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The map label for this gene is uvrC

Identifier: 17545790

GI number: 17545790

Start: 1123491

End: 1125455

Strand: Direct

Name: uvrC

Synonym: RSc1071

Alternate gene names: 17545790

Gene position: 1123491-1125455 (Clockwise)

Preceding gene: 17545787

Following gene: 17545791

Centisome position: 30.23

GC content: 69.57

Gene sequence:

>1965_bases
GTGCCGCCACCGGGCGCCCAGACGCCACCCGCACCCGCCGTCGACCCGAGCGAGGCGGCTTTCGATGCCAAGGCCCACAT
CGCCCGCCTGCCCAGCCTGCCGGGCGTCTACCGCTACTTCGATGCGCAGGGCAGCGTGCTCTACGTCGGGAAGGCACGCG
ATCTGAAGAAGCGCGTCTCGAGCTATTTCACCAAGACGCTGCTGTCGCCGCGCATCGCGATGATGGTGGCGAAGATCGCG
CATATCGAGACCACCGTGGTGCGCAGCGAGGCCGAGGCGCTGCTGCTGGAGAACAACCTGATCAAGGCGCTGGCGCCGCG
CTACAACATCCTGTTCCGCGACGACAAGTCGTACCCCTACCTGAAGCTCACGCAGCATGCGTATCCGCGCATGGCGTACT
ACCGCGGCGCGACCGATCGCAAGCACCAGTACTTCGGCCCGTTCCCGAGCGCGCATGCGGTGCGCGAGAGCATGCAGATC
CTGCAGAAGGTGTTCCAGCTGCGCACGTGCGAGGACACGGTGTTCAATAACCGCACGCGGCCGTGCCTGCTGCACCAGAT
CCACCGCTGCACCGCCCCATGCGTGCAGGCGATCAGCGCGGAAGACTATGCCCGCGACGTGGCCAACGCCGCGGGCTTCC
TGCTGGGCCGGCAGGATGAGGTCATGCAGACCCTGCAGGACAAGATGCAGCGGCATGCCGCGGCGCTGGAGTTCGAGCAG
GCCGCGACGGTGCGCGACCAGATCGGGGCACTGTCGACGGTGCTCACGCGGCAGTCGGTGGAGGAGGTCGGCCAGGCCAG
CGATATCGACATCCTCGCCGTGGCGATCAAGGGCGGCCATGCCTGCGTGAACCTGGCGATGGTGCGCGGCGGCCGGCACC
TCGGCGACAAGGCGTACTTTCCGACCCACGTGGAGGAGGGGGCCGCCATCGTCGGCGTGGACGTCGAGGCCGACGTGCCG
GAAGGCGCCGAGACGCAGCCCGAGCCGGCGCGCGATCCCGAGCGTATGGCGCGCGACATTCTCGAGGCCTTCGTCGCGCA
GCATTATCTCGACCAGTTCGTGCCGCCGGTGCTGGTGGTCAGCCACCCGATCCGGGCGGCCGGGCTGATCGAGGCGCTGG
CCGCGCAGGCCGGGCGGCGCGTGTCGGTGGTGCGACAGCCGCAGGGCGCGCGCCGCGCCTGGCTGGAGATGGCGGAGAAG
GGCGCGGAGCTGTCGCTGGCGCGGCGGCTGTCGGAGCAGGGTAGCCAGCAGGCCCGCACGCGCGCGCTGGCCGAGACCAT
CGGCGTCGATCTGGAAGACCTCGCCGCCCTGCGCGTCGAGTGCTTCGACATCAGCCACACCGCCGGCGAGGCGACGCAGG
CATCGTGCGTGGTCTTTCACAGCCACGCCATGCAGAACGGCGAATACCGCCGCTACAACATCCAGGACATCATTCCCGGC
GACGACTACGCCGCCATGCGCCAGGTGCTGACGCGCCGCTACCAGAAGGTGGTCGAGCAGGCCGCCGAGGATGCGCCCGA
CATGCCCCGCGTCGTGCTGATCGACGGCGGCAAGGGGCAGGTGGAAGTGGCGCGCCAAGTCTTCGAGGAGCTGGGGCTGG
ACATTGGCCTGCTGGTCGGCGTGGCCAAGGGCGAAGGCCGCAAGGTCGGTCTGGAGACGCTGGTCTTCGCCGACGGGCGG
CCGTCGCTGGAGTTGGGGCAGGGCAGCGCCGCGCTGATGCTGGTCGCGCAGATTCGCGACGAGGCGCACCGCTTCGCCAT
CACCGGCATGCGCGCCAAGCGGGCCAAGGCGCGCAACACCTCGCGGCTGGAGGAGATCGAAGGCATCGGGGCCAAGCGGC
GGCAGCGGCTGCTGGCGCGCTTTGGCGGCCTGCGCGGCGTGATGGCCGCCAGCGTGGAGGAGCTGGCCACGGTCGAGGGC
ATCTCGCAGACGCTGGCCGAAGAAATCTACCGCCAATTGCACTGA

