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The map label for this gene is parC [H]

Identifier: 17545697

GI number: 17545697

Start: 1027781

End: 1030126

Strand: Direct

Name: parC [H]

Synonym: RSc0978

Alternate gene names: 17545697

Gene position: 1027781-1030126 (Clockwise)

Preceding gene: 17545696

Following gene: 17545698

Centisome position: 27.66

GC content: 69.48

Gene sequence:

>2346_bases
ATGGAACAACAAGACATCCTCTTCGACCCCCGCGAGCCGGCCGAAGCGCTCACGCTCGCGCACTACGCCGAGCGCGCGTA
CCTGGACTATGCCGTCAGCGTGGTCAAGGGCCGTGCGCTGCCCGAGGTGGCCGACGGCCAGAAGCCGGTGCAGCGCCGCA
TCCTGTTCGCGATGCACGAGATGGGCCTGCGCGCCGATGCCAAGCCGGTGAAGTCGGCGCGCGTGGTCGGCGACGTGCTC
GGCAAGTACCACCCGCACGGCGACCAGTCGGCGTACGACGCGCTGGTGCGCCTGGCGCAGGACTTCTCGCTGCGCTACCC
GCTGATCGACGGCCAGGGCAACTTCGGCTCGCGCGACGGCGACGGCGCGGCGGCCATGCGCTACACCGAAGCGCGCCTGA
CGCCGATCTCGCGCCTGCTGCTCGAGGAACTCGACCAGGGCACGGTCGACTTCATCCCCAACTACGACGGCTCGATGGAT
GAGCCCAGGCTGCTGCCGGCGCGGCTGCCGTTCGTGCTGCTCAACGGCGCATCGGGCATCGCCGTGGGCATGGCGACGGA
GATCCCCTCGCACAACCTGCGCGAAGTGGCCACCGCCGCCGTGGCGCTGATCCGCGACGACAAGCTCACCAGCACCGACC
TGATGCAGTACATGCCGGGGCCGGACTTTCCGGGCGGCGGGCAGATCATCTCGTCGGCGGCGGACATCGCGCAGATCTAC
GAGACCGGGCGCGGCAGCCTGAAGGTGCGCGCGCGCTGGAAGATCGAAGACCTCGCGCGCGGCCAGTGGCAACTGGTGGT
GACGGAGCTGCCGCCCAACACCTCGTCGCAGAAGGTGCTGGAGGAGATCGAGGAGCTGACCAACCCGAAGGTGCGCGCCG
GCAAGAAGTCGCTGACGCCGGAACAGCTGCAGCTCAAGCAGACCCTGCTCGGCCTGCTCGACGCGGTGCGCGACGAGTCG
GGCAAGGACGCGCCGGTGCGGTTGGTGTTCGAGCCCAAGAGCAAGAACATCGGCCAGCAGGAGTTCGCCAACGCGCTGCT
GGCGCATACGTCGCTGGAATCGGGCGCGGCCATCAACCTGGTGATGATCGGCACGGATGGCCGGCCGCGCCAGAAGGGCC
TGCGCGAAATTCTGCGCGAGTGGATCGACTACCGGTTCGCCACGGTCACGCGCCGCACGCGCCATCGCCTGGGCAAGGTG
GAGGACCGCATCCACATCCTCGAAGGGCGGCAACTGGTGCTGCTCAACATCGACGAGGTGATCCGCATCATCCGCGAGAG
CGACGAGCCCAAGCCGGCGCTGATGCAGGCGTTCGGCCTCTCCGAGCGCCAGGCCGAGGACATCCTGGAAATCCGTCTGC
GCCAATTGGCGCGGCTGGAGGCCATCAAGATCGAGCAGGAGCTGAAGGACCTGCGCGAGGAGCAGGCCGAGCTGGACGTG
CTGCTGAAGTCCGAGACCATGATGCGCCGCCGCATCGTCAAGGAGATCGAGACCGACGCCAAGCAGTTCGGCGACGACCG
CCGCACGCTGATCCAGGAAGAGCGCCGCGCCGCCGCCGAGGTGAAGGTGGTCGACGAGCCCGTCACCGTGATCGTCTCGC
AGAAGGGCTGGGTGCGCACGCGCCAGGGCCATGGCCACGACGCCACCCAGTTCGGCTTCAAGGCGGGCGACACGCTGTAC
GACACCTTCGAGTGCCGCACCACCGACGCGCTGCTGATCTTCGGCACGCGCGACGACAAGGGCACGGGCCGGGTCTACTC
GGTGGCGGTGGCCAACCTGCCGGGCGGCCGCGGCGACGGTGTGCCGCTGACCACGCTGATCGAACTGGCGCCGGGCACGC
ACATCGCGCATACCCTGGCGAGCCACGCCGAGCAGAACGTGCTGATCTCCACGCAAGGGGGCAACGGCTTCCTGGCCAAG
GTGGGCGACATGGTGGGCCGCCAGAAGGGCGGCAAGGCTTTCCTCACGCTCGATGAGGGCGATCAGCCCAACAAGCCGGC
CGCCGTGCCGGAAGACGCCTATGGCGCGGCCTGCCTGTCGGCGAACGGCCGCCTGCTGCTGTTCCCGCTGGCGGAGGTGA
AGACGCTGGCCAGCGGCGGCCGCGGTGTGATCCTGATGGAGCTGGAGAAGAACGAGACGCTCGCGCAGGCGCTGGCCTTC
GGGCCGGCCGGGTTCGTGGTGTCGGGCGCTGGCCCGCGCAGCGGCAAGGCGACCGAACAGACGTTCACGACGACCCGCGC
GCAGGAGCCGTACGCCGGCAAGCGCGCGCGCAAGGGCCGGGCGATCGAGCCCAAGCTGCGCGACCCGCAGCTGGCGTTGC
CCAAGCCCGCACCCGCCGCGGCCTGA

