACATGTGGCAGCCGATCCCGAAGGAGTTCGACGACTACATCTCGCGTCCCAAGACCAAT
GGCTACAAGTCGCTGCACACGGTGGTGATCGGTGACGACGGCCGCGCGCTGGAGGTGCAGATCCGCACGCGCGAAATGCA
CCACTTCGCCGAATACGGCGTGGCCGCGCACTGGCGCTACAAGGAGGCCGGCAGCAAGGGCTACGCCGGCCAGTTCTCCG
CCAGCGAGCGCTACGACGAGAAGATCGCCTGGCTGCGCCAGCTGCTGGCCTGGAAGGACGATGCCGAGCACACCGTCGCC
CAGGAAGACTCGCCGTGGGAGCAGCTCAAGCATACCGAGCTCGATGACCACATCTACGTGCTGACGCCGCAGGCGCGCGT
GATCGCGCTGCCGCAGGGCGCCACGCCGGTCGATTTCGCGTACTACCTGCACAGCGATCTCGGCCACCGGTGCCGCGGCG
CGCGCGTCGACGGCACGATGGTGCCGCTGAACACGCCGCTCAAGAACGGGCAGACGGTCGAGATCGTCACCGTCAAGCAG
GGTGGGCCGTCGCGCGACTGGCTCAACCCCGAACTGCACTATCTGGCGAGCAATCGGGCCCGTGCCAAGGTGCGCGCGTG
GTTCAACGCGCTGGAATTGGAAGAAACGCTCGCCCAGGGCCGCATCCTGATCGACAAGACCTTGCAGCGCGAAGGCAAGA
CCGCCGTCAACCTGGAGGAGCTCGCCGCCAAGCTGGGCTTCAAGACGCCGGACGAGCTGTACGCCATGGTGGCCAAGGAT
GAGTTCAGCTTGCGCCACGTCGAGGCGGTGCTGCGCACGGATGGCGCGCCGCCCGCGCCGGCCGACGACGAGGCGTCGAT
CACCAAGAAGAGCCGCGCCACCAGCGTGGCCCGCGGCGCCAAGAGCGGCGTGCTGGTGGTGGGGGTCGATTCGCTGCTCA
CGCAGATGTCGCGCTGCTGCAAGCCTGCGCCGCCGGACCTGATTGTCGGTTTCGTGACCCGTGGGCGCGGCGTGTCGATC
CACCGGCAGAATTGCGCGACGTTCCAGCAACTGGCGGCGCGCGCGCCGGGTCGCGTGATCCAGACCGAGTGGGGCAACCG
CGGCGAGGCGGTCTATCCGGTCGATATCCACGTCGAGGCGCTGGACCGCCAGGGGCTGCTGCGCGACATCTCGGAAATCC
TCTCGCGCGAGAAGATCAACGTGACCGGCGTGCGCACGCTGTCGAGCAAGGGCGTCGCCAAGATGCAGTTCACGGCCGAG
GTATCAGAAGCGACACAATTGCAACGGGCGCTGATATTAATCGAGGAAGTTACTGGGGTATTGTCAGCGCGGCGAAAGTG
A

Upstream 100 bases:

>100_bases
GCCACCGTGGAGGCCGCGCTGGCCAATCCGAAGTACCGCATCGAGATCGTCGTGACGGCGGCGCGCAAGGGCTGATCCGC
ATCCGTTTGCAAGACGCACT

Downstream 100 bases:

>100_bases
TGGTATAGTTTCGTCTTTCGGCAGGCTCGTAGCTCAGCTGGTTAGAGCACCACCTTGACATGGTGGGGGTCGTTGGTTCG
AGTCCAATCGAGCCTACCAA

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 746; Mature: 746

Protein sequence:

>746_residues
MNSKTDRPAEGAGATADRAAREAAVARALECLADHAGDHQTLTGEPLVSHARGTVAILEGLRVDAPSLQAAALFLLPILA
TDNEKAIEPAFGGEVARLVHDVRQLLRIGAIAGMASPAEAGVTRKNEAEARRAQVEALRKMLLAFAQDIRVVLIRLASRL
QSLRWLAQNKLPAPEGMARETLDIYAPLANRLGIWQLKWELEDLGFRFEDPDTYKRIARLLDEKRIEREQFIGEAIARLQ
QTLRDAGIHAEVSGRPKHIYSIWRKMRGKDLDFADLYDVRAFRVIVDDIKDCYTVLGFVHHMWQPIPKEFDDYISRPKTN
GYKSLHTVVIGDDGRALEVQIRTREMHHFAEYGVAAHWRYKEAGSKGYAGQFSASERYDEKIAWLRQLLAWKDDAEHTVA
QEDSPWEQLKHTELDDHIYVLTPQARVIALPQGATPVDFAYYLHSDLGHRCRGARVDGTMVPLNTPLKNGQTVEIVTVKQ
GGPSRDWLNPELHYLASNRARAKVRAWFNALELEETLAQGRILIDKTLQREGKTAVNLEELAAKLGFKTPDELYAMVAKD
EFSLRHVEAVLRTDGAPPAPADDEASITKKSRATSVARGAKSGVLVVGVDSLLTQMSRCCKPAPPDLIVGFVTRGRGVSI
HRQNCATFQQLAARAPGRVIQTEWGNRGEAVYPVDIHVEALDRQGLLRDISEILSREKINVTGVRTLSSKGVAKMQFTAE
VSEATQLQRALILIEEVTGVLSARRK

Sequences:

>Translated_746_residues
MNSKTDRPAEGAGATADRAAREAAVARALECLADHAGDHQTLTGEPLVSHARGTVAILEGLRVDAPSLQAAALFLLPILA
TDNEKAIEPAFGGEVARLVHDVRQLLRIGAIAGMASPAEAGVTRKNEAEARRAQVEALRKMLLAFAQDIRVVLIRLASRL
QSLRWLAQNKLPAPEGMARETLDIYAPLANRLGIWQLKWELEDLGFRFEDPDTYKRIARLLDEKRIEREQFIGEAIARLQ
QTLRDAGIHAEVSGRPKHIYSIWRKMRGKDLDFADLYDVRAFRVIVDDIKDCYTVLGFVHHMWQPIPKEFDDYISRPKTN
GYKSLHTVVIGDDGRALEVQIRTREMHHFAEYGVAAHWRYKEAGSKGYAGQFSASERYDEKIAWLRQLLAWKDDAEHTVA
QEDSPWEQLKHTELDDHIYVLTPQARVIALPQGATPVDFAYYLHSDLGHRCRGARVDGTMVPLNTPLKNGQTVEIVTVKQ
GGPSRDWLNPELHYLASNRARAKVRAWFNALELEETLAQGRILIDKTLQREGKTAVNLEELAAKLGFKTPDELYAMVAKD
EFSLRHVEAVLRTDGAPPAPADDEASITKKSRATSVARGAKSGVLVVGVDSLLTQMSRCCKPAPPDLIVGFVTRGRGVSI
HRQNCATFQQLAARAPGRVIQTEWGNRGEAVYPVDIHVEALDRQGLLRDISEILSREKINVTGVRTLSSKGVAKMQFTAE
VSEATQLQRALILIEEVTGVLSARRK
>Mature_746_residues
MNSKTDRPAEGAGATADRAAREAAVARALECLADHAGDHQTLTGEPLVSHARGTVAILEGLRVDAPSLQAAALFLLPILA
TDNEKAIEPAFGGEVARLVHDVRQLLRIGAIAGMASPAEAGVTRKNEAEARRAQVEALRKMLLAFAQDIRVVLIRLASRL
QSLRWLAQNKLPAPEGMARETLDIYAPLANRLGIWQLKWELEDLGFRFEDPDTYKRIARLLDEKRIEREQFIGEAIARLQ
QTLRDAGIHAEVSGRPKHIYSIWRKMRGKDLDFADLYDVRAFRVIVDDIKDCYTVLGFVHHMWQPIPKEFDDYISRPKTN
GYKSLHTVVIGDDGRALEVQIRTREMHHFAEYGVAAHWRYKEAGSKGYAGQFSASERYDEKIAWLRQLLAWKDDAEHTVA
QEDSPWEQLKHTELDDHIYVLTPQARVIALPQGATPVDFAYYLHSDLGHRCRGARVDGTMVPLNTPLKNGQTVEIVTVKQ
GGPSRDWLNPELHYLASNRARAKVRAWFNALELEETLAQGRILIDKTLQREGKTAVNLEELAAKLGFKTPDELYAMVAKD
EFSLRHVEAVLRTDGAPPAPADDEASITKKSRATSVARGAKSGVLVVGVDSLLTQMSRCCKPAPPDLIVGFVTRGRGVSI
HRQNCATFQQLAARAPGRVIQTEWGNRGEAVYPVDIHVEALDRQGLLRDISEILSREKINVTGVRTLSSKGVAKMQFTAE
VSEATQLQRALILIEEVTGVLSARRK

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=735, Percent_Identity=40.5442176870748, Blast_Score=548, Evalue=1e-157,
Organism=Escherichia coli, GI1790082, Length=693, Percent_Identity=34.6320346320346, Blast_Score=394, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 83049; Mature: 83049