Upstream 100 bases:

>100_bases
GACATTGTAGTCCGCCGCTTGCTCTACACTTGCAGCCTCCGCCAGCGCGAACGCCATGCCGTCCGACCCCACGCCACCCG
ATTCCCCCGAAGTCCCCGGG

Downstream 100 bases:

>100_bases
TCGGCGACAATGGCCCCTCGTGCCGCGCCGGGGCTGGAACCGCGCGGCGGTTGTCCTGTCGACTAGCCATGCCTTTCAAC
TTCCCGATCCTCCTGACCTG

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 654; Mature: 653

Protein sequence:

>654_residues
MPPPGAQTPPAPAVDPSEAAFDAKAHIARLPSLPGVYRYFDAQGSVLYVGKARDLKKRVSSYFTKTLLSPRIAMMVAKIA
HIETTVVRSEAEALLLENNLIKALAPRYNILFRDDKSYPYLKLTQHAYPRMAYYRGATDRKHQYFGPFPSAHAVRESMQI
LQKVFQLRTCEDTVFNNRTRPCLLHQIHRCTAPCVQAISAEDYARDVANAAGFLLGRQDEVMQTLQDKMQRHAAALEFEQ
AATVRDQIGALSTVLTRQSVEEVGQASDIDILAVAIKGGHACVNLAMVRGGRHLGDKAYFPTHVEEGAAIVGVDVEADVP
EGAETQPEPARDPERMARDILEAFVAQHYLDQFVPPVLVVSHPIRAAGLIEALAAQAGRRVSVVRQPQGARRAWLEMAEK
GAELSLARRLSEQGSQQARTRALAETIGVDLEDLAALRVECFDISHTAGEATQASCVVFHSHAMQNGEYRRYNIQDIIPG
DDYAAMRQVLTRRYQKVVEQAAEDAPDMPRVVLIDGGKGQVEVARQVFEELGLDIGLLVGVAKGEGRKVGLETLVFADGR
PSLELGQGSAALMLVAQIRDEAHRFAITGMRAKRAKARNTSRLEEIEGIGAKRRQRLLARFGGLRGVMAASVEELATVEG
ISQTLAEEIYRQLH

Sequences:

>Translated_654_residues
MPPPGAQTPPAPAVDPSEAAFDAKAHIARLPSLPGVYRYFDAQGSVLYVGKARDLKKRVSSYFTKTLLSPRIAMMVAKIA
HIETTVVRSEAEALLLENNLIKALAPRYNILFRDDKSYPYLKLTQHAYPRMAYYRGATDRKHQYFGPFPSAHAVRESMQI
LQKVFQLRTCEDTVFNNRTRPCLLHQIHRCTAPCVQAISAEDYARDVANAAGFLLGRQDEVMQTLQDKMQRHAAALEFEQ
AATVRDQIGALSTVLTRQSVEEVGQASDIDILAVAIKGGHACVNLAMVRGGRHLGDKAYFPTHVEEGAAIVGVDVEADVP
EGAETQPEPARDPERMARDILEAFVAQHYLDQFVPPVLVVSHPIRAAGLIEALAAQAGRRVSVVRQPQGARRAWLEMAEK
GAELSLARRLSEQGSQQARTRALAETIGVDLEDLAALRVECFDISHTAGEATQASCVVFHSHAMQNGEYRRYNIQDIIPG
DDYAAMRQVLTRRYQKVVEQAAEDAPDMPRVVLIDGGKGQVEVARQVFEELGLDIGLLVGVAKGEGRKVGLETLVFADGR
PSLELGQGSAALMLVAQIRDEAHRFAITGMRAKRAKARNTSRLEEIEGIGAKRRQRLLARFGGLRGVMAASVEELATVEG
ISQTLAEEIYRQLH
>Mature_653_residues
PPPGAQTPPAPAVDPSEAAFDAKAHIARLPSLPGVYRYFDAQGSVLYVGKARDLKKRVSSYFTKTLLSPRIAMMVAKIAH
IETTVVRSEAEALLLENNLIKALAPRYNILFRDDKSYPYLKLTQHAYPRMAYYRGATDRKHQYFGPFPSAHAVRESMQIL
QKVFQLRTCEDTVFNNRTRPCLLHQIHRCTAPCVQAISAEDYARDVANAAGFLLGRQDEVMQTLQDKMQRHAAALEFEQA
ATVRDQIGALSTVLTRQSVEEVGQASDIDILAVAIKGGHACVNLAMVRGGRHLGDKAYFPTHVEEGAAIVGVDVEADVPE
GAETQPEPARDPERMARDILEAFVAQHYLDQFVPPVLVVSHPIRAAGLIEALAAQAGRRVSVVRQPQGARRAWLEMAEKG
AELSLARRLSEQGSQQARTRALAETIGVDLEDLAALRVECFDISHTAGEATQASCVVFHSHAMQNGEYRRYNIQDIIPGD
DYAAMRQVLTRRYQKVVEQAAEDAPDMPRVVLIDGGKGQVEVARQVFEELGLDIGLLVGVAKGEGRKVGLETLVFADGRP
SLELGQGSAALMLVAQIRDEAHRFAITGMRAKRAKARNTSRLEEIEGIGAKRRQRLLARFGGLRGVMAASVEELATVEGI
SQTLAEEIYRQLH