Upstream 100 bases:

>100_bases
CGGCCGAGGCGCATCGAACTGGTGCTGCCGGCCCCTTCACAAGAACATTGATCCAGCGGCGCCATCCACACGGTCGCGCG
CCGCTTTCGCCTGAGCCCCC

Downstream 100 bases:

>100_bases
GTCCGATGGGCGAGCGCAACCCTCCCGCAGACGCGATGGCCGCCGGGCGCGCCGCGCCGGCGCCTTCGTGCACCAAGCTC
TTCACGGAGTTTGCGCGCAT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 781; Mature: 781

Protein sequence:

>781_residues
MEQQDILFDPREPAEALTLAHYAERAYLDYAVSVVKGRALPEVADGQKPVQRRILFAMHEMGLRADAKPVKSARVVGDVL
GKYHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPISRLLLEELDQGTVDFIPNYDGSMD
EPRLLPARLPFVLLNGASGIAVGMATEIPSHNLREVATAAVALIRDDKLTSTDLMQYMPGPDFPGGGQIISSAADIAQIY
ETGRGSLKVRARWKIEDLARGQWQLVVTELPPNTSSQKVLEEIEELTNPKVRAGKKSLTPEQLQLKQTLLGLLDAVRDES
GKDAPVRLVFEPKSKNIGQQEFANALLAHTSLESGAAINLVMIGTDGRPRQKGLREILREWIDYRFATVTRRTRHRLGKV
EDRIHILEGRQLVLLNIDEVIRIIRESDEPKPALMQAFGLSERQAEDILEIRLRQLARLEAIKIEQELKDLREEQAELDV
LLKSETMMRRRIVKEIETDAKQFGDDRRTLIQEERRAAAEVKVVDEPVTVIVSQKGWVRTRQGHGHDATQFGFKAGDTLY
DTFECRTTDALLIFGTRDDKGTGRVYSVAVANLPGGRGDGVPLTTLIELAPGTHIAHTLASHAEQNVLISTQGGNGFLAK
VGDMVGRQKGGKAFLTLDEGDQPNKPAAVPEDAYGAACLSANGRLLLFPLAEVKTLASGGRGVILMELEKNETLAQALAF
GPAGFVVSGAGPRSGKATEQTFTTTRAQEPYAGKRARKGRAIEPKLRDPQLALPKPAPAAA

Sequences:

>Translated_781_residues
MEQQDILFDPREPAEALTLAHYAERAYLDYAVSVVKGRALPEVADGQKPVQRRILFAMHEMGLRADAKPVKSARVVGDVL
GKYHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPISRLLLEELDQGTVDFIPNYDGSMD
EPRLLPARLPFVLLNGASGIAVGMATEIPSHNLREVATAAVALIRDDKLTSTDLMQYMPGPDFPGGGQIISSAADIAQIY
ETGRGSLKVRARWKIEDLARGQWQLVVTELPPNTSSQKVLEEIEELTNPKVRAGKKSLTPEQLQLKQTLLGLLDAVRDES
GKDAPVRLVFEPKSKNIGQQEFANALLAHTSLESGAAINLVMIGTDGRPRQKGLREILREWIDYRFATVTRRTRHRLGKV
EDRIHILEGRQLVLLNIDEVIRIIRESDEPKPALMQAFGLSERQAEDILEIRLRQLARLEAIKIEQELKDLREEQAELDV
LLKSETMMRRRIVKEIETDAKQFGDDRRTLIQEERRAAAEVKVVDEPVTVIVSQKGWVRTRQGHGHDATQFGFKAGDTLY
DTFECRTTDALLIFGTRDDKGTGRVYSVAVANLPGGRGDGVPLTTLIELAPGTHIAHTLASHAEQNVLISTQGGNGFLAK
VGDMVGRQKGGKAFLTLDEGDQPNKPAAVPEDAYGAACLSANGRLLLFPLAEVKTLASGGRGVILMELEKNETLAQALAF
GPAGFVVSGAGPRSGKATEQTFTTTRAQEPYAGKRARKGRAIEPKLRDPQLALPKPAPAAA
>Mature_781_residues
MEQQDILFDPREPAEALTLAHYAERAYLDYAVSVVKGRALPEVADGQKPVQRRILFAMHEMGLRADAKPVKSARVVGDVL
GKYHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPISRLLLEELDQGTVDFIPNYDGSMD
EPRLLPARLPFVLLNGASGIAVGMATEIPSHNLREVATAAVALIRDDKLTSTDLMQYMPGPDFPGGGQIISSAADIAQIY
ETGRGSLKVRARWKIEDLARGQWQLVVTELPPNTSSQKVLEEIEELTNPKVRAGKKSLTPEQLQLKQTLLGLLDAVRDES
GKDAPVRLVFEPKSKNIGQQEFANALLAHTSLESGAAINLVMIGTDGRPRQKGLREILREWIDYRFATVTRRTRHRLGKV
EDRIHILEGRQLVLLNIDEVIRIIRESDEPKPALMQAFGLSERQAEDILEIRLRQLARLEAIKIEQELKDLREEQAELDV
LLKSETMMRRRIVKEIETDAKQFGDDRRTLIQEERRAAAEVKVVDEPVTVIVSQKGWVRTRQGHGHDATQFGFKAGDTLY
DTFECRTTDALLIFGTRDDKGTGRVYSVAVANLPGGRGDGVPLTTLIELAPGTHIAHTLASHAEQNVLISTQGGNGFLAK
VGDMVGRQKGGKAFLTLDEGDQPNKPAAVPEDAYGAACLSANGRLLLFPLAEVKTLASGGRGVILMELEKNETLAQALAF
GPAGFVVSGAGPRSGKATEQTFTTTRAQEPYAGKRARKGRAIEPKLRDPQLALPKPAPAAA

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=370, Percent_Identity=27.027027027027, Blast_Score=101, Evalue=3e-21,
Organism=Homo sapiens, GI19913406, Length=167, Percent_Identity=35.3293413173653, Blast_Score=96, Evalue=2e-19,
Organism=Escherichia coli, GI1789396, Length=756, Percent_Identity=44.5767195767196, Blast_Score=613, Evalue=1e-176,
Organism=Escherichia coli, GI1788562, Length=799, Percent_Identity=36.2953692115144, Blast_Score=401, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17535065, Length=173, Percent_Identity=37.5722543352601, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI212645657, Length=187, Percent_Identity=33.1550802139037, Blast_Score=91, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI212645845, Length=395, Percent_Identity=26.5822784810127, Blast_Score=90, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI115534553, Length=169, Percent_Identity=33.7278106508876, Blast_Score=87, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324241, Length=248, Percent_Identity=30.241935483871, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136538, Length=173, Percent_Identity=34.6820809248555, Blast_Score=96, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 85630; Mature: 85630

