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The map label for this gene is era

Identifier: 17545783

GI number: 17545783

Start: 1117363

End: 1118259

Strand: Direct

Name: era

Synonym: RSc1064

Alternate gene names: 17545783

Gene position: 1117363-1118259 (Clockwise)

Preceding gene: 17545782

Following gene: 17545784

Centisome position: 30.07

GC content: 65.44

Gene sequence:

>897_bases
GTGCCGGAGGGGTTCCGCTGCGGCATGGTCGCCATCGTCGGGCGGCCGAACGTCGGCAAGTCCACGCTGATGAACGCCCT
GGTGGGCCAGAAAGTCAGCATCACGTCGCGCAAGGCGCAGACTACGCGCCATCGCATCACCGGCATCCAGACCACCGACG
ATGCGCAGTTCGTCTTCGTCGATACGCCGGGCTTCCAGACACGGCATGCCACCGCGCTCAACCGCTCGCTGAACCGCGCC
GTCACGTCGACCCTGACGTCGGTCGACGCGGTGCTGTTCGTGGTCGAGGCCGGGCGCTACGGTCCGGACGATGCGAAGGT
CCTGTCGCTGCTGCCGCGCGAGACGCCCGTGATCCTGATCGTCAACAAGGTCGACCGGCTCGATGCGTACACGCGCGCCG
AGATGGTCGCCGTGTTCCTGCAGGAGATGGCGCAAGTGTTTCCGTTCAAGGAAATCGTGCCAATGTCGGCCAAGAACCGG
GACGACATCCTGCGGCTGCTCGGCATCGTCCGGCCGTACCTGCCCGAAGGCGAGCCGATGTATGACCCGGAGGCTCTGAC
GGACCGCAGCGAGCGGTTCCTGGCCGCCGAGATCGTCCGCGAGAAGGTGTTCCGCTGGACGGGCGACGAGTTGCCGTATT
CGAGCACCGTCGTGGTCGACAAGTTCGAGACCGAGGGCCGCCTGCGGCGCGTGTTCGTCACCATCCTGGTGGATCGCGAC
GCGCACAAGGCGATGATCATCGGTGCCAAGGGCGCCAAGCTCAAGCAGATCTCCACCGAAGCCCGCATGGACATGGAAAA
GCTGTTCGACGGCAAGGTCTACCTGGAGGTCTGGGTCAAGGTCAAGAGCGGCTGGGCCGACAACGAGGCCGGTCTGCGCG
CCTACGGCTACGAATAG

Upstream 100 bases:

>100_bases
GCAAGCAGGCCACGCCGCCGGATCCGCAGTTGTCTCTCAGGTTGAAGGAATGACCGACACCCCATTGCAGCCTCCGCAGC
CGCCGCAGTCACTCCCCGGC

Downstream 100 bases:

>100_bases
CCTTTCCCACGCACGCGTCGATGGCGGGACGATCCGATCCGATTCCGGACGAGGCGGCGGAATGGCTGGCCGAGGAGGGC
GTTGCCGGCGCCGCGCCGCG

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MPEGFRCGMVAIVGRPNVGKSTLMNALVGQKVSITSRKAQTTRHRITGIQTTDDAQFVFVDTPGFQTRHATALNRSLNRA
VTSTLTSVDAVLFVVEAGRYGPDDAKVLSLLPRETPVILIVNKVDRLDAYTRAEMVAVFLQEMAQVFPFKEIVPMSAKNR
DDILRLLGIVRPYLPEGEPMYDPEALTDRSERFLAAEIVREKVFRWTGDELPYSSTVVVDKFETEGRLRRVFVTILVDRD
AHKAMIIGAKGAKLKQISTEARMDMEKLFDGKVYLEVWVKVKSGWADNEAGLRAYGYE

Sequences:

>Translated_298_residues
MPEGFRCGMVAIVGRPNVGKSTLMNALVGQKVSITSRKAQTTRHRITGIQTTDDAQFVFVDTPGFQTRHATALNRSLNRA
VTSTLTSVDAVLFVVEAGRYGPDDAKVLSLLPRETPVILIVNKVDRLDAYTRAEMVAVFLQEMAQVFPFKEIVPMSAKNR
DDILRLLGIVRPYLPEGEPMYDPEALTDRSERFLAAEIVREKVFRWTGDELPYSSTVVVDKFETEGRLRRVFVTILVDRD
AHKAMIIGAKGAKLKQISTEARMDMEKLFDGKVYLEVWVKVKSGWADNEAGLRAYGYE
>Mature_297_residues
PEGFRCGMVAIVGRPNVGKSTLMNALVGQKVSITSRKAQTTRHRITGIQTTDDAQFVFVDTPGFQTRHATALNRSLNRAV
TSTLTSVDAVLFVVEAGRYGPDDAKVLSLLPRETPVILIVNKVDRLDAYTRAEMVAVFLQEMAQVFPFKEIVPMSAKNRD
DILRLLGIVRPYLPEGEPMYDPEALTDRSERFLAAEIVREKVFRWTGDELPYSSTVVVDKFETEGRLRRVFVTILVDRDA
HKAMIIGAKGAKLKQISTEARMDMEKLFDGKVYLEVWVKVKSGWADNEAGLRAYGYE

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain

Homologues:

Organism=Homo sapiens, GI24307899, Length=333, Percent_Identity=26.7267267267267, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1788919, Length=293, Percent_Identity=50.5119453924915, Blast_Score=286, Evalue=1e-78,
Organism=Escherichia coli, GI87082120, Length=174, Percent_Identity=31.0344827586207, Blast_Score=66, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24646434, Length=316, Percent_Identity=25.6329113924051, Blast_Score=81, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ERA_RALSO (Q8Y0I0)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_519185.1
- ProteinModelPortal:   Q8Y0I0
- SMR:   Q8Y0I0
- GeneID:   1219873
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc1064
- NMPDR:   fig|267608.1.peg.1064
- HOGENOM:   HBG561652
- OMA:   AKDWQRD
- ProtClustDB:   PRK00089
- BioCyc:   RSOL267608:RSC1064-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00367
- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PRINTS:   PR00326
- TIGRFAMs:   TIGR00436
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1; SSF54814 KH_prok

EC number: NA

Molecular weight: Translated: 33433; Mature: 33302

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEGFRCGMVAIVGRPNVGKSTLMNALVGQKVSITSRKAQTTRHRITGIQTTDDAQFVFV
CCCCCEECEEEEECCCCCCHHHHHHHHHCCCEEECHHHHHHHHHHHCCCEECCCCEEEEE
DTPGFQTRHATALNRSLNRAVTSTLTSVDAVLFVVEAGRYGPDDAKVLSLLPRETPVILI
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHCCCCCCEEEE
VNKVDRLDAYTRAEMVAVFLQEMAQVFPFKEIVPMSAKNRDDILRLLGIVRPYLPEGEPM
EECCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCC
YDPEALTDRSERFLAAEIVREKVFRWTGDELPYSSTVVVDKFETEGRLRRVFVTILVDRD
CCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHEEEEEEEEECCC
AHKAMIIGAKGAKLKQISTEARMDMEKLFDGKVYLEVWVKVKSGWADNEAGLRAYGYE
CCEEEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCCCCCCCCCEECCCC
>Mature Secondary Structure 
PEGFRCGMVAIVGRPNVGKSTLMNALVGQKVSITSRKAQTTRHRITGIQTTDDAQFVFV
CCCCEECEEEEECCCCCCHHHHHHHHHCCCEEECHHHHHHHHHHHCCCEECCCCEEEEE
DTPGFQTRHATALNRSLNRAVTSTLTSVDAVLFVVEAGRYGPDDAKVLSLLPRETPVILI
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHCCCCCCEEEE
VNKVDRLDAYTRAEMVAVFLQEMAQVFPFKEIVPMSAKNRDDILRLLGIVRPYLPEGEPM
EECCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCC
YDPEALTDRSERFLAAEIVREKVFRWTGDELPYSSTVVVDKFETEGRLRRVFVTILVDRD
CCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHEEEEEEEEECCC
AHKAMIIGAKGAKLKQISTEARMDMEKLFDGKVYLEVWVKVKSGWADNEAGLRAYGYE
CCEEEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCCCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11823852