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=643, Percent_Identity=45.8786936236392, Blast_Score=540, Evalue=1e-154,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_RALSO (Q8Y0H3)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_519192.1
- ProteinModelPortal:   Q8Y0H3
- GeneID:   1219880
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc1071
- NMPDR:   fig|267608.1.peg.1071
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   RSOL267608:RSC1071-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 71915; Mature: 71784

Theoretical pI: Translated: 7.48; Mature: 7.48

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPPGAQTPPAPAVDPSEAAFDAKAHIARLPSLPGVYRYFDAQGSVLYVGKARDLKKRVS
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHEECCCCCEEEEECHHHHHHHHH
SYFTKTLLSPRIAMMVAKIAHIETTVVRSEAEALLLENNLIKALAPRYNILFRDDKSYPY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCE
LKLTQHAYPRMAYYRGATDRKHQYFGPFPSAHAVRESMQILQKVFQLRTCEDTVFNNRTR
EEEHHHCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PCLLHQIHRCTAPCVQAISAEDYARDVANAAGFLLGRQDEVMQTLQDKMQRHAAALEFEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
AATVRDQIGALSTVLTRQSVEEVGQASDIDILAVAIKGGHACVNLAMVRGGRHLGDKAYF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCCCCCC
PTHVEEGAAIVGVDVEADVPEGAETQPEPARDPERMARDILEAFVAQHYLDQFVPPVLVV
CCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEC
SHPIRAAGLIEALAAQAGRRVSVVRQPQGARRAWLEMAEKGAELSLARRLSEQGSQQART
CCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
RALAETIGVDLEDLAALRVECFDISHTAGEATQASCVVFHSHAMQNGEYRRYNIQDIIPG
HHHHHHHCCCHHHHHHHHHHHEECCCCCCCCCCCCEEEEEHHHHCCCCEEEECCCCCCCC
DDYAAMRQVLTRRYQKVVEQAAEDAPDMPRVVLIDGGKGQVEVARQVFEELGLDIGLLVG
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEE
VAKGEGRKVGLETLVFADGRPSLELGQGSAALMLVAQIRDEAHRFAITGMRAKRAKARNT
EECCCCCEECCEEEEEECCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCH
SRLEEIEGIGAKRRQRLLARFGGLRGVMAASVEELATVEGISQTLAEEIYRQLH
HHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PPPGAQTPPAPAVDPSEAAFDAKAHIARLPSLPGVYRYFDAQGSVLYVGKARDLKKRVS
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHEECCCCCEEEEECHHHHHHHHH
SYFTKTLLSPRIAMMVAKIAHIETTVVRSEAEALLLENNLIKALAPRYNILFRDDKSYPY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCE
LKLTQHAYPRMAYYRGATDRKHQYFGPFPSAHAVRESMQILQKVFQLRTCEDTVFNNRTR
EEEHHHCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PCLLHQIHRCTAPCVQAISAEDYARDVANAAGFLLGRQDEVMQTLQDKMQRHAAALEFEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
AATVRDQIGALSTVLTRQSVEEVGQASDIDILAVAIKGGHACVNLAMVRGGRHLGDKAYF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCCCCCC
PTHVEEGAAIVGVDVEADVPEGAETQPEPARDPERMARDILEAFVAQHYLDQFVPPVLVV
CCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEC
SHPIRAAGLIEALAAQAGRRVSVVRQPQGARRAWLEMAEKGAELSLARRLSEQGSQQART
CCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
RALAETIGVDLEDLAALRVECFDISHTAGEATQASCVVFHSHAMQNGEYRRYNIQDIIPG
HHHHHHHCCCHHHHHHHHHHHEECCCCCCCCCCCCEEEEEHHHHCCCCEEEECCCCCCCC
DDYAAMRQVLTRRYQKVVEQAAEDAPDMPRVVLIDGGKGQVEVARQVFEELGLDIGLLVG
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEE
VAKGEGRKVGLETLVFADGRPSLELGQGSAALMLVAQIRDEAHRFAITGMRAKRAKARNT
EECCCCCEECCEEEEEECCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCH
SRLEEIEGIGAKRRQRLLARFGGLRGVMAASVEELATVEGISQTLAEEIYRQLH
HHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852