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQQDILFDPREPAEALTLAHYAERAYLDYAVSVVKGRALPEVADGQKPVQRRILFAMHE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
MGLRADAKPVKSARVVGDVLGKYHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDG
HCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEECCEECCCCCCCCCCC
DGAAAMRYTEARLTPISRLLLEELDQGTVDFIPNYDGSMDEPRLLPARLPFVLLNGASGI
CCHHHEEEHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECCCCE
AVGMATEIPSHNLREVATAAVALIRDDKLTSTDLMQYMPGPDFPGGGQIISSAADIAQIY
EEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
ETGRGSLKVRARWKIEDLARGQWQLVVTELPPNTSSQKVLEEIEELTNPKVRAGKKSLTP
HCCCCCEEEEEEECHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCHHCCCCCCCH
EQLQLKQTLLGLLDAVRDESGKDAPVRLVFEPKSKNIGQQEFANALLAHTSLESGAAINL
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEE
VMIGTDGRPRQKGLREILREWIDYRFATVTRRTRHRLGKVEDRIHILEGRQLVLLNIDEV
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEECCCEEEEECHHHH
IRIIRESDEPKPALMQAFGLSERQAEDILEIRLRQLARLEAIKIEQELKDLREEQAELDV
HHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLKSETMMRRRIVKEIETDAKQFGDDRRTLIQEERRAAAEVKVVDEPVTVIVSQKGWVRT
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECCCEEEEEECCCCEEE
RQGHGHDATQFGFKAGDTLYDTFECRTTDALLIFGTRDDKGTGRVYSVAVANLPGGRGDG
CCCCCCCHHHCCCCCCCCHHEEEEECCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCCC
VPLTTLIELAPGTHIAHTLASHAEQNVLISTQGGNGFLAKVGDMVGRQKGGKAFLTLDEG
CCHHHHEECCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCCEEEEECCC
DQPNKPAAVPEDAYGAACLSANGRLLLFPLAEVKTLASGGRGVILMELEKNETLAQALAF
CCCCCCCCCCCCCCCCEEECCCCCEEEEEHHHHHHHHCCCCEEEEEEECCCHHHHHHHHC
GPAGFVVSGAGPRSGKATEQTFTTTRAQEPYAGKRARKGRAIEPKLRDPQLALPKPAPAA
CCCCEEEECCCCCCCCCCHHHHHHCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCC
A
C
>Mature Secondary Structure
MEQQDILFDPREPAEALTLAHYAERAYLDYAVSVVKGRALPEVADGQKPVQRRILFAMHE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
MGLRADAKPVKSARVVGDVLGKYHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDG
HCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEECCEECCCCCCCCCCC
DGAAAMRYTEARLTPISRLLLEELDQGTVDFIPNYDGSMDEPRLLPARLPFVLLNGASGI
CCHHHEEEHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECCCCE
AVGMATEIPSHNLREVATAAVALIRDDKLTSTDLMQYMPGPDFPGGGQIISSAADIAQIY
EEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
ETGRGSLKVRARWKIEDLARGQWQLVVTELPPNTSSQKVLEEIEELTNPKVRAGKKSLTP
HCCCCCEEEEEEECHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCHHCCCCCCCH
EQLQLKQTLLGLLDAVRDESGKDAPVRLVFEPKSKNIGQQEFANALLAHTSLESGAAINL
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEE
VMIGTDGRPRQKGLREILREWIDYRFATVTRRTRHRLGKVEDRIHILEGRQLVLLNIDEV
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEECCCEEEEECHHHH
IRIIRESDEPKPALMQAFGLSERQAEDILEIRLRQLARLEAIKIEQELKDLREEQAELDV
HHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLKSETMMRRRIVKEIETDAKQFGDDRRTLIQEERRAAAEVKVVDEPVTVIVSQKGWVRT
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECCCEEEEEECCCCEEE
RQGHGHDATQFGFKAGDTLYDTFECRTTDALLIFGTRDDKGTGRVYSVAVANLPGGRGDG
CCCCCCCHHHCCCCCCCCHHEEEEECCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCCC
VPLTTLIELAPGTHIAHTLASHAEQNVLISTQGGNGFLAKVGDMVGRQKGGKAFLTLDEG
CCHHHHEECCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCCEEEEECCC
DQPNKPAAVPEDAYGAACLSANGRLLLFPLAEVKTLASGGRGVILMELEKNETLAQALAF
CCCCCCCCCCCCCCCCEEECCCCCEEEEEHHHHHHHHCCCCEEEEEEECCCHHHHHHHHC
GPAGFVVSGAGPRSGKATEQTFTTTRAQEPYAGKRARKGRAIEPKLRDPQLALPKPAPAA
CCCCEEEECCCCCCCCCCHHHHHHCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7830580 [H]