Click here to switch to the map view.

The map label for this gene is rnc

Identifier: 17545782

GI number: 17545782

Start: 1116545

End: 1117315

Strand: Direct

Name: rnc

Synonym: RSc1063

Alternate gene names: 17545782

Gene position: 1116545-1117315 (Clockwise)

Preceding gene: 17545781

Following gene: 17545783

Centisome position: 30.04

GC content: 64.72

Gene sequence:

>771_bases
ATGAGTCTGGAAGCATTGCAGCAACGCCTTGGCTATCGCTTCAGCAAACCGGAGTTGCTGCAGCAGGCGCTCACGCATCG
CAGCCACAACGCGATGCACAACGAGCGCCTGGAATTTCTCGGCGATTCGATCCTGAATTGCGCCGTGGCGGACATGCTCT
ATGGCATGTTCGGCAAGCTGGACGAGGGCGATCTGTCGCGCGTGCGGGCCAATCTGGTCAAGCAGCAGGCGCTGTACGAG
ATCGCGCAGATGCTGCTGTTGCCGGACGAGCTGCGCCTGGGCGAGGGCGAGCTCAAGAGCGGTGGGTTTCGCCGGCCGTC
GATCCTGGCCGATGCGCTGGAGGCGATCTTCGGCGCGGTGTTCCTCGATGGCGGCTTCGATGCGGCTCGTACCCTGATCC
GCAAGCTGTACATCCCGATCCTGGAGCAGGTCGATCCGCGCACGTTGGGCAAGGACGCCAAGACGCTGCTGCAGGAGTAT
CTCCAGGGTCATAAAATCGCGCTGCCGCAATACGCCGTGGTGGCCACGCACGGCGCGGCGCATAATCAGCAGTTCGAGGT
CGAGTGCACGATCCCGAAGCTGGAGATCCGTGTCTCCGGCAGCGGGGCATCGCGGCGCGCGGCCGAGCAGTCGGCGGCCA
AGCTGGCCCTGGAAGAAGCGCATCGCCTGGTGCCGCAGCTCGTCAAGCGCAGCCGCGCCGAGCGCACCGGCAAGACGCGC
AAGCAGGCCACGCCGCCGGATCCGCAGTTGTCTCTCAGGTTGAAGGAATGA

Upstream 100 bases:

>100_bases
ACGGCTCGGTGCAGATGGTACGGTTCTCCTACAAGCGTGAAGTGCCGCTGTACGGCCCGCTTGCCTTGCTGATCACCTAT
TCGGGGTCGCAGCGCTGAAC

Downstream 100 bases:

>100_bases
CCGACACCCCATTGCAGCCTCCGCAGCCGCCGCAGTCACTCCCCGGCGTGCCGGAGGGGTTCCGCTGCGGCATGGTCGCC
ATCGTCGGGCGGCCGAACGT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MSLEALQQRLGYRFSKPELLQQALTHRSHNAMHNERLEFLGDSILNCAVADMLYGMFGKLDEGDLSRVRANLVKQQALYE
IAQMLLLPDELRLGEGELKSGGFRRPSILADALEAIFGAVFLDGGFDAARTLIRKLYIPILEQVDPRTLGKDAKTLLQEY
LQGHKIALPQYAVVATHGAAHNQQFEVECTIPKLEIRVSGSGASRRAAEQSAAKLALEEAHRLVPQLVKRSRAERTGKTR
KQATPPDPQLSLRLKE

Sequences:

>Translated_256_residues
MSLEALQQRLGYRFSKPELLQQALTHRSHNAMHNERLEFLGDSILNCAVADMLYGMFGKLDEGDLSRVRANLVKQQALYE
IAQMLLLPDELRLGEGELKSGGFRRPSILADALEAIFGAVFLDGGFDAARTLIRKLYIPILEQVDPRTLGKDAKTLLQEY
LQGHKIALPQYAVVATHGAAHNQQFEVECTIPKLEIRVSGSGASRRAAEQSAAKLALEEAHRLVPQLVKRSRAERTGKTR
KQATPPDPQLSLRLKE
>Mature_255_residues
SLEALQQRLGYRFSKPELLQQALTHRSHNAMHNERLEFLGDSILNCAVADMLYGMFGKLDEGDLSRVRANLVKQQALYEI
AQMLLLPDELRLGEGELKSGGFRRPSILADALEAIFGAVFLDGGFDAARTLIRKLYIPILEQVDPRTLGKDAKTLLQEYL
QGHKIALPQYAVVATHGAAHNQQFEVECTIPKLEIRVSGSGASRRAAEQSAAKLALEEAHRLVPQLVKRSRAERTGKTRK
QATPPDPQLSLRLKE

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=245, Percent_Identity=28.1632653061224, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI155030236, Length=245, Percent_Identity=28.1632653061224, Blast_Score=82, Evalue=4e-16,
Organism=Escherichia coli, GI1788920, Length=206, Percent_Identity=52.4271844660194, Blast_Score=210, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI17506883, Length=231, Percent_Identity=30.7359307359307, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI193202651, Length=231, Percent_Identity=30.7359307359307, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323895, Length=120, Percent_Identity=32.5, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17137682, Length=244, Percent_Identity=29.5081967213115, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_RALSO (Q8Y0I1)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_519184.1
- ProteinModelPortal:   Q8Y0I1
- SMR:   Q8Y0I1
- GeneID:   1219872
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc1063
- NMPDR:   fig|267608.1.peg.1063
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- ProtClustDB:   PRK00102
- BioCyc:   RSOL267608:RSC1063-MONOMER
- BRENDA:   3.1.26.3
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 28502; Mature: 28371

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLEALQQRLGYRFSKPELLQQALTHRSHNAMHNERLEFLGDSILNCAVADMLYGMFGKL
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DEGDLSRVRANLVKQQALYEIAQMLLLPDELRLGEGELKSGGFRRPSILADALEAIFGAV
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FLDGGFDAARTLIRKLYIPILEQVDPRTLGKDAKTLLQEYLQGHKIALPQYAVVATHGAA
HHCCCHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCC
HNQQFEVECTIPKLEIRVSGSGASRRAAEQSAAKLALEEAHRLVPQLVKRSRAERTGKTR
CCCEEEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KQATPPDPQLSLRLKE
CCCCCCCCCEEEEECC
>Mature Secondary Structure 
SLEALQQRLGYRFSKPELLQQALTHRSHNAMHNERLEFLGDSILNCAVADMLYGMFGKL
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DEGDLSRVRANLVKQQALYEIAQMLLLPDELRLGEGELKSGGFRRPSILADALEAIFGAV
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FLDGGFDAARTLIRKLYIPILEQVDPRTLGKDAKTLLQEYLQGHKIALPQYAVVATHGAA
HHCCCHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCC
HNQQFEVECTIPKLEIRVSGSGASRRAAEQSAAKLALEEAHRLVPQLVKRSRAERTGKTR
CCCEEEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KQATPPDPQLSLRLKE
CCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852