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSKTDRPAEGAGATADRAAREAAVARALECLADHAGDHQTLTGEPLVSHARGTVAILEG
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHC
LRVDAPSLQAAALFLLPILATDNEKAIEPAFGGEVARLVHDVRQLLRIGAIAGMASPAEA
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHC
GVTRKNEAEARRAQVEALRKMLLAFAQDIRVVLIRLASRLQSLRWLAQNKLPAPEGMARE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
TLDIYAPLANRLGIWQLKWELEDLGFRFEDPDTYKRIARLLDEKRIEREQFIGEAIARLQ
HHHHHHHHHHCCCEEEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QTLRDAGIHAEVSGRPKHIYSIWRKMRGKDLDFADLYDVRAFRVIVDDIKDCYTVLGFVH
HHHHHCCCEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HMWQPIPKEFDDYISRPKTNGYKSLHTVVIGDDGRALEVQIRTREMHHFAEYGVAAHWRY
HHHCCCCHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEEEEHHHHHHHHHCCCCEEEEE
KEAGSKGYAGQFSASERYDEKIAWLRQLLAWKDDAEHTVAQEDSPWEQLKHTELDDHIYV
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHCCCCCCEEEE
LTPQARVIALPQGATPVDFAYYLHSDLGHRCRGARVDGTMVPLNTPLKNGQTVEIVTVKQ
ECCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCEEEEEEEEC
GGPSRDWLNPELHYLASNRARAKVRAWFNALELEETLAQGRILIDKTLQREGKTAVNLEE
CCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHCCCCCCCHHH
LAAKLGFKTPDELYAMVAKDEFSLRHVEAVLRTDGAPPAPADDEASITKKSRATSVARGA
HHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCC
KSGVLVVGVDSLLTQMSRCCKPAPPDLIVGFVTRGRGVSIHRQNCATFQQLAARAPGRVI
CCCEEEEEHHHHHHHHHHHCCCCCCHHEEEEEECCCCCEEEHHHHHHHHHHHHCCCCCEE
QTEWGNRGEAVYPVDIHVEALDRQGLLRDISEILSREKINVTGVRTLSSKGVAKMQFTAE
EECCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEHHH
VSEATQLQRALILIEEVTGVLSARRK
HHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNSKTDRPAEGAGATADRAAREAAVARALECLADHAGDHQTLTGEPLVSHARGTVAILEG
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHC
LRVDAPSLQAAALFLLPILATDNEKAIEPAFGGEVARLVHDVRQLLRIGAIAGMASPAEA
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHC
GVTRKNEAEARRAQVEALRKMLLAFAQDIRVVLIRLASRLQSLRWLAQNKLPAPEGMARE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
TLDIYAPLANRLGIWQLKWELEDLGFRFEDPDTYKRIARLLDEKRIEREQFIGEAIARLQ
HHHHHHHHHHCCCEEEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QTLRDAGIHAEVSGRPKHIYSIWRKMRGKDLDFADLYDVRAFRVIVDDIKDCYTVLGFVH
HHHHHCCCEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HMWQPIPKEFDDYISRPKTNGYKSLHTVVIGDDGRALEVQIRTREMHHFAEYGVAAHWRY
HHHCCCCHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEEEEHHHHHHHHHCCCCEEEEE
KEAGSKGYAGQFSASERYDEKIAWLRQLLAWKDDAEHTVAQEDSPWEQLKHTELDDHIYV
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHCCCCCCEEEE
LTPQARVIALPQGATPVDFAYYLHSDLGHRCRGARVDGTMVPLNTPLKNGQTVEIVTVKQ
ECCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCEEEEEEEEC
GGPSRDWLNPELHYLASNRARAKVRAWFNALELEETLAQGRILIDKTLQREGKTAVNLEE
CCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHCCCCCCCHHH
LAAKLGFKTPDELYAMVAKDEFSLRHVEAVLRTDGAPPAPADDEASITKKSRATSVARGA
HHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCC
KSGVLVVGVDSLLTQMSRCCKPAPPDLIVGFVTRGRGVSIHRQNCATFQQLAARAPGRVI
CCCEEEEEHHHHHHHHHHHCCCCCCHHEEEEEECCCCCEEEHHHHHHHHHHHHCCCCCEE
QTEWGNRGEAVYPVDIHVEALDRQGLLRDISEILSREKINVTGVRTLSSKGVAKMQFTAE
EECCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEHHH
VSEATQLQRALILIEEVTGVLSARRK
HHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7928955 [H]